Gene Symbol: Atp10a
Description: ATPase, class V, type 10A
Alias: Atp10c, pfatp, ATPase 10A, class V, ATPase, class 5, P-locus fat-associated ATPase, P4-ATPase flippase complex alpha subunit ATP10A
Species: mouse
Products:     Atp10a

Top Publications

  1. Kayashima T, Yamasaki K, Joh K, Yamada T, Ohta T, Yoshiura K, et al. Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting. Genomics. 2003;81:644-7 pubmed
    The mouse Atp10a gene is located at the border of an imprinted domain distal to the p-locus on mouse chromosome 7...
  2. Dhar M, Sommardahl C, Kirkland T, Nelson S, Donnell R, Johnson D, et al. Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes. J Nutr. 2004;134:799-805 pubmed
    b>Atp10c is a novel type IV P-type ATPase and is a putative phospholipid transporter...
  3. Herzing L, Kim S, Cook E, Ledbetter D. The human aminophospholipid-transporting ATPase gene ATP10C maps adjacent to UBE3A and exhibits similar imprinted expression. Am J Hum Genet. 2001;68:1501-5 pubmed
    ..Here we describe the characterization of ATP10C, a new human imprinted gene, which encodes a putative protein homologous to the mouse aminophospholipid-..
  4. Kashiwagi A, Meguro M, Hoshiya H, Haruta M, Ishino F, Shibahara T, et al. Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb. J Hum Genet. 2003;48:194-8 pubmed
    ..Recently we have identified a novel maternally expressed gene, ATP10C, that encodes a putative aminophospholipid translocase within this critical region, 200 kb distal to UBE3A in an ..
  5. Dhar M, Hauser L, Johnson D. An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes. Obes Res. 2002;10:695-702 pubmed
    ..shown that a region on proximal mouse chromosome 7, near the pink-eyed (p) dilution locus, contains an ATPase (pfatp), a putative aminophospholipid translocase...
  6. DuBose A, Johnstone K, Smith E, Hallett R, Resnick J. Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC. Neurogenetics. 2010;11:145-51 pubmed publisher
    ..b>ATP10A resides 200 kb telomeric to UBE3A and is of uncertain imprinted status...
  7. Halleck M, Pradhan D, Blackman C, Berkes C, Williamson P, Schlegel R. Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res. 1998;8:354-61 pubmed
  8. Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
    ..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..
  9. Halleck M, Lawler JF J, Blackshaw S, Gao L, Nagarajan P, Hacker C, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-50 pubmed
    ..These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths...

More Information


  1. Skryabin B, Gubar L, Seeger B, Pfeiffer J, Handel S, Robeck T, et al. Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007;3:e235 pubmed publisher
    ..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype. ..
  2. Chatzinikolaou G, Apostolou Z, Aid Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos G, et al. ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol. 2017;19:421-432 pubmed publisher
  3. Dhar M, Hauser L, Nicholls R, Johnson D. Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 and Ube3a. DNA Seq. 2004;15:306-9 pubmed
    ..Data show that Atp10c, a novel type IV ATPase a putative phospholipid transporter, is the only coding unit in this region of the ..
  4. Dhar M, Webb L, Smith L, Hauser L, Johnson D, West D. A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat. Physiol Genomics. 2000;4:93-100 pubmed
    ..This gene, which we have called p-locus fat-associated ATPase (pfatp) is differentially expressed in human and mouse tissues with predominant expression in the testis and lower levels ..
  5. Jiang Y, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, et al. Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS ONE. 2010;5:e12278 pubmed publisher
    ..6-Mb chromosomal deletion from Ube3a to Gabrb3, which inactivated the Ube3a and Gabrb3 genes and deleted the Atp10a gene...