Gene Symbol: Astl
Description: astacin-like metalloendopeptidase (M12 family)
Alias: 7420700F21, C87576, Sas1b, astacin-like metalloendopeptidase, astl, oocyte astacin, ovastacin, sperm acrosomal SLLP1, sperm acrosomal SLLP1-binding protein
Quesada V, Sanchez L, Alvarez J, Lopez Otin C. Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. J Biol Chem. 2004;279:26627-34 pubmed
..human and mouse ovary cDNAs encoding a new protein of the astacin family of metalloproteinases, called ovastacin because of its predominant expression in ovarian tissues...
Acloque H, Lavial F, Pain B. Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis. Dev Dyn. 2012;241:574-82 pubmed publisher
..In the chick, however, functions of Astacin-like proteins remain elusive.
We report here that Astacin-like (ASTL) is strongly expressed in mouse and chicken embryonic stem (ES) cells and exhibits a very dynamic expression ..
Sachdev M, Mandal A, Mulders S, Digilio L, Panneerdoss S, Suryavathi V, et al
. Oocyte specific oolemmal SAS1B involved in sperm binding through intra-acrosomal SLLP1 during fertilization. Dev Biol. 2012;363:40-51 pubmed publisher
..An oocyte specific membrane metalloproteinase, SAS1B (Sperm Acrosomal SLLP1 Binding), was identified as a SLLP1 binding partner...
Burkart A, Xiong B, Baibakov B, Jim nez Movilla M, Dean J. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012;197:37-44 pubmed publisher
..Based on the cleavage site of ZP2, ovastacin was selected as a candidate protease...
Xiong B, Zhao Y, Beall S, Sadusky A, Dean J. A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice. PLoS Genet. 2017;13:e1006580 pubmed publisher
..Sperm bind to the N-terminus of ZP2 which is cleaved after fertilization by ovastacin (encoded by Astl) exocytosed from egg cortical granules to prevent sperm binding...