Atoh7

Summary

Gene Symbol: Atoh7
Description: atonal bHLH transcription factor 7
Alias: Math5, bHLHa13, protein atonal homolog 7, atonal homolog 7, helix-loop-helix protein mATH-5
Species: mouse
Products:     Atoh7

Top Publications

  1. Brown N, Dagenais S, Chen C, Glaser T. Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. Mamm Genome. 2002;13:95-101 pubmed
    ..3-22.1, a region syntenic to the segment of mouse Chr 10 where Atoh7 (formerly Math5) is located...
  2. Brown N, Kanekar S, Vetter M, Tucker P, Gemza D, Glaser T. Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development. 1998;125:4821-33 pubmed
    We have identified Math5, a mouse basic helix-loop-helix (bHLH) gene that is closely related to Drosophila atonal and Xenopus Xath5 and is largely restricted to the developing eye...
  3. Saul S, Brzezinski J, Altschuler R, Shore S, Rudolph D, Kabara L, et al. Math5 expression and function in the central auditory system. Mol Cell Neurosci. 2008;37:153-69 pubmed
    The basic helix-loop-helix (bHLH) transcription factor Math5 (Atoh7) is required for retinal ganglion cell (RGC) and optic nerve development...
  4. Feng L, Xie X, Joshi P, Yang Z, Shibasaki K, Chow R, et al. Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development. 2006;133:4815-25 pubmed
    ..factor NeuroD and the expression of Bhlhb5 and NeuroD is negatively regulated by ganglion cell-competence factor Math5. Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell ..
  5. Mu X, Fu X, Sun H, Beremand P, Thomas T, Klein W. A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate. Dev Biol. 2005;280:467-81 pubmed
    b>Math5, a mouse homolog of the Drosophila proneural bHLH transcription factor Atonal, is essential in the developing retina to establish retinal progenitor cell competence for a ganglion cell fate...
  6. Brown N, Patel S, Brzezinski J, Glaser T. Math5 is required for retinal ganglion cell and optic nerve formation. Development. 2001;128:2497-508 pubmed
    ..b>Math5 (Atoh7) encodes a basic helix-loop-helix (bHLH) transcription factor that is specifically expressed by mouse ..
  7. Ding Q, Chen H, Xie X, Libby R, Tian N, Gan L. BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons. J Neurosci. 2009;29:3992-4003 pubmed publisher
    ..Genetic analysis revealed that Barhl2 functions downstream of the Atoh7-Pou4f3 regulatory pathway and regulates the maturation and/or survival of RGCs...
  8. Macgregor S, Hewitt A, Hysi P, Ruddle J, Medland S, Henders A, et al. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet. 2010;19:2716-24 pubmed publisher
    ..2x10(-10), near the ATOH7 gene as associated with the mean disc area...
  9. Mao C, Wang S, Pan P, Klein W. Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development. 2008;135:3379-88 pubmed publisher
    ..To address these issues, we replaced one bHLH gene with another. Math5 is a bHLH gene that is essential for establishing retinal ganglion cell (RGC) fate...

More Information

Publications76

  1. Mu X, Fu X, Sun H, Liang S, Maeda H, Frishman L, et al. Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina. Curr Biol. 2005;15:525-30 pubmed
    ..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate. ..
  2. Wang S, Kim B, Ding K, Wang H, Sun D, Johnson R, et al. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 2001;15:24-9 pubmed
    b>math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila...
  3. Hufnagel R, Le T, Riesenberg A, Brown N. Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Dev Biol. 2010;340:490-503 pubmed publisher
    ..Dorso-central retinal progenitor cells that give rise to the first postmitotic neurons express Neurog2/Ngn2 and Atoh7/Math5...
  4. Qiu F, Jiang H, Xiang M. A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J Neurosci. 2008;28:3392-403 pubmed publisher
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism. ..
  5. Le T, Wroblewski E, Patel S, Riesenberg A, Brown N. Math5 is required for both early retinal neuron differentiation and cell cycle progression. Dev Biol. 2006;295:764-78 pubmed
    ..In the mouse retina, removal of the bHLH factor Math5 (Atoh7) causes the loss of retinal ganglion cells (RGCs) and appearance of excess cone photoreceptors...
  6. Fu X, Kiyama T, Li R, Russell M, Klein W, Mu X. Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse. Dev Dyn. 2009;238:2309-17 pubmed publisher
    ..Here, we overcome these limitations by constructing genetically engineered alleles for Math5 and Pou4f2, two genes required for retinal ganglion cell (RGC) development...
  7. Brooks J, Su J, Levy C, Wang J, Seabrook T, Guido W, et al. A molecular mechanism regulating the timing of corticogeniculate innervation. Cell Rep. 2013;5:573-81 pubmed publisher
    ..Taken together, these studies reveal a molecular mechanism through which one class of axons coordinates the temporal targeting of another class of axons. ..
  8. Hufnagel R, Riesenberg A, Saul S, Brown N. Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes. Mol Cell Neurosci. 2007;36:435-48 pubmed
    Retinal ganglion cell genesis requires the proneural bHLH transcription factor Math5 (Atoh7), but little is known about the regulatory elements that control its expression. Here, we investigate Math5 gene regulation using transgenic mice...
  9. Brzezinski J, Brown N, Tanikawa A, Bush R, Sieving P, Vitaterna M, et al. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Invest Ophthalmol Vis Sci. 2005;46:2540-51 pubmed
    To determine how the absence of retinal ganglion cells (RGCs) in Math5 (Atoh7) mutant mice affects circadian behavior and retinal function...
  10. Lee H, Wroblewski E, Philips G, Stair C, Conley K, Reedy M, et al. Multiple requirements for Hes 1 during early eye formation. Dev Biol. 2005;284:464-78 pubmed
    ..In Hes1 mutants, Math5 expression is precocious along with retinal ganglion cell, amacrine, and horizontal neuron formation...
  11. Philips G, Stair C, Young Lee H, Wroblewski E, Berberoglu M, Brown N, et al. Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. Dev Biol. 2005;279:308-21 pubmed
    ..Subsequently, precocious neurons adopted a generic rather than a specific retinal neuron fate. Thus, Pax6 regulates the timing of retinal neurogenesis and couples it with specific neuron differentiation programs. ..
  12. Riesenberg A, Le T, Willardsen M, Blackburn D, Vetter M, Brown N. Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis. 2009;47:175-87 pubmed publisher
    Activation of the bHLH factor Math5 (Atoh7) is an initiating event for mammalian retinal neurogenesis, as it is critically required for retinal ganglion cell formation...
  13. Prasov L, Brown N, Glaser T. A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina. PLoS ONE. 2010;5:e12315 pubmed publisher
    The Math5 (Atoh7) gene is transiently expressed during retinogenesis by progenitors exiting mitosis, and is essential for ganglion cell (RGC) development. Math5 contains a single exon, and its 1.7 kb mRNA encodes a 149-aa polypeptide...
  14. Seabrook T, El Danaf R, Krahe T, Fox M, Guido W. Retinal input regulates the timing of corticogeniculate innervation. J Neurosci. 2013;33:10085-97 pubmed publisher
    ..These studies suggest that retinal and cortical innervation of dLGN is highly coordinated and that input from retina plays an important role in regulating the rate of corticogeniculate innervation. ..
  15. Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013;288:18429-38 pubmed publisher
    ..In addition, we demonstrated that loss of Math5 impairs the expression of Sox4 and Sox11 in the ganglion cell layer while deletion of Brn3b has no effect on the ..
  16. Yang Z, Ding K, Pan L, Deng M, Gan L. Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol. 2003;264:240-54 pubmed
    ..Previously, we showed that targeted deletion of the atonal (ato) homologue math5 blocked the differentiation of most retinal ganglion cells (RGCs), revealing an essential role for math5 in RGC ..
  17. Feng L, Xie Z, Ding Q, Xie X, Libby R, Gan L. MATH5 controls the acquisition of multiple retinal cell fates. Mol Brain. 2010;3:36 pubmed publisher
    b>Math5-null mutation results in the loss of retinal ganglion cells (RGCs) and in a concurrent increase of amacrine and cone cells...
  18. Skowronska Krawczyk D, Chiodini F, Ebeling M, Alliod C, Kundzewicz A, Castro D, et al. Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. Development. 2009;136:3767-77 pubmed publisher
    ..The atonal homologue Atoh7 participates in the ontogenesis of the vertebrate retina...
  19. Wee R, Castrucci A, Provencio I, Gan L, Van Gelder R. Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. J Neurosci. 2002;22:10427-33 pubmed
    ..We investigated the circadian entrainment and clock properties of math5-/- mutant mice...
  20. Li S, Mo Z, Yang X, Price S, Shen M, Xiang M. Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron. 2004;43:795-807 pubmed
    ..Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent differentiation of retinal progenitors. ..
  21. Triplett J, Pfeiffenberger C, Yamada J, Stafford B, Sweeney N, Litke A, et al. Competition is a driving force in topographic mapping. Proc Natl Acad Sci U S A. 2011;108:19060-5 pubmed publisher
    ..To test this hypothesis experimentally, we determined the nature of the retinocollicular projection in Math5 (Atoh7) mutant mice, which have severely reduced numbers of retinal ganglion cell inputs into the SC...
  22. Brzezinski J, Prasov L, Glaser T. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol. 2012;365:395-413 pubmed publisher
    The basic helix-loop-helix (bHLH) transcription factor Math5 (Atoh7) is transiently expressed during early retinal histogenesis and is necessary for retinal ganglion cell (RGC) development...
  23. Chen S, Chew K, McNeill D, Keeley P, Ecker J, Mao B, et al. Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron. 2013;77:503-15 pubmed publisher
    ..Thus, for irradiance detection, developmental apoptosis is necessary for the spacing and connectivity of ipRGCs that underlie their functioning within a neural network. ..
  24. Bai L, Kiyama T, Li H, Wang S. Birth of cone bipolar cells, but not rod bipolar cells, is associated with existing RGCs. PLoS ONE. 2014;9:e83686 pubmed publisher
    ..However, generation of the rod bipolar cells is unaffected by RGC shortage. Results report the first observation that RGCs selectively influence the genesis of subsequent retinal cell types. ..
  25. Feng L, Eisenstat D, Chiba S, Ishizaki Y, Gan L, Shibasaki K. Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience. 2011;195:9-20 pubmed publisher
    During retinogenesis, the basic helix-loop-helix proneural gene math5 (atoh7) initiates the generation of the first-born neurons, retinal ganglion cells (RGCs), by activating a network of RGC transcription factors, including Brn-3b (..
  26. Xie B, Zhang X, Hashimoto T, Tien A, Chen A, Ge J, et al. Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an Atoh7/Math5 lineage reporter. PLoS ONE. 2014;9:e112175 pubmed publisher
    ..we have established mouse iPS cells that allow cell lineage tracing of progenitors that have expressed Atoh7/Math5, a bHLH transcription factor required for RGC production...
  27. Prasov L, Glaser T. Pushing the envelope of retinal ganglion cell genesis: context dependent function of Math5 (Atoh7). Dev Biol. 2012;368:214-30 pubmed publisher
    The basic-helix-loop helix factor Math5 (Atoh7) is required for retinal ganglion cell (RGC) development. However, only 10% of Math5-expressing cells adopt the RGC fate, and most become photoreceptors...
  28. Riesenberg A, Conley K, Le T, Brown N. Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye. Dev Dyn. 2018;247:212-221 pubmed publisher
    ..Developmental Dynamics 247:212-221, 2018. © 2017 Wiley Periodicals, Inc. ..
  29. Cai Z, Feng G, Zhang X. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci. 2010;30:4110-9 pubmed publisher
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate. ..
  30. Maurer K, Riesenberg A, Brown N. Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development. 2014;141:3243-54 pubmed publisher
    ..In the mouse retina, bHLH genes Atoh7 and Neurog2 have distinct functions, with Atoh7 regulating retinal competence and Neurog2 required for progression ..
  31. Hufnagel R, Riesenberg A, Quinn M, Brzezinski J, Glaser T, Brown N. Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013;54:108-20 pubmed publisher
    ..The transcription factors Atoh7/Math5 and Ascl1/Mash1 represent divergent bHLH clades, and exhibit distinct spatial and temporal retinal expression ..
  32. Ghiasvand N, Rudolph D, Mashayekhi M, Brzezinski J, Goldman D, Glaser T. Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Nat Neurosci. 2011;14:578-86 pubmed publisher
    ..found that NCRNA is caused by a 6,523-bp deletion that spans a remote cis regulatory element 20 kb upstream from ATOH7 (Math5), a bHLH transcription factor gene that is required for retinal ganglion cell (RGC) and optic nerve ..
  33. Mui S, Kim J, Lemke G, Bertuzzi S. Vax genes ventralize the embryonic eye. Genes Dev. 2005;19:1249-59 pubmed
  34. Mao C, Tsai W, Cho J, Pan P, Barton M, Klein W. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011;349:90-9 pubmed publisher
    ..often associated with retinal ganglion cell (RGC) genes whose expression in the retina is positively controlled by Atoh7, a factor essential for RGC formation...
  35. Prasov L, Nagy M, Rudolph D, Glaser T. Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis. Neuroreport. 2012;23:631-4 pubmed publisher
    The basic helix-loop-helix factor Math5 (Atoh7) is critical for the determination of retinal ganglion cell (RGC) fate in mice...
  36. Wu F, Sapkota D, Li R, Mu X. Onecut 1 and Onecut 2 are potential regulators of mouse retinal development. J Comp Neurol. 2012;520:952-69 pubmed publisher
    ..to be involved in retinal ganglion cell (RGC) development, we found that Oc1 and Oc2 had extensive overlap with Math5 in the NBL, and that they completely overlapped with Pou4f2 and Isl1 in the GCL, but only partially in the NBL...
  37. Chang K, Hertz J, Zhang X, Jin X, Shaw P, Derosa B, et al. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017;37:4967-4981 pubmed publisher
  38. Sapkota D, Wu F, Mu X. Focus on Molecules: Math5 and retinal ganglion cells. Exp Eye Res. 2011;93:796-7 pubmed publisher
  39. Orieux G, Picault L, Slembrouck A, Roger J, Guillonneau X, Sahel J, et al. Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. J Neurosci. 2014;34:1530-41 pubmed publisher
  40. O Sullivan M, Punal V, Kerstein P, Brzezinski J, Glaser T, Wright K, et al. Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. Glia. 2017;65:1697-1716 pubmed publisher
    ..Analysis of Robo1; Robo2 mutants, in which RGC axon guidance is disrupted, and Math5 (Atoh7) mutants, which lack RGCs, reveals that RGCs provide directional information to migrating astrocytes that sets ..
  41. Kronander E, Michalski N, Lebrand C, Hornung J, Schneggenburger R. An organotypic slice culture to study the formation of calyx of Held synapses in-vitro. PLoS ONE. 2017;12:e0175964 pubmed publisher
    ..newborn mice in which calyces have not yet formed; the presynaptic bushy cells were genetically labeled using the Math5 promoter...
  42. Brzezinski J, Kim E, Johnson J, Reh T. Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011;138:3519-31 pubmed publisher
    ..of RGCs and, interestingly, we observed that a subset of Ascl1+ cells could give rise to cells expressing Math5 (Atoh7), a transcription factor required for RGC competence...
  43. Sone M, Hayashi T, Tarui H, Agata K, Takeichi M, Nakagawa S. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. J Cell Sci. 2007;120:2498-506 pubmed
    ..We propose that Gomafu RNA represents a novel family of mRNA-like noncoding RNA that constitutes a cell-type-specific component of the nuclear matrix. ..
  44. El Danaf R, Krahe T, Dilger E, Bickford M, Fox M, Guido W. Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input. Neural Dev. 2015;10:19 pubmed publisher
    ..To accomplish this we utilized the math5 null (math5 (-/-) ) mouse, a mutant lacking retinal ganglion cells and central projections...
  45. Murali D, Kawaguchi Niida M, Deng C, Furuta Y. Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-? signaling system in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2011;52:2930-7 pubmed publisher
    ..In addition, genetic requirements for Smad4 in the embryonic retina are evident predominantly in the developmental events regulated by the BMP branch of the TGF-? signaling pathway. ..
  46. Triplett J, Owens M, Yamada J, Lemke G, Cang J, Stryker M, et al. Retinal input instructs alignment of visual topographic maps. Cell. 2009;139:175-85 pubmed publisher
    ..These data suggest a general model in which convergent maps use coincident activity patterns to achieve alignment. ..
  47. Zhao S, Hung F, Colvin J, White A, Dai W, Lovicu F, et al. Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development. 2001;128:5051-60 pubmed
    ..In mouse embryos lacking FGF9, the retinal pigment epithelium extends into the presumptive neural retina, indicating a role of FGF9 in defining the boundary of the neural retina. ..
  48. Shaw P, Fang J, Sang A, Wang Y, Kapiloff M, Goldberg J. Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci. 2016;57:5083-5092 pubmed publisher
    ..Here, we further investigate the role of sAC in neuronal differentiation during retinal development. Chx10 or Math5 promoter-driven Cre-Lox recombination were used to conditionally delete sAC from early and intermediate retinal ..
  49. Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, et al. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006;133:4439-50 pubmed
    ..These data, together with the previous findings on Foxn4, provide a model in which the Foxn4-Ptf1a pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine cell fates. ..
  50. Yan N, Cheng L, Cho K, Malik M, Xiao L, Guo C, et al. Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1. Sci Rep. 2016;6:33887 pubmed publisher
  51. Jones I, Hägglund A, Törnqvist G, Nord C, Ahlgren U, Carlsson L. A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis Model Mech. 2015;8:1517-29 pubmed publisher
  52. Cai Z, Grobe K, Zhang X. Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. Dev Dyn. 2014;243:1310-6 pubmed publisher
    ..These results suggest that HSPGs, depending on their HS sulfation pattern, regulate multiple signaling pathways in optic disc and stalk morphogenesis. ..
  53. Ma L, Cantrup R, Varrault A, Colak D, Klenin N, Gotz M, et al. Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina. Neural Dev. 2007;2:11 pubmed
    ..This raises the intriguing possibility that tumorigenicity may also be associated with the loss of feedback inhibition in mature tissues. ..
  54. Rosengauer E, Hartwich H, Hartmann A, Rudnicki A, Satheesh S, Avraham K, et al. Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of mammalian central auditory nuclei. PLoS ONE. 2012;7:e49503 pubmed publisher
    ..Mid-embryonic ablation of Dicer1 in the ventral cochlear nucleus by Atoh7::Cre-mediated recombination resulted in normal formation of the cochlear nucleus complex, indicating an early ..
  55. Yao J, Sun X, Wang Y, Xu G, Qian J. Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells. Mol Vis. 2007;13:1066-72 pubmed
    To investigate the role of over-expression of Math5 on the retinal ganglion cell (RGC) expression patterns in retinal progenitor cells (RPCs)...
  56. Sun Y, Kanekar S, Vetter M, Gorski S, Jan Y, Glaser T, et al. Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evol Dev. 2003;5:532-41 pubmed
    ..In contrast, mouse Ath5 (Math5) induces formation of very few ommatidia, and most of these lack R8 cells...
  57. Lee C, May N, Fan C. Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol. 2001;236:17-29 pubmed
    ..This defect is specific to the ventral region of the RPE. Using molecular markers for RPE (Mi and Tyrp2) and NR (Math5), we demonstrate that there is a gradual loss of Mi and Tyrp2 expression and an appearance of Math5 expression in ..
  58. Jiang S, Wang J. Msx2 alters the timing of retinal ganglion cells fate commitment and differentiation. Biochem Biophys Res Commun. 2010;395:524-9 pubmed publisher
    ..Meanwhile, overexpression of Msx2 delayed the expression of RGC-specific differentiation markers (Math5 and Brn3b), which showed that Msx2 could affect the timing of RGCs fate commitment and differentiation by delaying ..
  59. Hammer S, Carrillo G, Govindaiah G, Monavarfeshani A, Bircher J, Su J, et al. Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus. Neural Dev. 2014;9:16 pubmed publisher
    ..These results raise intriguing questions about the different functions of these nuclei in processing light-derived information, as well as differences in the mechanisms that underlie their unique, nuclei-specific development...
  60. Taranova O, Magness S, Fagan B, Wu Y, Surzenko N, Hutton S, et al. SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 2006;20:1187-202 pubmed
  61. Pan Y, Woodbury A, Esko J, Grobe K, Zhang X. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006;133:4933-44 pubmed
    ..Taken together, these results establish an important role of Ndst1 function in FGF signaling during lens development. ..
  62. Edwards M, McLeod D, Li R, Grebe R, Bhutto I, Mu X, et al. The deletion of Math5 disrupts retinal blood vessel and glial development in mice. Exp Eye Res. 2012;96:147-56 pubmed publisher
    ..The present study investigated the potential role played by ganglion cells in vascular development using Math5(-/-) mice...
  63. Nelson B, Hartman B, Ray C, Hayashi T, Bermingham McDonogh O, Reh T. Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn. 2009;238:2163-78 pubmed publisher
    ..Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina. ..
  64. Fu X, Sun H, Klein W, Mu X. Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development. Dev Biol. 2006;299:424-37 pubmed
    ..The results further imply that retinal lamination and retinal cell differentiation are genetically separable processes. ..
  65. Morcillo J, Martinez Morales J, Trousse F, Fermin Y, Sowden J, Bovolenta P. Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development. 2006;133:3179-90 pubmed
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc. ..
  66. Prasov L, Masud T, Khaliq S, Mehdi S, Abid A, Oliver E, et al. ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. Hum Mol Genet. 2012;21:3681-94 pubmed publisher
    The vertebrate basic helix-loop-helix (bHLH) transcription factor ATOH7 (Math5) is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves...
  67. Oron Karni V, Farhy C, Elgart M, Marquardt T, Remizova L, Yaron O, et al. Dual requirement for Pax6 in retinal progenitor cells. Development. 2008;135:4037-4047 pubmed publisher
    ..Together, these data suggest an intricate dual role for Pax6 in retinal neurogenesis, while pointing to the cryptic divergence of RPCs into distinct progenitor pools. ..