Atg7

Summary

Gene Symbol: Atg7
Description: autophagy related 7
Alias: 1810013K23Rik, Agp7, Apg7l, Atg7l, Gm21553, ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, autophagy-related protein 7, ubiquitin-activating enzyme E1-like protein
Species: mouse
Products:     Atg7

Top Publications

  1. Shibata M, Yoshimura K, Furuya N, Koike M, Ueno T, Komatsu M, et al. The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun. 2009;382:419-23 pubmed publisher
    ..Taken together, these results indicate that the LC3 conjugation system is critically involved in lipid metabolism via LD formation. ..
  2. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, et al. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 2009;461:654-8 pubmed publisher
    ..It is believed that Atg5 (ref. 4) and Atg7 (ref. 5) are essential genes for mammalian macroautophagy...
  3. Cadwell K, Patel K, Komatsu M, Virgin H, Stappenbeck T. A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy. 2009;5:250-2 pubmed
    ..In the mouse small intestine, one common cellular target of Atg16L1, Atg5 and Atg7 is the Paneth cell, a specialized epithelial cell whose main function is the delivery of antimicrobial factors into ..
  4. Zhang J, Randall M, Loyd M, Dorsey F, Kundu M, Cleveland J, et al. Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood. 2009;114:157-64 pubmed publisher
    ..b>Atg7 is an autophagy protein and an E1-like enzyme, which is required for the activity of dual ubiquitin-like ..
  5. Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher
    ..Here we describe mice deficient in an essential macroautophagy component, Atg7, specifically within postnatal CNS neurons.
  6. Komatsu M, Wang Q, Holstein G, Friedrich V, Iwata J, Kominami E, et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A. 2007;104:14489-94 pubmed
    ..We show that specific ablation of an essential autophagy gene, Atg7, in Purkinje cells initially causes cell-autonomous, progressive dystrophy (manifested by axonal swellings) and ..
  7. DeSelm C, Miller B, Zou W, Beatty W, van Meel E, Takahata Y, et al. Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell. 2011;21:966-74 pubmed publisher
    ..We show that proteins essential for autophagy, including Atg5, Atg7, Atg4B, and LC3, are important for generating the osteoclast ruffled border, the secretory function of osteoclasts, ..
  8. Ahmed I, Liang Y, Schools S, Dawson V, Dawson T, Savitt J. Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. J Neurosci. 2012;32:16503-9 pubmed publisher
    ..of either the dopamine transporter or the engrailed-1 promoters, we generated mice with the conditional deletion of Atg7 in the dopamine neurons of the substantia nigra pars compacta, other regions of the midbrain, and also the ..
  9. Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010;12:213-23 pubmed publisher

More Information

Publications81

  1. Sanjuan M, Dillon C, Tait S, Moshiach S, Dorsey F, Connell S, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature. 2007;450:1253-7 pubmed
    ..LC3 to be rapidly recruited to the phagosome in a manner that depends on the autophagy pathway proteins ATG5 and ATG7; this process is preceded by recruitment of beclin 1 and phosphoinositide-3-OH kinase activity...
  2. Fujishima Y, Nishiumi S, Masuda A, Inoue J, Nguyen N, Irino Y, et al. Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-?B activation. Arch Biochem Biophys. 2011;506:223-35 pubmed publisher
    ..We generated the mice with a conditional deletion of Atg7, which is one of the autophagy regulated gene, in intestinal epithelium...
  3. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, et al. Autophagy regulates lipid metabolism. Nature. 2009;458:1131-5 pubmed publisher
    ..This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome. ..
  4. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169:425-34 pubmed
    ..Here, we generated conditional knockout mice of Atg7, an essential gene for autophagy in yeast...
  5. Lee I, Kawai Y, Fergusson M, Rovira I, Bishop A, Motoyama N, et al. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science. 2012;336:225-8 pubmed publisher
    ..We found that starved mouse embryonic fibroblasts lacking the essential autophagy gene product Atg7 failed to undergo cell cycle arrest...
  6. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004;304:1500-2 pubmed
    ..Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition...
  7. Mortensen M, Soilleux E, Djordjevic G, Tripp R, Lutteropp M, Sadighi Akha E, et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011;208:455-67 pubmed publisher
    ..In this study, we crippled autophagy in HSCs by conditionally deleting the essential autophagy gene Atg7 in the hematopoietic system...
  8. Pua H, Guo J, Komatsu M, He Y. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol. 2009;182:4046-55 pubmed publisher
    ..Here we show that the essential autophagy gene Atg7 is required in a cell-intrinsic manner for the survival of mature primary T lymphocytes...
  9. Saitoh T, Fujita N, Jang M, Uematsu S, Yang B, Satoh T, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008;456:264-8 pubmed publisher
    ..These results demonstrate that Atg16L1 is an essential component of the autophagic machinery responsible for control of the endotoxin-induced inflammatory immune response. ..
  10. Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, et al. Autophagy is required to maintain muscle mass. Cell Metab. 2009;10:507-15 pubmed publisher
    ..Here, we report that muscle-specific deletion of a crucial autophagy gene, Atg7, resulted in profound muscle atrophy and age-dependent decrease in force...
  11. Bell B, Leverrier S, Weist B, Newton R, Arechiga A, Luhrs K, et al. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A. 2008;105:16677-82 pubmed publisher
    ..Inhibition of autophagic signaling with 3-methyladenine, dominant-negative Vps34, or Atg7 shRNA rescued T cells expressing a dominant-negative FADD protein...
  12. Jia W, Pua H, Li Q, He Y. Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol. 2011;186:1564-74 pubmed publisher
    ..We found that ER content is expanded in mature autophagy-related protein (Atg) 7-deficient T lymphocytes. Atg7-deficient T cells stimulated through the TCR display impaired influx, but not efflux, of calcium, and ER calcium ..
  13. Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008;8:325-32 pubmed publisher
    ..Genetic ablation of atg7 in beta cells resulted in degeneration of islets and impaired glucose tolerance with reduced insulin secretion...
  14. Raben N, Schreiner C, Baum R, Takikita S, Xu S, Xie T, et al. Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease. Autophagy. 2010;6:1078-89 pubmed publisher
    ..To clear the fibers of the autophagic debris, we have generated a Pompe model in which an autophagy gene, Atg7, is inactivated in muscle. Suppression of autophagy alone reduced the glycogen level by 50–60%...
  15. Yang L, Li P, Fu S, Calay E, Hotamisligil G. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010;11:467-78 pubmed publisher
    ..In both genetic and dietary models of obesity, we observed a severe downregulation of autophagy, particularly in Atg7 expression levels in liver...
  16. Riley B, Kaiser S, Shaler T, Ng A, Hara T, Hipp M, et al. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol. 2010;191:537-52 pubmed publisher
    ..We show that tissue-specific disruption of the essential autophagy genes Atg5 and Atg7 leads to the accumulation of all detectable Ub-Ub topologies, arguing against the hypothesis that any particular Ub ..
  17. Jung H, Chung K, Won Kim J, Kim J, Komatsu M, Tanaka K, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008;8:318-24 pubmed publisher
    ..We produced mice with beta cell-specific deletion of Atg7 (autophagy-related 7). Atg7 mutant mice showed impaired glucose tolerance and decreased serum insulin level...
  18. Martinez J, Almendinger J, Oberst A, Ness R, Dillon C, Fitzgerald P, et al. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A. 2011;108:17396-401 pubmed publisher
    ..This process is dependent on some members of the classical autophagy pathway, including Beclin1, ATG5, and ATG7. In contrast, ULK1, despite being required for autophagy, is dispensable for LAP induced by uptake of microbes or ..
  19. Friedman L, Lachenmayer M, Wang J, He L, Poulose S, Komatsu M, et al. Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of ?-synuclein and LRRK2 in the brain. J Neurosci. 2012;32:7585-93 pubmed publisher
    ..Cell-specific deletion of essential autophagy gene Atg7 in midbrain DA neurons causes delayed neurodegeneration, accompanied by late-onset locomotor deficits...
  20. Kaushik S, Arias E, Kwon H, Lopez N, ATHONVARANGKUL D, Sahu S, et al. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Rep. 2012;13:258-65 pubmed publisher
    ..Modulating hypothalamic autophagy might have implications for preventing obesity and metabolic syndrome of ageing. ..
  21. Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, et al. Atg7 is required for acrosome biogenesis during spermatogenesis in mice. Cell Res. 2014;24:852-69 pubmed publisher
    ..Here, we show that germ cell-specific Atg7-knockout mice were infertile due to a defect in acrosome biogenesis and displayed a phenotype similar to human ..
  22. Hubbard V, Valdor R, Patel B, Singh R, Cuervo A, Macian F. Macroautophagy regulates energy metabolism during effector T cell activation. J Immunol. 2010;185:7349-57 pubmed publisher
    ..Using a conditional KO mouse model where Atg7, a critical gene for macroautophagy, is specifically deleted in T cells, we have found that macroautophagy-..
  23. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13:619-24 pubmed
  24. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441:880-4 pubmed
    ..However, little is known about the precise roles of autophagy in neurons. Here we report that loss of Atg7 (autophagy-related 7), a gene essential for autophagy, leads to neurodegeneration...
  25. Kongara S, Kravchuk O, Teplova I, Lozy F, Schulte J, Moore D, et al. Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Mol Cancer Res. 2010;8:873-84 pubmed publisher
    ..High phospho(Ser73)-K8 expression may be a marker of autophagy functional status in breast tumors and, as such, could have therapeutic implications for breast cancer patients. ..
  26. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo A, Luu Y, et al. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest. 2009;119:3329-39 pubmed publisher
    ..examined in the current study by genetic inhibition of the critical macroautophagy gene autophagy-related 7 (Atg7)...
  27. Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011;25:795-800 pubmed publisher
    ..Here, we report that mice with systemic mosaic deletion of Atg5 and liver-specific Atg7?/? mice develop benign liver adenomas...
  28. Mariño G, Fernández A, Cabrera S, LUNDBERG Y, Cabanillas R, Rodriguez F, et al. Autophagy is essential for mouse sense of balance. J Clin Invest. 2010;120:2331-44 pubmed publisher
  29. Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007;131:1149-63 pubmed
  30. Mortensen M, Ferguson D, Edelmann M, Kessler B, Morten K, Komatsu M, et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A. 2010;107:832-7 pubmed publisher
    ..Here we show that mice lacking the essential autophagy gene Atg7 in the hematopoietic system develop severe anemia...
  31. Hernandez D, Torres C, Setlik W, Cebrián C, Mosharov E, Tang G, et al. Regulation of presynaptic neurotransmission by macroautophagy. Neuron. 2012;74:277-84 pubmed publisher
    ..Macroautophagy that follows mTOR inhibition in presynaptic terminals, therefore, rapidly alters presynaptic structure and neurotransmission. ..
  32. Patel K, Miyoshi H, Beatty W, Head R, Malvin N, Cadwell K, et al. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J. 2013;32:3130-44 pubmed publisher
    ..These findings provide a novel mechanism by which autophagy proteins can control secretion. ..
  33. Bejarano E, Girao H, Yuste A, Patel B, Marques C, Spray D, et al. Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol Biol Cell. 2012;23:2156-69 pubmed publisher
    ..This study reveals a novel regulatory role for macroautophagy in GJ function that is directly dependent on the ubiquitinylation of plasma membrane connexins. ..
  34. Frudd K, Burgoyne T, Burgoyne J. Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. Nat Commun. 2018;9:95 pubmed publisher
    ..This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7. When inactive Atg3 and Atg7 are protected from oxidation due to stable covalent interaction with their substrate ..
  35. Schmidt E, Fee B, Henry S, Nichols A, Shinohara M, Rathmell J, et al. Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. J Biol Chem. 2017;292:4651-4662 pubmed publisher
    ..This may be a significant contributor to excessive inflammation seen in Irgm1-deficient mice in different contexts. ..
  36. Martinet W, Verheye S, De Meyer I, Timmermans J, Schrijvers D, Van Brussel I, et al. Everolimus triggers cytokine release by macrophages: rationale for stents eluting everolimus and a glucocorticoid. Arterioscler Thromb Vasc Biol. 2012;32:1228-35 pubmed publisher
    ..Everolimus-induced cytokine release was similar in macrophages lacking the essential autophagy gene Atg7 but was inhibited when macrophages were cotreated with p38 MAPK inhibitor SB202190 or the glucocorticoid clobetasol...
  37. Torisu K, Singh K, Torisu T, Lovren F, Liu J, Pan Y, et al. Intact endothelial autophagy is required to maintain vascular lipid homeostasis. Aging Cell. 2016;15:187-91 pubmed publisher
    ..Transient knockdown of the essential autophagy gene ATG7 resulted in higher levels of intracellular (125) I-LDL and oxidized LDL (OxLDL) accumulation, suggesting that in ..
  38. Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, et al. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J Cell Sci. 2015;128:4453-61 pubmed publisher
    ..These results indicate that Sqstm1-GFP(KI/+) mice are a useful tool for analyzing Sqstm1 in living cells and intact animals. ..
  39. Zhang C, Gruber F, Ni C, Mildner M, Koenig U, Karner S, et al. Suppression of autophagy dysregulates the antioxidant response and causes premature senescence of melanocytes. J Invest Dermatol. 2015;135:1348-1357 pubmed publisher
    ..To determine the contribution of autophagy to melanocyte (MC) biology, we inactivated the essential autophagy gene Atg7 specifically in MCs using the Cre-loxP system...
  40. Qiang L, Zhao B, Ming M, Wang N, He T, Hwang S, et al. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci U S A. 2014;111:9241-6 pubmed publisher
  41. Jang Y, Choi K, Min D. Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death Differ. 2014;21:533-46 pubmed publisher
    ..PLD inhibition enhances autophagic flux via ATG1 (ULK1), ATG5 and ATG7, which are essential autophagy gene products critical for autophagosome formation...
  42. Amir M, Zhao E, Fontana L, Rosenberg H, Tanaka K, Gao G, et al. Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation. Cell Death Differ. 2013;20:878-87 pubmed publisher
    ..b>Atg7?hep mice with a hepatocyte-specific knockout of the autophagy gene atg7 were generated and cotreated with D-..
  43. Zhang Y, Cross S, Stanton J, Marmorstein A, Le Y, Marmorstein L. Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7. Mol Vis. 2017;23:228-241 pubmed
    To examine the effects of autophagy deficiency induced by RPE-specific deletion of Atg5 or Atg7 in mice as a function of age...
  44. Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, et al. Inducible disruption of autophagy in the lung causes airway hyper-responsiveness. Biochem Biophys Res Commun. 2011;405:13-8 pubmed publisher
    ..To investigate the importance of autophagy in lung physiology, we used an inducible system to ablate Atg7 expression, which is a protein essential for autophagy, in the respiratory epithelial cells of adult mice...
  45. Martínez López N, ATHONVARANGKUL D, Mishall P, Sahu S, Singh R. Autophagy proteins regulate ERK phosphorylation. Nat Commun. 2013;4:2799 pubmed publisher
    ..ERK2 interacts with ATG proteins via its substrate-binding domains. Deleting Atg7 or Atg5 or blocking LC3 lipidation or ATG5-ATG12 conjugation decreases ERK phosphorylation...
  46. Henault J, Martinez J, Riggs J, Tian J, Mehta P, Clarke L, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity. 2012;37:986-997 pubmed publisher
  47. Lee H, Kim J, Quan W, Lee J, Kim M, Kim S, et al. Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis. Autophagy. 2016;12:1390-403 pubmed publisher
    ..We produced mice with myeloid cell-specific deletion of Atg7 (autophagy-related 7), an essential autophagy gene (Atg7 conditional knockout [cKO] mice)...
  48. Kanayama M, Inoue M, Danzaki K, Hammer G, He Y, Shinohara M. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun. 2015;6:5779 pubmed publisher
    ..Thus, at least in the specific aforementioned tissues, autophagy appears to break A20-dependent suppression in F4/80(hi) macrophages, which express abundant A20 and contribute to the initiation of efficient innate immune responses. ..
  49. Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, et al. Exendin-4 improves ?-cell function in autophagy-deficient ?-cells. Endocrinology. 2013;154:4512-24 pubmed publisher
    ..Also in ?-cell-specific Atg7-deficient mice, exendin-4 efficiently improved blood glucose level and glucose tolerance mainly by enhanced insulin ..
  50. Ye Y, Li X, Wang W, Ouedraogo K, Li Y, Gan C, et al. Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice. Am J Physiol Lung Cell Mol Physiol. 2014;307:L355-63 pubmed publisher
    ..Autophagy-related gene 7 (Atg7) has been implicated in certain bacterial infections; however, the role of Atg7 in macrophage-mediated immunity ..
  51. Yang J, Zhu L, Yuan G, Chen Y, Zhang L, Zhang L, et al. Autophagy appears during the development of the mouse lower first molar. Histochem Cell Biol. 2013;139:109-18 pubmed publisher
    ..The transcripts of autophagy-related genes (Atg5, Atg7, and Atg12) were positively detected in tooth germs at embryonic day (E) 14.5 and postnatal day (P) 5...
  52. Bhattacharya A, Parillon X, Zeng S, Han S, Eissa N. Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis. J Biol Chem. 2014;289:26525-32 pubmed publisher
    ..Here, we report that loss of autophagy-related gene 7 (Atg7) in DCs ameliorated experimental autoimmune encephalomyelitis (EAE), a CD4 T cell-mediated mouse model of multiple ..
  53. Pampliega O, Orhon I, Patel B, Sridhar S, Díaz Carretero A, Beau I, et al. Functional interaction between autophagy and ciliogenesis. Nature. 2013;502:194-200 pubmed publisher
    ..We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies. ..
  54. McMillan E, Quadrilatero J. Autophagy is required and protects against apoptosis during myoblast differentiation. Biochem J. 2014;462:267-77 pubmed publisher
    ..Furthermore, BECN1 (beclin 1), ATG7 (autophagy-related 7) and ATG12-5 protein increased, whereas SQSTM1/p62 (sequestosome 1) protein was rapidly ..
  55. Huebener P, Gwak G, Pradere J, Quinzii C, Friedman R, Lin C, et al. High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab. 2014;19:539-47 pubmed publisher
    ..Collectively, our findings suggest that HMGB1 is dispensable for autophagy, mitochondrial quality control, the regulation of gene expression, and organ function in the adult organism. ..
  56. Shin J, Fattah E, Bhattacharya A, Ko S, Eissa N. Inflammasome activation by altered proteostasis. J Biol Chem. 2013;288:35886-95 pubmed publisher
    ..Our results suggest that altered proteostasis results in inflammasome activation and thus provide mechanisms for the association of altered proteostasis with inflammatory disorders. ..
  57. Tanida I, Yamasaki M, Komatsu M, Ueno T. The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. Autophagy. 2012;8:88-97 pubmed publisher
    b>ATG7 is an autophagy-related E1-like enzyme that is essential for two ubiquitination-like reactions, ATG12-conjugation and LC3-lipidation. The existence of functional sequences at the amino-terminal region of human ATG7 remains uncertain...
  58. Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, et al. A? secretion and plaque formation depend on autophagy. Cell Rep. 2013;5:61-9 pubmed publisher
    ..Our results establish a function for autophagy in A? metabolism: autophagy influences secretion of A? to the extracellular space and thereby directly affects A? plaque formation, a pathological hallmark of AD. ..
  59. Martinez J, Cunha L, Park S, Yang M, Lu Q, Orchard R, et al. Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature. 2016;533:115-9 pubmed publisher
    ..Genome-wide association studies have identified polymorphisms in the Atg5 (ref. 8) and possibly Atg7 (ref. 9) genes, involved in both canonical autophagy and LAP, as markers of a predisposition for SLE...
  60. Zhou J, Ng S, Huang Q, Wu Y, Li Z, Yao S, et al. AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents. FEBS Lett. 2013;587:170-7 pubmed publisher
    ..Taken together, data from this study reveal a novel mechanism in controlling MNNG-mediated autophagy via AMPK activation downstream of PARP-1 activation and ATP depletion. ..
  61. Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A. 2009;106:20842-6 pubmed publisher
    ..The loss of Atg9a, but not that of another autophagy-related gene (Atg7), greatly enhances the assembly of STING and TBK1 by dsDNA, leading to aberrant activation of the innate immune ..
  62. Tang G, Gudsnuk K, Kuo S, Cotrina M, Rosoklija G, Sosunov A, et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 2014;83:1131-43 pubmed publisher
    ..The mTOR inhibitor rapamycin corrected ASD-like behaviors and spine pruning defects in Tsc2 ± mice, but not in Atg7(CKO) neuronal autophagy-deficient mice or Tsc2 ± :Atg7(CKO) double mutants...
  63. Kimmey J, Huynh J, Weiss L, Park S, Kambal A, Debnath J, et al. Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015;528:565-9 pubmed publisher
    ..tuberculosis infection, reveal new outcomes of ATG5 activity, and shed light on early events in innate immunity that are required to regulate disease pathology and bacterial replication. ..
  64. Riahi Y, Wikstrom J, Bachar Wikstrom E, Polin N, Zucker H, Lee M, et al. Autophagy is a major regulator of beta cell insulin homeostasis. Diabetologia. 2016;59:1480-1491 pubmed publisher
    ..Confocal and electron microscopy showed proinsulin localised in autophagosomes and lysosomes. Beta-Atg7 (-/-) mice had proinsulin-containing sequestosome 1 (p62 [also known as SQSTM1])(+) aggregates in beta cells, ..
  65. Jacquel A, Obba S, Boyer L, Dufies M, Robert G, Gounon P, et al. Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions. Blood. 2012;119:4527-31 pubmed publisher
    ..We show here, using pharmacologic inhibitors, siRNA approaches, and Atg7-/- mice, that autophagy initiated by ULK1 is required for proper colony stimulating factor-1-driven differentiation ..
  66. Oliva Trejo J, Asanuma K, Kim E, Takagi Akiba M, Nonaka K, Hidaka T, et al. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Biochem Biophys Res Commun. 2014;446:1190-6 pubmed publisher
    ..explore the significance of podocyte autophagy after unilateral nephrectomy, we investigated podocyte-specific Atg7-deficient mice...
  67. Kenific C, Stehbens S, Goldsmith J, Leidal A, Faure N, Ye J, et al. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016;212:577-90 pubmed publisher
    ..Our findings provide mechanistic insight into how autophagy promotes migration by revealing a requirement for NBR1-mediated selective autophagy in enabling FA disassembly in motile cells. ..
  68. Vazquez P, Arroba A, Cecconi F, de la Rosa E, Boya P, de Pablo F. Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells. Autophagy. 2012;8:187-99 pubmed publisher
    ..Here we report an increase in the expression of the autophagy genes Atg7, Becn1, Ambra1 and LC3 in vivo in the mouse embryonic olfactory bulb (OB) during the initial period of neuronal ..
  69. Watanabe Y, Honda S, Konishi A, Arakawa S, Murohashi M, Yamaguchi H, et al. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 2016;7:13508 pubmed publisher
    ..In vivo, hematopoietic cells from autophagy-deficient and p62-/- mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63. ..
  70. Feeley E, Pilla Moffett D, Zwack E, Piro A, Finethy R, Kolb J, et al. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A. 2017;114:E1698-E1706 pubmed publisher
    ..Our results illustrate that insertion of bacterial secretion systems into PV membranes stimulates Galectin-3-dependent recruitment of antimicrobial GBPs to PVs as part of a coordinated host defense program. ..
  71. Torisu T, Torisu K, Lee I, Liu J, Malide D, Combs C, et al. Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nat Med. 2013;19:1281-7 pubmed publisher
    ..Pharmacological inhibitors of autophagy or knockdown of the essential autophagy genes Atg5 or Atg7 inhibits the in vitro secretion of VWF...
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