Gene Symbol: Arid1b
Description: AT rich interactive domain 1B (SWI-like)
Alias: 8030481M12, 9330189K18Rik, AI836955, Ardi1b, B230217J03Rik, BAF250B, mKIAA1235, AT-rich interactive domain-containing protein 1B, ARID domain-containing protein 1B, AT rich interactive domain 1B (Swi1 like), BRG1-associated factor 250b
Species: mouse
Products:     Arid1b

Top Publications

  1. Notwell J, Heavner W, Darbandi S, Katzman S, McKenna W, Ortiz Londono C, et al. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016;26:1013-22 pubmed publisher
    ..Our findings highlight a TBR1-regulated network of ASD genes in the developing neocortex that are relatively intolerant to LoF mutations, indicating that these genes may play critical roles in normal cortical development. ..
  2. Yan Z, Wang Z, Sharova L, Sharov A, Ling C, Piao Y, et al. BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells. Stem Cells. 2008;26:1155-65 pubmed publisher
    ..Moreover, the levels of BAF250A and BAF250B decrease during the differentiation of ES cells, whereas that of BRM increases...
  3. Chandler R, Brennan J, Schisler J, Serber D, Patterson C, Magnuson T. ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013;33:265-80 pubmed publisher
    ..These findings support the model wherein cooperative interactions among intrinsic subunit-chromatin interaction domains and sequence-specific transcription factors drive SWI/SNF recruitment. ..
  4. Staahl B, Tang J, Wu W, Sun A, Gitler A, Yoo A, et al. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013;33:10348-61 pubmed publisher
  5. Wu J, Keng V, Patmore D, Kendall J, Patel A, Jousma E, et al. Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation. Cell Rep. 2016;14:1979-90 pubmed publisher
    ..We mapped an Nf1-Stat3-Arid1b/?-catenin pathway that becomes active in the context of Nf1 loss...
  6. Ka M, Chopra D, Dravid S, Kim W. Essential Roles for ARID1B in Dendritic Arborization and Spine Morphology of Developing Pyramidal Neurons. J Neurosci. 2016;36:2723-42 pubmed publisher
    De novo truncating mutations in ARID1B, a chromatin-remodeling gene, cause Coffin-Siris syndrome, a developmental disorder characterized by intellectual disability and speech impairment; however, how the genetic elimination leads to ..
  7. Nagl N, Wang X, Patsialou A, Van Scoy M, Moran E. Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J. 2007;26:752-63 pubmed
    ..The specific complexes control access of factors such as E2F1, Tip60, and HDAC1/2/3 to the promoters of various cell-cycle-specific genes, with c-Myc emerging as a particularly critical target. ..
  8. Kawazu M, Saso K, Tong K, McQuire T, Goto K, Son D, et al. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS ONE. 2011;6:e17830 pubmed publisher
    ..Taken together, these findings suggest an essential role for JMJD2B in the estrogen signaling, and identify JMJD2B as a potential therapeutic target in breast cancer. ..
  9. Flores Alcantar A, Gonzalez Sandoval A, Escalante Alcalde D, Lomeli H. Dynamics of expression of ARID1A and ARID1B subunits in mouse embryos and in cells during the cell cycle. Cell Tissue Res. 2011;345:137-48 pubmed publisher
    ..ARID1A and ARID1B are mutually exclusive subunits of the BAF complex...

More Information


  1. Kadoch C, Crabtree G. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell. 2013;153:71-85 pubmed publisher
    ..This mechanism of transformation depends on only two amino acids of SSX, providing a potential foundation for therapeutic intervention. ..
  2. Dykhuizen E, Hargreaves D, Miller E, Cui K, Korshunov A, Kool M, et al. BAF complexes facilitate decatenation of DNA by topoisomerase II?. Nature. 2013;497:624-7 pubmed publisher
    ..These studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF complexes and suggest that this activity contributes to the role of BAF subunits as tumour suppressors. ..
  3. Jung E, Moffat J, Liu J, DRAVID S, Gurumurthy C, Kim W. Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017;20:1694-1707 pubmed publisher
    Haploinsufficiency of the AT-rich interactive domain 1B (ARID1B) gene causes autism spectrum disorder and intellectual disability; however, the neurobiological basis for this is unknown...
  4. Hurlstone A, Olave I, Barker N, van Noort M, Clevers H. Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein. Biochem J. 2002;364:255-64 pubmed
    ..EHD1 and EHD2 also appear capable of interacting with each other. Using an antibody raised against EHD2 of hELD/OSA1, we detected Eld/Osa1 in endogenous SWI/SNF complexes derived from mouse brain. ..
  5. Wilsker D, Probst L, Wain H, Maltais L, Tucker P, Moran E. Nomenclature of the ARID family of DNA-binding proteins. Genomics. 2005;86:242-51 pubmed
  6. Celen C, Chuang J, Luo X, Nijem N, Walker A, Chen F, et al. Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. elife. 2017;6: pubmed publisher
    Sequencing studies have implicated haploinsufficiency of ARID1B, a SWI/SNF chromatin-remodeling subunit, in short stature (Yu et al., 2015), autism spectrum disorder (O'Roak et al...