Asic1

Summary

Gene Symbol: Asic1
Description: acid-sensing (proton-gated) ion channel 1
Alias: AI843610, ASIC, ASIC1a, Accn2, B530003N02Rik, BNaC2, acid-sensing ion channel 1, amiloride-sensitive cation channel 2, neuronal, brain sodium channel 2, degenerin 2
Species: mouse
Products:     Asic1

Top Publications

  1. Wemmie J, Chen J, Askwith C, Hruska Hageman A, Price M, Nolan B, et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 2002;34:463-77 pubmed
    ..We found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons...
  2. Wemmie J, Askwith C, Lamani E, Cassell M, Freeman J, Welsh M. Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci. 2003;23:5496-502 pubmed
    The acid-sensing ion channel, ASIC1, contributes to synaptic plasticity in the hippocampus and to hippocampus-dependent spatial memory. To explore the role of ASIC1 in brain, we examined the distribution of ASIC1 protein...
  3. Jin W, Shen C, Jing L, Zha X, Xia J. PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner. Mol Brain. 2010;3:39 pubmed publisher
    Acid-sensing ion channel 1a (ASIC1a) is the major ASIC subunit determining acid-activated currents in brain neurons. Recent studies show that ASIC1a play critical roles in acid-induced cell toxicity...
  4. Benson C, Xie J, Wemmie J, Price M, Henss J, Welsh M, et al. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A. 2002;99:2338-43 pubmed
    ..The biophysical properties of three degenerin/epithelial sodium (DEG/ENaC) channel subunits (BNC1, ASIC, and DRASIC), and their expression in DRG, suggest that they might underlie these H(+)-gated currents and function ..
  5. Friese M, Craner M, Etzensperger R, Vergo S, Wemmie J, Welsh M, et al. Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med. 2007;13:1483-9 pubmed
    ..The neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) is permeable to Na+ and Ca2+, and excessive accumulation of these ions is associated with axonal degeneration...
  6. Vukicevic M, Weder G, Boillat A, Boesch A, Kellenberger S. Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating. J Biol Chem. 2006;281:714-22 pubmed
    ..Trypsin cleaves ASIC1a with a similar time course as it changes ASIC1a function, whereas ASIC1b, whose function is not modified by ..
  7. Petroff E, Price M, Snitsarev V, Gong H, Korovkina V, Abboud F, et al. Acid-sensing ion channels interact with and inhibit BK K+ channels. Proc Natl Acad Sci U S A. 2008;105:3140-4 pubmed publisher
    ..Therefore, we tested the hypothesis that ASIC channels might inhibit K(+) channel function by coexpressing ASIC1a and the high-conductance Ca(2+)- and voltage-activated K(+) (BK) channel...
  8. Wu L, Duan B, Mei Y, Gao J, Chen J, Zhuo M, et al. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem. 2004;279:43716-24 pubmed
    ..Reverse transcriptase-nested PCR and Western blotting showed that three ASIC isoforms, ASIC1a, ASIC2a, and ASIC2b, are expressed at a high level in dorsal horn neurons...
  9. Price M, Thompson R, Eshcol J, Wemmie J, Benson C. Stomatin modulates gating of acid-sensing ion channels. J Biol Chem. 2004;279:53886-91 pubmed
    ..We found that stomatin co-immunoprecipitated and co-localized with ASIC proteins in heterologous cells. Moreover, stomatin altered the function of ASIC channels...

More Information

Publications82

  1. Ziemann A, Schnizler M, Albert G, Severson M, Howard M, Welsh M, et al. Seizure termination by acidosis depends on ASIC1a. Nat Neurosci. 2008;11:816-22 pubmed publisher
    ..Because acid-sensing ion channel 1a (ASIC1a) is exquisitely sensitive to extracellular pH and regulates neuron excitability, we hypothesized that acidosis ..
  2. Sherwood T, Askwith C. Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. J Neurosci. 2009;29:14371-80 pubmed publisher
    Acid-sensing ion channel 1a (ASIC1a) promotes neuronal damage during pathological acidosis...
  3. Passero C, Okumura S, Carattino M. Conformational changes associated with proton-dependent gating of ASIC1a. J Biol Chem. 2009;284:36473-81 pubmed publisher
    ..technique to define the role of the region preceding TM2 (pre-TM2) in activation and desensitization of mouse ASIC1a. Oocytes expressing E425C channels labeled with Alexa Fluor 488 C5-maleimide showed a change in the emission of ..
  4. Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, Voilley N, et al. A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat Neurosci. 2007;10:943-5 pubmed
    ..The analgesic properties of the peptide are suppressed by antagonists of the mu and delta-opioid receptors and are lost in Penk1-/- mice. ..
  5. Drew L, Rohrer D, Price M, Blaver K, Cockayne D, Cesare P, et al. Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol. 2004;556:691-710 pubmed
    ..Amongst candidate transducer molecules are members of the acid-sensing ion channel (ASIC) family; nerve fibre recordings have shown ASIC2 and ASIC3 null mutants have aberrant responses to suprathreshold ..
  6. Alvarez de la Rosa D, Krueger S, Kolar A, Shao D, Fitzsimonds R, Canessa C. Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J Physiol. 2003;546:77-87 pubmed
    The acid-sensitive ion channel ASIC1 is a proton-gated ion channel from the mammalian nervous system...
  7. Chu X, Wemmie J, Wang W, Zhu X, Saugstad J, Price M, et al. Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci. 2004;24:8678-89 pubmed
    ..With ASICs expressed in Chinese hamster ovary cells, Zn2+ inhibits currents mediated by homomeric ASIC1a and heteromeric ASIC1a-ASIC2a channels, without affecting currents mediated by homomeric ASIC1beta, ASIC2a, or ..
  8. Cho J, Askwith C. Presynaptic release probability is increased in hippocampal neurons from ASIC1 knockout mice. J Neurophysiol. 2008;99:426-41 pubmed
    ..Transfection of ASIC1a into ASIC1 knockout neurons increased the PPRs, suggesting that alterations in release probability were not the ..
  9. Leonard A, Yermolaieva O, Hruska Hageman A, Askwith C, Price M, Wemmie J, et al. cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A. 2003;100:2029-34 pubmed
    The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis...
  10. Coryell M, Wunsch A, Haenfler J, Allen J, McBride J, Davidson B, et al. Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. J Neurosci. 2008;28:13738-41 pubmed publisher
    Acid-sensing ion channel-1a (ASIC1a) contributes to multiple fear behaviors, however the site of ASIC1a action in behavior is not known...
  11. Chai S, Li M, Branigan D, Xiong Z, Simon R. Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem. 2010;285:13002-11 pubmed publisher
    Acid-sensing ion channels (ASICs) are voltage-independent Na(+) channels activated by extracellular protons. ASIC1a is expressed in neurons in mammalian brain and is implicated in long term potentiation of synaptic transmission that ..
  12. Bässler E, Ngo Anh T, Geisler H, Ruppersberg J, Grunder S. Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. J Biol Chem. 2001;276:33782-7 pubmed
    ..Recently, a splice variant, ASIC-beta, has been described for ASIC1a. In this variant about one-third of the protein is exchanged at the N terminus...
  13. Zha X, Wemmie J, Green S, Welsh M. Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proc Natl Acad Sci U S A. 2006;103:16556-61 pubmed
    ..Using organotypic hippocampal slices and biolistic transfection, we found the acid-sensing ion channel 1a (ASIC1a), localized in dendritic spines where it functioned as a proton receptor...
  14. Li T, Yang Y, Canessa C. Impact of recovery from desensitization on acid-sensing ion channel-1a (ASIC1a) current and response to high frequency stimulation. J Biol Chem. 2012;287:40680-9 pubmed publisher
    Consecutive proton stimulation reduces ASIC1a peak currents leading to silencing of channels.
  15. Askwith C, Wemmie J, Price M, Rokhlina T, Welsh M. Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. J Biol Chem. 2004;279:18296-305 pubmed
    ..We found that much of the current was produced by ASIC1a/2a heteromultimeric channels, and individual subunits made distinct contributions...
  16. Kusama N, Harding A, Benson C. Extracellular chloride modulates the desensitization kinetics of acid-sensing ion channel 1a (ASIC1a). J Biol Chem. 2010;285:17425-31 pubmed publisher
    Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. The recent crystallization of ASIC1a identified potential binding sites for Cl(-) in the extracellular domain that are highly conserved between ASIC ..
  17. Coryell M, Ziemann A, Westmoreland P, Haenfler J, Kurjakovic Z, Zha X, et al. Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biol Psychiatry. 2007;62:1140-8 pubmed
    ..Previous studies indicated that the acid sensing ion channel ASIC1a influences fear behavior in conditioning paradigms...
  18. Jiang Q, Li M, Papasian C, Branigan D, Xiong Z, Wang J, et al. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience. 2009;162:55-66 pubmed publisher
    ..The pH value for half-maximal activation was 6.25, close to that obtained in homomeric ASIC1a channels. Based on psalmotoxin 1 and zinc sensitivity, ASIC1a (70...
  19. Wu P, Huang Y, Chen C, Hsu T, Lin Y, Weng J, et al. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J Neurosci. 2013;33:1828-32 pubmed publisher
    Acid-sensing ion channel-1a (ASIC1a) is localized in brain regions with high synaptic density and is thought to contribute to synaptic plasticity, learning, and memory...
  20. Wemmie J, Coryell M, Askwith C, Lamani E, Leonard A, Sigmund C, et al. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A. 2004;101:3621-6 pubmed
    The acid-sensing ion channel 1a (ASIC1a) is abundantly expressed in the amygdala complex and other brain regions associated with fear. Studies of mice with a disrupted ASIC1 gene suggested that ASIC1a may contribute to learned fear...
  21. Jiang Q, Wang C, Fibuch E, Wang J, Chu X. Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice. Neuroscience. 2013;246:170-8 pubmed publisher
    Acid-sensing ion channels (ASICs) are densely expressed in the brain with ASIC1a and ASIC2 channels being the predominant subtypes...
  22. Sherwood T, Askwith C. Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. J Biol Chem. 2008;283:1818-30 pubmed
    ..b>ASIC1a plays a role in learning, pain, and fear-related behaviors...
  23. Cho J, Askwith C. Potentiation of acid-sensing ion channels by sulfhydryl compounds. Am J Physiol Cell Physiol. 2007;292:C2161-74 pubmed
    ..analyze the impact of sulfhydryls on H(+)-gated currents from Chinese hamster ovary (CHO) cells expressing human ASIC1a (hASIC1a). We found that hASIC1a currents activated by pH 6...
  24. Xiong Z, Zhu X, Chu X, Minami M, Hey J, Wei W, et al. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 2004;118:687-98 pubmed
    ..Cells lacking endogenous ASICs are resistant to acid injury, while transfection of Ca2+ -permeable ASIC1a establishes sensitivity...
  25. Ziemann A, Allen J, Dahdaleh N, Drebot I, Coryell M, Wunsch A, et al. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell. 2009;139:1012-21 pubmed publisher
    ..Because the amygdala expresses acid-sensing ion channel-1a (ASIC1a), and ASIC1a is required for normal fear responses, we hypothesized that the amygdala might detect a reduced pH...
  26. Garcia Anoveros J, Derfler B, Neville Golden J, Hyman B, Corey D. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A. 1997;94:1459-64 pubmed
    ..We have identified two new members of this superfamily (BNaC1 and BNaC2) in a human brain cDNA library...
  27. Zha X, Costa V, Harding A, Reznikov L, Benson C, Welsh M. ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci. 2009;29:8438-46 pubmed publisher
    Acid-sensing ion channel-1a (ASIC1a) mediates H(+)-gated current to influence normal brain physiology and impact several models of disease...
  28. Donier E, Rugiero F, Okuse K, Wood J. Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. J Biol Chem. 2005;280:38666-72 pubmed
    ..We found that annexin II light chain p11 physically interacts with the N terminus of ASIC1a, but not other ASIC isoforms...
  29. Zeng W, Liu D, Duan B, Song X, Wang X, Wei D, et al. Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. J Neurosci. 2013;33:7066-78 pubmed publisher
    ..Here, we demonstrate that ASIC1a, the main ASIC subunit in the brain, undergoes constitutive endocytosis in a clathrin- and dynamin-dependent ..
  30. Price M, Gong H, Parsons M, Kundert J, Reznikov L, Bernardinelli L, et al. Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes Brain Behav. 2014;13:179-94 pubmed publisher
    ..Like ASIC1, ASIC2 subunits are expressed in the brain and multimerize with ASIC1 to influence acid-evoked currents and ..
  31. Page A, Brierley S, Martin C, Martinez Salgado C, Wemmie J, Brennan T, et al. The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology. 2004;127:1739-47 pubmed
    ..We examined the influence of the DEG/ENaC channel ASIC1 on gastrointestinal mechanosensory function, on gastric emptying, and on fecal output...
  32. Wang Y, Wang J, Huang Y, Liu F, Zeng W, Li Y, et al. Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. elife. 2015;4: pubmed publisher
    ..Traditionally, Ca(2+) influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity...
  33. Li T, Yang Y, Canessa C. A method for activation of endogenous acid-sensing ion channel 1a (ASIC1a) in the nervous system with high spatial and temporal precision. J Biol Chem. 2014;289:15441-8 pubmed publisher
    Protons activate acid-sensing ion channel 1a (ASIC1a) in the central nervous system (CNS) although the impact of such activation on brain outputs remains elusive...
  34. Drummond H, Xiang L, Chade A, Hester R. Enhanced maximal exercise capacity, vasodilation to electrical muscle contraction, and hind limb vascular density in ASIC1a null mice. Physiol Rep. 2017;5: pubmed publisher
    ..Therefore, the purpose of this study was to determine if one ASIC protein, ASIC1a, contributes to extracellular proton-gated vascular responses and exercise tolerance...
  35. Wang Y, Zeng W, Xiao X, Huang Y, Song X, Yu Z, et al. Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell Death Differ. 2013;20:1359-69 pubmed publisher
    Acid-sensing ion channel 1a (ASIC1a) is the key proton receptor in nervous systems, mediating acidosis-induced neuronal injury in many neurological disorders, such as ischemic stroke...
  36. Kusama N, Gautam M, Harding A, Snyder P, Benson C. Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition. Am J Physiol Cell Physiol. 2013;304:C89-101 pubmed publisher
    Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl(-)-binding sites in the extracellular domain, which are highly conserved between ASIC subunits...
  37. Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy V, Colding J, et al. A selectivity filter at the intracellular end of the acid-sensing ion channel pore. elife. 2017;6: pubmed publisher
    ..We observed no preference for sodium at the "GAS belt" in the central constriction. Instead, we identified a band of glutamate and aspartate side chains at the lower end of the pore that enables preferential sodium conduction. ..
  38. Komnig D, Imgrund S, Reich A, Grunder S, Falkenburger B. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease. PLoS ONE. 2016;11:e0165235 pubmed publisher
    ..To complement these findings we determined MPTP toxicity in mice deficient for ASIC1a, the most common ASIC isoform in neurons. MPTP was applied i.p. in doses of 30 mg per kg on five consecutive days...
  39. Lapatsina L, Jira J, Smith E, Poole K, Kozlenkov A, Bilbao D, et al. Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. Open Biol. 2012;2:120096 pubmed publisher
    A complex of stomatin-family proteins and acid-sensing (proton-gated) ion channel (ASIC) family members participate in sensory transduction in invertebrates and vertebrates...
  40. Staniland A, McMahon S. Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test. Eur J Pain. 2009;13:554-63 pubmed publisher
    ..This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli ..
  41. Duan B, Liu D, Huang Y, Zeng W, Wang X, Yu H, et al. PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci. 2012;32:6351-63 pubmed publisher
    ..is modulated by brain-derived neurotrophic factor (BDNF) and also involves the type 1a acid-sensing ion channel (ASIC1a). However, the interactions between the BDNF receptor, tropomyosin-related kinase B (TrkB), and ASIC1a are unclear...
  42. Taugher R, Lu Y, Wang Y, Kreple C, Ghobbeh A, Fan R, et al. The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis. J Neurosci. 2014;34:10247-55 pubmed publisher
    ..terminalis (BNST) contributes to fear- and anxiety-related behaviors and expresses acid-sensing ion channel-1A (ASIC1A), we hypothesized that the BNST plays an important role in CO2-evoked fear-related behaviors in mice...
  43. Hughes P, Brierley S, Young R, Blackshaw L. Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. J Comp Neurol. 2007;500:863-75 pubmed
    ..We determined relative expression of ASIC1, 2, and 3 in mouse thoracolumbar dorsal root ganglia (DRG) by quantitative reverse-transcriptase polymerase chain ..
  44. Jing L, Chu X, Zha X. Three distinct motifs within the C-terminus of acid-sensing ion channel 1a regulate its surface trafficking. Neuroscience. 2013;247:321-7 pubmed publisher
    ..Here, we discovered that three distinct motifs regulate the trafficking of acid-sensing ion channel 1a (ASIC1a), the primary neuronal proton receptor which plays critical roles in neurological diseases including stroke, ..
  45. Kreple C, Lu Y, Taugher R, Schwager Gutman A, Du J, Stump M, et al. Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci. 2014;17:1083-91 pubmed publisher
    Acid-sensing ion channel 1A (ASIC1A) is abundant in the nucleus accumbens (NAc), a region known for its role in addiction...
  46. Duan B, Wang Y, Yang T, Chu X, Yu Y, Huang Y, et al. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 2011;31:2101-12 pubmed publisher
    ..spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis...
  47. Li M, Leng T, Feng X, Yang T, Simon R, Xiong Z. Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke. J Biol Chem. 2016;291:18370-83 pubmed publisher
    ..infarct volume in vivo Moreover, we find that the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits...
  48. Du J, Price M, Taugher R, Grigsby D, Ash J, Stark A, et al. Transient acidosis while retrieving a fear-related memory enhances its lability. elife. 2017;6: pubmed publisher
    ..The results suggest that transient acidosis during retrieval renders the memory of an aversive event more labile and suggest a strategy to modify debilitating memories. ..
  49. Li W, Liu M, Deng S, Liu Y, Shang L, Ding J, et al. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun. 2016;7:13770 pubmed publisher
    Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term depression (LTD) at mouse insular synapses...
  50. Krauson A, Rued A, Carattino M. Independent contribution of extracellular proton binding sites to ASIC1a activation. J Biol Chem. 2013;288:34375-83 pubmed publisher
    ..substituted cysteine accessibility method and site-directed mutagenesis to examine the mechanism of activation of ASIC1a by extracellular protons...
  51. Liu M, Li H, Li W, Wu Y, Deng S, Huang C, et al. Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms. Sci Rep. 2016;6:23350 pubmed publisher
    ..Here, we address the contribution of ASIC1a to five forms of synaptic plasticity in the mouse hippocampus using an in vitro multi-electrode array recording ..
  52. Chai S, Li M, Lan J, Xiong Z, Saugstad J, Simon R. A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem. 2007;282:22668-77 pubmed
    Acid-sensing ion channel (ASIC) 1a and ASIC2a are acid-sensing ion channels in central and peripheral neurons. ASIC1a has been implicated in long-term potentiation of synaptic transmission and ischemic brain injury, whereas ASIC2a is ..
  53. Taugher R, Lu Y, Fan R, Ghobbeh A, Kreple C, Faraci F, et al. ASIC1A in neurons is critical for fear-related behaviors. Genes Brain Behav. 2017;16:745-755 pubmed publisher
    ..While these effects have been attributed to ASIC1A in neurons, it has been reported that ASICs may also function in nonneuronal cells...
  54. Vann K, Xiong Z. Acid-sensing ion channel 1 contributes to normal olfactory function. Behav Brain Res. 2018;337:246-251 pubmed publisher
    Acid-sensing ion channels (ASICs) are cation channels activated by protons. ASIC1a, a primary ASIC subunit in the brain, was recently characterized in the olfactory bulb...
  55. Gao S, Yu Y, Ma Z, Sun H, Zhang Y, Wang X, et al. NMDAR-Mediated Hippocampal Neuronal Death is Exacerbated by Activities of ASIC1a. Neurotox Res. 2015;28:122-37 pubmed publisher
    NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions, but the functional relationship between them is unclear...
  56. Mazzone G, Veeraraghavan P, Gonzalez Inchauspe C, Nistri A, Uchitel O. ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury. Neuroscience. 2017;343:398-410 pubmed publisher
    ..01mM concentration that is near-threshold for damage) increased mRNA expression of ASIC1a, ASIC1b, ASIC2 and ASIC3, an effect reversed by the ASIC inhibitor 4',6-diamidino-2-phenylindole (DAPI)...
  57. Detweiler N, Vigil K, Resta T, Walker B, Jernigan N. Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. PLoS ONE. 2018;13:e0192724 pubmed publisher
    ..Whole-body plethysmography was used to monitor ventilatory parameters in conscious, unrestrained ASIC1, ASIC2, or ASIC3 knockout (-/-) and wild-type (WT) mice at baseline, during isocapnic hypoxemia and during ..
  58. Borzan J, Zhao C, Meyer R, Raja S. A role for acid-sensing ion channel 3, but not acid-sensing ion channel 2, in sensing dynamic mechanical stimuli. Anesthesiology. 2010;113:647-54 pubmed publisher
    ..However, the ASIC3 channel significantly modulates the sensing of dynamic mechanical stimuli in physiologic condition. ..
  59. Carattino M, Della Vecchia M. Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivity. J Biol Chem. 2012;287:12927-34 pubmed publisher
    ..The ion permeation pathway of ASIC1a is defined by residues 426-450 in the second transmembrane (TM2) segment...
  60. Krauson A, Carattino M. The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization. J Biol Chem. 2016;291:11407-19 pubmed publisher
    ..Our studies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization...
  61. Reznikov L, Meyerholz D, Adam R, Abou Alaiwa M, Jaffer O, Michalski A, et al. Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. PLoS ONE. 2016;11:e0166089 pubmed publisher
    ..Moreover, airway acidification activates ASIC currents and depolarizes neurons innervating airways. We found ASIC1a protein in vagal ganglia neurons, but not airway epithelium or smooth muscle...
  62. Kozlenkov A, Lapatsina L, Lewin G, Smith E. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. J Physiol. 2014;592:557-69 pubmed publisher
    ..STOML1 profoundly inhibits ASIC1a, but has no effect on the splice variant ASIC1b...
  63. Kong X, Tang X, Du W, Tong J, Yan Y, Zheng F, et al. Extracellular acidosis modulates the endocytosis and maturation of macrophages. Cell Immunol. 2013;281:44-50 pubmed publisher
    ..the endocytosis, surface molecular expression and interleukin-10 secretion of BMMs, in which the expression of ASIC1 and ASIC3 was detected...
  64. Jing L, Chu X, Jiang Y, Collier D, Wang B, Jiang Q, et al. N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling. J Neurosci. 2012;32:4080-91 pubmed publisher
    Acid-sensing ion channel-1a (ASIC1a) is a potential therapeutic target for multiple neurological diseases...
  65. Gautam M, Benson C. Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits. FASEB J. 2013;27:793-802 pubmed publisher
    ..ASICs are formed as homotrimers or heterotrimers of several isoforms (ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3), with each channel displaying distinct properties...
  66. Cittaro D, Lampis V, Luchetti A, Coccurello R, Guffanti A, Felsani A, et al. Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes. Sci Rep. 2016;6:25131 pubmed publisher
    ..Among these genes, Asic1 showed heightened mRNA expression, coherent with RCF-mice's respiratory hypersensitivity to CO2 and altered ..
  67. Lin S, Cheng Y, Banks R, Min M, Bewick G, Chen C. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors. Nat Commun. 2016;7:11460 pubmed publisher
    ..We conclude that, at least in mouse, ASIC3 is a molecular determinant contributing to dynamic mechanosensitivity in proprioceptors. ..
  68. Jing L, Jiang Y, Jiang Q, Wang B, Chu X, Zha X. The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking. PLoS ONE. 2011;6:e26909 pubmed publisher
    Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multiple diseases including stroke, epilepsy and multiple sclerosis...
  69. Baron A, Voilley N, Lazdunski M, Lingueglia E. Acid sensing ion channels in dorsal spinal cord neurons. J Neurosci. 2008;28:1498-508 pubmed publisher
    ..We show here that ASIC1a and ASIC2a are the most abundant ASICs in mouse adult spinal cord and are coexpressed by most neurons throughout ..
  70. Lin S, Chien Y, Chiang W, Liu Y, Lien C, Chen C. Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur J Neurosci. 2015;41:1553-68 pubmed publisher
    ..To probe the possible role of ASIC4, we hypothesised that ASIC4 could modulate the membrane expression of ASIC1a and thus ASIC1a signaling in vivo...
  71. Du J, Reznikov L, Price M, Zha X, Lu Y, Moninger T, et al. Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci U S A. 2014;111:8961-6 pubmed publisher
    ..They also indicate that protons and ASICs are a neurotransmitter/receptor pair critical for amygdala-dependent learning and memory. ..
  72. Hattori T, Chen J, Harding A, Price M, Lu Y, Abboud F, et al. ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ Res. 2009;105:279-86 pubmed publisher
    ..Four genes encode six different ASIC subunits, however it is not yet clear which of the ASIC subunits contribute to the composition of ASICs in cardiac ..
  73. Ugawa S, Inagaki A, Yamamura H, Ueda T, Ishida Y, Kajita K, et al. Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair cells. Neuroreport. 2006;17:1235-9 pubmed
    We investigated whether amiloride-blockable proton-gated cation channels ASIC1a (acid-sensing ion channel-1a) and ASIC1b are expressed in the stereocilia of mouse cochlear hair cells...