Art1

Summary

Gene Symbol: Art1
Description: ADP-ribosyltransferase 1
Alias: ADPRT, ARTC1, Yac-1, ADP-ribosyltransferase C2 and C3 toxin-like 1, GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, mono(ADP-ribosyl)transferase 1
Species: mouse

Top Publications

  1. doi NAD induces astrocyte calcium flux and cell death by ART2 and P2X7 pathway
    Jianbiao Wang
    Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
    Am J Pathol 181:746-52. 2012
  2. ncbi Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities
    Christelle Bourgeois
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 278:26351-5. 2003
  3. pmc The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse
    Gustavo Glowacki
    Institute of Immunology, University Hospital, Martinistrasse 52, D 20246 Hamburg, Germany
    Protein Sci 11:1657-70. 2002
  4. ncbi Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5
    G Glowacki
    Institute for Immunology, University Hospital, Martinistrasse 52, 20246 Hamburg, Germany
    Gene 275:267-77. 2001
  5. pmc Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1
    R Braren
    Institute for Immunology, University Hospital, Martinistr 52, D 20246 Hamburg, Germany
    Biochem J 336:561-8. 1998
  6. ncbi Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells
    Y Yu
    Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033, USA
    DNA Cell Biol 16:235-44. 1997
  7. ncbi Prostate cancer progression, metastasis, and gene expression in transgenic mice
    C Perez-stable
    Veterans Affairs Medical Center, and Department of Medicine, University of Miami School of Medicine, Florida 33101, USA
    Cancer Res 57:900-6. 1997
  8. ncbi Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7
    F Koch-Nolte
    Department of Immunology, University Hospital, Hamburg, 20246, Federal Republic of Germany
    Genomics 36:215-6. 1996
  9. ncbi Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Blood 88:915-21. 1996
  10. ncbi Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:22052-7. 1996

Scientific Experts

  • Jianbiao Wang
  • F Koch-Nolte
  • G Glowacki
  • R Braren
  • Christelle Bourgeois
  • F Haag
  • Gustavo Glowacki
  • I J Okazaki
  • Cui Li
  • Puqing Liu
  • Junhua Yang
  • Keqing Zhu
  • Xiwen Bi
  • E H Leiter
  • M Cetkovic-Cvrlje
  • Y Yu
  • C Perez-stable
  • Maria Nightingale
  • Ian Okazaki
  • Joel Moss
  • Eleanor Cavanaugh
  • Edward Leiter
  • Maren Kühl
  • Marina Cetkovic-Cvrlje
  • Pedro Reche
  • Kathrin Firner
  • J Moss
  • Fernando Bazan
  • Rickmer Braren
  • Friedrich Haag
  • Friedrich Koch-Nolte
  • H J Kim
  • Marion Nissen
  • M Nissen
  • E Nemoto
  • L J Deftos
  • S Okamoto
  • P P Mehta
  • B A Roos
  • N H Altman
  • G Dennert
  • N G McElvaney
  • H G Thiele
  • M Kuhl
  • E Lesma

Detail Information

Publications10

  1. doi NAD induces astrocyte calcium flux and cell death by ART2 and P2X7 pathway
    Jianbiao Wang
    Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
    Am J Pathol 181:746-52. 2012
    ..The results suggest a novel approach for manipulating astrocyte death...
  2. ncbi Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities
    Christelle Bourgeois
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    J Biol Chem 278:26351-5. 2003
    Mono-ADP-ribosyltransferases (ART1-7) transfer ADP-ribose from NAD+ to proteins (transferase activity) or water (NAD glycohydrolase activity)...
  3. pmc The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse
    Gustavo Glowacki
    Institute of Immunology, University Hospital, Martinistrasse 52, D 20246 Hamburg, Germany
    Protein Sci 11:1657-70. 2002
    ..This suggests that the two enzyme families that catalyze reversible mono-ADP-ribosylation either were lost from the genomes of these nonchordata eucaryotes or were subject to horizontal gene transfer between kingdoms...
  4. ncbi Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5
    G Glowacki
    Institute for Immunology, University Hospital, Martinistrasse 52, 20246 Hamburg, Germany
    Gene 275:267-77. 2001
    ..6 cM in close proximity to the Art1, Art2a and Art2b genes...
  5. pmc Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1
    R Braren
    Institute for Immunology, University Hospital, Martinistr 52, D 20246 Hamburg, Germany
    Biochem J 336:561-8. 1998
    ..We have characterized the gene for mouse arginine-specific ADP-ribosyltransferase, Art1. Southern blot analyses indicate that Art1 is a single-copy gene...
  6. ncbi Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells
    Y Yu
    Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033, USA
    DNA Cell Biol 16:235-44. 1997
    A protein mono-ADP-ribosyltransferase (ADPRT), anchored in the cell membrane as a glycosylphosphatidylinositol (GPI)-anchored cell-surface enzyme, was recently described on murine cytotoxic T cells (CTL)...
  7. ncbi Prostate cancer progression, metastasis, and gene expression in transgenic mice
    C Perez-stable
    Veterans Affairs Medical Center, and Department of Medicine, University of Miami School of Medicine, Florida 33101, USA
    Cancer Res 57:900-6. 1997
    ..We propose the Ggamma/T-15 transgenic line as a model of highly aggressive androgen-independent metastatic prostate carcinoma with features similar to end-stage prostate cancer in humans...
  8. ncbi Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7
    F Koch-Nolte
    Department of Immunology, University Hospital, Hamburg, 20246, Federal Republic of Germany
    Genomics 36:215-6. 1996
  9. ncbi Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Blood 88:915-21. 1996
    ..Thus, we have cloned a novel gene that has properties identical to the transferase detected in CTL, and may be involved in the NAD-dependent regulation of proliferation and cytotoxicity...
  10. ncbi Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:22052-7. 1996
    ....