Arnt

Summary

Gene Symbol: Arnt
Description: aryl hydrocarbon receptor nuclear translocator
Alias: D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051, aryl hydrocarbon receptor nuclear translocator, HIF-1-beta, HIF1-beta, dioxin receptor, nuclear translocator, hypoxia-inducible factor 1-beta
Species: mouse
Products:     Arnt

Top Publications

  1. Probst M, Fan C, Tessier Lavigne M, Hankinson O. Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem. 1997;272:4451-7 pubmed
    ..its two mouse homologs SIM1 and SIM2, and the mammalian aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) proteins are members of the basic-helix-loop-helix.PAS family of transcription factors...
  2. Kozak K, Abbott B, Hankinson O. ARNT-deficient mice and placental differentiation. Dev Biol. 1997;191:297-305 pubmed
    ..recombination in embryonic stem cells to generate mice heterozygous for an aryl hydrocarbon nuclear translocator (ARNT) null mutation...
  3. Tomita S, Jiang H, Ueno T, Takagi S, Tohi K, Maekawa S, et al. T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution. J Immunol. 2003;171:4113-20 pubmed
    The arylhydrocarbon receptor nuclear translocator (ARNT) is a member of the basic helix-loop-helix, PER-ARNT-SIM family of heterodimeric transcription factors, and serves as a dimerization partner for arylhydrocarbon receptor (AHR) and ..
  4. Lee K, Gesta S, Boucher J, Wang X, Kahn C. The differential role of Hif1?/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. Cell Metab. 2011;14:491-503 pubmed publisher
    ..response is mediated by hypoxia-inducible factors (Hif1?, Hif2?, and Hif3?) and their obligate partner, Hif1? (Arnt)...
  5. Choi S, Oh H, Park H. Microarray analyses of hypoxia-regulated genes in an aryl hydrocarbon receptor nuclear translocator (Arnt)-dependent manner. FEBS J. 2008;275:5618-34 pubmed publisher
    ..BpRc1 cells are a hepa1c1c7 variant defective in HIF-beta/aryl hydrocarbon receptor nuclear translocator (Arnt), and are therefore unable to induce HIF target genes in response to hypoxia...
  6. Sekine H, Mimura J, Yamamoto M, Fujii Kuriyama Y. Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses. J Biol Chem. 2006;281:37507-16 pubmed
    b>Arnt and the homologous Arnt2 share a high degree of sequence similarity and are believed to function as obligate common partners for a number of basic helix-loop-helix (bHLH)-PAS transcription factors including arylhydrocarbon receptor (..
  7. Numayama Tsuruta K, Kobayashi A, Sogawa K, Fujii Kuriyama Y. A point mutation responsible for defective function of the aryl-hydrocarbon-receptor nuclear translocator in mutant Hepa-1c1c7 cells. Eur J Biochem. 1997;246:486-95 pubmed
    ..for the mutation that causes the defective function of aryl-hydrocarbon receptor (AHR) nuclear translocator (Arnt). Arnt dimerizes with AHR and mediates the induction signal of aryl-hydrocarbon hydroxylase activity...
  8. Tomita S, Sinal C, Yim S, Gonzalez F. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol. 2000;14:1674-81 pubmed
    To determine the function of the aryl hydrocarbon receptor nuclear translocator (ARNT), a conditional gene knockout mouse was made using the Cre-loxP system...
  9. Lau S, Cha K, Karunatillake A, Stokes R, Cheng K, McLean M, et al. Beta-cell ARNT is required for normal glucose tolerance in murine pregnancy. PLoS ONE. 2013;8:e77419 pubmed publisher
    ..We have previously shown that the expression of the transcription factor ARNT (Aryl-hydrocarbon Receptor Nuclear Translocator) is reduced in the islets of humans with type 2 diabetes...

More Information

Publications93

  1. Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, et al. Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes. 2011;60:2484-95 pubmed publisher
    ..Mice with adipocyte-specific targeted disruption of the genes encoding the HIF1 obligatory subunits Hif1? or Arnt (Hif1?) were generated using an aP2-Cre transgene with the Cre/LoxP system...
  2. Arpiainen S, Lämsä V, Pelkonen O, Yim S, Gonzalez F, Hakkola J. Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. J Mol Biol. 2007;369:640-52 pubmed
    The aryl hydrocarbon receptor nuclear translocator (ARNT) belongs to the basic-helix-loop-helix (bHLH) transcription factors and regulates several genes as heterodimers with other bHLH proteins...
  3. Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A. 1997;94:4273-8 pubmed
    We have isolated and characterized a cDNA for a novel Per-Arnt/AhR-Sim basic helix-loop-helix (bHLH-PAS) factor that interacts with the Ah receptor nuclear translocator (Arnt), and its predicted amino acid sequence exhibits significant ..
  4. Yim S, Shah Y, Tomita S, Morris H, Gavrilova O, Lambert G, et al. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology. 2006;44:550-60 pubmed
    ..The aryl hydrocarbon receptor nuclear translocator (Arnt), also called Hif-1beta, serves as an obligate heterodimerization partner of Hif-1alpha ..
  5. Chapman Smith A, Lutwyche J, Whitelaw M. Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. J Biol Chem. 2004;279:5353-62 pubmed
    ..of partner choice such that HIF-alpha and DR must dimerize with the aryl hydrocarbon nuclear translocator (Arnt) to form functional DNA binding complexes...
  6. Lau S, Lin S, Stokes R, Cheng K, Baldock P, Enriquez R, et al. Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice. Diabetologia. 2011;54:910-21 pubmed publisher
    ..Beta cell-specific aryl-hydrocarbon receptor nuclear translocator-null (?Arnt) mice develop GDM from beta cell dysfunction...
  7. Cheng K, Ho K, Stokes R, Scott C, Lau S, Hawthorne W, et al. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest. 2010;120:2171-83 pubmed publisher
    ..Increasing HIF-1alpha levels markedly increased expression of ARNT and other genes in human T2D islets and improved their function...
  8. Abbott B, Buckalew A. Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2. Dev Dyn. 2000;219:526-38 pubmed
    The aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcriptional regulator that heterodimerizes with Per-ARNT-Sim (PAS) proteins...
  9. Wang X, Suzuki R, Lee K, Tran T, Gunton J, Saha A, et al. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009;9:428-39 pubmed publisher
    We have previously shown that expression of the transcription factor ARNT/HIF1beta is reduced in islets of humans with type 2 diabetes. We have now found that ARNT is also reduced in livers of diabetics...
  10. Geng S, Mezentsev A, Kalachikov S, Raith K, Roop D, Panteleyev A. Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function. J Cell Sci. 2006;119:4901-12 pubmed
    ..The aryl hydrocarbon receptor nuclear translocator (Arnt) lies at the intersection of several crucial adaptive pathways...
  11. Gunton J, Kulkarni R, Yim S, Okada T, Hawthorne W, Tseng Y, et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005;122:337-49 pubmed
    ..There was also a 90% decrease in expression of the transcription factor ARNT. Reducing ARNT levels in Min6 cells with small interfering RNA (siRNA) resulted in markedly impaired glucose-..
  12. Williams C, Crawford R, Holsapple M, Kaminski N. Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes. Biochem Pharmacol. 1996;52:771-80 pubmed
    ..of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes...
  13. Keith B, Adelman D, Simon M. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A. 2001;98:6692-7 pubmed
    The ubiquitously expressed basic helix-loop-helix (bHLH)-PAS protein ARNT (arylhydrocarbon receptor nuclear transporter) forms transcriptionally active heterodimers with a variety of other bHLH-PAS proteins, including HIF-1alpha (hypoxia-..
  14. Chapman Smith A, Whitelaw M. Novel DNA binding by a basic helix-loop-helix protein. The role of the dioxin receptor PAS domain. J Biol Chem. 2006;281:12535-45 pubmed
    ..For the two subgroups within the family, dimerization is further regulated by an adjacent Per-Arnt-Sim homology (PAS) or leucine zipper (LZ) domain. We provide evidence that for the bHLH...
  15. Rantakokko J, Kiviranta R, Eerola R, Aro H, Vuorio E. Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3. Matrix Biol. 1999;18:155-61 pubmed
    ..extending further upstream of the Ctsk gene identified the 3' end of the gene coding for arylhydrocarbon-receptor nuclear translocator (Arnt). This places Ctsk approximately 4.5 kb downstream of Arnt on mouse chromosome 3 at locus 47.9.
  16. Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, et al. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med. 2010;16:678-86 pubmed publisher
    ..Hence, HIF-2alpha is a central transactivator that targets several crucial genes for endochondral ossification and may represent a therapeutic target for osteoarthritis. ..
  17. Taylor M, Qu A, Anderson E, Matsubara T, Martin A, Gonzalez F, et al. Hypoxia-inducible factor-2? mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011;140:2044-55 pubmed publisher
    ..suppressor protein (Vhl), hypoxia-inducible factor (HIF)-1?, HIF-2?, and aryl hydrocarbon nuclear translocator (ARNT). We observed biphasic regulation of Fpn during iron deficiency...
  18. Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T, et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science. 2009;323:1488-92 pubmed publisher
    ..Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells. ..
  19. Adelman D, Maltepe E, Simon M. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev. 1999;13:2478-83 pubmed
    ..This pathway requires HIF-1 (HIF-1alpha/ARNT heterodimers) because Arnt(-/-) embryoid bodies fail to exhibit hypoxia-mediated progenitor proliferation...
  20. Wong W, Richardson T, Seykora J, Cotsarelis G, Simon M. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 2015;135:454-461 pubmed publisher
    ..Therefore, low O2 tension is an essential component of the epidermal environment that contributes to skin development and function. ..
  21. Ishqi H, Ur Rehman S, Sarwar T, Husain M, Tabish M. Identification of differentially expressed three novel transcript variants of mouse ARNT gene. IUBMB Life. 2016;68:122-35 pubmed publisher
    The aryl hydrocarbon receptor nuclear translocator (ARNT/HIF1-β) is an obligatory transcriptional partner of the aryl hydrocarbon receptor (AHR) and hypoxia-inducible factor-1α (HIF-1α)...
  22. Schnekenburger M, Peng L, Puga A. HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation. Biochim Biophys Acta. 2007;1769:569-78 pubmed
    ..by the heterodimeric transcriptional complex formed by the liganded Ah receptor (AHR) and its partner, ARNT. Previously, we showed that constitutively bound HDAC1 dissociates from Cyp1a1 promoter chromatin after ligand-..
  23. Korkalainen M, Törrönen A, Karenlampi S. Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells. Chem Biol Interact. 1995;94:121-34 pubmed
    ..The results with these mutants suggested that Ah receptor nuclear translocator protein, ARNT, is needed for ALDH3 expression...
  24. Sekine H, Mimura J, Oshima M, Okawa H, Kanno J, Igarashi K, et al. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol. 2009;29:6391-400 pubmed publisher
    ..regulates the expression of Pai-2 through a mechanism involving NF-kappaB but not AhR nuclear translocator (Arnt), in an LPS-dependent manner...
  25. Wondimu A, Weir L, Robertson D, Mezentsev A, Kalachikov S, Panteleyev A. Loss of Arnt (Hif1?) in mouse epidermis triggers dermal angiogenesis, blood vessel dilation and clotting defects. Lab Invest. 2012;92:110-24 pubmed publisher
    Targeted ablation of Aryl hydrocarbon receptor nuclear translocator (Arnt) in the mouse epidermis results in severe abnormalities in dermal vasculature reminiscent of petechia induced in human skin by anticoagulants or certain genetic ..
  26. Yamagishi H, Olson E, Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000;105:261-70 pubmed
    ..These results suggest that dHAND is required for vascular development and regulates angiogenesis, possibly through a VEGF signaling pathway. ..
  27. Takagi S, Tojo H, Tomita S, Sano S, Itami S, Hara M, et al. Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. J Clin Invest. 2003;112:1372-82 pubmed
    b>Aryl hydrocarbon receptor nuclear translocator (ARNT), a transcription factor of the Per/AHR/ARNT/Sim family, regulates gene expression in response to environmental stimuli including xenobiotics and hypoxia...
  28. Ramirez Bergeron D, Runge A, Dahl K, Fehling H, Keller G, Simon M. Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development. 2004;131:4623-34 pubmed
    Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation. Arnt(-/-) mice exhibit substantial defects in blood cell and vessel development...
  29. Woods S, Whitelaw M. Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem. 2002;277:10236-43 pubmed
    The basic helix-loop-helix/Per-Arnt-Sim homology (bHLH/PAS) protein family comprises a group of transcriptional regulators that often respond to a variety of developmental and environmental stimuli...
  30. Abbott B, Probst M. Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo. Dev Dyn. 1995;204:144-55 pubmed
    The aryl hydrocarbon receptor (AhR) and the AhR nuclear translocator protein (ARNT) are basic-helix-loop-helix (bHLH) proteins involved in transcriptional regulation. The AhR is a ligand-activated partner of the ARNT protein...
  31. Moser M, Knoth R, Bode C, Patterson C. LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element. Brain Res Mol Brain Res. 2004;128:141-9 pubmed
    ..that LE-PAS transactivates the CNS midline enhancer (CME) motif but not the xenobiotic response element in an Arnt-dependent fashion and without prior activation of LE-PAS protein...
  32. Castellani L, Weinreb A, Bodnar J, Goto A, Doolittle M, Mehrabian M, et al. Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998;18:374-7 pubmed
    ..This region is syntenic to human chromosome 1q21-q23, which has recently been shown to harbour a gene associated with FCHL in families from a Finnish isolate. ..
  33. Copple B, Bustamante J, Welch T, Kim N, Moon J. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009;29:1010-21 pubmed publisher
    ..Collectively, our results suggest that HIFs may be important regulators of profibrotic and vasoactive mediators by hypoxic hepatocytes. ..
  34. Nishizawa H, Imanishi S, Manabe N. Effects of exposure in utero to bisphenol a on the expression of aryl hydrocarbon receptor, related factors, and xenobiotic metabolizing enzymes in murine embryos. J Reprod Dev. 2005;51:593-605 pubmed
    ..in their metabolism) and related factors [aryl hydrocarbon receptor repressor (AhRR) and AhR nuclear translocator (Arnt)], xenobiotic metabolizing enzymes [XMEs; cytochrome P450 1A1 (CYP1A1) and UDP-glucuronosyltransferase, and the ..
  35. Farsijani N, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, et al. Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest. 2016;126:1425-37 pubmed publisher
    ..Our genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO production under conditions of epithelial HIF activation in the kidney. ..
  36. Zhou S, Degan S, Potts E, Foster W, Sunday M. NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proc Natl Acad Sci U S A. 2009;106:11691-6 pubmed publisher
    ..Therefore, absence of a developmentally expressed transcription factor can alter downstream gene expression and multiple signaling pathways in organogenesis. NPAS3 haploinsufficiency may also lead to emphysema and asthma. ..
  37. Zhang H, Bosch Marce M, Shimoda L, Tan Y, Baek J, Wesley J, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 2008;283:10892-903 pubmed publisher
  38. Dougherty E, Pollenz R. Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture. Toxicol Sci. 2008;103:191-206 pubmed
    b>ARNT and ARNT2 proteins are expressed in mammalian and aquatic species and exhibit a high level of amino acid identity in the basic-helix loop-helix PER/ARNT/SIM domains involved in protein interactions and DNA binding...
  39. Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, et al. A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014;10:e1004589 pubmed publisher
  40. Rankin E, Tomaszewski J, Haase V. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006;66:2576-83 pubmed
    ..Inactivation of the HIF-alpha binding partner, arylhydrocarbon receptor nuclear translocator (Arnt), but not Hif-1alpha, suppressed the development of renal cysts...
  41. Corrada D, Denison M, Bonati L. Structural modeling of the AhR:ARNT complex in the bHLH-PASA-PASB region elucidates the key determinants of dimerization. Mol Biosyst. 2017;13:981-990 pubmed publisher
    Elucidation of the dimerization process of the aryl hydrocarbon receptor (AhR) with the AhR nuclear translocator (ARNT) is crucial for understanding the mechanisms underlying the functional activity of AhR, including mediation of the ..
  42. van Uden P, Kenneth N, Webster R, Müller H, Mudie S, Rocha S. Evolutionary conserved regulation of HIF-1β by NF-κB. PLoS Genet. 2011;7:e1001285 pubmed publisher
    ..These results reveal a novel mechanism of HIF regulation, with impact in the development of novel therapeutic strategies for HIF-related pathologies including ageing, ischemia, and cancer. ..
  43. Han Y, Kuang S, Gomer A, Ramirez Bergeron D. Hypoxia influences the vascular expansion and differentiation of embryonic stem cell cultures through the temporal expression of vascular endothelial growth factor receptors in an ARNT-dependent manner. Stem Cells. 2010;28:799-809 pubmed publisher
    ..When stabilized by hypoxia, bHLH-PAS alpha- and beta- (HIF-1beta or ARNT) HIF complex regulate the expression of multiple genes, including vascular endothelial growth factor (VEGF)...
  44. Maltepe E, Krampitz G, Okazaki K, Red Horse K, Mak W, Simon M, et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005;132:3393-403 pubmed
    ..is a heterodimeric transcription factor composed of HIFalpha and the arylhydrocarbon receptor nuclear translocator (ARNT/HIF1beta). Previously, we have reported that ARNT function is required for murine placental development...
  45. Sheen M, Warner S, Fields J, Conejo Garcia J, Fiering S. Myristoylated p110? Causes Embryonic Death Due to Developmental and Vascular Defects. Open Life Sci. 2015;10:461-478 pubmed
    ..i>These finding demonstrate the importance of tight regulation of PI3K signaling during embryonic vasculogenesis/angiogenesis.. ..
  46. Imamura Y, Tomita S, Imanishi M, Kihira Y, Ikeda Y, Ishizawa K, et al. HIF-2?/ARNT complex regulates hair development via induction of p21(Waf1/Cip1) and p27(Kip1). FASEB J. 2014;28:2517-24 pubmed publisher
    The hypoxia-inducible factors HIF-1? or HIF-2? form heterodimeric complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT)...
  47. Wagner K, Hellberg A, Balenger S, Depping R, Dodd O J, Johns R, et al. Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha. Am J Respir Cell Mol Biol. 2004;31:276-82 pubmed
    ..These results indicate a role for HIMF in lung development, possibly under the control of HIF-2, and suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation. ..
  48. Sadek C, Jalaguier S, Feeney E, Aitola M, Damdimopoulos A, Pelto Huikko M, et al. Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mech Dev. 2000;97:13-26 pubmed
    Basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) proteins form dimeric transcription factors to mediate diverse biological functions including xenobiotic metabolism, hypoxic response, circadian rhythm and central nervous system midline ..
  49. Probst M, Reisz Porszasz S, Agbunag R, Ong M, Hankinson O. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Mol Pharmacol. 1993;44:511-8 pubmed
    ..shock protein and the Ah receptor protein but reveal that it does not contain the Ah receptor nuclear translocator (ARNT) protein...
  50. Lee K, Yang S, Kim Y, Choi Y, Nam J, Choi C, et al. Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice. Diabetes. 2013;62:1855-64 pubmed publisher
    ..These results provide the first in vivo evidence that Crbn is a negative modulator of AMPK, which suggests that Crbn may be a potential target for metabolic disorders of the liver. ..
  51. Reyes H, Reisz Porszasz S, Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science. 1992;256:1193-5 pubmed
    ..The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function...
  52. Takahashi Y, Nakayama K, Shimojima T, Itoh S, Kamataki T. Expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt) in adult rabbits known to be non-responsive to cytochrome P-450 1A1 (CYP1A1) inducers. Eur J Biochem. 1996;242:512-8 pubmed
    ..In the present study, we isolated cDNA clones encoding aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt) from adult rabbits...
  53. Krock B, Eisinger Mathason T, Giannoukos D, Shay J, Gohil M, Lee D, et al. The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability. Blood. 2015;125:3263-72 pubmed publisher
    ..To this end, we have conditionally deleted the HIF-α dimerization partner, the aryl hydrocarbon receptor nuclear translocator (ARNT) in the hematopoietic system to ablate activity of both HIF-1α and HIF-2α and ..
  54. Nishiumi S, Yoshida K, Ashida H. Curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation. Arch Biochem Biophys. 2007;466:267-73 pubmed
    ..In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation ..
  55. Semenza G. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol. 2000;59:47-53 pubmed
    ..Pharmacologic manipulation of HIF-1 levels may provide a novel therapeutic approach to diseases that represent the most common causes of mortality in Western society, including cancer, chronic lung disease, and myocardial ischemia. ..
  56. Ding M, Coward R, Jeansson M, Kim W, Quaggin S. Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier. Am J Physiol Renal Physiol. 2013;304:F120-6 pubmed publisher
    ..Genetic deletion of the obligate dimerization partner Arnt/Hif1b that is essential for Hif transcriptional function rescues the phenotype...
  57. Scott C, Cha K, Rao R, Liddle C, George J, Gunton J. Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury. PLoS ONE. 2015;10:e0121650 pubmed publisher
    ..b>Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2α transcriptional activity and has previously been shown to ..
  58. Pollenz R, Sullivan H, Holmes J, Necela B, Peterson R. Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic helix-loop-Helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor. Evidence for alternativ. J Biol Chem. 1996;271:30886-96 pubmed
    cDNAs encoding two distinct basic helix-loop-helix/PER-ARNT-SIM (bHLH/PAS) proteins with similarity to the mammalian aryl hydrocarbon nuclear translocator (ARNT) protein were isolated from RTG-2 rainbow trout gonad cells...
  59. Glover L, Bowers B, Saeedi B, Ehrentraut S, Campbell E, Bayless A, et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A. 2013;110:19820-5 pubmed publisher
    ..These findings establish a role for HIF-regulated CK in epithelial homeostasis and reveal a fundamental link between cellular bioenergetics and mucosal barrier. ..
  60. Levesque B, Zhou S, Shan L, Johnston P, Kong Y, Degan S, et al. NPAS1 regulates branching morphogenesis in embryonic lung. Am J Respir Cell Mol Biol. 2007;36:427-34 pubmed
    ..NPAS1 immunostaining occurs in nuclei of parabronchial mesenchymal cells, especially at the tracheal bifurcation. Arnt, the murine homolog of Tango (the heterodimerization partner for Trl) is also expressed in developing lung but at ..
  61. Vanderlinden L, Saba L, Bennett B, Hoffman P, Tabakoff B. Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption. Mamm Genome. 2015;26:43-56 pubmed publisher
    ..The resulting candidate genes (in particular, Arntl/Bmal1) focused attention on the influence of circadian regulation on the variation in the DID phenotype in this population of mice. ..
  62. Chen H, Houshmand G, Mishra S, Fong G, Gittes G, Esni F. Impaired pancreatic development in Hif2-alpha deficient mice. Biochem Biophys Res Commun. 2010;399:440-5 pubmed publisher
    ..These results suggest that HIF2-alpha is required for normal mouse pancreatic development. ..
  63. MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 2013;41:1604-21 pubmed publisher
    ..in CYP1A1-reporter gene activity, which was restored by overexpression of AHR, but not aryl hydrocarbon receptor nuclear translocator. Deletion and mutagenesis studies showed that TiPARP-mediated inhibition of AHR required the ..
  64. Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature. 2015;524:303-8 pubmed publisher
    ..Transcriptionally active HIFs consist of HIF-α and ARNT (also called HIF-1β) subunits...
  65. Wood S, Gleadle J, Pugh C, Hankinson O, Ratcliffe P. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J Biol Chem. 1996;271:15117-23 pubmed
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    ..We generated mice with floxed alleles at the Hif1a or Arnt locus encoding HIF-1? and HIF-1?, respectively...
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    ..In murine models, deletion of the gene encoding aryl hydrocarbon nuclear translocator (ARNT, also known as HIF1β) in the liver or pancreas leads to a diabetic phenotype; however, the role of ARNT in cardiac ..
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    ..The present study demonstrates that hypoxic activation of hepatic HIF-2? leads to an adaptive increase in cholesterol levels through inhibition of bile acid synthesis. ..
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    The basic helix-loop-helix (bHLH-PAS) proteins aryl hydrocarbon receptor nuclear translocator (Arnt) and Arnt2 are transcriptional regulators that function as dimerizing partners for several bHLH-PAS proteins and also some nonrelated ..
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    ..AhR translocates to the nucleus and forms a heterodimer with its partner protein, AhR nuclear translocator (Arnt)...
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    ..Our results show that, although HIF2alpha was widely transcribed by kidney endothelium and vascular smooth muscle, knockouts displayed no detectable deficits in vessel development or VEGF or Flk-1 expression. ..
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    ..Thus, different "adipocyte-specific" Cre lines display different degrees of efficiency and specificity, illustrating important differences that must be taken into account in their use for studying adipose biology. ..
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    ..by the Ahr gene, which, upon ligand binding, translocates to the nucleus in a heterodimeric complex with the ARNT (Ah receptor nuclear translocator) component...
  76. Shah Y, Ito S, Morimura K, Chen C, Yim S, Haase V, et al. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology. 2008;134:2036-48, 2048.e1-3 pubmed publisher
    ..tumor suppressor protein (Vhl), hypoxia-inducible factor (Hif)-1alpha, and aryl hydrocarbon nuclear translocator (Arnt) was generated...
  77. Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher
    ..Vorinostat inhibits STS tumour growth, an effect ameliorated by HIF-2α deletion, implicating HIF-2α as a biomarker for Vorinostat efficacy in STS. ..
  78. Ramakrishnan S, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, et al. HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. Cell Metab. 2016;23:505-16 pubmed publisher
    ..This study reveals that HIF2α is essential for the acute postprandial regulation of hepatic glucagon signaling and suggests HIF2α as a potential therapeutic target in the treatment of diabetes. ..
  79. Iyer N, Kotch L, Agani F, Leung S, Laughner E, Wenger R, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998;12:149-62 pubmed
    ..5 and E9.5, coincident with the onset of developmental defects and cell death in Hif1a-/- embryos. These results demonstrate that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis. ..
  80. Sarkar K, Cai Z, Gupta R, Parajuli N, Fox Talbot K, Darshan M, et al. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc Natl Acad Sci U S A. 2012;109:10504-9 pubmed publisher
    ..Expression and dimerization of the HIF-1? and HIF-1? subunits is required, suggesting that the heterodimer is functioning as a transcriptional activator, despite the acute nature of the response. ..
  81. Zhang H, Zhang G, Gonzalez F, Park S, Cai D. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011;9:e1001112 pubmed publisher
    ..In conclusion, HIF controls hypothalamic POMC gene to direct the central nutrient sensing in regulation of energy and body weight balance. ..
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    b>Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that binds to partners to mediate responses to environmental signals...
  83. Madan A, Varma S, Cohen H. Developmental stage-specific expression of the alpha and beta subunits of the HIF-1 protein in the mouse and human fetus. Mol Genet Metab. 2002;75:244-9 pubmed
    ..Although expression of HIF-1alpha and -beta did not decrease immediately after birth, it is possible that the HIF-1 protein is involved in the various events that occur during transition after birth. ..
  84. Hirose K, Morita M, Ema M, Mimura J, Hamada H, Fujii H, et al. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol. 1996;16:1706-13 pubmed
    ..Arnt2) that are highly similar to but distinct from the aryl hydrocarbon receptor (AhR) nuclear translocator (Arnt)...