Gene Symbol: Art1
Description: ADP-ribosyltransferase 1
Alias: ADPRT, ARTC1, Yac-1, GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, ADP-ribosyltransferase C2 and C3 toxin-like 1, mono(ADP-ribosyl)transferase 1
Species: mouse
Products:     Art1

Top Publications

  1. Wang J, Yang J, Liu P, Bi X, Li C, Zhu K. NAD induces astrocyte calcium flux and cell death by ART2 and P2X7 pathway. Am J Pathol. 2012;181:746-52 pubmed publisher
    ..The results suggest a novel approach for manipulating astrocyte death. ..
  2. Koch Nolte F, Kuhl M, Haag F, Cetkovic Cvrlje M, Leiter E, Thiele H. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. Genomics. 1996;36:215-6 pubmed
  3. Okazaki I, Kim H, McElvaney N, Lesma E, Moss J. Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes. Blood. 1996;88:915-21 pubmed
    ..Thus, we have cloned a novel gene that has properties identical to the transferase detected in CTL, and may be involved in the NAD-dependent regulation of proliferation and cytotoxicity. ..
  4. Perez Stable C, Altman N, Mehta P, Deftos L, Roos B. Prostate cancer progression, metastasis, and gene expression in transgenic mice. Cancer Res. 1997;57:900-6 pubmed
    ..We propose the Ggamma/T-15 transgenic line as a model of highly aggressive androgen-independent metastatic prostate carcinoma with features similar to end-stage prostate cancer in humans. ..
  5. Yang L, Xiao M, Li X, Tang Y, Wang Y. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway. Int J Mol Med. 2016;37:734-42 pubmed publisher
    Arginine adenosine diphosphate (ADP)-ribosyl-transferase 1 (ART1) is known to play an important role in many physiological and pathological processes...
  6. Xu J, Xiong W, Zeng Z, Tang Y, Wang Y, Xiao M, et al. Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo. Mol Med Rep. 2017;15:1222-1228 pubmed publisher
    Arginine-specific mono-ADP-ribosyltransferase 1 (ART1) is an important enzyme that catalyzes arginine-specific mono?ADP?ribosylation...
  7. Okazaki I, Kim H, Moss J. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. J Biol Chem. 1996;271:22052-7 pubmed
  8. Yu Y, Okamoto S, Nemoto E, Dennert G. Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells. DNA Cell Biol. 1997;16:235-44 pubmed
    A protein mono-ADP-ribosyltransferase (ADPRT), anchored in the cell membrane as a glycosylphosphatidylinositol (GPI)-anchored cell-surface enzyme, was recently described on murine cytotoxic T cells (CTL)...
  9. Glowacki G, Braren R, Cetkovic Cvrlje M, Leiter E, Haag F, Koch Nolte F. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Gene. 2001;275:267-77 pubmed
    ..6 cM in close proximity to the Art1, Art2a and Art2b genes...

More Information


  1. Glowacki G, Braren R, Firner K, Nissen M, Kühl M, Reche P, et al. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Protein Sci. 2002;11:1657-70 pubmed
    ..This suggests that the two enzyme families that catalyze reversible mono-ADP-ribosylation either were lost from the genomes of these nonchordata eucaryotes or were subject to horizontal gene transfer between kingdoms. ..
  2. Bourgeois C, Okazaki I, Cavanaugh E, Nightingale M, Moss J. Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities. J Biol Chem. 2003;278:26351-5 pubmed
    Mono-ADP-ribosyltransferases (ART1-7) transfer ADP-ribose from NAD+ to proteins (transferase activity) or water (NAD glycohydrolase activity)...
  3. Xiao M, Tang Y, Wang Y, Yang L, Li X, Kuang J, et al. ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-?B pathway. Cell Physiol Biochem. 2013;32:1587-99 pubmed publisher
    ..Arginine ADP-ribosyltransferase 1(ART1) is an important ecto-ADP-ribose transferase and has been proven to be intimately involved in a number of ..
  4. Kuang J, Wang Y, Xiao M, Tang Y, Chen W, Song G, et al. Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells. Oncol Rep. 2014;31:2335-43 pubmed publisher
    Arginine-specific ADP-ribosyltransferase 1 (ART1) and poly(ADP-ribose) polymerase-1 (PARP-1) are both post?translational modification proteins...
  5. Braren R, Glowacki G, Nissen M, Haag F, Koch Nolte F. Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1. Biochem J. 1998;336 ( Pt 3):561-8 pubmed
    ..We have characterized the gene for mouse arginine-specific ADP-ribosyltransferase, Art1. Southern blot analyses indicate that Art1 is a single-copy gene...