Gene Symbol: Atp2a3
Description: ATPase, Ca++ transporting, ubiquitous
Alias: SERCA3b, Serca3, sarcoplasmic/endoplasmic reticulum calcium ATPase 3, SR Ca(2+)-ATPase 3, calcium pump 3, sarco /endoplasmic reticulum Ca2+ -ATPase, sarcoendoplasmic reticulum Ca2+ ATPase type 3
Species: mouse
Products:     Atp2a3

Top Publications

  1. Slack J, Grupp I, Ferguson D, Rosenthal N, Kranias E. Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation. J Biol Chem. 1997;272:18862-8 pubmed
    There are three isoforms of the sarcoplasmic reticulum Ca2+-ATPase; they are known as SERCA1, SERCA2, and SERCA3. Phospholamban is present in tissues that express the SERCA2 isoform and is an inhibitor of the affinity of SERCA2 for ..
  2. Liu L, Paul R, Sutliff R, Miller M, Lorenz J, Pun R, et al. Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. J Biol Chem. 1997;272:30538-45 pubmed
    Sarco(endo)plasmic reticulum Ca2+ ATPase isoform 3 (SERCA3) is one of two Ca2+ pumps serving intracellular Ca2+ signaling pools in non-muscle tissues; however, unlike the ubiquitous SERCA2b, it exhibits a restricted cell-type distribution...
  3. Arredouani A, Guiot Y, Jonas J, Liu L, Nenquin M, Pertusa J, et al. SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. Diabetes. 2002;51:3245-53 pubmed
    Two sarcoendoplasmic reticulum Ca(2+)-ATPases, SERCA3 and SERCA2b, are expressed in pancreatic islets. Immunocytochemistry showed that SERCA3 is restricted to beta-cells in the mouse pancreas...
  4. Luciani D, Gwiazda K, Yang T, Kalynyak T, Bychkivska Y, Frey M, et al. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes. 2009;58:422-32 pubmed publisher
    ..Our results also suggest the involvement of mitochondria in beta-cell apoptosis associated with dysfunctional beta-cell ER Ca(2+) homeostasis and ER stress. ..
  5. Iguchi N, Ohkuri T, Slack J, Zhong P, Huang L. Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception. PLoS ONE. 2011;6:e23165 pubmed publisher
    ..We found that Serca3, a member of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) family that sequesters cytosolic Ca(2+) into ..
  6. Ravier M, Daro D, Roma L, Jonas J, Cheng Xue R, Schuit F, et al. Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic ?-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3. Diabetes. 2011;60:2533-45 pubmed publisher
    Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic ?-cells...
  7. Yang Y, Kim M, Son A, Hong J, Kim K, Seo J, et al. Alteration of RANKL-induced osteoclastogenesis in primary cultured osteoclasts from SERCA2+/- mice. J Bone Miner Res. 2009;24:1763-9 pubmed publisher
    ..These results suggest that RANKL-mediated induction of SERCA2 plays a critical role in the RANKL-induced [Ca(2+)](i) oscillations that are essential for osteoclastogenesis. ..
  8. Borge P, Wolf B. Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. J Biol Chem. 2003;278:11359-68 pubmed
    ..Furthermore, immuno-electron microscopy studies confirm that IRS-1 and SERCA3b localize to vesicles derived from the ER...
  9. Kao J, Fortner C, Liu L, Shull G, Paul R. Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle. Am J Physiol. 1999;277:L264-70 pubmed
    Sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 3 (SERCA3), an isoform of the intracellular Ca(2+) pump that has been shown to mediate endothelium-dependent relaxation of vascular smooth muscle, is also expressed in tracheal epithelium...

More Information


  1. Kulkarni R, Roper M, Dahlgren G, Shih D, Kauri L, Peters J, et al. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes. 2004;53:1517-25 pubmed
  2. Jaisser F, Beggah A. The nongastric H+-K+-ATPases: molecular and functional properties. Am J Physiol. 1999;276:F812-24 pubmed
    ..Extensive studies will be required in the future to better understand the physiological role of these H-K-ATPases, especially in disease processes including ionic or acid-base disorders. ..
  3. Ozog A, Pouzet B, Bobe R, Lompre A. Characterization of the 3' end of the mouse SERCA 3 gene and tissue distribution of mRNA spliced variants. FEBS Lett. 1998;427:349-52 pubmed
  4. Nakagawa H, Oberwinkler H, Nikolaev V, Ga├čner B, Umbenhauer S, Wagner H, et al. Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation. Circ Heart Fail. 2014;7:814-21 pubmed publisher
    ..ANP counter-regulates cardiac MR activation in hypertensive heart disease. An imbalance in cardiac ANP/GC-A (inhibition) and aldosterone/MR signaling (augmentation) favors adverse cardiac remodeling in chronic pressure overload. ..
  5. Hadri L, Ozog A, Soncin F, Lompre A. Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1. J Biol Chem. 2002;277:36471-8 pubmed
    We reported previously that the sarco(endo)plasmic reticulum Ca(2+)-ATPase type 3 (SERCA3) gene is expressed in many tissues and in a subset of cells such as endothelial, epithelial, and lymphoid lineages...
  6. Shull G. Gene knockout studies of Ca2+-transporting ATPases. Eur J Biochem. 2000;267:5284-90 pubmed
    ..These studies are yielding important insights regarding the physiological functions of individual Ca2+-transporting ATPases in vivo. ..
  7. Tuvia S, Buhusi M, Davis L, Reedy M, Bennett V. Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. J Cell Biol. 1999;147:995-1008 pubmed
    ..Similar mechanisms involving ankyrins may be essential for segregation of functionally defined proteins within specialized regions of the plasma membrane and within the Ca(2+) homeostasis compartment of the ER. ..
  8. Paul R. The role of phospholamban and SERCA3 in regulation of smooth muscle-endothelial cell signalling mechanisms: evidence from gene-ablated mice. Acta Physiol Scand. 1998;164:589-97 pubmed
    ..Data from smooth muscle tissues of the SERCA3 gene-ablated mouse demonstrate that this isoform affects endothelium-dependent function, but not that of smooth ..
  9. Dode L, De Greef C, Mountian I, Attard M, Town M, Casteels R, et al. Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA. J Biol Chem. 1998;273:13982-94 pubmed
    ..included, or totally included, thus generating, respectively, SERCA3a (human and mouse, 999 amino acids (aa)), SERCA3b (human, 1043 aa; mouse, 1038 aa), or SERCA3c (human, 1024 aa; mouse, 1021 aa) isoforms with different C termini...
  10. Anderson D, Anderson K, Chang C, Makarewich C, Nelson B, McAnally J, et al. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell. 2015;160:595-606 pubmed publisher
    ..These findings identify MLN as an important regulator of skeletal muscle physiology and highlight the possibility that additional micropeptides are encoded in the many RNAs currently annotated as noncoding. ..
  11. Elaib Z, Adam F, Berrou E, Bordet J, Prevost N, Bobe R, et al. Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores. Blood. 2016;128:1129-38 pubmed publisher
    The role of the sarco-endoplasmic reticulum calcium (Ca(2+)) adenosine triphosphatase (ATPase) 3 (SERCA3) in platelet physiology remains poorly understood...