Gene Symbol: Aspn
Description: asporin
Alias: 4631401G09Rik, AA986886, Plap1, Slrr1c, asporin, periodontal ligament-associated protein 1
Species: mouse
Products:     Aspn

Top Publications

  1. Chakraborty S, Cheek J, Sakthivel B, Aronow B, Yutzey K. Shared gene expression profiles in developing heart valves and osteoblast progenitor cells. Physiol Genomics. 2008;35:75-85 pubmed publisher
    ..enriched genes during valvulogenesis were members of the small leucine-rich proteoglycan (SLRP) family including Asporin, a known negative regulator of osteoblast differentiation and mineralization...
  2. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..effects on collagen and extracellular matrix in vivo have been elucidated; one of the less investigated SLRPs is asporin. Here we describe the successful generation of an Aspn-/- mouse model and the investigation of the Aspn-/- skin ..
  3. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, et al. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet. 2005;37:138-44 pubmed
    Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with osteoarthritis, in the ..
  4. Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S. Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem. 2007;282:32185-92 pubmed
    ..Recently, we demonstrated a genetic association between the cartilage extracellular matrix protein asporin and OA (Kizawa, H., Kou, I., Iida, A., Sudo, A., Miyamoto, Y., Fukuda, A., Mabuchi, A., Kotani, A., Kawakami, A...
  5. Awata T, Yamada S, Tsushima K, Sakashita H, Yamaba S, Kajikawa T, et al. PLAP-1/Asporin Positively Regulates FGF-2 Activity. J Dent Res. 2015;94:1417-24 pubmed publisher
    ..Extracellular matrix-growth factor interactions have considerable effects; thus, this approach may be useful in several regenerative medicine applications. ..
  6. Lorenzo P, Aspberg A, Onnerfjord P, Bayliss M, Neame P, Heinegard D. Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan. J Biol Chem. 2001;276:12201-11 pubmed
    b>Asporin, a novel member of the leucine-rich repeat family of proteins, was partially purified from human articular cartilage and meniscus...
  7. Yamada S, Tomoeda M, Ozawa Y, Yoneda S, Terashima Y, Ikezawa K, et al. PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization. J Biol Chem. 2007;282:23070-80 pubmed
    Periodontal ligament-associated protein-1 (PLAP-1)/asporin is a recently identified novel member of the small leucine-rich repeat proteoglycan family...
  8. Kou I, Nakajima M, Ikegawa S. Expression and regulation of the osteoarthritis-associated protein asporin. J Biol Chem. 2007;282:32193-9 pubmed
    b>Asporin (ASPN) is a small leucine-rich proteoglycan that is involved in pathological processes of osteoarthritis...
  9. Wurtz T, Houari S, Mauro N, Macdougall M, Peters H, Berdal A. Fluoride at non-toxic dose affects odontoblast gene expression in vitro. Toxicology. 2008;249:26-34 pubmed publisher
    ..At 1mM fluoride, RNAs encoding the extracellular matrix proteins asporin and fibromodulin, and the cell membrane associated proteins periostin and IMT2A were 10-fold reduced...

More Information


  1. Beiser K, Glaser A, Kleinschmidt K, Scholl I, Röth R, Li L, et al. Identification of novel SHOX target genes in the developing limb using a transgenic mouse model. PLoS ONE. 2014;9:e98543 pubmed publisher
    ..This finding was confirmed in human NHDF and U2OS cells and chicken micromass culture, demonstrating the value of the SHOX-transgenic mouse for the characterization of SHOX-dependent genes and pathways in early limb development. ..
  2. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010;24:1173-85 pubmed publisher
    ..We show that miR-140 regulates cartilage development and homeostasis, and its loss contributes to the development of age-related OA-like changes. ..
  3. Nuka S, Zhou W, Henry S, Gendron C, Schultz J, Shinomura T, et al. Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage. 2010;18:88-96 pubmed publisher
    ..expression compared with wild type mice, including other small leucine-rich proteoglycan (SLRP) members such as asporin, fibromodulin and lumican...
  4. Bianchi E, Ferrari S. Beta-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFkappaB gene expression network in osteoblasts. Bone. 2009;45:716-25 pubmed publisher
    ..of a genomic cluster coding for small leucin-rich proteins (SLRPs) including osteoglycin, osteomodulin and asporin. Pathway analyses identified a main gene network centered on p38 MAPK and NFkappaB that requires beta-arrestin2 ..
  5. Tomoeda M, Yamada S, Shirai H, Ozawa Y, Yanagita M, Murakami S. PLAP-1/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif. Biochem Biophys Res Commun. 2008;371:191-6 pubmed publisher
    We previously identified the novel gene, periodontal ligament-associated protein-1 (PLAP-1)/asporin and reported that PLAP-1/asporin inhibited bone morphogenetic protein-2 (BMP-2)-induced cytodifferentiation of periodontal ligament (PDL) ..
  6. Henry S, Takanosu M, Boyd T, Mayne P, Eberspaecher H, Zhou W, et al. Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family. J Biol Chem. 2001;276:12212-21 pubmed
    ..For this reason, we called the molecule asporin. The deduced amino acid sequence is about 50% identical (and 70% similar) to decorin and biglycan...
  7. Kou I, Nakajima M, Ikegawa S. Binding characteristics of the osteoarthritis-associated protein asporin. J Bone Miner Metab. 2010;28:395-402 pubmed publisher
    b>Asporin is an extracellular matrix (ECM) protein that regulates cartilage matrix gene expression and cartilage formation by modulating the transforming growth factor-beta (TGF-beta) signaling pathway...
  8. Yamaba S, Yamada S, Kajikawa T, Awata T, Sakashita H, Tsushima K, et al. PLAP-1/Asporin Regulates TLR2- and TLR4-induced Inflammatory Responses. J Dent Res. 2015;94:1706-14 pubmed publisher
    Periodontal ligament-associated protein 1 (PLAP-1)/asporin is an extracellular matrix protein preferentially expressed in periodontal ligaments...