Gene Symbol: Asgr2
Description: asialoglycoprotein receptor 2
Alias: ASGPR2, Asgr, Asgr-2, HL-2, asialoglycoprotein receptor 2, hepatic lectin 2
Species: mouse
Products:     Asgr2

Top Publications

  1. Mi Y, Coonce M, Fiete D, Steirer L, Dveksler G, Townsend R, et al. Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation. J Biol Chem. 2016;291:18700-17 pubmed publisher
    The mannose receptor (ManR, Mrc1) and asialoglycoprotein receptor (ASGR, Asgr1 and Asgr2) are highly abundant endocytic receptors expressed by sinusoidal endothelial cells and parenchymal cells in the liver, respectively...
  2. Sanford J, Elliott R, Doyle D. Asialoglycoprotein receptor genes are linked on chromosome 11 in the mouse. DNA. 1988;7:721-8 pubmed
    ..b>Asgr is designated to name asialoglycoprotein gene loci. Coordinate regulation of this linked gene family is discussed.
  3. Ishibashi S, Hammer R, Herz J. Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. J Biol Chem. 1994;269:27803-6 pubmed
    ..Although these mice are completely unable to clear asialoorosomucoid, a high affinity ligand for asialoglycoprotein receptor, they do not accumulate desialylated glycoproteins or lipoproteins in their circulation. ..
  4. Braun J, Willnow T, Ishibashi S, Ashwell G, Herz J. The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit. J Biol Chem. 1996;271:21160-6 pubmed
    ..However, competitive in vitro degradation experiments suggest that other endogenous ASGPR ligands, the nature of which remain to be determined, accumulate in serum of knockout animals. ..
  5. Grozovsky R, Begonja A, Liu K, Visner G, Hartwig J, Falet H, et al. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015;21:47-54 pubmed publisher
  6. Blackburn C, Griffith J, Morahan G. A high-resolution map of the chromosomal region surrounding the nude gene. Genomics. 1995;26:308-17 pubmed
    ..We also report the typing of the above microsatellite markers in the AKXD, AKXL, BXD, CXB, and BXH recombinant inbred strains, which confirmed the relative order and separation of loci in this region. ..
  7. Guy C, Rankin S, Michalak T. Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor. Hepatology. 2011;54:1043-50 pubmed publisher
    ..The study adds a new dimension to the physiological role of hepatic ASGPR and provides further evidence that hepatocytes can actively contribute to intrahepatic immune regulation and moderation of the local inflammatory response. ..
  8. Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, et al. APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans. Stem Cell Rev. 2011;7:43-52 pubmed publisher
    ..Moreover, APOA-1 gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans. ..
  9. Rumjantseva V, Grewal P, Wandall H, Josefsson E, Sørensen A, Larson G, et al. Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nat Med. 2009;15:1273-80 pubmed publisher
    ..Inhibition of chilled platelet clearance by both beta(2) integrin and Ashwell-Morell receptors may afford a potentially simple method for storing platelets in the cold. ..

More Information


  1. Steirer L, Park E, Townsend R, Baenziger J. The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid alpha2,6-galactose. J Biol Chem. 2009;284:3777-83 pubmed publisher
    ..We propose that the ASGP-R mediates the clearance of glycoproteins that bear oligosaccharides terminating with Siaalpha2,6Gal and thereby helps maintain the relative concentrations of these glycoproteins in the blood. ..
  2. Dalton S, Wiegert R, Baldwin C, Kassel K, Casey C. Impaired receptor-mediated endocytosis by the asialoglycoprotein receptor in ethanol-fed mice: implications for studying the role of this receptor in alcoholic apoptosis. Biochem Pharmacol. 2003;65:535-43 pubmed
    ..These results support the use of the ASGPR-deficient mouse model for studying ethanol-induced liver injury, specifically ethanol-induced apoptosis. ..
  3. Yang W, Aziz P, Heithoff D, Mahan M, Smith J, Marth J. An intrinsic mechanism of secreted protein aging and turnover. Proc Natl Acad Sci U S A. 2015;112:13657-62 pubmed publisher
    ..This intrinsic multifactorial mechanism of secreted protein aging and turnover contributes to health and the outcomes of disease. ..
  4. Grewal P, Uchiyama S, Ditto D, Varki N, Le D, Nizet V, et al. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008;14:648-55 pubmed publisher
    ..Hemostatic adaptation by the Ashwell receptor moderates the onset and severity of disseminated intravascular coagulation during sepsis and improves the probability of host survival. ..
  5. Baron B, Poirier C, Simon Chazottes D, Barnier C, Guenet J. A new strategy useful for rapid identification of microsatellites from DNA libraries with large size inserts. Nucleic Acids Res. 1992;20:3665-9 pubmed
    ..Primers were designed for each of them and polymorphism between the genomes of several inbred strain of mouse have been determined. These microsatellites were mapped, three of them to chromosome 19 and two to chromosome 11. ..
  6. Park C, Takahara K, Umemoto E, Yashima Y, Matsubara K, Matsuda Y, et al. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol. 2001;13:1283-90 pubmed
    ..This family of mouse C-type lectins is therefore complex, but only one of the new genes, DC-SIGN, is juxtaposed to CD23 and is expressed at high levels in DC. ..
  7. Malo D, Schurr E, Levenson R, Gros P. Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11. Genomics. 1990;6:697-9 pubmed
  8. Hsieh C, Cheng Deutsch A, Gloor S, Schachner M, Francke U. Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17. Somat Cell Mol Genet. 1990;16:401-5 pubmed
    ..Recombinant inbred strain mapping has placed the Amog locus close to genes for zinc finger protein-3 and the asialoglycoprotein receptor in a region of mouse chromosome 11 that is homologous to human 17p. ..
  9. Sanford J, Doyle D. Mouse asialoglycoprotein receptor cDNA sequence: conservation of receptor genes during mammalian evolution. Biochim Biophys Acta. 1990;1087:259-61 pubmed
    ..Conserved regions may correlate with functional domains. The membrane-bound M (mouse) HL polypeptide does not contain a cleavable N-terminal signal sequence and is probably anchored to the membrane via an internal insertion sequence. ..