Bace1

Summary

Gene Symbol: Bace1
Description: beta-site APP cleaving enzyme 1
Alias: ASP2, Bace, C76936, beta-secretase 1, APP beta-secretase, asp 2, aspartyl protease 2, beta-site amyloid precursor protein cleaving enzyme 1, memapsin-2, membrane-associated aspartic protease 2
Species: mouse
Products:     Bace1

Top Publications

  1. Rabe S, Reichwald J, Ammaturo D, De Strooper B, Saftig P, Neumann U, et al. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. J Neurochem. 2011;119:231-9 pubmed publisher
    Inhibition of ?-secretase (BACE1) is a key therapeutic approach in Alzheimer's disease (AD), as BACE1 initiates amyloid-? (A?) cleavage from the ?-amyloid precursor protein (APP)...
  2. Buggia Prevot V, Fernandez C, Udayar V, Vetrivel K, Elie A, Roseman J, et al. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease A? production. Cell Rep. 2013;5:1552-63 pubmed publisher
    Abnormal accumulation of ?-secretase (BACE1) in dystrophic neurites and presynaptic ?-amyloid (A?) production contribute to Alzheimer's disease pathogenesis. Little, however, is known about BACE1 sorting and dynamic transport in neurons...
  3. Cao L, Rickenbacher G, Rodriguez S, Moulia T, Albers M. The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease. Sci Rep. 2012;2:231 pubmed publisher
    The ?-site amyloid precursor protein cleaving enzyme 1 (BACE1) is necessary to generate the A? peptide, which is implicated in Alzheimer's disease pathology...
  4. Hitt B, JARAMILLO T, Chetkovich D, Vassar R. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener. 2010;5:31 pubmed publisher
    b>BACE1 is a key enzyme in the generation of the Abeta peptide that plays a central role in the pathogenesis of Alzheimer's disease. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown...
  5. Wang H, Song L, Laird F, Wong P, Lee H. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. J Neurosci. 2008;28:8677-81 pubmed publisher
    beta-Amyloid precursor protein cleavage enzyme 1 (BACE1) has been identified as a major neuronal beta-secretase critical for the formation of beta-amyloid (Abeta) peptide, which is thought responsible for the pathology of Alzheimer's ..
  6. Yan R, Bienkowski M, Shuck M, Miao H, Tory M, Pauley A, et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature. 1999;402:533-7 pubmed
    ..Here we identify a new membrane-bound aspartyl protease (Asp2) with beta-secretase activity. The Asp2 gene is expressed widely in brain and other tissues...
  7. Wang R, Li J, Diao S, Kwak Y, Liu L, Zhi L, et al. Metabolic stress modulates Alzheimer's ?-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons. Cell Metab. 2013;17:685-94 pubmed publisher
    ..We found increased transcription of ?-secretase/BACE1, the rate-limiting enzyme for A? generation, in eNOS-deficient mouse brains and after feeding mice a high-fat, ..
  8. Sachse C, Kim Y, Agsten M, Huth T, Alzheimer C, Kovacs D, et al. BACE1 and presenilin/?-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. FASEB J. 2013;27:2458-67 pubmed publisher
    b>BACE1 and presenilin (PS)/?-secretase play a major role in Alzheimer's disease pathogenesis by regulating amyloid-? peptide generation...
  9. Hitt B, Riordan S, Kukreja L, Eimer W, Rajapaksha T, Vassar R. ?-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J Biol Chem. 2012;287:38408-25 pubmed publisher
    b>BACE1 is the ?-secretase enzyme that initiates production of the ?-amyloid peptide involved in Alzheimer disease. However, little is known about the functions of BACE1...

More Information

Publications61

  1. Kim D, Carey B, Wang H, Ingano L, Binshtok A, Wertz M, et al. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol. 2007;9:755-64 pubmed
    b>BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration...
  2. Willem M, Garratt A, Novak B, Citron M, Kaufmann S, Rittger A, et al. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. 2006;314:664-6 pubmed
    Although BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is essential for the generation of amyloid-b peptide in Alzheimer's disease, its physiological function is unclear...
  3. Deng M, He W, Tan Y, Han H, Hu X, Xia K, et al. Increased expression of reticulon 3 in neurons leads to reduced axonal transport of ? site amyloid precursor protein-cleaving enzyme 1. J Biol Chem. 2013;288:30236-45 pubmed publisher
    b>BACE1 is the sole enzyme responsible for cleaving amyloid precursor protein at the ?-secretase site, and this cleavage initiates the generation of ?-amyloid peptide (A?)...
  4. Ohno M, Sametsky E, Younkin L, Oakley H, Younkin S, Citron M, et al. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 2004;41:27-33 pubmed
    beta-site APP cleaving enzyme 1 (BACE1) is the beta-secretase enzyme required for generating pathogenic beta-amyloid (Abeta) peptides in Alzheimer's disease (AD)...
  5. Devi L, Ohno M. Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice. Eur J Neurosci. 2010;31:110-8 pubmed publisher
    ..that were genetically engineered to have reduced levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) (BACE1(+/-).5XFAD) exhibited improved CTA memory, which was equivalent to the performance of wild-type controls...
  6. Zhang X, Zhou K, Wang R, Cui J, Lipton S, Liao F, et al. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem. 2007;282:10873-80 pubmed
    ..is derived from the beta-amyloid precursor protein (APP) by sequential proteolytic cleavages from beta-secretase (BACE1) and presenilin-1 (PS1)/gamma-secretase, is widely believed to trigger a cascade of pathological events ..
  7. Pastorino L, Ikin A, Lamprianou S, Vacaresse N, Revelli J, Platt K, et al. BACE (beta-secretase) modulates the processing of APLP2 in vivo. Mol Cell Neurosci. 2004;25:642-9 pubmed
    b>BACE is an aspartyl protease that cleaves the amyloid precursor protein (APP) at the beta-secretase cleavage site and is involved in Alzheimer's disease...
  8. Chang W, Downs D, Huang X, Da H, Fung K, Tang J. Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization. FASEB J. 2007;21:3184-96 pubmed
    b>Memapsin 2 (beta-secretase, BACE1) is the protease that initiates cleavage of beta-amyloid precursor protein leading to the production of amyloid-beta (Abeta) and the onset of Alzheimer's disease (AD)...
  9. Walker K, Kang E, Whalen M, Shen Y, Tesco G. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 2012;32:10423-37 pubmed publisher
    ..However, the underlying molecular mechanisms remain unknown. We report here that the BACE1 interacting protein, GGA3, is depleted while BACE1 levels increase in the acute phase after injury (48 h) in a ..
  10. Savonenko A, Melnikova T, Laird F, Stewart K, Price D, Wong P. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A. 2008;105:5585-90 pubmed publisher
    beta-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-beta precursor protein (APP) leading to the generation of amyloid-beta peptides that is central to the pathogenesis of Alzheimer's disease...
  11. Kang E, Cameron A, Piazza F, Walker K, Tesco G. Ubiquitin regulates GGA3-mediated degradation of BACE1. J Biol Chem. 2010;285:24108-19 pubmed publisher
    b>BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of beta-amyloid, a toxic peptide that accumulates in the brain of subjects affected by ..
  12. Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, et al. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 2009;12:1506-13 pubmed publisher
    ..On the basis of these data, we propose that NRDc regulates axonal maturation and myelination in the CNS and PNS, in part, through the modulation of NRG1 shedding. ..
  13. Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, et al. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. J Biol Chem. 2012;287:25927-40 pubmed publisher
    The ?-site amyloid precursor protein-cleaving enzyme BACE1 is a prime drug target for Alzheimer disease. However, the function and the physiological substrates of BACE1 remain largely unknown...
  14. Kuhn P, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, et al. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J. 2012;31:3157-68 pubmed publisher
    ..SPECS identified 34, mostly novel substrates of the Alzheimer protease BACE1 in primary neurons, making BACE1 a major sheddase in the nervous system...
  15. Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, et al. ?-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med. 2012;4:980-91 pubmed publisher
    Secretase (BACE1) is a major drug target for combating Alzheimer's disease (AD)...
  16. Cai H, Wang Y, McCarthy D, Wen H, Borchelt D, Price D, et al. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci. 2001;4:233-4 pubmed
  17. Vassar R, Bennett B, Babu Khan S, Kahn S, Mendiaz E, Denis P, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286:735-41 pubmed
    ..Overexpression of this protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were ..
  18. Boissonneault V, Plante I, Rivest S, Provost P. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem. 2009;284:1971-81 pubmed publisher
    ..Here we also observed a loss of correlation between BACE1 mRNA and protein levels in the hippocampus of a mouse model of AD...
  19. Kuhn P, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler S. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem. 2007;282:11982-95 pubmed
    ..Surprisingly, the beta-secretase BACE1 and its homolog BACE2 increased IL-1R2 secretion resulting in C-terminal fragments nearly identical to the ones ..
  20. Tan J, Li Q, Ciccotosto G, Crouch P, Culvenor J, White A, et al. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein. PLoS ONE. 2013;8:e61246 pubmed publisher
    b>BACE1 is responsible for ?-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid ? (A?) peptides...
  21. Cole S, Vassar R. The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology. J Biol Chem. 2008;283:29621-5 pubmed publisher
    ..Abeta generation is initiated by proteolysis of amyloid precursor protein (APP) by the beta-secretase enzyme BACE1. Bace1 knockout (Bace1(-/-)) mice have validated BACE1 as the authentic beta-secretase in vivo...
  22. Sadleir K, Vassar R. Cdk5 protein inhibition and A?42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease. J Biol Chem. 2012;287:7224-35 pubmed publisher
    The ?-secretase enzyme BACE1 initiates production of the amyloid-? (A?) peptide that comprises plaques in Alzheimer disease (AD) brain...
  23. Luo Y, Bolon B, Damore M, Fitzpatrick D, Liu H, Zhang J, et al. BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol Dis. 2003;14:81-8 pubmed
    ..Abeta peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme beta-secretase (BACE1); inhibition of this cleavage has been proposed as a means of treating Alzheimer's disease...
  24. Rajapaksha T, Eimer W, BOZZA T, Vassar R. The Alzheimer's ?-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb. Mol Neurodegener. 2011;6:88 pubmed publisher
    The ?-secretase, ?-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral ?-amyloid (A?) levels in Alzheimer's disease (AD)...
  25. Wang H, Song L, Lee A, Laird F, Wong P, Lee H. Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. J Neurosci. 2010;30:13808-13 pubmed publisher
    Site amyloid precursor protein-cleaving enzyme 1 (BACE1)-the neuronal ?-secretase responsible for producing ?-amyloid (A?) peptides-emerged as one of the key therapeutic targets of Alzheimer's disease (AD)...
  26. Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, et al. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005;280:30797-806 pubmed
    Beta-secretase (BACE1) is the rate-limiting protease for the generation of the amyloid beta-peptide (Abeta) in Alzheimer disease. Mice in which the bace1 gene is inactivated are reported to be healthy...
  27. Farah M, Pan B, Hoffman P, Ferraris D, Tsukamoto T, Nguyen T, et al. Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. J Neurosci. 2011;31:5744-54 pubmed publisher
    Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is an aspartyl protease best known for its role in generating the amyloid-? peptides that are present in plaques of Alzheimer's disease...
  28. Sala Frigerio C, Fadeeva J, Minogue A, Citron M, Van Leuven F, Staufenbiel M, et al. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS J. 2010;277:1503-18 pubmed publisher
    ..APP and that is essential for generation of the amyloid beta-protein is the beta-site APP-cleaving enzyme 1 (BACE1)...
  29. Wong H, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, et al. beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem. 2005;280:23009-17 pubmed
    Sequential processing of amyloid precursor protein (APP) by membrane-bound proteases, BACE1 and gamma-secretase, plays a crucial role in the pathogenesis of Alzheimer disease...
  30. Zhang Y, Xiong M, Yan R, Sun F. Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats. J Cereb Blood Flow Metab. 2010;30:566-75 pubmed publisher
    ..have demonstrated that ischemic stroke increases beta-amyloid (Abeta) production by increasing beta-secretase (BACE1) through activation of caspase-3, and stimulates generation of mutant ubiquitin (UBB(+1)) in rat brains...
  31. Wen Y, Yu W, Maloney B, Bailey J, Ma J, Marie I, et al. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 2008;57:680-90 pubmed publisher
    ..Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo...
  32. Hébert S, Horré K, Nicolaï L, Papadopoulou A, Mandemakers W, Silahtaroglu A, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008;105:6415-20 pubmed publisher
    ..Deficiency in Abeta clearance is certainly a possibility, but increased expression of proteins like APP or BACE1/beta-secretase may also be associated with the disease...
  33. Harrison S, Harper A, Hawkins J, Duddy G, Grau E, Pugh P, et al. BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci. 2003;24:646-55 pubmed
    b>BACE1 is a key enzyme in the generation of Abeta, the major component of senile plaques in the brains of Alzheimer's disease patients...
  34. Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, et al. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci. 2008;28:14537-45 pubmed publisher
  35. Zhang X, Cai Y, Xiong K, Cai H, Luo X, Feng J, et al. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci. 2009;30:2271-83 pubmed publisher
    ..The present study attempted to explore plaque pathogenesis by localizing beta-secretase-1 (BACE1) elevation relative to Abeta accumulation and synaptic/neuritic alterations in the forebrain, using transgenic ..
  36. Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert M, Fischer T, Rossner M, et al. Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination. Glia. 2012;60:203-17 pubmed publisher
    ..It has been proposed that the protease BACE1 activates NRG1 dependent myelination...
  37. Hu X, Zhou X, He W, Yang J, Xiong W, Wong P, et al. BACE1 deficiency causes altered neuronal activity and neurodegeneration. J Neurosci. 2010;30:8819-29 pubmed publisher
    b>BACE1 is required for the release of beta-amyloid (Abeta) in vivo, and inhibition of BACE1 activity is targeted for reducing Abeta generation in Alzheimer's patients...
  38. Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein W, et al. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. Eur J Neurosci. 2006;23:251-60 pubmed
    ..Importantly, Tg6799 mice engineered to lack the major Alzheimer's beta-secretase (beta-site APP-cleaving enzyme 1: BACE1) showed behavioral rescue from temporal memory deficits...
  39. Zhou J, Cheng X, Cheng J, Zhou W, Zhang Y. The activity and mRNA expression of ?-secretase, cathepsin D, and cathepsin B in the brain of senescence-accelerated mouse. J Alzheimers Dis. 2012;28:471-80 pubmed publisher
    ..There was a tendency toward decreased mRNA expression of BACE1, cathepsin D, and cathepsin B in the hippocampus of SAMR1 and SAMP8 with aging...
  40. Roberds S, Anderson J, Basi G, Bienkowski M, Branstetter D, Chen K, et al. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001;10:1317-24 pubmed
    ..The gene encoding a beta-secretase for beta-site APP cleaving enzyme (BACE) was identified recently...
  41. Cheret C, Willem M, Fricker F, Wende H, Wulf Goldenberg A, Tahirovic S, et al. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO J. 2013;32:2015-28 pubmed publisher
    The protease ?-secretase 1 (Bace1) was identified through its critical role in production of amyloid-? peptides (A?), the major component of amyloid plaques in Alzheimer's disease...
  42. Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, et al. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A. 2011;108:E559-68 pubmed publisher
    ..are generated through the sequential cleavage of amyloid precursor protein (APP) by ?-site APP cleaving enzyme 1 (BACE1) and ?-secretase...
  43. Bhattacharyya R, Barren C, Kovacs D. Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci. 2013;33:11169-83 pubmed publisher
    ..In later compartments, palmitoylated APP (palAPP) was specifically enriched in lipid rafts. In vitro BACE1 cleavage assays using cell or mouse brain lipid rafts showed that APP palmitoylation enhanced BACE1-mediated ..
  44. McConlogue L, Buttini M, Anderson J, Brigham E, Chen K, Freedman S, et al. Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice. J Biol Chem. 2007;282:26326-34 pubmed
    The aspartyl protease beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates processing of amyloid precursor protein (APP) into amyloid beta (Abeta) peptide, the major component of Alzheimer disease (AD) plaques...
  45. Chen Y, Huang X, Zhang Y, Rockenstein E, Bu G, Golde T, et al. Alzheimer's ?-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of ?-amyloid. J Neurosci. 2012;32:11390-5 pubmed
    ..is derived from proteolytic cleavages of the amyloid precursor protein (APP) by ?-site APP-cleaving enzyme 1 (BACE1) and the ?-secretase complex...
  46. Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O CONNOR T, et al. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci. 2007;27:3639-49 pubmed
    Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) (beta-secretase) initiates generation of beta-amyloid (Abeta), which plays an early role in Alzheimer's disease (AD)...
  47. Ohno M, Cole S, Yasvoina M, Zhao J, Citron M, Berry R, et al. BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiol Dis. 2007;26:134-45 pubmed
    ..Here, we demonstrate that genetic deletion of the beta-secretase (BACE1) not only abrogates Abeta generation and blocks amyloid deposition but also prevents neuron loss found in the ..
  48. Westmeyer G, Willem M, Lichtenthaler S, Lurman G, Multhaup G, Assfalg Machleidt I, et al. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. J Biol Chem. 2004;279:53205-12 pubmed
    Cleavage of the beta-amyloid precursor protein (APP) by the aspartyl protease beta-site APP-cleaving enzyme (BACE) is the first step in the generation of the amyloid beta-peptide, which is deposited in the brain of Alzheimer's disease ..
  49. von Arnim C, Tangredi M, Peltan I, Lee B, Irizarry M, Kinoshita A, et al. Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. J Cell Sci. 2004;117:5437-45 pubmed
    beta-Secretase (BACE) carries out the first of two proteolysis steps to generate the amyloid-beta peptides that accumulate in the senile plaques in Alzheimer's disease (AD)...
  50. Marques S, Lemos R, Ferreiro E, Martins M, de Mendonca A, Santana I, et al. Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice. Neuroscience. 2012;220:256-66 pubmed publisher
    ..b>BACE1 mRNA levels were increased in aged 3xTg-AD mice as well as in AD PBMCs along with an increase in promoter ..
  51. Jonas M, Costantini C, Puglielli L. PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1. EMBO Rep. 2008;9:916-22 pubmed publisher
    We have recently identified a new form of post-translational regulation of BACE1 (beta-site amyloid precursor protein (APP)-cleaving enzyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer ..
  52. Giusti Rodríguez P, Gao J, Graff J, Rei D, Soda T, Tsai L. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of ?-secretase (BACE1). J Neurosci. 2011;31:15751-6 pubmed publisher
    ..Levels of A?, as well as the APP processing enzyme, ?-secretase (BACE1), are also increased in CK-p25 mice...