Arntl

Summary

Gene Symbol: Arntl
Description: aryl hydrocarbon receptor nuclear translocator-like
Alias: Arnt3, BMAL1b, Bmal1, MOP3, bHLHe5, bmal1b', aryl hydrocarbon receptor nuclear translocator-like protein 1, brain and muscle ARNT-like 1
Species: mouse
Products:     Arntl

Top Publications

  1. Sun Y, Yang Z, Niu Z, Peng J, Li Q, Xiong W, et al. MOP3, a component of the molecular clock, regulates the development of B cells. Immunology. 2006;119:451-60 pubmed
    ..MOP3 (also known as brain and muscle Arnt-like protein-1, BMAL1), a master regulator of circadian rhythm, plays important roles in the regulation of cell differentiation and ..
  2. Anea C, Zhang M, Stepp D, Simkins G, Reed G, Fulton D, et al. Vascular disease in mice with a dysfunctional circadian clock. Circulation. 2009;119:1510-7 pubmed publisher
    ..study, we found increased pathological remodeling and vascular injury in mice with aberrant circadian rhythms, Bmal1-knockout and Clock mutant...
  3. Ozber N, Baris I, Tatlici G, Gur I, Kilinc S, Unal E, et al. Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol. 2010;11:69 pubmed publisher
    ..In mammals, the CLOCK-BMAL1 heterodimer activates transcription of the Per and Cry genes as well as clock-regulated genes...
  4. Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008;134:317-28 pubmed publisher
    ..b>BMAL1 and CLOCK activate the expression of Period (Per) and Cryptochrome (Cry) genes, and once PER and CRY proteins ..
  5. Zhang L, Abraham D, Lin S, Oster H, Eichele G, Fu Y, et al. PKC? participates in food entrainment by regulating BMAL1. Proc Natl Acad Sci U S A. 2012;109:20679-84 pubmed publisher
    ..by stabilizing the core clock component brain and muscle aryl hydrocarbon receptor nuclear translocator like 1 (BMAL1) and reducing its ubiquitylation in a deubiquitination-dependent manner...
  6. Nader N, Chrousos G, Kino T. Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 2009;23:1572-83 pubmed publisher
    ..The basic helix-loop-helix protein CLOCK, a histone acetyltransferase (HAT), and its heterodimer partner BMAL1 are self-oscillating transcription factors that generate circadian rhythms in both the central nervous system and ..
  7. Kondratov R, Chernov M, Kondratova A, Gorbacheva V, Gudkov A, Antoch M. BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 2003;17:1921-32 pubmed
    Mammalian CLOCK and BMAL1 are two members of bHLH-PAS-containing family of transcription factors that represent the positive elements of circadian autoregulatory feedback loop...
  8. Akashi M, Takumi T. The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat Struct Mol Biol. 2005;12:441-8 pubmed
    The PAS (PER-ARNT-SIM) helix-loop-helix transcription factor BMAL1 (also known as MOP3) is an essential component of the circadian pacemaker in mammals...
  9. Andrews J, Zhang X, McCarthy J, McDearmon E, Hornberger T, Russell B, et al. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A. 2010;107:19090-5 pubmed publisher
    ..We report that MyoD is a direct target of the circadian transcriptional activators CLOCK and BMAL1, which bind in a rhythmic manner to the core enhancer of the MyoD promoter...

More Information

Publications94

  1. Hemmeryckx B, Himmelreich U, Hoylaerts M, Lijnen H. Impact of clock gene Bmal1 deficiency on nutritionally induced obesity in mice. Obesity (Silver Spring). 2011;19:659-61 pubmed publisher
    To evaluate the hypothesis that the clock gene Bmal1 (brain and muscle arnt like protein-1) plays a role in the development of obesity, 5-week-old male Bmal1-deficient (Bmal1(-/-)) mice and wild-type littermates (Bmal1(+/+)) were kept on ..
  2. Maywood E, O Brien J, Hastings M. Expression of mCLOCK and other circadian clock-relevant proteins in the mouse suprachiasmatic nuclei. J Neuroendocrinol. 2003;15:329-34 pubmed
    ..interlocked feedback loops in which periodic transcriptional drive to core clock genes is mediated by CLOCK/BMAL1 heterodimers. Negative-feedback actions of the encoded proteins PER and CRY terminate this phase of the cycle...
  3. Hirota T, Kon N, Itagaki T, Hoshina N, Okano T, Fukada Y. Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. Genes Cells. 2010;15:111-21 pubmed publisher
    ..In vitro experiments showed that TIEG1 bound to Bmal1 gene promoter and repressed its transcriptional activity through two juxtaposed GC boxes near the transcription ..
  4. Amano T, Matsushita A, Hatanaka Y, Watanabe T, Oishi K, Ishida N, et al. Expression and functional analyses of circadian genes in mouse oocytes and preimplantation embryos: Cry1 is involved in the meiotic process independently of circadian clock regulation. Biol Reprod. 2009;80:473-83 pubmed publisher
    In mammals, circadian genes, Clock, Arntl (also known as Bmal1), Cry1, Cry2, Per1, Per2, and Per3, are rhythmically transcribed every 24 h in almost all organs and tissues to tick the circadian clock...
  5. Lamia K, Storch K, Weitz C. Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A. 2008;105:15172-7 pubmed publisher
    ..plays a well known role in glucose homeostasis, and we report here that mice with a liver-specific deletion of Bmal1, an essential clock component, exhibited hypoglycemia restricted to the fasting phase of the daily feeding cycle, ..
  6. Jeyaraj D, Haldar S, Wan X, McCauley M, Ripperger J, Hu K, et al. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012;483:96-9 pubmed publisher
    ..These findings identify circadian transcription of ion channels as a mechanism for cardiac arrhythmogenesis. ..
  7. Hayashi M, Shimba S, Tezuka M. Characterization of the molecular clock in mouse peritoneal macrophages. Biol Pharm Bull. 2007;30:621-6 pubmed
    ..The expression of the clock genes including brain and muscle Arnt-like protein-1 (BMAL1) exhibited robust circadian rhythms in macrophages...
  8. Hamaguchi H, Fujimoto K, Kawamoto T, Noshiro M, Maemura K, Takeda N, et al. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem J. 2004;382:43-50 pubmed
    ..in the suprachiasmatic nucleus, and Dec2 inhibits transcription from the Per1 promoter induced by Clock/Bmal1 [Honma, Kawamoto, Takagi, Fujimoto, Sato, Noshiro, Kato and Honma (2002) Nature (London) 419, 841-844]...
  9. Schroder E, Lefta M, Zhang X, Bartos D, Feng H, Zhao Y, et al. The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility. Am J Physiol Cell Physiol. 2013;304:C954-65 pubmed publisher
    ..b>Bmal1 encodes a core molecular clock transcription factor...
  10. Ward S, Fernando S, Hou T, Duffield G. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010;285:38987-9000 pubmed publisher
    ..ID2 can suppress the transactivation potential of the positive elements of the clock, CLOCK-BMAL1, on mPer1 and clock-controlled gene (CCG) activity...
  11. Oishi K, Fukui H, Ishida N. Rhythmic expression of BMAL1 mRNA is altered in Clock mutant mice: differential regulation in the suprachiasmatic nucleus and peripheral tissues. Biochem Biophys Res Commun. 2000;268:164-71 pubmed
    b>BMAL1 is a putative clock gene which encodes a basic helix-loop-helix (bHLH)-PAS transcription factor...
  12. Sasaki M, Yoshitane H, Du N, Okano T, Fukada Y. Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem. 2009;284:25149-59 pubmed publisher
    In the molecular oscillatory mechanism governing circadian rhythms, positive regulators, including CLOCK and BMAL1, transactivate Per and Cry genes through E-box elements, and translated PER and CRY proteins negatively regulate their own ..
  13. Fuller P, Lu J, Saper C. Differential rescue of light- and food-entrainable circadian rhythms. Science. 2008;320:1074-7 pubmed publisher
    ..basis for entrainment of circadian rhythms by food and light in mice with targeted disruption of the clock gene Bmal1, which lack circadian rhythmicity...
  14. Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, et al. CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature. 2007;450:1086-90 pubmed
    ..The CLOCK-BMAL1 complex activates clock-controlled genes, including cryptochromes (Crys), the products of which act as repressors ..
  15. Rey G, Cesbron F, Rougemont J, Reinke H, Brunner M, Naef F. Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol. 2011;9:e1000595 pubmed publisher
    ..uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator...
  16. Wyse C, Coogan A. Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain. Brain Res. 2010;1337:21-31 pubmed publisher
    ..of this study was to investigate the effect of aging on the daily oscillation of two clock gene proteins (CLOCK, BMAL1) in the mouse brain...
  17. Shende V, GOLDRICK M, Ramani S, Earnest D. Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice. PLoS ONE. 2011;6:e22586 pubmed publisher
    ..miRNAs are present in the circulatory system, we examined miRNAs predicted to target the clock gene, Bmal1, for evidence of rhythmic fluctuations in circulating levels and modulatory effects on the 3' UTR activity of ..
  18. Kwon I, Lee J, Chang S, Jung N, Lee B, Son G, et al. BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol Cell Biol. 2006;26:7318-30 pubmed
    CLOCK and BMAL1 are bHLH-PAS-containing transcription factors that bind to E-box elements and are indispensable for expression of core circadian clock components such as the Per and Cry genes...
  19. Shimba S, Ogawa T, Hitosugi S, Ichihashi Y, Nakadaira Y, Kobayashi M, et al. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS ONE. 2011;6:e25231 pubmed publisher
    ..Among clock genes, the brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) play important roles in the regulation of the positive ..
  20. Fu L, Patel M, Bradley A, Wagner E, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell. 2005;122:803-15 pubmed
    ..Thus, leptin determines the extent of bone formation by modulating, via sympathetic signaling, osteoblast proliferation through two antagonistic pathways, one of which involves the molecular clock. ..
  21. Lee C, Etchegaray J, Cagampang F, Loudon A, Reppert S. Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001;107:855-67 pubmed
    ..The mouse PERIOD proteins (mPER1 and mPER2), CLOCK, and BMAL1 undergo robust circadian changes in phosphorylation...
  22. Guillaumond F, Dardente H, Giguere V, Cermakian N. Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms. 2005;20:391-403 pubmed
    ..2 orphan nuclear receptors, REV-ERBalpha and RORalpha, play important roles in the transcription of the clock gene Bmal1. The authors now considerably extend these findings with the demonstration that all members of the REV-ERB (alpha ..
  23. Zeng Z, Wu M, Sun J, Sun Y, Cai Y, Huang Y, et al. Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. J Biochem. 2010;148:319-26 pubmed publisher
    The Bmal1 gene plays a key role in controlling circadian rhythms...
  24. Rudic R, McNamara P, Curtis A, Boston R, Panda S, Hogenesch J, et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004;2:e377 pubmed
    ..Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis...
  25. Shi S, Ansari T, McGuinness O, Wasserman D, Johnson C. Circadian disruption leads to insulin resistance and obesity. Curr Biol. 2013;23:372-81 pubmed publisher
    ..Moreover, clock-disrupted Bmal1-knockout mice are locked into the trough of insulin action and lack rhythmicity in insulin action and activity ..
  26. Kondratov R, Vykhovanets O, Kondratova A, Antoch M. Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1. Aging (Albany NY). 2009;1:979-87 pubmed
    Deficiency of the circadian clock protein BMAL1 leads to premature aging and increased levels of reactivate oxygen species in several tissues of mice...
  27. Ramsey K, Yoshino J, Brace C, Abrassart D, Kobayashi Y, Marcheva B, et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009;324:651-4 pubmed publisher
    ..Inhibition of NAMPT promotes oscillation of the clock gene Per2 by releasing CLOCK:BMAL1 from suppression by SIRT1...
  28. Hogenesch J, Gu Y, Jain S, Bradfield C. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998;95:5474-9 pubmed
    We report that MOP3 is a general dimerization partner for a subset of the basic-helix-loop-helix (bHLH)-PER-ARNT-SIM (PAS) superfamily of transcriptional regulators...
  29. Mendez Ferrer S, Lucas D, Battista M, Frenette P. Haematopoietic stem cell release is regulated by circadian oscillations. Nature. 2008;452:442-7 pubmed publisher
    ..These data indicate that a circadian, neurally driven release of HSC during the animal's resting period may promote the regeneration of the stem cell niche and possibly other tissues. ..
  30. Khapre R, Kondratova A, Patel S, Dubrovsky Y, Wrobel M, Antoch M, et al. BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). 2014;6:48-57 pubmed
    ..b>BMAL1 is a transcriptional factor and core component of the circadian clock; BMAL1 deficiency is associated with ..
  31. Cai W, Rambaud J, Teboul M, Masse I, Benoit G, Gustafsson J, et al. Expression levels of estrogen receptor beta are modulated by components of the molecular clock. Mol Cell Biol. 2008;28:784-93 pubmed
    ..Interestingly, this oscillation is abolished in clock-deficient BMAL1 knockout mice...
  32. Bunger M, Walisser J, Sullivan R, Manley P, Moran S, Kalscheur V, et al. Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis. 2005;41:122-32 pubmed
    Disruption of the murine Mop3 (also known as Bmal1 or Arntl) locus results in a loss of behavioral and molecular circadian rhythms...
  33. Chen R, Schirmer A, Lee Y, Lee H, Kumar V, Yoo S, et al. Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell. 2009;36:417-30 pubmed publisher
    ..is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional activators, CLOCK and BMAL1. Current models posit that CRY is the dominant repressor, while PER may play an accessory role...
  34. Ko C, Yamada Y, Welsh D, Buhr E, Liu A, Zhang E, et al. Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol. 2010;8:e1000513 pubmed publisher
    b>Bmal1 is an essential transcriptional activator within the mammalian circadian clock...
  35. Shearman L, Sriram S, Weaver D, Maywood E, Chaves I, Zheng B, et al. Interacting molecular loops in the mammalian circadian clock. Science. 2000;288:1013-9 pubmed
    ..mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal1 loop...
  36. Duong H, Robles M, Knutti D, Weitz C. A molecular mechanism for circadian clock negative feedback. Science. 2011;332:1436-9 pubmed publisher
    ..the three PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the CLOCK-BMAL1 dimer, which represses their own expression...
  37. Doi R, Oishi K, Ishida N. CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J Biol Chem. 2010;285:22114-21 pubmed publisher
    ..Thus, CLOCK regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. ..
  38. Canaple L, Rambaud J, Dkhissi Benyahya O, Rayet B, Tan N, Michalik L, et al. Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol. 2006;20:1715-27 pubmed
    ..it is required to maintain the circadian rhythm of the master clock gene brain and muscle Arnt-like protein 1 (bmal1) in vivo...
  39. Myung J, Hong S, Hatanaka F, Nakajima Y, De Schutter E, Takumi T. Period coding of Bmal1 oscillators in the suprachiasmatic nucleus. J Neurosci. 2012;32:8900-18 pubmed publisher
    ..2003; Foley et al., 2011) and its plasticity. We found that the period of the oscillation in Bmal1 expression, a positive-feedback component of the circadian clock, preserves the behavioral circadian period under ..
  40. Czarna A, Breitkreuz H, Mahrenholz C, Arens J, Strauss H, Wolf E. Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. J Biol Chem. 2011;286:22414-25 pubmed publisher
    ..Moreover, our study suggests the design of peptidic inhibitors targeting the interaction of the mCRY1 tail with mBMAL1. ..
  41. Shimba S, Ishii N, Ohta Y, Ohno T, Watabe Y, Hayashi M, et al. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc Natl Acad Sci U S A. 2005;102:12071-6 pubmed
    Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm...
  42. Mistlberger R, Yamazaki S, Pendergast J, Landry G, Takumi T, Nakamura W. Comment on "Differential rescue of light- and food-entrainable circadian rhythms". Science. 2008;322:675; author reply 675 pubmed publisher
    Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms...
  43. Cheng B, Anea C, Yao L, Chen F, Patel V, Merloiu A, et al. Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis. Proc Natl Acad Sci U S A. 2011;108:17147-52 pubmed publisher
    ..In contrast, aortic grafts from Bmal1 knockout (KO) or Period-2,3 double-KO mice transplanted into littermate control WT mice developed robust ..
  44. Preitner N, Damiola F, Lopez Molina L, Zakany J, Duboule D, Albrecht U, et al. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002;110:251-60 pubmed
    Mammalian circadian rhythms are generated by a feedback loop in which BMAL1 and CLOCK, players of the positive limb, activate transcription of the cryptochrome and period genes, components of the negative limb...
  45. Huang N, Chelliah Y, Shan Y, Taylor C, Yoo S, PARTCH C, et al. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012;337:189-94 pubmed publisher
    ..activator consisting of two basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain protein subunits, CLOCK and BMAL1. Here, we report the crystal structure of a complex containing the mouse CLOCK:BMAL1 bHLH-PAS domains at 2...
  46. Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo J, Sassone Corsi P. Circadian clock control by SUMOylation of BMAL1. Science. 2005;309:1390-4 pubmed
    ..Here, we show that BMAL1, an essential transcription factor component of the clock mechanism, is SUMOylated on a highly conserved lysine ..
  47. Wang T, Yu Y, Govindaiah G, Ye X, Artinian L, Coleman T, et al. Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons. Science. 2012;337:839-42 pubmed publisher
    ..Thus, dynamic regulation of SCN excitability appears to be closely tied to metabolism that engages the clockwork machinery. ..
  48. Lee J, Lee Y, Lee M, Park E, Kang S, Chung C, et al. Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol. 2008;28:6056-65 pubmed publisher
    Heterodimers of BMAL1 and CLOCK drive rhythmic expression of clock-controlled genes, thereby generating circadian physiology and behavior...
  49. Kiyohara Y, Tagao S, Tamanini F, Morita A, Sugisawa Y, Yasuda M, et al. The BMAL1 C terminus regulates the circadian transcription feedback loop. Proc Natl Acad Sci U S A. 2006;103:10074-9 pubmed
    The circadian clock is driven by cell-autonomous transcription/translation feedback loops. The BMAL1 transcription factor is an indispensable component of the positive arm of this molecular oscillator in mammals...
  50. Khapre R, Kondratova A, Susova O, Kondratov R. Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle. 2011;10:4162-9 pubmed publisher
    Deficiency of the circadian clock transcriptional factor BMAL1 results in the development of premature aging in mice...
  51. Pfeffer M, Müller C, Mordel J, Meissl H, Ansari N, Deller T, et al. The mammalian molecular clockwork controls rhythmic expression of its own input pathway components. J Neurosci. 2009;29:6114-23 pubmed publisher
    ..nucleus (SCN) is based on autoregulatory feedback loops of transcriptional activators (CLOCK/NPAS2 and BMAL1) and inhibitors (mPER1-2 and mCRY1-2)...
  52. Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, et al. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004;313:117-24 pubmed
    ..The autofeedback loop of Dec1 may be interlocked with the core feedback loop of Per in some situations. ..
  53. Liu A, Tran H, Zhang E, Priest A, Welsh D, Kay S. Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008;4:e1000023 pubmed publisher
    ..In particular, the ROR/REV/Bmal1 loop, consisting of ROR activators and REV-ERB repressors that regulate Bmal1 expression, is thought to "..
  54. Storch K, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, et al. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell. 2007;130:730-741 pubmed publisher
    ..Here we show that mice lacking Bmal1, a gene required for clock function, had abnormal retinal transcriptional responses to light and defective inner ..
  55. Kondratov R, Kondratova A, Gorbacheva V, Vykhovanets O, Antoch M. Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev. 2006;20:1868-73 pubmed
    Mice deficient in the circadian transcription factor BMAL1 (brain and muscle ARNT-like protein) have impaired circadian behavior and demonstrate loss of rhythmicity in the expression of target genes...
  56. Guo B, Chatterjee S, Li L, Kim J, Lee J, Yechoor V, et al. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012;26:3453-63 pubmed publisher
    ..Here we report that disruption of the clock gene, brain and muscle Arnt-like 1 (Bmal1), in mice led to increased adipogenesis, adipocyte hypertrophy, and obesity, compared to wild-type (WT) mice...
  57. Bunger M, Wilsbacher L, Moran S, Clendenin C, Radcliffe L, Hogenesch J, et al. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 2000;103:1009-17 pubmed
    ..Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in constant darkness...
  58. Ye R, Selby C, Ozturk N, Annayev Y, Sancar A. Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem. 2011;286:25891-902 pubmed publisher
    ..CRY and PER proteins repress their own transcription by suppressing the transactivator function of the CLOCK:BMAL1 heterodimer directly (physical model) and by facilitating post-translational modifications (chemical model)...
  59. Lee J, Kim M, Li R, Liu V, Fu L, Moore D, et al. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in ?-cells. Islets. 2011;3:381-8 pubmed publisher
    The circadian clock has been shown to regulate metabolic homeostasis. Mice with a deletion of Bmal1, a key component of the core molecular clock, develop hyperglycemia and hypoinsulinemia, suggesting ?-cell dysfunction...
  60. Lee C, Weaver D, Reppert S. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004;24:584-94 pubmed
    ..We thus propose that the CKIepsilon-binding domain is critical not only for mPER phosphorylation but also for a functioning circadian clock. ..
  61. Dunlap J. Molecular bases for circadian clocks. Cell. 1999;96:271-90 pubmed
  62. Jouffe C, Cretenet G, Symul L, Martin E, Atger F, Naef F, et al. The circadian clock coordinates ribosome biogenesis. PLoS Biol. 2013;11:e1001455 pubmed publisher
    ..Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis. ..
  63. Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda K, Honma S, et al. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem. 2004;271:4409-19 pubmed
    ..nucleus where it seems to play a role in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoter...
  64. Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008;134:329-40 pubmed publisher
    ..It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for circadian function...
  65. Boden M, Varcoe T, Voultsios A, Kennaway D. Reproductive biology of female Bmal1 null mice. Reproduction. 2010;139:1077-90 pubmed publisher
    ..function in female heterozygous and homozygous brain and muscle ARNT-like protein 1 (Bmal1, also known as Arntl) null mice, which lack central and peripheral cellular rhythms...
  66. Kondratov R, Kondratova A, Lee C, Gorbacheva V, Chernov M, Antoch M. Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle. 2006;5:890-5 pubmed
    Mammalian CLOCK(NPAS2), BMAL1 and CRYPTOCHROMEs are core components of the circadian oscillatory mechanism. The active CLOCK/BMAL1 or NPAS2/BMAL1 complexes regulate expression of numerous genes including two Cryptochromes...
  67. Kondratov R, Shamanna R, Kondratova A, Gorbacheva V, Antoch M. Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation. FASEB J. 2006;20:530-2 pubmed
    The basic helix-loop-helix (bHLH) -PAS domain containing transcription factors CLOCK and BMAL1 are two major components of the circadian molecular oscillator...
  68. Robles M, Boyault C, Knutti D, Padmanabhan K, Weitz C. Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. Science. 2010;327:463-6 pubmed publisher
    ..core of the mammalian circadian clock is a negative feedback loop in which the dimeric transcription factor CLOCK-BMAL1 drives processes that in turn suppress its transcriptional activity...
  69. Lin F, Chen Y, Li X, Zhao Q, Tan Z. Over-expression of circadian clock gene Bmal1 affects proliferation and the canonical Wnt pathway in NIH-3T3 cells. Cell Biochem Funct. 2013;31:166-72 pubmed publisher
    b>Bmal1 is a transcription factor that plays a central role in the regulation of circadian rhythms. Recent study reported that Bmal1-/- mice displayed many known features of premature ageing, such as reduction of bone mass...
  70. Bouchard Cannon P, Mendoza Viveros L, Yuen A, Kærn M, Cheng H. The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep. 2013;5:961-73 pubmed publisher
    ..The clock proteins PERIOD2 and BMAL1 are critical for proper control of neurogenesis...
  71. Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, et al. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002;419:841-4 pubmed
    ..The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter ..
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    To determine if elasticity in blood vessels is compromised in circadian clock-mutant mice (Bmal1-knockout [KO] and Per-triple KO) and if matrix metalloproteinases (MMPs) might confer these changes in compliance...
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    ..that signaling mediated by the dopamine D2 receptor (D2R) enhances the transcriptional capacity of the CLOCK:BMAL1 complex...
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    ..Furthermore, Cry2 mediated repression of NPAS2:BMAL1 is overcome by overexpression of p300 in transactivation assays...
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    ..The core clock protein BMAL1 undergoes several PTMs...
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    ..p21WAF1/CIP1 circadian expression is dramatically increased and no longer rhythmic in clock-deficient Bmal1-/- knock-out mice...
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    ..islets possess self-sustained circadian gene and protein oscillations of the transcription factors CLOCK and BMAL1. The phase of oscillation of islet genes involved in growth, glucose metabolism and insulin signalling is delayed ..
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    ..Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction. ..
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    The basic helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) domain transcription factor BMAL1 is an essential component of the mammalian circadian pacemaker...
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