Gene Symbol: Atp11c
Description: ATPase, class VI, type 11C
Alias: A330005H02Rik, AI315324, phospholipid-transporting ATPase 11C, Atpase 11c, p type, P4-ATPase flippase complex alpha subunit ATP11C
Species: mouse
Products:     Atp11c

Top Publications

  1. Yabas M, Teh C, Frankenreiter S, Lal D, Roots C, Whittle B, et al. ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol. 2011;12:441-9 pubmed publisher
    ..Here we describe a previously unknown X-linked B cell-deficiency syndrome in mice caused by mutations in Atp11c, which encodes a member of the P4 ATPase family thought to serve as 'flippases' that concentrate ..
  2. Nelms K, Goodnow C. Genome-wide ENU mutagenesis to reveal immune regulators. Immunity. 2001;15:409-18 pubmed
    ..Our recent experience indicates that genome-wide chemical mutagenesis in the mouse is an extremely powerful methodology for the identification of genes required for complex immunological processes. ..
  3. Siggs O, Arnold C, Huber C, Pirie E, Xia Y, Lin P, et al. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol. 2011;12:434-40 pubmed publisher
    ..The causative mutations were ascribed to Atp11c, which encodes a P4-type ATPase with no previously described function...
  4. Siggs O, Schnabl B, Webb B, Beutler B. X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proc Natl Acad Sci U S A. 2011;108:7890-5 pubmed publisher
    ..Mutation of the X-linked mouse gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes ..
  5. Arnold C, Pirie E, Dosenovic P, McInerney G, Xia Y, Wang N, et al. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012;109:12286-93 pubmed publisher
    ..All of the mutations identified to date directly affect lymphocyte development or function; none have an exclusive effect on cells of the innate immune system. ..
  6. Segawa K, Kurata S, Yanagihashi Y, Brummelkamp T, Matsuda F, Nagata S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014;344:1164-8 pubmed publisher
    ..Using a haploid genetic screen in human cells, we found that ATP11C (adenosine triphosphatase type 11C) and CDC50A (cell division cycle protein 50A) are required for ..
  7. Yabas M, Jing W, Shafik S, Bröer S, Enders A. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PLoS ONE. 2016;11:e0146774 pubmed publisher
    ..We demonstrate here that the P4-type ATPase ATP11C mediates significant flippase activity in all murine leukocyte subsets...
  8. Tanimizu N, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, et al. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice. Hepatology. 2016;64:175-88 pubmed publisher
    ..Hepatology 2016;64:175-188). ..
  9. Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
    ..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...

More Information


  1. Yabas M, Coupland L, Cromer D, Winterberg M, Teoh N, D Rozario J, et al. Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span. J Biol Chem. 2014;289:19531-7 pubmed publisher
    ..Here, we report that developing erythrocytes from mice lacking the putative phosphatidylserine flippase ATP11C showed a lower rate of PS translocation in vitro compared with erythrocytes from wild-type littermates...
  2. Naik J, de Waart D, Utsunomiya K, Duijst S, Mok K, Oude Elferink R, et al. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function. Dig Dis. 2015;33:314-8 pubmed publisher
    ..Recently it was shown that loss of the P4 ATPases ATP8B1 and ATP11C are associated with severe Cholestatic liver disease...