Gene Symbol: Atat1
Description: alpha tubulin acetyltransferase 1
Alias: 0610011P08Rik, 2610008K08Rik, 2610110G12Rik, 3110080J08Rik, Mec17, TAT, alpha-tubulin N-acetyltransferase 1, acetyltransferase mec-17 homolog, alpha-TAT, alpha-TAT1
Friedmann D, Aguilar A, Fan J, Nachury M, Marmorstein R. Structure of the ?-tubulin acetyltransferase, ?TAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012;109:19655-60 pubmed publisher
Kalebic N, Sorrentino S, Perlas E, Bolasco G, Martínez C, Heppenstall P. ?TAT1 is the major ?-tubulin acetyltransferase in mice. Nat Commun. 2013;4:1962 pubmed publisher
..elegans. Here we generate mice with a targeted deletion of Atat1 to determine its function in mammals...
Zhang Y, Ma C, Delohery T, Nasipak B, Foat B, Bounoutas A, et al
. Identification of genes expressed in C. elegans touch receptor neurons. Nature. 2002;418:331-5 pubmed
..Using regions 5' of the start codon of the first 20 genes, we have also identified an over-represented heptanucleotide, AATGCAT, that is needed for the expression of touch receptor genes. ..
Akella J, Wloga D, Kim J, Starostina N, Lyons Abbott S, Morrissette N, et al
. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010;467:218-22 pubmed publisher
..In summary, we identify MEC-17 as an enzyme that acetylates the K40 residue of alpha-tubulin, the only PTM known to occur on the luminal surface of microtubules...
Kim G, Li L, Ghorbani M, You L, Yang X. Mice lacking ?-tubulin acetyltransferase 1 are viable but display ?-tubulin acetylation deficiency and dentate gyrus distortion. J Biol Chem. 2013;288:20334-50 pubmed publisher
..There is one such protein known as Atat1 (?-tubulin acetyltransferase 1) per higher organism...
Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, et al
. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;14:454-60 pubmed publisher
..Therefore, in addition to direct activation of NLRP3, the creation of optimal sites for signal transduction by microtubules is required for activation of the entire NLRP3 inflammasome. ..
Montagnac G, Meas Yedid V, Irondelle M, Castro Castro A, Franco M, Shida T, et al
. ?TAT1 catalyses microtubule acetylation at clathrin-coated pits. Nature. 2013;502:567-70 pubmed publisher
..In migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis. ..
Yang W, Guo X, Thein S, Xu F, Sugii S, Baas P, et al
. Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of ?-tubulin. Biochem J. 2013;449:605-12 pubmed publisher
Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury M. ?-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol Biol Cell. 2014;25:1854-66 pubmed publisher
..Because ?-tubulin K40 acetylation is largely eliminated by deletion of ?TAT1, we propose that acetylated microtubules regulate contact inhibition of proliferation through the Hippo pathway. ..