Gene Symbol: Asic3
Description: acid-sensing (proton-gated) ion channel 3
Alias: AW742291, Accn3, DRASIC, SLNAC1, TNAC1, acid-sensing ion channel 3, amiloride-sensitive cation channel 3, dorsal root ASIC
Species: mouse
Products:     Asic3

Top Publications

  1. Mogil J, Breese N, Witty M, Ritchie J, Rainville M, Ase A, et al. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J Neurosci. 2005;25:9893-901 pubmed
    ..Therefore, we have generated transgenic mice that express a dominant-negative form of the ASIC3 subunit that inactivates all native neuronal ASIC-like currents by oligomerization...
  2. Staniland A, McMahon S. Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test. Eur J Pain. 2009;13:554-63 pubmed publisher
    ..This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) ..
  3. Cheng C, Chen I, Cheng M, Lian W, Lin C, Kuo T, et al. Acid-sensing ion channel 3, but not capsaicin receptor TRPV1, plays a protective role in isoproterenol-induced myocardial ischemia in mice. Circ J. 2011;75:174-8 pubmed
    ..Recently, both acid-sensing ion channel 3 (ASIC3) and capsaicin receptor (TRPV1) have been suggested as important mediators in sensing cardiac ischemia...
  4. Walder R, Rasmussen L, Rainier J, Light A, Wemmie J, Sluka K. ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J Pain. 2010;11:210-8 pubmed publisher
    ..We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation...
  5. Walder R, Gautam M, Wilson S, Benson C, Sluka K. Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation. Pain. 2011;152:2348-56 pubmed publisher
    ..Earlier studies show ASIC3 is important for induction of hyperalgesia after muscle insult using ASIC3-/- mice...
  6. Lin Y, Min M, Lin C, Chen W, Wu W, Yu H, et al. Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3. Neuroscience. 2008;151:544-57 pubmed
    Acid-sensing ion channel 3 (ASIC3) is the most sensitive acid sensor in sensory neurons that innervate into skin, muscle, heart, and visceral tissues...
  7. Xie J, Price M, Berger A, Welsh M. DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels. J Neurophysiol. 2002;87:2835-43 pubmed
    ..Large DRG neurons express the dorsal root acid sensing ion channel (DRASIC), suggesting that DRASIC might contribute to H+-gated DRG currents...
  8. Hughes P, Brierley S, Young R, Blackshaw L. Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. J Comp Neurol. 2007;500:863-75 pubmed
    ..QPCR of whole thoracolumbar DRG revealed and abundance of ASIC2 > ASIC1 > ASIC3. Similarly, FISH of all neurons in thoracolumbar DRG demonstrated that ASIC2 was expressed in the most (40 +/- 1%) ..
  9. Hildebrand M, de Silva M, Klockars T, Rose E, Price M, Smith R, et al. Characterisation of DRASIC in the mouse inner ear. Hear Res. 2004;190:149-60 pubmed
    ..of 1536 cDNA clones isolated from the mouse inner ear, suggested that the expression of the mechanoreceptor DRASIC was enriched in the cochlea compared to other tissues...

More Information


  1. Hruska Hageman A, Benson C, Leonard A, Price M, Welsh M. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004;279:46962-8 pubmed
    The acid-sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral nervous system...
  2. Huang C, Tzeng J, Chen Y, Tsai W, Chen C, Sun W. Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors. Mol Cell Neurosci. 2007;36:195-210 pubmed
    ..We have also demonstrated that gene expression of proton-sensing GPCRs is changed in ASIC3 knockout mice...
  3. Ikeuchi M, Kolker S, Sluka K. Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis. J Pain. 2009;10:336-42 pubmed publisher
    Arthritis is associated with decreases in local pH. Of the acid-sensing ion channels (ASIC), ASIC3 is most sensitive to such a pH change, abundantly expressed in dorsal root ganglion (DRG), and critical for the development of secondary ..
  4. Price M, Thompson R, Eshcol J, Wemmie J, Benson C. Stomatin modulates gating of acid-sensing ion channels. J Biol Chem. 2004;279:53886-91 pubmed
    ..Stomatin potently reduced acid-evoked currents generated by ASIC3 without changing steady state protein levels or the amount of ASIC3 expressed at the cell surface...
  5. Price M, McIlwrath S, Xie J, Cheng C, Qiao J, Tarr D, et al. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron. 2001;32:1071-83 pubmed
    ..We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in ..
  6. Yen Y, Tu P, Chen C, Lin Y, Hsieh S, Chen C. Role of acid-sensing ion channel 3 in sub-acute-phase inflammation. Mol Pain. 2009;5:1 pubmed publisher
    ..Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators...
  7. Page A, Brierley S, Martin C, Price M, Symonds E, Butler R, et al. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut. 2005;54:1408-15 pubmed
    ..Here they investigate further ASIC1a in gut mechanoreceptors, and compare its influence with ASIC2 and ASIC3. Expression of ASIC1a, 2, and 3 mRNA was found in vagal (nodose) and dorsal root ganglia (DRG), and was lost in ..
  8. Chen C, Zimmer A, Sun W, Hall J, Brownstein M, Zimmer A. A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc Natl Acad Sci U S A. 2002;99:8992-7 pubmed
    Acid-sensing ion channel 3 (ASIC3), a proton-gated ion channel of the degenerins/epithelial sodium channel (DEG/ENaC) receptor family is expressed predominantly in sensory neurons including nociceptive neurons responding to protons...
  9. Jones R, Xu L, Gebhart G. The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci. 2005;25:10981-9 pubmed
    ..We tested the hypothesis that transient receptor potential vanilloid 1 (TRPV1) and acid-sensing ion channel 3 (ASIC3) are peripheral mechanosensors in colon afferent neuronal fibers that mediate visceral nociceptive behavior in ..
  10. Gautam M, Benson C. Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits. FASEB J. 2013;27:793-802 pubmed publisher
    ..ASICs are formed as homotrimers or heterotrimers of several isoforms (ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3), with each channel displaying distinct properties...
  11. Page A, Brierley S, Martin C, Hughes P, Blackshaw L. Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain. 2007;133:150-60 pubmed
    ..Inhibition of colonic afferent mechanosensitivity by benzamil was markedly diminished in ASIC2-/- and ASIC3-/- mice, but unchanged in ASIC1a-/-...
  12. Hattori T, Chen J, Harding A, Price M, Lu Y, Abboud F, et al. ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ Res. 2009;105:279-86 pubmed publisher
    ..This was supported by studies in ASIC-null mice: acid-evoked currents from ASIC3(-/-) cardiac afferents matched the properties of ASIC2a channels, and currents from ASIC2(-/-) cardiac afferents ..
  13. Lee C, Sun S, Lin S, Chen C. Role of the acid-sensing ion channel 3 in blood volume control. Circ J. 2011;75:874-83 pubmed
    ..We hypothesized that the acid-sensing ion channel 3 (ASIC3) might be a candidate for the mechanically sensitive molecules expressed in the volume receptors...
  14. Benson C, Xie J, Wemmie J, Price M, Henss J, Welsh M, et al. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A. 2002;99:2338-43 pubmed
    ..The biophysical properties of three degenerin/epithelial sodium (DEG/ENaC) channel subunits (BNC1, ASIC, and DRASIC), and their expression in DRG, suggest that they might underlie these H(+)-gated currents and function as sensory ..
  15. Drew L, Rohrer D, Price M, Blaver K, Cockayne D, Cesare P, et al. Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol. 2004;556:691-710 pubmed
    ..molecules are members of the acid-sensing ion channel (ASIC) family; nerve fibre recordings have shown ASIC2 and ASIC3 null mutants have aberrant responses to suprathreshold mechanical stimuli...
  16. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  17. Lin C, Chen W, Chen C, Lin Y, Zimmer A, Chen C. An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci U S A. 2012;109:E76-83 pubmed publisher
    ..m. acid injection. ..
  18. Sluka K, Radhakrishnan R, Benson C, Eshcol J, Price M, Babinski K, et al. ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain. 2007;129:102-12 pubmed
    ..The current study tested the hypothesis that ASIC3 in muscle is necessary for development of cutaneous mechanical, but not heat, hyperalgesia induced by muscle ..
  19. Sluka K, Price M, Breese N, Stucky C, Wemmie J, Welsh M. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain. 2003;106:229-39 pubmed
    ..Dorsal root ganglion neurons innervating muscle express ASIC3 and respond to acidic pH with fast, transient inward and sustained currents that resemble those of ASICs...
  20. Fromy B, Lingueglia E, Sigaudo Roussel D, Saumet J, Lazdunski M. Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers. Nat Med. 2012;18:1205-7 pubmed publisher
    ..Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and ..
  21. Ikeuchi M, Kolker S, Burnes L, Walder R, Sluka K. Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain. 2008;137:662-9 pubmed publisher
    The acid sensing ion channel 3 (ASIC3) is critical for the development of secondary hyperalgesia as measured by mechanical stimulation of the paw following muscle insult...
  22. Chen X, Whissell P, Orser B, MacDonald J. Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. PLoS ONE. 2011;6:e21970 pubmed publisher
    ..We conclude that GABA(A) receptors and glycine receptors modify ASICs in neurons through mechanisms that require the opening of chloride channels. ..
  23. Ettaiche M, Deval E, Pagnotta S, Lazdunski M, Lingueglia E. Acid-sensing ion channel 3 in retinal function and survival. Invest Ophthalmol Vis Sci. 2009;50:2417-26 pubmed publisher
    ..The authors analyzed the expression in rodent retina of ASIC3, a sensor of extracellular acidosis, and used ASIC3 knockout mice to explore its role in retinal function and ..
  24. Gong W, Kolker S, USACHEV Y, Walder R, Boyle D, Firestein G, et al. Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. Arthritis Res Ther. 2014;16:R121 pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis...
  25. Petroff E, Snitsarev V, Gong H, Abboud F. Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels. Biochem Biophys Res Commun. 2012;426:511-5 pubmed publisher
    ..Our data suggest that ASICs can act as endogenous pH-dependent inhibitors of BK channels, and thereby can reduce neuronal excitability. ..
  26. Reimers C, Lee C, Kalbacher H, Tian Y, Hung C, Schmidt A, et al. Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain. Proc Natl Acad Sci U S A. 2017;114:E3507-E3515 pubmed publisher
    ..conopeptide of only four amino acids from the venom of Conus textile that strongly potentiated currents of ASIC3, which has a specific role in the pain pathway. This peptide, RPRFamide, belongs to the subgroup of cono-RFamides...
  27. Chu X, Wemmie J, Wang W, Zhu X, Saugstad J, Price M, et al. Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci. 2004;24:8678-89 pubmed
    ..and heteromeric ASIC1a-ASIC2a channels, without affecting currents mediated by homomeric ASIC1beta, ASIC2a, or ASIC3. Consistent with ASIC1a-specific modulation, high-affinity Zn2+ inhibition is absent in neurons from ASIC1a knock-..
  28. Sluka K, Rasmussen L, Edgar M, O Donnell J, Walder R, Kolker S, et al. Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis. Arthritis Rheum. 2013;65:1194-202 pubmed publisher
  29. Huang S, Yang W, Lin Y, Wang H, Chen C. Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3. Biochem Biophys Res Commun. 2008;371:729-34 pubmed publisher
    ..Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells...
  30. Burnes L, Kolker S, Danielson J, Walder R, Sluka K. Enhanced muscle fatigue occurs in male but not female ASIC3-/- mice. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1347-55 pubmed publisher
    ..Decreases in extracellular pH activates acid-sensing ion channel 3 (ASIC3), depolarizes muscle, protects against fatigue, and produces pain...
  31. Auer J, Reeh P, Fischer M. Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3. Neurogastroenterol Motil. 2010;22:680-7 pubmed publisher
    ..Both transient receptor potential vanilloid type 1 (TRPV1) and acid-sensing ion channel type 3 (ASIC3) are expressed in the sensory neurons innervating the stomach walls and are responsible for the transduction of ..
  32. Tong J, Wu W, Kong X, Wu P, Tian L, Du W, et al. Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells. J Immunol. 2011;186:3686-92 pubmed publisher
    ..We found that ASIC1, ASIC2, and ASIC3 are expressed in DCs at the mRNA and protein levels, and extracellular acid can evoke ASIC-like currents in DCs...
  33. Lin S, Cheng Y, Banks R, Min M, Bewick G, Chen C. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors. Nat Commun. 2016;7:11460 pubmed publisher
    Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed...
  34. Cheng C, Kuo T, Chen W, Lin C, Chen C. Abnormal cardiac autonomic regulation in mice lacking ASIC3. Biomed Res Int. 2014;2014:709159 pubmed publisher
    ..Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a ..
  35. Hiasa M, Okui T, Allette Y, Ripsch M, Sun Wada G, Wakabayashi H, et al. Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3. Cancer Res. 2017;77:1283-1295 pubmed publisher
    ..CGRP+ sensory nerves also expressed increased levels of the acid-sensing nociceptor ASIC3. Notably, a single injection of the selective ASIC3 antagonist APETx2 dramatically reduced MMBP in the model...
  36. Gregory N, Brito R, Fusaro M, Sluka K. ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia. Mol Neurobiol. 2016;53:1020-30 pubmed publisher
    ..We hypothesized that proton accumulation during muscle fatigue activates acid-sensing ion channel 3 (ASIC3) on muscle nociceptors to produce hyperalgesia...
  37. Marra S, Ferru Clément R, Breuil V, Delaunay A, Christin M, Friend V, et al. Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids. EMBO J. 2016;35:414-28 pubmed publisher
    ..that human painful inflammatory exudates, displaying non-acidic pH, induce a slow constitutive activation of human ASIC3 channels...
  38. Chen W, Hsieh C, Huang C, Lin T, Tzen J, Ho T, et al. Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain. J Biomed Sci. 2011;18:82 pubmed publisher
    ..Recent studies have suggested a significantly increased expression of acid-sensing ion channel 3 (ASIC3) in both carrageenan- and complete Freund's adjuvant (CFA)-induced inflammation...
  39. Jones R, Otsuka E, Wagstrom E, Jensen C, Price M, Gebhart G. Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Gastroenterology. 2007;133:184-94 pubmed
    ..the contributions of 2 proteins, transient receptor potential vanilloid 1 (TRPV1) and acid-sensing ion channel 3 (ASIC3), on development of behavioral hypersensitivity and assessed the function of colon mechanoreceptors of ..
  40. Wang X, Li W, Yu Y, Xiao X, Cheng J, Zeng W, et al. Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. J Neurosci. 2013;33:4265-79 pubmed publisher
    ..mediator, specifically enhances the proton-evoked sustained, but not transient, currents mediated by homomeric ASIC3 channels and heteromeric ASIC3/1a and ASIC3/1b channels...
  41. Lin S, Steinhoff M, Ikoma A, Chang Y, Cheng Y, Chandra Kopparaju R, et al. Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis. J Invest Dermatol. 2017;137:170-178 pubmed publisher
    ..Results indicate that TRPV1, but neither ASIC3 nor TRPA1, is involved in the acidic citrate-induced scratching response...
  42. Dykes I, Lanier J, Eng S, Turner E. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3 pubmed publisher
    ..Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes. ..
  43. Kanaya K, Iba K, Abe Y, Dohke T, Okazaki S, Matsumura T, et al. Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice. J Orthop Res. 2016;34:566-73 pubmed publisher
    ..These results indicated that the skeletal pain accompanying osteoporosis is possibly associated with the acidic microenvironment and increased ATP level caused by osteoclast activation under a high bone turnover state. ..
  44. Xin J, Su Y, Yang Z, He W, Shi H, Wang X, et al. Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia. Front Med. 2016;10:465-472 pubmed publisher
    ..This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia...
  45. Ross J, Queme L, Cohen E, Green K, Lu P, Shank A, et al. Muscle IL1? Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization. J Neurosci. 2016;36:6857-71 pubmed publisher
    ..on acid-sensing ion channels (ASICs) because treatment of sensory afferents in vitro with IL1?-upregulated ASIC3 in single cells, and nerve-specific knock-down of ASIC3 recapitulated the results of inhibiting the enhanced IL1?/..
  46. Peng Z, Li W, Huang C, Jiang Y, Wang X, Zhu M, et al. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Rep. 2015;13:387-98 pubmed publisher
    ..Here, we report a role for acid-sensing ion channel 3 (ASIC3) in mediating itch evoked by certain pruritogens during tissue acidosis...
  47. Jiang Y, Huang C, Peng Z, Han S, Li W, Zhu M, et al. Acidosis counteracts itch tachyphylaxis to consecutive pruritogen exposure dependent on acid-sensing ion channel 3. Mol Pain. 2017;13:1744806917721114 pubmed publisher
  48. Wu W, Wang C, Huang E, Chen C. Asic3(-/-) female mice with hearing deficit affects social development of pups. PLoS ONE. 2009;4:e6508 pubmed publisher
    ..Here we used mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to create a hearing deficit to probe the effect of caregiver hearing on maternal care and adolescent social ..
  49. Detweiler N, Vigil K, Resta T, Walker B, Jernigan N. Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. PLoS ONE. 2018;13:e0192724 pubmed publisher
    ..Whole-body plethysmography was used to monitor ventilatory parameters in conscious, unrestrained ASIC1, ASIC2, or ASIC3 knockout (-/-) and wild-type (WT) mice at baseline, during isocapnic hypoxemia and during hypercapnia...
  50. Wu W, Lin Y, Min M, Chen C. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes Brain Behav. 2010;9:603-14 pubmed publisher
    ..Here we created a sensory deficit model of mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to probe behavioral alterations. ASIC3 is predominately distributed in the peripheral nervous system...
  51. Chen W, Lee C, Lin S, Wong C, Sun W, Wood J, et al. Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain. 2014;10:40 pubmed publisher
    ..changes of muscle nociceptors were modality-specific and required the activation of acid-sensing ion channel 3 (ASIC3) or transient receptor potential cation channel V1 (TRPV1)...
  52. Kong X, Tang X, Du W, Tong J, Yan Y, Zheng F, et al. Extracellular acidosis modulates the endocytosis and maturation of macrophages. Cell Immunol. 2013;281:44-50 pubmed publisher
    ..surface molecular expression and interleukin-10 secretion of BMMs, in which the expression of ASIC1 and ASIC3 was detected...
  53. Bielefeldt K, Davis B. Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice. Am J Physiol Gastrointest Liver Physiol. 2008;294:G130-8 pubmed
    Using a recently developed in vitro preparation of vagal afferent pathways, we examined the role of TRPV1 and ASIC3 on the mechano- and chemosensitive properties of gastroesophageal sensory neurons...
  54. Li M, Leng T, Feng X, Yang T, Simon R, Xiong Z. Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke. J Biol Chem. 2016;291:18370-83 pubmed publisher
    ..that the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits...
  55. Yudin Y, Tamarova Z, Krishtal O. Peripherally applied neuropeptide SF is equally algogenic in wild type and ASIC3-/- mice. Neurosci Res. 2006;55:421-5 pubmed
    ..We have addressed this question by comparing the effects of neuropeptide SF (NPSF), mammalian RFa peptide, in ASIC3-/- and wild-type C57BL/6J mice. Knockout of ASIC3 gene results in the changes in some of the behavioral parameters...
  56. Wultsch T, Painsipp E, Shahbazian A, Mitrovic M, Edelsbrunner M, Lazdunski M, et al. Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis. Pain. 2008;134:245-53 pubmed
    ..Since the acid-sensing ion channels ASIC2 and ASIC3 are expressed by primary afferent neurons, we examined whether knockout of the ASIC2 or ASIC3 gene modifies ..
  57. Osmakov D, Kozlov S, Andreev Y, Koshelev S, Sanamyan N, Sanamyan K, et al. Sea anemone peptide with uncommon ?-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity. J Biol Chem. 2013;288:23116-27 pubmed publisher Ugr 9-1), produced a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in Xenopus laevis oocytes. It completely blocked the transient component (IC50 10 ± 0...
  58. Moshourab R, Wetzel C, Martinez Salgado C, Lewin G. Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity. J Physiol. 2013;591:5555-74 pubmed publisher
    ..Single gene deletion of asic3, asic2, stomatin, or stoml3 all result in deficits in the mechanosensitivity of distinct cutaneous afferents in ..
  59. Askwith C, Cheng C, Ikuma M, Benson C, Price M, Welsh M. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron. 2000;26:133-41 pubmed
    ..on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels. The neuropeptides slowed inactivation and induced sustained currents during acidification...
  60. Lopes C, Liu Z, Xu Y, Ma Q. Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci. 2012;32:9706-15 pubmed publisher
    ..Collectively, these studies suggest that genetically Tlx3 acts in combination with Runx1 to control the development of a cohort of nociceptors, thermoceptors, and pruriceptors in mice. ..
  61. Deval E, Salinas M, Baron A, Lingueglia E, Lazdunski M. ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J Biol Chem. 2004;279:19531-9 pubmed
    b>ASIC3, an acid-sensing ion channel subunit expressed essentially in sensory neurons, has been proposed to be involved in pain...
  62. Vralsted V, Price M, Du J, Schnizler M, Wunsch A, Ziemann A, et al. Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes Brain Behav. 2011;10:444-50 pubmed publisher
    ..effects of altering the subunit composition of brain ASICs on behavior, we developed transgenic mice expressing ASIC3 via the pan-neuronal synapsin I promoter...