Gene Symbol: Atf6
Description: activating transcription factor 6
Alias: 9130025P16Rik, 9630036G24, AA789574, Atf6alpha, ESTM49, cyclic AMP-dependent transcription factor ATF-6 alpha, ATF6-alpha, activating transcription factor 6 alpha, cAMP-dependent transcription factor ATF-6 alpha
Species: mouse
Products:     Atf6

Top Publications

  1. Sato Y, Nadanaka S, Okada T, Okawa K, Mori K. Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus. Cell Struct Funct. 2011;36:35-47 pubmed
    The transcription factor ATF6 is constitutively synthesized as a type II transmembrane protein embedded in the endoplasmic reticulum (ER)...
  2. Teske B, Wek S, Bunpo P, Cundiff J, McClintick J, Anthony T, et al. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell. 2011;22:4390-405 pubmed publisher
    ..Three ER stress sensors (PERK, ATF6, and IRE1) implement the UPR...
  3. Yamamoto K, Yoshida H, Kokame K, Kaufman R, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem. 2004;136:343-50 pubmed
    b>ATF6 and XBP1 are transcription factors activated specifically in response to endoplasmic reticulum (ER) stress...
  4. Rutkowski D, Arnold S, Miller C, Wu J, Li J, Gunnison K, et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006;4:e374 pubmed
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome. ..
  5. Lee A, Iwakoshi N, Glimcher L. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol. 2003;23:7448-59 pubmed
    ..We have investigated here the contribution of the UPR transcription factors XBP-1, ATF6alpha, and ATF6beta to UPR target gene expression...
  6. Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct. 2008;33:75-89 pubmed
    ..transcription factor activated by ER stress-induced proteolysis which consists of two closely related factors, ATF6alpha and ATF6beta, in mammals. ATF6alpha but not ATF6beta plays an important role in transcriptional control...
  7. Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, et al. Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell. 2010;21:2975-86 pubmed publisher
    ..enzymes as well as components of ER-associated degradation, and thereby mouse embryonic fibroblasts deficient in ATF6alpha are sensitive to ER stress...
  8. Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell. 2007;13:365-76 pubmed
    ..Here, we generated ATF6alpha- and ATF6beta-knockout mice, which developed normally, and then found that their double knockout caused ..
  9. Wu J, Rutkowski D, Dubois M, Swathirajan J, Saunders T, Wang J, et al. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell. 2007;13:351-64 pubmed
    In vertebrates, three proteins--PERK, IRE1alpha, and ATF6alpha--sense protein-misfolding stress in the ER and initiate ER-to-nucleus signaling cascades to improve cellular function...

More Information


  1. Sharma M, Bhattacharyya S, Sharma K, Chauhan S, Asthana S, Abdin M, et al. Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells. J Gen Virol. 2017;98:1027-1039 pubmed publisher
    ..of neuronal cells led to activation of all three sensors of ER stress mediated by eIF2?/PERK, IRE1/XBP1 and ATF6. The kinetics of autophagy induction as monitored by levels of SQSTM1 and LC3-II paralleled activation of ER stress...
  2. Hashida K, Kitao Y, Sudo H, Awa Y, Maeda S, Mori K, et al. ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease. PLoS ONE. 2012;7:e47950 pubmed publisher
    ..Enhanced activation of the UPR branches, including ATF6? and PERK/eIF2?/ATF4, was observed after MPTP/P injections into mice...
  3. Firtina Z, Duncan M. Unfolded Protein Response (UPR) is activated during normal lens development. Gene Expr Patterns. 2011;11:135-43 pubmed publisher
    ..These fiber cells also expressed the UPR-associated molecules; XBP1, ATF6, phospho-PERK and ATF4 during embryogenesis...
  4. Gupta A, Hossain M, Read D, Hetz C, Samali A, Gupta S. PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Sci Rep. 2015;5:18304 pubmed publisher
    ..restoration of cellular homeostasis, via the concerted activation of three ER stress sensors, namely IRE1, PERK and ATF6. Global approaches in several cellular contexts have revealed that UPR regulates the expression of many miRNAs that ..
  5. Madhusudhan T, Wang H, Dong W, Ghosh S, Bock F, Thangapandi V, et al. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. Nat Commun. 2015;6:6496 pubmed publisher
    ..spliced X-box binding protein-1 (sXBP1) is selectively impaired in DN, inducing activating transcription factor-6 (ATF6) and C/EBP homology protein (CHOP)...
  6. Gomez J, Rutkowski D. Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression. elife. 2016;5: pubmed publisher
    ..This suppression was due to both silencing of the ATF6α pathway of UPR-dependent transcription and enhancement of mRNA degradation, possibly via regulated IRE1-..
  7. Zhao Z, Cao L, Reece E. Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. Proc Natl Acad Sci U S A. 2017;114:4489-4494 pubmed publisher
    ..Enhancing protein folding could be a potential interventional approach to preventing embryonic malformations in diabetic pregnancies. ..
  8. Upton J, Wang L, Han D, Wang E, Huskey N, Lim L, et al. IRE1? cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012;338:818-22 pubmed publisher
    ..Thus, IRE1? regulates translation of a proapoptotic protein through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response. ..
  9. Ozcan L, Ghorpade D, Zheng Z, de Souza J, Chen K, Bessler M, et al. Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance. Cell Rep. 2016;15:2214-2225 pubmed publisher
    ..In obesity, activation of calcium/calmodulin-dependent protein kinase II (CaMKII) in hepatocytes suppresses ATF6, which triggers a PERK-ATF4-TRB3 pathway that disrupts insulin signaling...
  10. Gomez J, Tyra H, Dezwaan McCabe D, Olivier A, Rutkowski D. Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6?. Biochem Biophys Res Commun. 2014;443:115-9 pubmed publisher
    ..The UPR effector ATF6? augments-but is not essential for-maximal induction of ER chaperones during stress, yet its role, if any, in ..
  11. Lynch J, Maillet M, Vanhoutte D, Schloemer A, Sargent M, Blair N, et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012;149:1257-68 pubmed publisher
    ..Thbs bind the ER lumenal domain of activating transcription factor 6? (Atf6?) to promote its nuclear shuttling...
  12. Ambrose R, Mackenzie J. ATF6 signaling is required for efficient West Nile virus replication by promoting cell survival and inhibition of innate immune responses. J Virol. 2013;87:2206-14 pubmed publisher
    ..To extend our previous observations, we aimed to investigate the contribution of ATF6- and IRE1-mediated signaling during WNV(KUN) replication and how the two sensors contribute to the inhibition of ..
  13. Yoshikawa A, Kamide T, Hashida K, Ta H, Inahata Y, Takarada Iemata M, et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice. J Neurochem. 2015;132:342-53 pubmed publisher
    ..protein response in brain ischemia, we investigated the relevance of activating transcription factor 6α (ATF6α), a master transcriptional factor in the unfolded protein response, after permanent middle cerebral artery ..
  14. Xiong Y, Li W, Lin P, Wang L, Wang N, Chen F, et al. Expression and regulation of ATF6? in the mouse uterus during embryo implantation. Reprod Biol Endocrinol. 2016;14:65 pubmed
    b>ATF6?, one of the sensor proteins in the stress signaling pathway of the endoplasmic reticulum, is located in the membrane of the endoplasmic reticulum...
  15. Xiong Z, Jiang R, Zhang P, Han X, Guo F. Transmission of ER stress response by ATF6 promotes endochondral bone growth. J Orthop Surg Res. 2015;10:141 pubmed publisher
    ..However, the influence of activating transcription factor 6 (ATF6), another transcriptional arm of UPR, in BMP2-induced chondrocyte differentiation has not yet been elucidated...
  16. Smith S, Granell S, Salcedo Sicilia L, Baldini G, Egea G, Teckman J, et al. Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells. J Biol Chem. 2011;286:41563-77 pubmed publisher
    ..Activation of the activating transcription factor 6 (ATF6) branch of the UPR by expression of spliced ATF6(1-373) decreased intracellular accumulation of ATZ and the ..
  17. Wang X, Rao R, Kosakowska Cholody T, Masood M, Southon E, Zhang H, et al. Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009;184:143-58 pubmed publisher
    ..Thus, global compromise of ER and mitochondrial integrity caused by ceramide accumulation in CERT mutant mice primarily affects organogenesis rather than causing cell death via apoptotic pathways. ..
  18. Bobrovnikova Marjon E, Diehl J. Coping with stress: ATF6alpha takes the stage. Dev Cell. 2007;13:322-4 pubmed
    ..and Wu et al., describe the generation of mice with targeted deletion of the ATF6alpha gene...
  19. Scaiewicz V, Nahmias A, Chung R, Mueller T, Tirosh B, Shibolet O. CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. PLoS ONE. 2013;8:e81065 pubmed publisher
    ..Characterization of pathways that may contribute to preferential expression of CHOP in the tumor identified ATF6 as a potential candidate...
  20. Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, et al. Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice. Neurosci Lett. 2016;612:199-203 pubmed publisher
    ..Activating transcription factor 6α (ATF6α) is an ER stress transducer which increases the expression of ER chaperones and ER-associated degradation (ERAD)..
  21. Naranjo J, Zhang H, Villar D, González P, Dopazo X, Morón Oset J, et al. Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. J Clin Invest. 2016;126:627-38 pubmed publisher an interaction between DREAM and the unfolded protein response (UPR) sensor activating transcription factor 6 (ATF6)...
  22. Lowe C, Dennis R, Obi U, O Rahilly S, Rochford J. Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis. Int J Obes (Lond). 2012;36:1248-51 pubmed publisher
    ..In this study, we investigate the importance of ATF6α during adipogenesis using stable knockdown of this protein in the model adipogenic cell line, C3H10T1/2...
  23. Belmont P, Chen W, San Pedro M, Thuerauf D, Gellings Lowe N, Gude N, et al. Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Circ Res. 2010;106:307-16 pubmed publisher
    ..Recently, it was shown that the mouse heart is protected from ischemic damage by ATF6; however, ERAD has not been studied in the cardiac context...
  24. Usui M, Yamaguchi S, Tanji Y, Tominaga R, Ishigaki Y, Fukumoto M, et al. Atf6?-null mice are glucose intolerant due to pancreatic ?-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism. 2012;61:1118-28 pubmed publisher
    Activating transcription factor 6? (ATF6?) is essential for the endoplasmic reticulum (ER) stress response...
  25. Morishima N, Nakanishi K, Nakano A. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. J Biol Chem. 2011;286:35227-35 pubmed publisher
    ..Among the three proximal sensors of ER stress, activating transcription factor-6 (ATF6) is specifically activated in apoptotic myoblasts during myoblast differentiation...
  26. Zhang W, Chen L, Dong Q, He J, Zhao H, Li F, et al. Mmu-miR-702 functions as an anti-apoptotic mirtron by mediating ATF6 inhibition in mice. Gene. 2013;531:235-42 pubmed publisher
    ..well as the expression levels of a subset of apoptosis-related genes including activating transcription factor 6 (ATF6)...
  27. Liu L, Qi X, Chen Z, Shaw L, Cai J, Smith L, et al. Targeting the IRE1?/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. Am J Pathol. 2013;182:1412-24 pubmed publisher
    ..the X-box binding protein-1/inositol-requiring protein-1 (IRE1) ? and activating transcription factor 6 (ATF6) arms of the UPR compared with untreated cells...
  28. Ono Y, Tanaka H, Tsuruma K, Shimazawa M, Hara H. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013;434:904-9 pubmed publisher
    ..These findings suggest that NE-100 suppresses ER stress-induced cell death via CHOP expression by the upregulation of GRP78 through ATF6 pathway, independent sigma-1 receptor antagonist effect.
  29. Oh hashi K, Koga H, Ikeda S, Shimada K, Hirata Y, Kiuchi K. CRELD2 is a novel endoplasmic reticulum stress-inducible gene. Biochem Biophys Res Commun. 2009;387:504-10 pubmed publisher
    ..a luciferase reporter analyses, we demonstrated that the ERSE in mouse CRELD2 is functional and responds to Tg and ATF6-overexpression...
  30. Xiong Y, Chen H, Lin P, Wang A, Wang L, Jin Y. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. Am J Physiol Cell Physiol. 2017;312:C341-C353 pubmed publisher
    Activating transcription factor 6 (ATF6), a sensor protein located in the endoplasmic reticulum (ER) membrane, is an important factor in the ER stress signaling pathway...
  31. Mao H, Ehrhardt N, Bedoya C, Gomez J, Dezwaan McCabe D, Mungrue I, et al. Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6? (Atf6?) signaling. J Biol Chem. 2014;289:24417-27 pubmed publisher
    ..Using genetic deficiencies in mouse embryonic fibroblasts and mouse liver, we identified the Atf6? arm of the unfolded protein response as being responsible for the up-regulation of Lmf1 in ER stress...
  32. Gade P, Manjegowda S, Nallar S, Maachani U, Cross A, Kalvakolanu D. Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1. Mol Cell Biol. 2014;34:4033-48 pubmed publisher
    ..Recently, we have identified that ATF6, an endoplasmic reticulum-resident transcription factor, in association with the transcription factor CEBP-?, ..
  33. Kohl S, Zobor D, Chiang W, Weisschuh N, Staller J, González Menéndez I, et al. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet. 2015;47:757-65 pubmed publisher
    ..gene sequencing, we identified ten families carrying six homozygous and two compound-heterozygous mutations in the ATF6 gene (encoding activating transcription factor 6A), a key regulator of the unfolded protein response (UPR) and ..
  34. Wang Y, Vera L, Fischer W, Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature. 2009;460:534-7 pubmed publisher
    ..which in turn promoted the expression of ER quality control genes through an association with activating transcription factor 6 alpha (ATF6alpha, also known as ATF6)--an integral branch of the unfolded protein response...
  35. Zhang X, Szabo E, Michalak M, Opas M. Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Int J Dev Neurosci. 2007;25:455-63 pubmed
    ..Partially glycosylated form of activating transcription factor 6 alpha, another ER stress indicator, was detected predominantly in embryonic brain...
  36. Ta H, Le T, Ishii H, Takarada Iemata M, Hattori T, Hashida K, et al. Atf6? deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis. J Neurochem. 2016;139:1124-1137 pubmed publisher
    ..In this study, we investigated the relevance of activating transcription factor 6? (ATF6?), an upstream regulator of part of the unfolded protein response, in EAE...
  37. Iwawaki T, Akai R, Yamanaka S, Kohno K. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009;106:16657-62 pubmed publisher
    ..These findings reveal that IRE1alpha plays an essential function in extraembryonic tissues and highlight the relationship of physiological ER stress and angiogenesis in the placenta during pregnancy in mammals. ..
  38. Mao M, Kiss M, Ou Y, Gould D. Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. Dis Model Mech. 2017;10:475-485 pubmed publisher
    ..5. Our results show that the lens and possibly vasculature play important roles in Col4a1-related ASD and that the pathogenic events occur at mid-embryogenesis in mice, during early stages of ocular development. ..
  39. Bilger A, Bennett L, Carabeo R, Chiaverotti T, Dvorak C, Liss K, et al. A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics. 2004;167:859-66 pubmed
    ..Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer. ..
  40. Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, et al. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009;106:3300-5 pubmed publisher
    ..Because S1P has a nonredundant function in the ATF6-dependent unfolded protein response (UPR), woodrat mice show diminished levels of major endoplasmic reticulum ..
  41. Kezuka D, Tkarada Iemata M, Hattori T, Mori K, Takahashi R, Kitao Y, et al. Deletion of Atf6α enhances kainate-induced neuronal death in mice. Neurochem Int. 2016;92:67-74 pubmed publisher
    ..In the present study, we analyzed the role of activating transcription factor 6α (ATF6α), an upstream transcriptional factor critical for the operation of the ER, using mouse intrahippocampal kainate ..
  42. Belmont P, Chen W, Thuerauf D, Glembotski C. Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response. J Mol Cell Cardiol. 2012;52:1176-82 pubmed publisher
    A nodal regulator of endoplasmic reticulum stress is the transcription factor, ATF6, which is activated by ischemia and protects the heart from ischemic damage, in vivo...
  43. Teodoro T, Odisho T, Sidorova E, Volchuk A. Pancreatic ?-cells depend on basal expression of active ATF6?-p50 for cell survival even under nonstress conditions. Am J Physiol Cell Physiol. 2012;302:C992-1003 pubmed publisher
    Activating transcription factor 6 (ATF6) is one of three principle endoplasmic reticulum (ER) stress response proteins and becomes activated when ER homeostasis is perturbed...
  44. Byrd A, Aragon I, Brewer J. MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. J Cell Biol. 2012;196:689-98 pubmed publisher
  45. Mao C, Tai W, Bai Y, Poizat C, Lee A. In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4. J Biol Chem. 2006;281:8877-87 pubmed
    ..Previous studies establish that endoplasmic reticulum stress induces in vivo binding of YY1 and the nuclear form of ATF6 to the ERSE...
  46. Kanekura K, Ma X, Murphy J, Zhu L, Diwan A, Urano F. IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Sci Signal. 2015;8:ra62 pubmed publisher
    ..Our results reveal a role for IRE1 in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome. ..
  47. Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, et al. MANF is indispensable for the proliferation and survival of pancreatic ? cells. Cell Rep. 2014;7:366-75 pubmed publisher
    ..We demonstrate that MANF specifically promotes ? cell proliferation and survival, thereby constituting a therapeutic candidate for ? cell protection and regeneration. ..
  48. Wu J, Ruas J, Estall J, Rasbach K, Choi J, Ye L, et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1?/ATF6? complex. Cell Metab. 2011;13:160-9 pubmed publisher
    ..aspects of skeletal muscle function, mediates the UPR in myotubes and skeletal muscle through coactivation of ATF6?. Efficient recovery from acute exercise is compromised in ATF6?(-/-) mice...
  49. Pena J, Harris E. Dengue virus modulates the unfolded protein response in a time-dependent manner. J Biol Chem. 2011;286:14226-36 pubmed publisher
    ..then suppresses PERK-mediated eIF2? phosphorylation and that in mid and late DENV-2 infection, the IRE1-XBP1 and ATF6 pathways are activated, respectively...
  50. Senkal C, Ponnusamy S, Manevich Y, Meyers Needham M, Saddoughi S, Mukhopadyay A, et al. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. J Biol Chem. 2011;286:42446-58 pubmed publisher
    ..This resulted in the accumulation of pro-ATF-6 in the disrupted ER/Golgi membrane network, where pro-ATF6 is activated...
  51. Kim J, Park S, Kim T, Park H, Park J, Kim B, et al. Testicular hyperthermia induces Unfolded Protein Response signaling activation in spermatocyte. Biochem Biophys Res Commun. 2013;434:861-6 pubmed publisher
    ..These results suggest a link between the UPR signaling pathway and testicular hyperthermia. ..
  52. Schewe D, Aguirre Ghiso J. ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci U S A. 2008;105:10519-24 pubmed publisher
    ..Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells...
  53. Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K, et al. The endoplasmic reticulum stress sensor, ATF6?, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem. 2011;286:7947-57 pubmed publisher
    ..b>ATF6? is an ER-membrane-bound transcription factor that is activated by protein misfolding in the ER and functions as a ..
  54. Jin J, Blackwood E, Azizi K, Thuerauf D, Fahem A, Hofmann C, et al. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circ Res. 2017;120:862-875 pubmed publisher
    ..the accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha), which induces ER stress response genes...
  55. Yu Z, Sheng H, Liu S, Zhao S, Glembotski C, Warner D, et al. Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. J Cereb Blood Flow Metab. 2017;37:1069-1079 pubmed publisher
    ..response (UPR) is induced, which activates 3 ER stress sensor proteins including activating transcription factor 6 (ATF6). ATF6 is then cleaved by proteases to form the short-form ATF6 (sATF6), a transcription factor...
  56. Belmont P, Tadimalla A, Chen W, Martindale J, Thuerauf D, Marcinko M, et al. Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. J Biol Chem. 2008;283:14012-21 pubmed publisher
    ..impair endoplasmic reticulum (ER) protein folding, leading to ER stress and activation of the transcription factor, ATF6. ATF6 binds to ER stress response elements in target genes, inducing expression of proteins that enhance the ER ..
  57. Guo F, Han X, Wu Z, Cheng Z, Hu Q, Zhao Y, et al. ATF6a, a Runx2-activable transcription factor, is a new regulator of chondrocyte hypertrophy. J Cell Sci. 2016;129:717-28 pubmed publisher
    ..Herein, we report that ATF6 and its cleaved N-terminal cytoplasmic domain (known as ATF6a) are expressed in growth plate chondrocytes...
  58. Wang X, Karamariti E, Simpson R, Wang W, Xu Q. Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling. J Biol Chem. 2015;290:19844-52 pubmed publisher
    ..Further investigation indicates that DKK3 added as a cytokine activates activating transcription factor 6 (ATF6), leading to the increased binding of ATF6 on the myocardin promoter and increased its expression...
  59. Credle J, Forcelli P, Delannoy M, Oaks A, Permaul E, Berry D, et al. ?-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease. Neurobiol Dis. 2015;76:112-125 pubmed publisher
    ..b>ATF6, a protective branch of the UPR, is processed via COPII mediated ER-Golgi transit following its activation via ER ..
  60. Afrazi A, Branca M, Sodhi C, Good M, Yamaguchi Y, Egan C, et al. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014;289:9584-99 pubmed publisher
    ..ER kinase), CHOP (C/EBP homologous protein), and MyD88 (myeloid differentiation primary response gene 88), but not ATF6 (activating transcription factor 6) or XBP1 (X-box-binding protein 1)...
  61. Benosman S, Ravanan P, Correa R, Hou Y, Yu M, Gulen M, et al. Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling. PLoS ONE. 2013;8:e64256 pubmed publisher
    ..The action of IRAK2 maps to the IRE1 pathway, rather than the PERK or ATF6 components of the UPR...
  62. Aragon I, Barrington R, Jackowski S, Mori K, Brewer J. The specialized unfolded protein response of B lymphocytes: ATF6?-independent development of antibody-secreting B cells. Mol Immunol. 2012;51:347-55 pubmed publisher
    ..UPR is comprised of three signaling pathways initiated by the ER transmembrane stress sensors, IRE1?/?, PERK and ATF6?/?...
  63. Jegal K, Park S, Cho S, Byun S, Ku S, Kim S, et al. Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury. Biochim Biophys Acta Mol Cell Res. 2017;1864:1295-1307 pubmed publisher
    ..Activating transcription factor 6 (ATF6) bound to unfolded protein response elements of SESN2 promoter, transactivated SESN2, and increased SESN2 protein ..
  64. Engin F, Yermalovich A, Nguyen T, Ngyuen T, Hummasti S, Fu W, et al. Restoration of the unfolded protein response in pancreatic ? cells protects mice against type 1 diabetes. Sci Transl Med. 2013;5:211ra156 pubmed publisher
    ..We identified defects in the expression of unfolded protein response (UPR) mediators ATF6 (activating transcription factor 6) and XBP1 (X-box binding protein 1) in ? cells from two different T1D mouse ..
  65. Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, et al. Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor ?. Diabetes. 2016;65:1904-15 pubmed publisher
    The endoplasmic reticulum quality control protein activating transcription factor 6 (ATF6) has emerged as a novel metabolic regulator...
  66. Han X, Zhang P, Jiang R, Xia F, Li M, Guo F. Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development. Histochem Cell Biol. 2014;142:497-509 pubmed publisher
    We previously report that BMP2 mediates mild ER stress-activated ATF6 and directly regulates XBP1S splicing in the course of chondrogenesis...
  67. Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, et al. Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology. 2014;155:4905-14 pubmed publisher
    Activating transcription factor 6α (ATF6α) is a sensor of endoplasmic reticulum (ER) stress and increases the expression of ER chaperones and molecules related to the ER-associated degradation of unfolded/misfolded proteins...
  68. Firtina Z, Danysh B, Bai X, Gould D, Kobayashi T, Duncan M. Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. J Biol Chem. 2009;284:35872-84 pubmed publisher
    ..Transgenic mice expressing ectopic Col4a3 and Col4a4 genes in the lens exhibited activation of IRE1, ATF6, and PERK associated with expansion of the endoplasmic reticulum and attenuation of general protein translation...
  69. Elimam H, Papillon J, Takano T, Cybulsky A. Calcium-independent phospholipase A2γ enhances activation of the ATF6 transcription factor during endoplasmic reticulum stress. J Biol Chem. 2015;290:3009-20 pubmed publisher
    ..that fails to associate with the ER, augmented tunicamycin-induced activation of activating transcription factor-6 (ATF6) and induction of the ER chaperones, glucose-regulated protein 94 (GRP94) and glucose-regulated protein 78 (GRP78)...
  70. Gade P, Ramachandran G, Maachani U, Rizzo M, Okada T, Prywes R, et al. An IFN-?-stimulated ATF6-C/EBP-?-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. Proc Natl Acad Sci U S A. 2012;109:10316-21 pubmed publisher
    ..Here, we show that ATF6, an ER stress-induced transcription factor, interacts with C/EBP-? in an IFN-stimulated manner and is obligatory ..