Arrb1

Summary

Gene Symbol: Arrb1
Description: arrestin, beta 1
Alias: 1200006I17Rik, AW208571, G430100A01Rik, beta-arrestin-1, beta-arrestin1
Species: mouse
Products:     Arrb1

Top Publications

  1. Shenoy S, Barak L, Xiao K, Ahn S, Berthouze M, Shukla A, et al. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J Biol Chem. 2007;282:29549-62 pubmed
  2. Beaulieu J, Sotnikova T, Marion S, Lefkowitz R, Gainetdinov R, Caron M. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 2005;122:261-73 pubmed
  3. Kumar P, Lau C, Mathur M, Wang P, Defea K. Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. Am J Physiol Cell Physiol. 2007;293:C346-57 pubmed
    ..Together, these data suggest distinct temporal and functional roles for beta-arrestins in PAR-2 signaling, desensitization, and internalization. ..
  4. Hanson S, Gurevich E, Vishnivetskiy S, Ahmed M, Song X, Gurevich V. Each rhodopsin molecule binds its own arrestin. Proc Natl Acad Sci U S A. 2007;104:3125-8 pubmed
    ..Thus, a single Rh molecule is necessary and sufficient to bind Arr. Remarkable structural conservation among receptors and Arrs strongly suggests that all Arr subtypes bind individual molecules of their cognate receptors. ..
  5. Kim J, Zhang L, Peppel K, Wu J, Zidar D, Brian L, et al. Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circ Res. 2008;103:70-9 pubmed publisher
    ..These findings identify inhibition of beta-arrestin2 as a novel therapeutic strategy for combating atherosclerosis and arterial restenosis after angioplasty. ..
  6. Conner D, Mathier M, Mortensen R, Christe M, Vatner S, Seidman C, et al. beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation. Circ Res. 1997;81:1021-6 pubmed
    ..However, beta-arrestin1 does not appear to be required for development or for other essential biological functions. ..
  7. Kohout T, Lin F, Perry S, Conner D, Lefkowitz R. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A. 2001;98:1601-6 pubmed
    The two widely coexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid sequence...
  8. Sneddon W, Friedman P. Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization. Endocrinology. 2007;148:4073-9 pubmed
    ..Furthermore, the betaAr-dependent late phase of ERK activation by PTH requires the participation of betaAr2 and PTH1R internalization. ..
  9. Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen Y, et al. Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell. 2008;31:695-707 pubmed publisher
    ..Our results reveal that nuclear beta-arrestin1, acting as a scaffold for the dephosphorylation of STAT1, is an essential negative regulator of IFN-gamma signaling and participates in the IFN-gamma-induced cellular antiviral response. ..

More Information

Publications90

  1. Sun J, Lin X. Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A. 2008;105:17085-90 pubmed publisher
    ..Together, our results provide the genetic evidence that beta-arrestin 2 serves as a positive regulator in NF-kappaB signaling pathway by connecting CARMA3 to GPCRs. ..
  2. Hara M, Kovacs J, Whalen E, Rajagopal S, Strachan R, Grant W, et al. A stress response pathway regulates DNA damage through ?2-adrenoreceptors and ?-arrestin-1. Nature. 2011;477:349-53 pubmed publisher
    ..In mice and in human cell lines, ?-arrestin-1 (ARRB1), activated via ?(2)-adrenoreceptors, facilitates AKT-mediated activation of MDM2 and also promotes MDM2 binding ..
  3. Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, et al. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell. 2005;123:833-47 pubmed
  4. Xu J, Dodd R, Makino C, Simon M, Baylor D, Chen J. Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature. 1997;389:505-9 pubmed
    ..The intensity dependence of the photoresponse in rods lacking arrestin further suggests that, although arrestin is required for normal signal termination, it does not participate directly in light adaptation. ..
  5. Buelli S, Rosanò L, Gagliardini E, Corna D, Longaretti L, Pezzotta A, et al. ?-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury. J Am Soc Nephrol. 2014;25:523-33 pubmed publisher
  6. Chu C, Chen S, Wang Q, Langenbach R, Li H, ZELDIN D, et al. PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition. Mol Neurobiol. 2015;52:587-600 pubmed publisher
    ..In conclusion, we have demonstrated that COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and β-arrestin-dependent signaling pathway. ..
  7. Mittal N, Roberts K, Pal K, Bentolila L, Fultz E, Minasyan A, et al. Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and ?-arrestin 1 pathway. Cell Rep. 2013;5:1010-21 pubmed publisher
    ..This pathway allows ?OR and ORL1 agonists to rapidly regulate receptor function. ..
  8. Mendez A, Lem J, Simon M, Chen J. Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling. J Neurosci. 2003;23:3124-9 pubmed
    ..These results exclude passive diffusion and point toward active transport as the mechanism for light-dependent arrestin movement in rod photoreceptor cells. ..
  9. Fu Y, Kefalov V, Luo D, Xue T, Yau K. Quantal noise from human red cone pigment. Nat Neurosci. 2008;11:565-71 pubmed publisher
    ..Our measurements provide a rationale for why mammalian red, green and blue cones have comparable sensitivities, unlike their amphibian counterparts. ..
  10. Bryja V, Schambony A, Cajanek L, Dominguez I, Arenas E, Schulte G. Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep. 2008;9:1244-50 pubmed publisher
    ..Thus, our results indicate that the balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated. ..
  11. Walters R, Shukla A, Kovacs J, Violin J, DeWire S, Lam C, et al. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J Clin Invest. 2009;119:1312-21 pubmed publisher
    ..Furthermore, G protein-biased ligands that activate GPR109A in a beta-arrestin-independent fashion may represent an improved therapeutic option for the treatment of dyslipidemia...
  12. Girnita L, Shenoy S, Sehat B, Vasilcanu R, Girnita A, Lefkowitz R, et al. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem. 2005;280:24412-9 pubmed
    ..To our knowledge this is the first study demonstrating a defined molecular role of beta-arrestin with direct relevance to cell growth and cancer. ..
  13. Ma X, España Serrano L, Kim W, Thayele Purayil H, Nie Z, Daaka Y. ?Arrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility. J Biol Chem. 2014;289:13638-50 pubmed publisher
    ..Together, these results suggest that ?arrestin1 regulates rasgrf2 gene expression and Rac activation to affect membrane protrusion and cell migration and invasion. ..
  14. Thibault D, Albert P, Pineyro G, Trudeau L. Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism. J Biol Chem. 2011;286:9174-84 pubmed publisher
    ..Taken together, our data suggest that NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC-mediated phosphorylation of the D2R, leading to heterologous receptor desensitization. ..
  15. Li J, Wei B, Guo A, Liu C, Huang S, Du F, et al. Deficiency of ?-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation. Proc Natl Acad Sci U S A. 2013;110:7395-400 pubmed publisher
    ..These findings indicate a critical role for ?-arrestin1 in the pathogenesis of collagen-induced arthritis and T(H)17 cell differentiation and suggest ?-arrestin1 as a potential diagnostic biomarker and therapeutic target for RA. ..
  16. Kikuchi T, Raju K, Breitman M, Shinohara T. The proximal promoter of the mouse arrestin gene directs gene expression in photoreceptor cells and contains an evolutionarily conserved retinal factor-binding site. Mol Cell Biol. 1993;13:4400-8 pubmed
  17. Doan T, Azevedo A, Hurley J, Rieke F. Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors. J Neurosci. 2009;29:11867-79 pubmed publisher
    ..Competition between arrestins and kinases may be a general means of influencing signals mediated by G-protein-coupled receptors, particularly when activation of a few receptors produces signals of functional importance. ..
  18. Liu X, Zhao X, Zeng X, Bossers K, Swaab D, Zhao J, et al. ?-arrestin1 regulates ?-secretase complex assembly and modulates amyloid-? pathology. Cell Res. 2013;23:351-65 pubmed publisher
    ..Thus, our study identifies a regulatory mechanism underlying both ?-secretase assembly and AD pathogenesis, and indicates that specific reduction of A? pathology can be achieved by regulation of the ?-secretase assembly. ..
  19. Chun K, Lao H, Langenbach R. The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. J Biol Chem. 2010;285:39672-81 pubmed publisher
    ..Therefore, the results indicate that EP2 contributed to mouse keratinocyte proliferation by G protein-independent, ?-arrestin1-dependent activation of EGFR and G protein-dependent activation of PKA. ..
  20. Choi S, Hao W, Chen C, Simon M. Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas. Proc Natl Acad Sci U S A. 2001;98:13096-101 pubmed
    ..Transcript analysis provides insight into the patterns of gene expression that are associated with the different stages of retinal degeneration in this model system. ..
  21. Wang C, Zeng X, Zhou Z, Zhao J, Pei G. β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ. Sci Rep. 2016;6:26999 pubmed publisher
    ..Further mechanistic studies showed that β-arrestin-1 promotes PPARα- but represses PPARγ-mediated transcriptional activities, providing potential regulatory pathway for BAT function. ..
  22. Wickman K, Seldin M, James M, Gendler S, Clapham D. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 1997;40:402-8 pubmed
  23. Shi G, Chen J, Concepcion F, Motamedchaboki K, Marjoram P, Langen R, et al. Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. J Biol Chem. 2005;280:41184-91 pubmed
    ..These results may also have implications for other GPCR signaling pathways. ..
  24. Roca A, Shin K, Liu X, Simon M, Chen J. Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration. Neuroscience. 2004;129:779-90 pubmed
    ..These expression changes may constitute the underlying initiating events leading to the two distinct mechanisms of light damage...
  25. Venkatesha R, Ahamed J, Nuesch C, Zaidi A, Ali H. Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. J Biol Chem. 2004;279:44606-12 pubmed
    ..However, receptor phosphorylation and beta-arrestin recruitment inhibit CCL2 production by blocking both NF-kappaB activation and Ca2+/calcineurin-dependent signaling pathways. ..
  26. Lyubarsky A, Lem J, Chen J, Falsini B, Iannaccone A, Pugh E. Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. Vision Res. 2002;42:401-15 pubmed
    ..The desensitizing effect of the 530 nm background on UV-pigment driven responses provides new evidence in support of the hypothesis of functional co-expression of the M-pigment in cones expressing primarily the UV-pigment. ..
  27. Hara M, Sachs B, Caron M, Lefkowitz R. Pharmacological blockade of a ?(2)AR-?-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle. 2013;12:219-24 pubmed publisher
    ..These data suggest that the ?(2)AR-?-arrestin-1 signaling pathway may represent an attractive therapeutic target to prevent some of the negative consequences of stress in the treatment of stress-related disorders. ..
  28. Schaff M, Receveur N, Bourdon C, Ohlmann P, Lanza F, Gachet C, et al. ?-arrestin-1 participates in thrombosis and regulates integrin aIIb?3 signalling without affecting P2Y receptors desensitisation and function. Thromb Haemost. 2012;107:735-48 pubmed publisher
  29. Song X, Vishnivetskiy S, Gross O, Emelianoff K, Mendez A, Chen J, et al. Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Curr Biol. 2009;19:700-5 pubmed publisher
    ..Successful modification of protein-protein interactions by appropriate mutations paves the way to targeted redesign of signaling pathways to achieve desired functional outcomes. ..
  30. Kawamata Y, Imamura T, Babendure J, Lu J, Yoshizaki T, Olefsky J. Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex. J Biol Chem. 2007;282:28549-56 pubmed
  31. Xie L, Qiao X, Wu Y, Tang J. ?-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor. PLoS ONE. 2011;6:e16428 pubmed publisher
    ..arrestin1 is also involved in endocytotic MIF signaling, leading to sustained ERK activation. Therefore ?-arrestin1 plays a central role in coupling MIF endocytosis to sustained ERK activation. ..
  32. Zhan Y, Xu C, Liu Z, Tan S, Yang Y, Jiang J, et al. β-Arrestin1 inhibits chemotherapy-induced intestinal stem cell apoptosis and mucositis. Cell Death Dis. 2016;7:e2229 pubmed publisher
    ..Our study indicates that β-arr1 inhibits chemotherapy-induced ISC apoptosis to alleviate intestinal mucositis in CIGIS. ..
  33. Liu C, Gong Z, Liang Z, Liu Z, Yang F, Sun Y, et al. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun. 2017;8:14335 pubmed publisher
    ..This fast communication pathway might be a common mechanism of several cellular processes. ..
  34. Gross O, Burns M. Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods. J Neurosci. 2010;30:3450-7 pubmed publisher
  35. Brill E, Malanson K, Radu R, Boukharov N, Wang Z, Chung H, et al. A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin. Invest Ophthalmol Vis Sci. 2007;48:5445-53 pubmed
    ..Consistent with this, the lipofuscin fluorophores A2PE, A2E, and A2PE-H(2), which form from retinaldehyde, were elevated in Pro347Ser transgenic mice. ..
  36. Wang P, Xu T, Wei K, Guan Y, Wang X, Xu H, et al. ARRB1/?-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia. Autophagy. 2014;10:1535-48 pubmed publisher
    ..Here, we show that both ARRB1 (arrestin, ? 1) and ARRB2 (arrestin, ? 2) were upregulated by cerebral ischemic stress...
  37. Lyubarsky A, Chen C, Simon M, Pugh E. Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci. 2000;20:2209-17 pubmed
  38. Rajagopal K, Whalen E, Violin J, Stiber J, Rosenberg P, Premont R, et al. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A. 2006;103:16284-9 pubmed
    ..Such ligands may have potential as a novel class of therapeutic agents. ..
  39. Shinohara T, Kikuchi T, Tsuda M, Yamaki K. A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila. Comp Biochem Physiol B. 1992;103:505-9 pubmed
  40. Zhang M, Teng H, Shi J, Zhang Y. Disruption of ?-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice. Mech Dev. 2011;128:368-75 pubmed publisher
    In this study, the role of ?-arrestin 1 and ?-arrestin 2 in fetal lung and liver development was examined using Arrb1(-/-)Arrb2(-/-) mouse embryos...
  41. Bibb L, Holt J, Tarttelin E, Hodges M, Gregory Evans K, Rutherford A, et al. Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet. 2001;10:1571-9 pubmed
    ..These data support concerns about the extent to which we can extrapolate from rodent models regarding embryonic development and disease pathophysiology. ..
  42. Imai H, Kefalov V, Sakurai K, Chisaka O, Ueda Y, Onishi A, et al. Molecular properties of rhodopsin and rod function. J Biol Chem. 2007;282:6677-84 pubmed
    ..Thus, the present study clearly reveals how the molecular properties of rhodopsin affect the amplitude, shape, and kinetics of the rod response. ..
  43. Liu J, Li Q, Wang X, Zhang C, Duan Y, Wang Z, et al. ?-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy. Cell Death Dis. 2016;7:e2183 pubmed publisher
    ..We further revealed that either ?-arrestin-1 or ?-arrestin-2 deficiency (Arrb1(-/-) or Arrb2(-/-)) ameliorated renal injury in diabetic mice...
  44. Pradhan A, Perroy J, Walwyn W, Smith M, Vicente Sánchez A, Segura L, et al. Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function. J Neurosci. 2016;36:3541-51 pubmed publisher
    ..This study reveals a novel role for arrestin 3 as a facilitator of receptor resensitization. ..
  45. Kovacs J, Whalen E, Liu R, Xiao K, Kim J, Chen M, et al. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science. 2008;320:1777-81 pubmed publisher
    ..These results suggest roles for beta-arrestins in mediating the intracellular transport of a 7TMR to its obligate subcellular location for signaling. ..
  46. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, et al. KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology. 2014;155:4433-46 pubmed publisher
    ..This novel and important finding could explain why patients bearing some types of Gαq/11-uncoupled KISS1R mutants display partial gonadotropic deficiency and even a reversal of the condition, idiopathic hypogonadotropic hypogonadism. ..
  47. Pal K, Mathur M, Kumar P, DeFea K. Divergent ?-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem. 2013;288:3265-74 pubmed publisher
  48. Nikonov S, Brown B, Davis J, Zuniga F, Bragin A, Pugh E, et al. Mouse cones require an arrestin for normal inactivation of phototransduction. Neuron. 2008;59:462-74 pubmed publisher
    ..Dual arrestin expression in cones could be a holdover from ancient genome duplication events that led to multiple isoforms of arrestin, allowing evolutionary specialization of one form while the other maintains the basic function. ..
  49. Daigle T, Wetsel W, Caron M. Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. Eur J Neurosci. 2011;34:1378-89 pubmed publisher
    ..These results support the hypothesis that dopamine D1 receptors and N-methyl-D-aspartate receptors act in an opposite manner to regulate striatal CB1 cannabinoid receptor signal transduction. ..
  50. Parathath S, Mainwaring L, Fernandez L A, Guldal C, Nahle Z, Kenney A. ?-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors. Cell Cycle. 2010;9:4013-24 pubmed
  51. Porter K, Gonipeta B, Parvataneni S, Appledorn D, Patial S, Sharma D, et al. Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins. J Cell Physiol. 2010;225:406-16 pubmed publisher
  52. Zoudilova M, Min J, Richards H, Carter D, Huang T, DeFea K. beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2. J Biol Chem. 2010;285:14318-29 pubmed publisher
  53. Pontrello C, Sun M, Lin A, Fiacco T, DeFea K, Ethell I. Cofilin under control of ?-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. Proc Natl Acad Sci U S A. 2012;109:E442-51 pubmed publisher
    ..Our studies demonstrate unique functions of ?-arrestin-2 in NMDAR-mediated dendritic spine and synapse plasticity through spatial control over cofilin activation. ..
  54. Zhou X, He Y, de Waal P, Gao X, Kang Y, Van Eps N, et al. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell. 2017;170:457-469.e13 pubmed publisher
    ..Based on these observations, we derived and validated a set of phosphorylation codes that serve as a common mechanism for phosphorylation-dependent recruitment of arrestins by GPCRs. ..
  55. Quoyer J, Longuet C, Broca C, Linck N, Costes S, Varin E, et al. GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem. 2010;285:1989-2002 pubmed publisher
    ..Such signaling mechanism may serve as a prototype to generate new therapeutic GLP-1R ligands. ..
  56. Mittal N, Minasyan A, Romaneschi N, Hakimian J, Gonzalez Fernandez G, Albert R, et al. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PLoS ONE. 2017;12:e0185796 pubmed publisher
    ..This intervention substantially reduced food-motivated behavior. Together these findings identify a previously unknown role of ?arr1 in regulating specific reward-motivated behaviors and glutamatergic function. ..
  57. Esposito G, Perrino C, Cannavo A, Schiattarella G, Borgia F, Sannino A, et al. EGFR trans-activation by urotensin II receptor is mediated by ?-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy. Basic Res Cardiol. 2011;106:577-89 pubmed publisher
    ..Our data show, for the first time in vivo, a new UTR signalling pathway which is mediated by EGFR trans-activation, dependent by ?-arrestin 1/2, promoting cell survival and cardioprotection. ..
  58. Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell L, et al. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. J Biol Chem. 2001;276:43663-7 pubmed
  59. Grotegut C, Feng L, Mao L, Heine R, Murtha A, Rockman H. ?-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration. Am J Physiol Endocrinol Metab. 2011;300:E468-77 pubmed publisher
    ..The development of unique OXTR ligands that prevent receptor desensitization may be a novel approach in the treatment of adverse clinical events secondary to prolonged oxytocin therapy. ..
  60. Zhang M, Liu X, Zhang Y, Zhao J. Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice. Dev Biol. 2010;339:407-17 pubmed publisher
    ..Together, our study demonstrates that betaarrestin1 and betaarrestin2 collaborate in embryonic development processes for epithelial pneumocyte differentiation and lung maturation. ..
  61. Li P, Cook J, Gilkeson G, Luttrell L, Wang L, Borg K, et al. Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation. Mol Immunol. 2011;49:64-74 pubmed publisher
    ..Thus ?-arrestin 2 is anti-inflammatory in CAIA. These composite observations suggest that ?-arrestin 1 and 2 differentially regulate FLS inflammation and increased ?-arrestin 2 may reduce experimental arthritis severity. ..
  62. Pelzel C, Begitt A, Wenta N, Vinkemeier U. Evidence against a role for ?-arrestin1 in STAT1 dephosphorylation and the inhibition of interferon-? signaling. Mol Cell. 2013;50:149-56 pubmed publisher
    ..Our data indicate that ?-arrestin1 is dispensable for STAT1 dephosphorylation and the termination of IFN? signaling. ..
  63. Simonin A, Fuster D. Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function. J Biol Chem. 2010;285:38293-303 pubmed publisher
    ..Our data suggest a broader role for ?-arrestins in the regulation of membrane ion transport proteins than currently known. ..
  64. Qian H, Pipolo L, Thomas W. Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. Mol Endocrinol. 2001;15:1706-19 pubmed
  65. Ge L, Ly Y, Hollenberg M, DeFea K. A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem. 2003;278:34418-26 pubmed
  66. Fernández Arenas E, Calleja E, Martinez Martin N, Gharbi S, Navajas R, García Medel N, et al. ?-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism. EMBO J. 2014;33:559-77 pubmed publisher
    ..This receptor crosstalk mechanism is critical to sustain the TCR signal. ..
  67. Bryja V, Gradl D, Schambony A, Arenas E, Schulte G. Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proc Natl Acad Sci U S A. 2007;104:6690-5 pubmed
  68. McGinnis J, Austin B, Stepanik P, Lerious V. Light-dependent regulation of the transcriptional activity of the mammalian gene for arrestin. J Neurosci Res. 1994;38:479-82 pubmed
  69. Chen J, Simon M, Matthes M, Yasumura D, LaVail M. Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness). Invest Ophthalmol Vis Sci. 1999;40:2978-82 pubmed
  70. Wang P, Kumar P, Wang C, DeFea K. Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins. Biochem J. 2007;408:221-30 pubmed
  71. Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, et al. β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes. J Immunol. 2015;194:1867-73 pubmed publisher
    ..Taken together, our results indicate that β-arrestin1 plays a critical role in the assembly and activation of two major canonical inflammasomes, and it may provide a new therapeutic target for inflammatory diseases. ..
  72. Cottrell G, Padilla B, Amadesi S, Poole D, Murphy J, Hardt M, et al. Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. J Biol Chem. 2009;284:22411-25 pubmed publisher
    ..We propose that agonist availability in endosomes, here regulated by ECE-1, controls beta-arrestin-dependent signaling of endocytosed GPCRs. ..
  73. Kim I, Wang Y, Park K, Tang Y, Teoh J, Vinson J, et al. ?-arrestin1-biased ?1-adrenergic receptor signaling regulates microRNA processing. Circ Res. 2014;114:833-44 pubmed publisher
    ..Our findings indicate a novel function for ?1AR-mediated ?-arrestin1 signaling activated by carvedilol in miR biogenesis, which may be linked, in part, to its mechanism for cell survival. ..
  74. Zou L, Yang R, Chai J, Pei G. Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis. FASEB J. 2008;22:355-64 pubmed
    ..Our data reveal a functional role for beta-arrestin1 in tumor progression in vivo, in which overexpression of beta-Arr1 promotes MMP9 activity and tumor angiogenesis by providing a suitable microenvironment for tumor progression. ..
  75. DeWire S, Kim J, Whalen E, Ahn S, Chen M, Lefkowitz R. Beta-arrestin-mediated signaling regulates protein synthesis. J Biol Chem. 2008;283:10611-20 pubmed publisher
    ..This novel demonstration that beta-arrestins regulate protein synthesis reveals that the spectrum of beta-arrestin-mediated signaling events is broader than previously imagined. ..
  76. Hegde A, Strachan R, Walker J. Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. PLoS ONE. 2015;10:e0116458 pubmed publisher
  77. Williams Bey Y, Boularan C, Vural A, Huang N, Hwang I, Shan Shi C, et al. Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-?B activation and enhancing autophagy. PLoS ONE. 2014;9:e97957 pubmed publisher
    ..Thus, DHA suppresses inflammasome activation by two distinct mechanisms, inhibiting the initial priming step and by augmenting autophagy, which limits inflammasome activity. ..
  78. Rakesh K, Yoo B, Kim I, Salazar N, Kim K, Rockman H. beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci Signal. 2010;3:ra46 pubmed publisher
    ..These data show that the heart responds to acute increases in mechanical stress by activating beta-arrestin-mediated cell survival signals. ..
  79. Yang X, Zhou G, Ren T, Li H, Zhang Y, Yin D, et al. ?-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways. Apoptosis. 2012;17:1019-26 pubmed publisher
    ..Our study thus demonstrates that ?-arrestin inhibits cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt signaling pathways. ..
  80. Santos Zas I, Lodeiro M, Gurriaran Rodriguez U, Bouzo Lorenzo M, Mosteiro C, Casanueva F, et al. ?-Arrestin signal complex plays a critical role in adipose differentiation. Int J Biochem Cell Biol. 2013;45:1281-92 pubmed publisher
  81. Lee T, Lee E, Irwin R, Lucas P, McCabe L, Parameswaran N. ?-Arrestin-1 deficiency protects mice from experimental colitis. Am J Pathol. 2013;182:1114-23 pubmed publisher
    ..Taken together, our results demonstrate that decreased IL-6 production and enhanced IL-10 and IL-22 production in ?-arrestin-1-deficient mice likely lead to attenuated gut inflammation. ..