Atmin

Summary

Gene Symbol: Atmin
Description: ATM interactor
Alias: Asciz, gpg6, mKIAA0431, ATM interactor, ASCIZ, ATM/ATR-substrate CHEK2-interacting zinc finger protein, ATM/ATR-substrate CHK2-interacting zinc finger protein, atmin
Species: mouse
Products:     Atmin

Top Publications

  1. Zhang T, Penicud K, Bruhn C, Loizou J, Kanu N, Wang Z, et al. Competition between NBS1 and ATMIN controls ATM signaling pathway choice. Cell Rep. 2012;2:1498-504 pubmed publisher
    ..kinase activation by DNA double-strand breaks (DSBs) requires the Mre11-Rad50-NBS1 (MRN) complex, whereas ATM interactor (ATMIN) protein is required for ATM signaling induced by changes in chromatin structure...
  2. Ermakov A, Stevens J, Whitehill E, Robson J, Pieles G, Brooker D, et al. Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development. Dev Dyn. 2009;238:581-94 pubmed publisher
  3. Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, et al. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010;285:38534-42 pubmed publisher
    ..Here we identify ATM interactor (ATMIN) as an essential component of the ATM signaling pathway in response to oxidative stress and aging...
  4. Heierhorst J, Smyth I, Jurado S. A breathtaking phenotype: unexpected roles of the DNA base damage response protein ASCIZ as a key regulator of early lung development. Cell Cycle. 2011;10:1222-4 pubmed
    The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to ..
  5. Jurado S, Conlan L, Baker E, Ng J, Tenis N, Hoch N, et al. ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. J Biol Chem. 2012;287:3156-64 pubmed publisher
    ..Despite its important roles, DYNLL1's own regulation remains poorly understood. Here we identify ASCIZ (ATMIN/ZNF822), an essential Zn(2+) finger protein with dual roles in the DNA base damage response and as a ..
  6. Loizou J, Sancho R, Kanu N, Bolland D, Yang F, Rada C, et al. ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma. Cancer Cell. 2011;19:587-600 pubmed publisher
    ..Here, we show that mice lacking the ATM cofactor ATMIN in B cells (ATMIN(?B/?B)) have impaired ATM signaling and develop B cell lymphomas...
  7. Jurado S, Gleeson K, O Donnell K, Izon D, Walkley C, Strasser A, et al. The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. J Exp Med. 2012;209:1629-39 pubmed publisher
    ..absence of the essential ATM (ataxia telangiectasia mutated) substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ; also known as ATMIN/ZNF822), a protein with dual functions in the DNA damage response and as a transcription ..
  8. Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, et al. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet. 2010;6:e1001170 pubmed publisher
    ..The ATM substrate Chk2-interacting Zn²(+)-finger protein (ASCIZ; also known as ATMIN and ZNF822) was originally linked to functions in the DNA base damage response and has also ..
  9. Quwailid M, Hugill A, Dear N, Vizor L, Wells S, Horner E, et al. A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome. 2004;15:585-91 pubmed
    ..It is now available to academic collaborators as a community resource. ..

More Information

Publications18

  1. Goggolidou P, Hadjirin N, Bak A, Papakrivopoulou E, Hilton H, Norris D, et al. Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet. 2014;23:5303-16 pubmed publisher
    The DNA damage protein and transcription factor Atmin (Asciz) is required for both lung tubulogenesis and ciliogenesis...
  2. Blake S, Stricker S, Halavach H, Poetsch A, Cresswell G, Kelly G, et al. Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation. elife. 2016;5: pubmed publisher
    ..Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development, strongly suppresses GBM formation...
  3. Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, et al. DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS Genet. 2015;11:e1005645 pubmed publisher
    ..The role of a second ATM cofactor, ATMIN (also known as ASCIZ) in T cells is much less clear, and whether ATMIN and NBS1 function in synergy in T cells is ..
  4. Goggolidou P, Stevens J, Agueci F, Keynton J, Wheway G, Grimes D, et al. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014;141:3966-77 pubmed publisher
    Initially identified in DNA damage repair, ATM-interactor (ATMIN) further functions as a transcriptional regulator of lung morphogenesis...
  5. Wong D, Li L, Jurado S, King A, Bamford R, Wall M, et al. The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma. Cell Rep. 2016;14:1488-1499 pubmed publisher
    ..Here, we report that the Zn(2+)-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-..
  6. Anjos Afonso F, Loizou J, Bradburn A, Kanu N, Purewal S, Da Costa C, et al. Perturbed hematopoiesis in mice lacking ATMIN. Blood. 2016;128:2017-2021 pubmed publisher
    The ataxia telangiectasia mutated (ATM)-interacting protein ATMIN mediates noncanonical ATM signaling in response to oxidative and replicative stress conditions...
  7. King A, Li L, Wong D, Liu R, Bamford R, Strasser A, et al. Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms. PLoS Genet. 2017;13:e1007010 pubmed publisher
    ..B-1a and early B-2 cell development in a single, linear pathway with its direct transcriptional activator ASCIZ (ATMIN/ZNF822), and that the two genes also have complementary functions during late B-2 cell development...
  8. Zhang T, Cronshaw J, Kanu N, Snijders A, Behrens A. UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function. Proc Natl Acad Sci U S A. 2014;111:12091-6 pubmed publisher
    The Mre11/Rad50/NBS1 (MRN) protein complex and ATMIN protein mediate ATM kinase signaling in response to ionizing radiation (IR) and chromatin changes, respectively...
  9. Liu R, King A, Hoch N, Chang C, Kelly G, Deans A, et al. ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress. DNA Repair (Amst). 2017;57:29-34 pubmed publisher
    ..It has recently been proposed that replication stress-dependent ATM activation is mediated by ASCIZ (also known as ATMIN, ZNF822), an essential developmental transcription factor...