Gene Symbol: Atp8a1
Description: ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Alias: AI481521, AI853962, APLT, AW743152, AW822227, Atp3a2, B230107D19Rik, ClassI, phospholipid-transporting ATPase IA, ATPase 8A1, aminophospholipid transporter (APLT), class I, ATPase 8A1, p type, ATPase class I type 8A member 1, P4-ATPase flippase complex alpha subunit ATP8A1, chromaffin granule ATPase II
Species: mouse
Products:     Atp8a1

Top Publications

  1. Owens S, Broman K, Wiltshire T, Elmore J, Bradley K, Smith J, et al. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet. 2005;14:1549-58 pubmed
  2. Paterson J, Renkema K, Burden L, Halleck M, Schlegel R, Williamson P, et al. Lipid specific activation of the murine P4-ATPase Atp8a1 (ATPase II). Biochemistry. 2006;45:5367-76 pubmed
    ..A candidate PS flippase ATP8A1 (ATPase II), originally isolated from bovine secretory vesicles, is a member of this subfamily based on sequence ..
  3. Ding J, Wu Z, Crider B, Ma Y, Li X, Slaughter C, et al. Identification and functional expression of four isoforms of ATPase II, the putative aminophospholipid translocase. Effect of isoform variation on the ATPase activity and phospholipid specificity. J Biol Chem. 2000;275:23378-86 pubmed
    ..Without phosphatidylserine, ATPase II would be accumulated as phosphoenzyme in the presence of ATP, resulting in the interruption of its catalytic cycle. ..
  4. Tyurina Y, Basova L, Konduru N, Tyurin V, Potapovich A, Cai P, et al. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J Biol Chem. 2007;282:8498-509 pubmed
    ..which is normally maintained within the cytosolic leaflet of the plasma membrane by aminophospholipid translocase (APLT). APLT is sensitive to redox modifications of its -SH groups...
  5. Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
    ..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...
  6. Wang L, Beserra C, Garbers D. A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization. Dev Biol. 2004;267:203-15 pubmed
    ..Thus, a new aminophospholipid transporter expressed exclusively in spermatozoa is critical for normal phospholipid distribution in the bilayer, and for normal binding, penetration, and signaling by the zona pellucida. ..
  7. Levano K, Punia V, Raghunath M, Debata P, Curcio G, Mogha A, et al. Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. J Neurochem. 2012;120:302-13 pubmed publisher
    ..that ablation of transbilayer amphipath transporter-1 (TAT-1), which is an ortholog of a mammalian P-type ATPase, Atp8a1, causes PS externalization in the germ cells...
  8. Kerr D, Marsillo A, Guariglia S, Budylin T, Sadek R, Menkes S, et al. Aberrant hippocampal Atp8a1 levels are associated with altered synaptic strength, electrical activity, and autistic-like behavior. Biochim Biophys Acta. 2016;1862:1755-65 pubmed publisher
    ..A pronounced induction of the flippase Atp8a1 was observed in post-mortem tissue homogenates from the hippocampus and temporal lobe of juvenile autistic ..
  9. Sobocki T, Jayman F, Sobocka M, Marmur J, Banerjee P. Isolation, sequencing, and functional analysis of the TATA-less murine ATPase II promoter and structural analysis of the ATPase II gene. Biochim Biophys Acta. 2007;1769:61-75 pubmed
    The P-type Mg2+-ATPase, termed ATPase II (Atp8a1), is a putative aminophospholipid transporting enzyme, which helps to maintain phospholipid asymmetry in cell membranes...

More Information


  1. Kato U, Inadome H, Yamamoto M, Emoto K, Kobayashi T, Umeda M. Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J Biol Chem. 2013;288:4922-34 pubmed publisher
    ..We demonstrated that CDC50A associated with and recruited P4-ATPase ATP8A1 to the plasma membrane...
  2. Wang Y, Saigoh K, Osaka H, Yamanishi T, Suh J, Kiyosawa H, et al. YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes. Genomics. 2000;66:333-6 pubmed
    ..We also mapped three other recently identified genes: Hip2, encoding Huntingtin interacting protein 2; Atp3a2, encoding a P-type ATPase; and Pmx2b, encoding PHOX2b.
  3. Soupene E, Kuypers F. Identification of an erythroid ATP-dependent aminophospholipid transporter. Br J Haematol. 2006;133:436-8 pubmed
    ..We report the identification of two different isoforms of the aminophospholipid translocase, Atp8a1, or flippase, in the murine red blood cell membrane.
  4. Halleck M, Pradhan D, Blackman C, Berkes C, Williamson P, Schlegel R. Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res. 1998;8:354-61 pubmed
  5. Paulusma C, Oude Elferink R. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Biochim Biophys Acta. 2005;1741:11-24 pubmed