B7 1

Summary

Gene Symbol: B7 1
Description: CD80 antigen
Alias: B71, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7 protein, T-lymphocyte activation antigen CD80, activation B7-1 antigen
Species: mouse

Top Publications

  1. ncbi Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice
    L Van Parijs
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:5336-44. 1997
  2. ncbi Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity
    Young Ju Jang
    Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea
    Mol Cells 13:130-6. 2002
  3. ncbi Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells
    James P O'Keefe
    Committee on Cancer Biology, University of Chicago, IL 60637, USA
    J Immunol 175:5581-5. 2005
  4. pmc Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:111-22. 2007
  5. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
  6. ncbi CD4(+) T cells stimulate memory CD8(+) T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion
    Meiqing Shi
    Saskatchewan Cancer Agency, Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, 20 Campus Dr, Saskatoon S7N 4H4, Canada
    J Leukoc Biol 80:1354-63. 2006
  7. ncbi Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
    S Wong
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011
    Diabetes 44:326-9. 1995
  8. pmc T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    P S Linsley
    Oncogen, Seattle, WA 98121
    Proc Natl Acad Sci U S A 87:5031-5. 1990
  9. doi Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation
    Sumeena Bhatia
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1821-8. 2010
  10. ncbi B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    B Salomon
    Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 12:431-40. 2000

Research Grants

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice
    L Van Parijs
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:5336-44. 1997
    ..Therefore, functionally significant levels of B7 expressed constitutively on mature lymphocytes are not, by themselves, sufficient to abrogate T cell tolerance or induce autoimmune disease...
  2. ncbi Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity
    Young Ju Jang
    Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea
    Mol Cells 13:130-6. 2002
    ..1 for their efficacy as preventive tumor vaccines in vivo. The results indicate that the A20 cells that express both the I-Ab and B7.1 have more potent vaccinating potential, compared to the cells that express only one of the molecules...
  3. ncbi Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells
    James P O'Keefe
    Committee on Cancer Biology, University of Chicago, IL 60637, USA
    J Immunol 175:5581-5. 2005
    ..Together, our results indicate that the formation of a cSMAC is not required for cytolytic activity in CD8+ effector T cells...
  4. pmc Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:111-22. 2007
    ..Our findings point to a substantial bidirectional inhibitory interaction between B7-1 and PD-L1 and add an additional dimension to immunoregulatory functions of the B7:CD28 family...
  5. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  6. ncbi CD4(+) T cells stimulate memory CD8(+) T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion
    Meiqing Shi
    Saskatchewan Cancer Agency, Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, 20 Campus Dr, Saskatoon S7N 4H4, Canada
    J Leukoc Biol 80:1354-63. 2006
    ..These results highlight a previously undescribed role of active CD4(+) T cells in triggering expansion of memory CD8(+) T cells...
  7. ncbi Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
    S Wong
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011
    Diabetes 44:326-9. 1995
    ..This illustrates that B7-1 is a very potent co-stimulatory molecule in vivo and that its presence on the surface of tissue cells can potentiate the autoimmune process...
  8. pmc T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    P S Linsley
    Oncogen, Seattle, WA 98121
    Proc Natl Acad Sci U S A 87:5031-5. 1990
    ....
  9. doi Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation
    Sumeena Bhatia
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1821-8. 2010
    ..These events regulate signaling through TCR/CD28 to maximize T cell activation to proliferation...
  10. ncbi B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    B Salomon
    Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 12:431-40. 2000
    ..The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases...
  11. ncbi In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis
    Aurore Saudemont
    Unite Inserm 524, Institut de Recherche sur le Cancer de Lille, Lille, France
    Blood 104:2124-33. 2004
    ..Thus, escape of leukemic cells from tumor immunity via overexpression of B7-H1 or B7.1 might represent a new mechanism of tumor dormancy in acute leukemia...
  12. pmc B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    MELANIE A RUFFNER
    Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Immunol 39:3084-90. 2009
    ..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
  13. ncbi Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent
    Avijit Ray
    Division of Immunology and Vaccine Development, National Institute of Cholera and Enteric Diseases, P 33, C I T Road, Scheme XM, Kolkata 700010, West Bengal, India
    Mol Immunol 41:1167-75. 2004
    ..4- and 2.6-fold, respectively. The IgA expressed on both B-1a and B-1b cell surfaces after 72 h of culture was found to bind to the 38 kDa monomer of porin confirming it to be anti-porin IgA antibody...
  14. ncbi IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2
    R M Stack
    Committee on Developmental Biology, University of Chicago, IL 60637
    J Immunol 152:5723-33. 1994
    ..Additionally, these findings support our previous findings that an alternative ligand for CD28 and CTLA4 is important in providing costimulation...
  15. pmc CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis
    Anna Nolan
    Oregon Health and Science University, Division of Pulmonary and Critical Care, Mail Code UHN67, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Am J Respir Crit Care Med 177:301-8. 2008
    ..Studies from our group and others suggest a potentially important role for these costimulatory cascades in innate immunity as well...
  16. ncbi In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function
    Thomas J Lang
    Research Service, Baltimore Veterans Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 168:3786-92. 2002
    ..In contrast, CD86 is critical for the activation of naive CD4(+) T cells in either a Th1 or a Th2 cytokine-mediated response...
  17. ncbi B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 6:303-13. 1997
    ..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2...
  18. pmc Induction of B7-1 in podocytes is associated with nephrotic syndrome
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 113:1390-7. 2004
    ..Our findings suggest a novel function for B7-1 in danger signaling by nonimmune cells...
  19. ncbi Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice
    E Gärdby
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    J Immunol 161:49-59. 1998
    ..This study reveals a paradox in the regulation of mucosal IgA responses...
  20. ncbi Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
    A N Schweitzer
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2762-71. 1998
    ....
  21. ncbi CD80/CD86 costimulation regulates acute vascular rejection
    Karoline A Hosiawa
    Division of Experimental Therapeutics, University Health Network, Toronto General Research Institute, Toronto General Hospital, Toronto, Ontario, Canada
    J Immunol 175:6197-204. 2005
    ..Most strikingly, indefinite xenograft survival can be achieved by suppressing AVR with CD86 neutralization in combination of CsA therapy, which inhibits CMR...
  22. ncbi Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1
    Justine D Mintern
    Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
    J Immunol 177:8422-31. 2006
    ..These results show a novel function for m138 in MCMV infection and identify the first viral protein to target B7-1...
  23. doi B-1 cell-derived monoclonal antibodies and costimulatory molecules
    Juyoun Lee
    Department of Periodontology, School of Dentistry, Pusan National University and Medical Research Institute, Pusan National University, Seo Ku, Pusan, Korea
    J Surg Res 154:293-8. 2009
    ..1 and B7.2) by splenic and peritoneum-derived (PerC) B cells to a different antigenic stimulation...
  24. ncbi Acquisition of CD80 (B7-1) by T cells
    H Sabzevari
    Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2505-13. 2001
    ..Thus we demonstrate both immunostimulatory and immunoregulatory functions as a result of CD80 acquisition by different T cell populations...
  25. pmc B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    D A Mandelbrot
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:881-7. 2001
    ..Finally, administration of CTLA4-Ig to CD28/CTLA4(-/-) cardiac allograft recipients significantly prolongs graft survival. These data support the existence of an additional receptor for B7 molecules that is neither CD28 nor CTLA4...
  26. pmc Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells
    Jian Xin Gao
    Department of Pathology and Comprehensive Cancer Center, Division of Cancer Immunology, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Exp Med 195:959-71. 2002
    ..The strong pathogenicity of the self-reactive T cells supports a central hypothesis in immunology, which is that clonal deletion plays an important role in preventing autoimmune diseases...
  27. ncbi The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery
    Jianguo Liu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Int J Cancer 119:2113-8. 2006
    ..1 expression. We therefore propose a 2-signal stimulation model to explain the synergistic effect of the coadministration of IL-12 and B7.1 on the regression of the tumors...
  28. ncbi Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice
    Wolfram Karges
    Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany
    Diabetes 51:3237-44. 2002
    ..In antigen-based prevention of type 1 diabetes, diabetes acceleration should be considered as a potential adverse result...
  29. ncbi The B7 and CD28 receptor families
    C H June
    Immune Cell Biology Program, Naval Medical Research Institute, Bethesda, MD
    Immunol Today 15:321-31. 1994
    ..Here, Carl June and colleagues highlight recent advances in the understanding of the CD28 and B7 receptor families...
  30. ncbi Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
    D J Lenschow
    Committee on Immunology, University of Chicago, IL 60637
    J Immunol 153:1990-7. 1994
    ..Thus, the effectiveness of Ag-specific B cells as APCs depends on both their enhanced Ag uptake, mediated by the B cell receptor, and immediate up-regulation of a potent costimulatory molecule, B7-2...
  31. ncbi Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
    C P Larsen
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322
    J Immunol 152:5208-19. 1994
    ....
  32. ncbi Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen
    Y Liu
    Section of Immunobiology, Yale University School of Medicine, New Haven
    Eur J Immunol 22:2855-9. 1992
    ..These results demonstrate that functionally defined co-stimulation involves at least B7 and HSA and suggest that signals delivered by B7 and HSA synergize in promoting T cell growth...
  33. pmc Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
    T T Chang
    Immunology Research Division, Department of Pathology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 190:733-40. 1999
    ....
  34. ncbi B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]
    Patricia A Taylor
    Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, 425 East River Road, Minneapolis, MN 55455, USA
    J Immunol 172:34-9. 2004
    ..The up-regulation of B7 on T cells may be an important component of normal immune homeostasis...
  35. pmc Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    Silke Paust
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, 44 Binney Street, SM 722, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10398-403. 2004
    ..Because expression of these B7 truncation mutants restores CD28-dependent costimulatory activity, these findings that indicate B7-based transmission of suppressive activity suggest new approaches to modifying autoimmune responses...
  36. ncbi Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice
    G J Freeman
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA
    Science 262:907-9. 1993
    ..These receptors are functionally important because the residual allogenic mixed lymphocyte responses were blocked by CTLA4Ig. Characterization of these CTLA-4 ligands should lead to strategies for manipulating the immune response...
  37. ncbi The role of B7 costimulation in CD4/CD8 T cell homeostasis
    X Yu
    Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3543-53. 2000
    ..These reciprocal effects of genetically engineered increase or decrease in B7 expression indicate that B7 costimulation plays a physiological role in the regulation of CD4+ and CD8+ T cell homeostasis...
  38. ncbi In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1
    Masashi Nagamori
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Japan
    Anticancer Res 22:2009-13. 2002
    ..B7 family members play a central costimulatory role in T cell activation. We have previously identified B7-1a, an alternatively spliced form of B7-1. The function of B7-1a in induction of anti-tumor immunity remains uncertain...
  39. ncbi The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3
    R H Reeves
    Department of Physiology, 202 Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Mamm Genome 8:581-2. 1997
  40. ncbi A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection
    Janet E Buhlmann
    Department of Pathology, Immunology Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:5421-8. 2003
    ..Finally, CTLA-4 delivers signals that inhibit selection, suggesting that CTLA-4 and CD28 have opposing functions in thymic development. Combined, the data demonstrate that B7-1/B7-2-dependent signals help shape the T cell repertoire...
  41. pmc Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor
    Tahiro Shin
    Sidneu Kimmel Comprehensive Cancer Centre, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Exp Med 198:31-8. 2003
    ..Finally, costimulation with B7-DC alone or in conjunction with B7-1 is PD-1 independent, indicating that B7-DC costimulates T cells via a second receptor...
  42. ncbi B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice
    Chiara Buono
    Immunology Research Division and the Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 109:2009-15. 2004
    ..This study tested the hypothesis that the ability of T cells to influence atherosclerosis depends on B7-1/B7-2 costimulation...
  43. ncbi Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 153:5038-48. 1994
    ..In addition, we report the chromosomal location of mB7-1 to chromosome 16, band B5...
  44. ncbi Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation
    M R Prabhu Das
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    Eur J Immunol 25:207-11. 1995
    ..This pattern of expression of B7-1 and B7-2 on T cells suggests that these two molecules may have different roles in the generation and regulation of immune responses...
  45. ncbi Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro
    T F Gajewski
    Ludwig Institute for Cancer Research, Brussels Branch, Belgium
    J Immunol 154:5637-48. 1995
    ....
  46. ncbi Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma
    C C Leong
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands
    Int J Cancer 71:476-82. 1997
    ..Our observations are relevant to human MM because these cell lines have been derived from asbestos-induced tumors and share many properties with human cell lines of the same histological type...
  47. pmc Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1
    P Lane
    Basal Institute for Immunology, Switzerland
    Immunology 80:56-61. 1993
    ..These findings are discussed in the light of the physiological activation of T cells in secondary lymphoid organs...
  48. pmc Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    R J Peach
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    J Exp Med 180:2049-58. 1994
    ..Thus, the MYPPPY motifs of CTLA4Ig and CD28Ig are important for their binding to B7-1, but the increased strength of this binding by CTLA4Ig is mediated by nonconserved residues in the CDR1- and CDR3-analogous regions...
  49. ncbi Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus
    B Liang
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 165:3436-43. 2000
    ..By comparison, B7-1-deficient MRL-lpr/lpr mice had more severe IgG and C3 deposits in glomeruli...
  50. ncbi The role of donor and recipient B7-1 (CD80) in allograft rejection
    X X Zheng
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 159:1169-73. 1997
    ..These data also indicate that B7-1 and B7-2 are the only CD28 ligands relevant to cardiac allograft rejection in mice...
  51. pmc Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4
    C A Fargeas
    Laboratoire d Immunologie, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Exp Med 182:667-75. 1995
    ..One of these residues, Y87, is conserved in all CD80 and CD86 cloned from various species. These results being to unravel the structural requirements for binding to CD28 and CTLA4...
  52. pmc Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function
    K S Hathcock
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 180:631-40. 1994
    ..Moreover, expression of B7-1 and B7-2 can be independently regulated by the same stimulus, providing an additional complexity in the mechanisms available for regulating costimulation and hence immune response...
  53. ncbi Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression
    H Ozawa
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Immunol 26:648-52. 1996
    ..The inhibitory effect of IFN-gamma on CD80 expression on LC appears to be partially mediated through the suppression of GM-CSF production by KC...
  54. pmc Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus
    Eulogia Roman
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 185:3819-23. 2010
    ..In addition, Treg selection requires the TCR signal and CD28 costimulation presented in cis on the same APC type in vivo. This study demonstrates a new role, to our knowledge, for HCs in the development of Tregs in thymus...
  55. doi Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity
    Shirley G K Seah
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Eur J Immunol 42:1744-54. 2012
    ..We suggest that direct CD28 costimulation of CD8(+) T cells is more critical in their priming during primary influenza infection than previously appreciated...
  56. doi Mcl-1 is essential for the survival of plasma cells
    Victor Peperzak
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 14:290-7. 2013
    ..Our results identify a critical role for Mcl-1 in the maintenance of plasma cells...
  57. doi Trogocytosis of CD80 and CD86 by induced regulatory T cells
    Peng Gu
    University of Toronto Transplant Institute, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Cell Mol Immunol 9:136-46. 2012
    ..These findings provide novel understanding of the interaction between iTregs and DCs, suggesting that trogocytosis may play a significant role in iTreg-mediated immune suppression...
  58. doi Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 41:291-8. 2011
    ....
  59. ncbi CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells
    Rongcun Yang
    Department of Immunology, College of Medicine, Nankai University, Tianjin, China
    Cancer Res 66:6807-15. 2006
    ..Thus, CD80-dependent responses to myeloid suppressor cells may contribute to tumor tolerance and the progression of ovarian carcinoma...
  60. ncbi Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis
    Shabbir Hussain
    Autoimmunity Diabetes Group, Robarts Research Institute, University of Western Ontario, London, Canada
    J Immunol 174:680-7. 2005
    ..These results suggest that increased B7-1 and B7-2 expression on islet-infiltrated NOD B cells is associated with increased T cell costimulation and the development of inflammatory insulitis in NOD mice...
  61. pmc B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion
    Friederike C Rau
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    J Immunol 183:7661-71. 2009
    ..Taken together, these results identify direct signaling through B7-1/2 as a potent regulator of IgG secretion by previously activated B cells...
  62. pmc Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation
    Haiyan Ying
    Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    J Immunol 185:1375-8. 2010
    ..With these results, we are the first to demonstrate that CTLA-4-B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity...
  63. doi Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1
    Jianxiong Wang
    Department of Biochemistry and Molecular Biology, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 182:6644-7. 2009
    ..The opposing functions of CD28 and PD-1 thus tightly regulate the unique effector function iNKT cells...
  64. pmc Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling
    Sumeena Bhatia
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:15569-74. 2005
    ....
  65. pmc An obligate cell-intrinsic function for CD28 in Tregs
    Ruan Zhang
    Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 123:580-93. 2013
    ....
  66. doi Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity
    Siew Cheng Wong
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore
    Cell Immunol 256:64-71. 2009
    ..Taken together, our data reveal a functional hierarchy of the CD28/B7 and ICOS/B7-H2 pathways and delineated their relative contributions to the elicitation of a DTH response...
  67. pmc CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
    Josef Kurtz
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 113:3475-84. 2009
    ..This tolerance is independent of regulatory T cells and culminates in the deletion of directly alloreactive CD4 T cells...
  68. ncbi [Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
    Jun Fa Xu
    Department of Immunology, Tongji Medical College, Huazhong Universite of Science and Technology, Wuhan 430030, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:413-6. 2006
    ..4...
  69. ncbi A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Eur J Immunol 35:418-27. 2005
    ..Together these findings demonstrate a novel negative regulatory role for CD28 in inhibiting differentiation of SP thymocytes, probably through inhibition of thymic selection...
  70. pmc Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection
    Edward Seung
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 186:6830-8. 2011
    ..These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8(+) Teff into the target organ and suggest a novel approach to achieve transplant tolerance...
  71. pmc CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis
    Xue Feng Bai
    Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Ave, Columbus 43210, USA
    J Exp Med 200:447-58. 2004
    ....
  72. pmc The costimulatory molecule B7 is expressed in the medullary region of the murine thymus
    H Reiser
    Division of Lymphocyte Biology, Dana Farber Cancer Institute, Boston, MA 02115
    Immunology 81:532-7. 1994
    ..Finally, although we have demonstrated expression of mB7 in the murine thymus, we have been unable to detect a function for this antigen in this organ. The implications of these findings are discussed...
  73. pmc Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells
    Zhe Shi
    Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Immunology 124:121-8. 2008
    ..These results indicate that CD8+CD122(+) regulatory T cells recognize target T cells via the interaction of CD80/CD86-CD28 molecules to become active regulatory cells that produce suppressive factors such as IL-10...
  74. pmc Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells
    Michael G Strainic
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Immunity 28:425-35. 2008
    ..These local paracrine and autocrine interactions thus operate constitutively in naive T cells to maintain viability, and their amplification by cognate APC partners thus is critical to T cell costimulation...
  75. pmc Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus
    Biyan Duan
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
    Lab Invest 88:1008-20. 2008
    ..These results suggest that follicular exclusion of IgM+ CD1d(hi)/MZ B cells is an important B-cell tolerance mechanism, and that B7-2 signaling is involved in breaching this tolerance checkpoint...
  76. pmc Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation
    Tadashi Yokosuka
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Immunity 29:589-601. 2008
    ..Thus, costimulation is mediated by the generation of a unique costimulatory compartment in the cSMAC via the dynamic regulation of MC translocation...
  77. pmc Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation
    Xincheng Zheng
    Department of Surgery, Comprehensive Cancer Center, Program of Molecular Mechanism of Diseases, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2703. 2008
    ..As such, costimulation may modulate all major branches of cell-mediated immunity, including T cells, NK cells and NKT cells...
  78. pmc Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation
    Nicolas Perez
    Department of Surgery, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 180:6566-76. 2008
    ....
  79. pmc CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection
    Charles H Cook
    Department of Surgery, Ohio State University Medical College, Columbus, Ohio 43210, USA
    Viral Immunol 22:91-103. 2009
    ..Cytokine evaluations confirm that CD28/B7 co-stimulation is not required for non-specific antiviral responses. We conclude that CD28-mediated co-stimulation is critical for early viral control during acute MCMV infection...
  80. ncbi Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    S Han
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Immunol 155:556-67. 1995
    ..Once B cells have entered the differentiation pathway to Ab production, neither CD40L nor B7-2 is necessary for their continued differentiation and persistence...
  81. pmc Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
    P S Linsley
    Oncogen Division, Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 91821
    J Exp Med 173:721-30. 1991
    ..Cellular interactions mediated by B7 and CD28 may represent an important component of the functional interactions between T and B lymphoid cells...
  82. ncbi In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice
    B R Blazar
    Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis
    Blood 83:3815-25. 1994
    ..Neither hCTLA4-Ig nor mCTLA4-Ig interfered with hematopoietic recovery post-BMT. We conclude that CTLA4-Ig (most likely in combination with other agents) may represent an important new modality for GVHD prevention...
  83. ncbi B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
    John R Sedy
    Department of Pathology and Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 6:90-8. 2005
    ..The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response...
  84. ncbi The role of the B7-1a molecule, an alternatively spliced form of murine B7-1 (CD80), on T cell activation
    M Inobe
    Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Japan
    J Immunol 157:582-8. 1996
    ..Therefore the IgV-like region of CD80 contains a critical region for functional interaction with its ligands and can transduce a costimulatory signal for T cell proliferation...
  85. doi CD80 blockade enhance glucocorticoid-induced leucine zipper expression and suppress experimental autoimmune encephalomyelitis
    Shailesh P Dudhgaonkar
    Department of Oral Pathology, Medicine and Radiology, School of Dentistry, Indiana University Purdue University, Indianapolis, IN 46202, USA
    J Immunol 183:7505-13. 2009
    ..The CD80-CAP mediates protection by inhibiting proinflammatory cytokines and skewing toward anti-inflammatory response presumably by enhancing the expression of glucocorticoid-induced leucine zipper in activated CD4(+) T cells...
  86. ncbi Interleukin-12-activated natural killer cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells
    A B Geldhof
    Laboratory of Cellular Immunology, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel VUB, Brussels
    Blood 91:196-206. 1998
    ..Hence, IL-12 triggers the expression of both CD28-dependent and CD28-independent mechanisms that allow NK cells to eliminate B7-positive target cells including autologous dendritic cells...
  87. pmc Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis
    Anna Nolan
    Division of Pulmonary Critical Care, New York University, School of Medicine, New York, NY, USA
    PLoS ONE 4:e6600. 2009
    ..Therefore, the goal of this study was to determine the individual contribution of CD80/86 family members in regulating inflammation in sepsis...
  88. doi B7-1 induces immunosuppression when expressed in cultured neonatal mice keratinocytes
    Ke Nengwen
    Hepato bilio pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    Immunobiology 214:653-63. 2009
    ..The precise mechanisms underlying this process were unclear. To analyze how keratinocytes attenuated the immune response, we investigated the effect of culturing on neonatal murine keratinocytes and their immunomodulatory properties...
  89. ncbi Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
    M Detmar
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 111:1-6. 1998
    ....
  90. ncbi Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation
    H J Hernandez
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 162:2884-9. 1999
    ....
  91. pmc The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:1607-18. 2004
    ....
  92. ncbi Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c
    Yifang Chen
    Department of Pathology, Immunology, and Laboratory Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 175:1080-9. 2005
    ....
  93. ncbi Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction
    Mary T Litzinger
    Department of Immunology, George Washington University Medical Center, Washington, DC 20037, USA
    J Immunol 175:780-7. 2005
    ..We propose that tolerance may be induced in this model by B7-driven negative regulatory signaling, but tolerance is maintained by a lack of signal 2, because expression of B7 is eventually lost in vivo...
  94. ncbi CD80, but not CD86, express on cultured murine keratinocyte stem cells
    J Lei
    Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, P R China
    Transplant Proc 37:289-91. 2005
    ..The data indicate KSCs could act as antigen-presenting cells and thus provide an alternative explanation for the ultimate rejection of allogeneic keratinocytes...
  95. ncbi CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A
    Sambuddho Mukherjee
    Department of Biochemistry, Indian Institute of Science, Bangalore
    J Leukoc Biol 78:144-57. 2005
    ..In summary, CTLA4-CD80/CD86 interactions on T cells integrate signal strength, based on the dose of Con A, to enhance or inhibit primary mouse CD4(+) T cell cycling and survival...
  96. pmc Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
    Shuang Liang
    Department of Microbiology and Immunology, University of Louisville Health Science Center, Louisville, KY 40202, USA
    J Exp Med 201:127-37. 2005
    ....
  97. ncbi Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli
    Michael Martin
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 169:1744-52. 2002
    ..These findings demonstrate distinct differences in the ability of LT and LT (E112K) to enhance B7-1 and B7-2 on APC, as well as a dependence upon these costimulatory molecules for their adjuvant properties...
  98. ncbi Role of B7 in T cell tolerance
    Jens Lohr
    Department of Pathology, University of California San Francisco, School of Medicine, 94143, USA
    J Immunol 173:5028-35. 2004
    ..Thus, the obligatory role of B7 molecules paradoxically is to promote effective T cell priming and contain effector responses when self-Ags are presented as foreign...
  99. ncbi Genetic background determines the requirement for B7 costimulation in induction of autoimmunity
    Claudia Jabs
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 32:2687-97. 2002
    ..Thus, genetic background determines the B7 requirement for inducing autoimmunity. These data have important implications for developing B7-based immunotherapies for human diseases...
  100. ncbi Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways
    Richard J DiPaolo
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:2832-6. 2002
    ..Thus, the T cell response was generated toward the constellation of chemically dominant and subdominant epitopes as a whole, and did not discriminate among them based on their relative abundance...
  101. pmc Endotoxin-induced gamma interferon production: contributing cell types and key regulatory factors
    Tushar K Varma
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston 77555 0591, USA
    Clin Diagn Lab Immunol 9:530-43. 2002
    ..These data demonstrate that NK cells and NKT cells are the most abundant IFN-gamma-producing cells in the mouse spleen after LPS challenge and that IL-10 and IL-12 are key functional regulators of LPS-induced IFN-gamma production...

Research Grants12

  1. T Cell Memory to Respiratory Viral Infections
    Shahram Salek Ardakani; Fiscal Year: 2007
    ....
  2. Bacterial Sepsis & Reactivation of Latent Cytomegalovirus
    Charles Cook; Fiscal Year: 2007
    ..abstract_text> ..
  3. THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
    Charles Cook; Fiscal Year: 2007
    ..In general, these studies will explore the immunobiology of murine allograft acceptance, and its relationship to allograft tolerance. ..
  4. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..The specific aims are to determine the binding kinetics of the b7-CAPs to b7-1 and b7-2 and evaluate the preventive and therapeutic efficacy of the b7-CAPs and CD28 peptide mimics in DBA/1 Lac J mice induced CIA. ..
  5. THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
    Charles Cook; Fiscal Year: 2006
    ..In general, these studies will explore the immunobiology of murine allograft acceptance and its relationship to allograft tolerance. ..
  6. MYCOPLASMA SUPERANTIGEN MAM IN DISEASE AND AUTOIMMUNITY
    Hong Hua Mu; Fiscal Year: 2003
    ..Specifically the investigator shall define the role played by SAg-induced cytokines and protection against disease using the MAM vaccines described earlier. ..