Arg1

Summary

Gene Symbol: Arg1
Description: arginase, liver
Alias: AI256583, Arg-1, PGIF, arginase-1, arginase 1, liver, arginase I, liver-type arginase, type I arginase
Species: mouse
Products:     Arg1

Top Publications

  1. Gray M, Poljakovic M, Kepka Lenhart D, Morris S. Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. Gene. 2005;353:98-106 pubmed
    ..IL-4 alters macrophage arginine metabolism by inducing arginase I expression and inhibiting nitric oxide production...
  2. Herbert D, Orekov T, Roloson A, Ilies M, Perkins C, O BRIEN W, et al. Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J Immunol. 2010;184:6438-46 pubmed publisher
    ..This study demonstrates that arginase I (Arg I), a major product of IL-4- and IL-13-induced alternatively activated macrophages, prevents cachexia, ..
  3. Deignan J, Marescau B, Livesay J, Iyer R, De Deyn P, Cederbaum S, et al. Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia. Mol Genet Metab. 2008;93:172-8 pubmed
    In humans, arginase I (AI)-deficiency results in hyperargininemia, a metabolic disorder with symptoms of progressive neurological and intellectual impairment, spasticity, persistent growth retardation, and episodic hyperammonemia...
  4. Liu J, Copland D, Horie S, Wu W, Chen M, Xu Y, et al. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS ONE. 2013;8:e72935 pubmed publisher
  5. Centuori S, Trad M, LaCasse C, Alizadeh D, Larmonier C, Hanke N, et al. Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-?-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells. J Leukoc Biol. 2012;92:987-97 pubmed publisher
    ..process, requires inhibition of early T cell activation, and depends on ROS and IDO but does not require arginase 1, iNOS, NO, cystine/cysteine depletion, PD-1 and PD-L1 signaling, or COX-2...
  6. Stoermer K, Burrack A, Oko L, Montgomery S, Borst L, Gill R, et al. Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus. J Immunol. 2012;189:4047-59 pubmed publisher
    ..macrophages present in these lesions, have a unique gene-expression pattern characterized by high expression of arginase 1 and Ym1/Chi3l3 in the absence of FIZZ1/Relm? that is consistent with an M2-like activation phenotype...
  7. Qualls J, Neale G, Smith A, Koo M, DeFreitas A, Zhang H, et al. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal. 2010;3:ra62 pubmed publisher
    ..Macrophage arginase 1 (Arg1) competes with NO synthases for arginine, a substrate common to both types of enzymes, to inhibit NO ..
  8. North M, Khanna N, Marsden P, Grasemann H, Scott J. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol. 2009;296:L911-20 pubmed publisher
    ..To investigate the role of arginase isozymes (ARG1 and ARG2) in AHR, we determined the protein expression of ARG1, ARG2, the NOS isozymes, and other proteins involved ..
  9. Kämpfer H, Pfeilschifter J, Frank S. Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair. J Invest Dermatol. 2003;121:1544-51 pubmed

More Information

Publications79

  1. Bronte V, Serafini P, De Santo C, Marigo I, Tosello V, Mazzoni A, et al. IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J Immunol. 2003;170:270-8 pubmed
    ..MSC to block T cell proliferation and CTL generation in response to alloantigen, which is mediated by the enzyme arginase 1 (Arg1)...
  2. Gallardo Soler A, Gómez Nieto C, Campo M, Marathe C, Tontonoz P, Castrillo A, et al. Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Mol Endocrinol. 2008;22:1394-402 pubmed publisher
    ..Collectively, our results strongly suggest that ArgI is a key marker of the alternative program triggered by PPAR in macrophages. ..
  3. Iyer R, Yoo P, Kern R, Rozengurt N, Tsoa R, O Brien W, et al. Mouse model for human arginase deficiency. Mol Cell Biol. 2002;22:4491-8 pubmed
  4. Yang M, Rangasamy D, Matthaei K, Frew A, Zimmmermann N, Mahalingam S, et al. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J Immunol. 2006;177:5595-603 pubmed
    Increased arginase I activity is associated with allergic disorders such as asthma. How arginase I contributes to and is regulated by allergic inflammatory processes remains unknown...
  5. Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
    Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs)...
  6. Bratt J, Franzi L, Linderholm A, Last M, Kenyon N, Last J. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2009;234:273-80 pubmed publisher
    ..Both arginase I and arginase II were constitutively expressed in the airways of normal C57BL/6 mice...
  7. Deignan J, Livesay J, Yoo P, Goodman S, O Brien W, Iyer R, et al. Ornithine deficiency in the arginase double knockout mouse. Mol Genet Metab. 2006;89:87-96 pubmed
    ..Although most human AI-deficient patients have no symptomatic hyperammonemia at birth, it is possible that clinically significant ornithine deficiency is already present. ..
  8. Holan V, Pindjáková J, Krulova M, Neuwirth A, Fric J, Zajicova A. Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and L-arginine metabolism. Transplantation. 2006;81:1708-15 pubmed
  9. El Kasmi K, Qualls J, Pesce J, Smith A, Thompson R, Henao Tamayo M, et al. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008;9:1399-406 pubmed publisher
    ..Intracellular pathogens induced expression of the arginine hydrolytic enzyme arginase 1 (Arg1) in mouse macrophages through the TLR pathway...
  10. Elms S, Toque H, Rojas M, Xu Z, Caldwell R, Caldwell R. The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes. Diabetologia. 2013;56:654-62 pubmed publisher
    ..The diabetes-induced vascular dysfunction was markedly blunted in mice lacking one copy of the gene encoding arginase I and in mice treated with the arginase inhibitor 2(S)-amino-6-boronohexanoic acid...
  11. WU D, Molofsky A, Liang H, Ricardo Gonzalez R, Jouihan H, Bando J, et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011;332:243-7 pubmed publisher
    ..Our results suggest that eosinophils play an unexpected role in metabolic homeostasis through maintenance of adipose AAMs. ..
  12. Zhang C, Wu J, Xu X, Potter B, Gao X. Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injury. Basic Res Cardiol. 2010;105:453-64 pubmed publisher
  13. Duleu S, Vincendeau P, Courtois P, Semballa S, Lagroye I, Daulouede S, et al. Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect. J Immunol. 2004;172:6298-303 pubmed
    ..b>Arginase I and arginase II mRNA expression was higher in macrophages from infected BALB/c compared with those from C57BL/6 ..
  14. Pauleau A, Rutschman R, Lang R, Pernis A, Watowich S, Murray P. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol. 2004;172:7565-73 pubmed
    b>Arginase I expression in the liver must remain constant throughout life to eliminate excess nitrogen via the urea cycle...
  15. Van den Bossche J, Lamers W, Koehler E, Geuns J, Alhonen L, Uimari A, et al. Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes. J Leukoc Biol. 2012;91:685-99 pubmed publisher
    ..This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and ornithine can be decarboxylated by ODC to produce putrescine, ..
  16. Rodriguez P, Hernandez C, Quiceno D, Dubinett S, Zabaleta J, Ochoa J, et al. Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. J Exp Med. 2005;202:931-9 pubmed
    Myeloid suppressor cells (MSCs) producing high levels of arginase I block T cell function by depleting l-arginine in cancer, chronic infections, and trauma patients...
  17. Pesce J, Ramalingam T, Mentink Kane M, Wilson M, El Kasmi K, Smith A, et al. Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog. 2009;5:e1000371 pubmed publisher
    ..Here, however, we show that macrophage-specific Arg1 functions as an inhibitor of inflammation and fibrosis following infection with the Th2-inducing pathogen ..
  18. Hesse M, Modolell M, La Flamme A, Schito M, Fuentes J, Cheever A, et al. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol. 2001;167:6533-44 pubmed
  19. Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne J, et al. Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. Mol Genet Metab. 2013;110:222-30 pubmed publisher
    ..examined as outcome parameters after widespread Cre-recombinase activation in a conditional knockout model of arginase 1 deficiency. One hundred percent of adult female and 70% of adult male mice died an average of 21.0 and 21...
  20. Cloots R, Sankaranarayanan S, de Theije C, Poynter M, Terwindt E, Van Dijk P, et al. Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice. Am J Physiol Lung Cell Mol Physiol. 2013;305:L364-76 pubmed publisher
    ..Our objective was to investigate the importance of increased pulmonary arginase 1 expression on methacholine-induced AHR and lung inflammation in a mouse model of allergic asthma...
  21. Iniesta V, Carcelén J, Molano I, Peixoto P, Redondo E, Parra P, et al. Arginase I induction during Leishmania major infection mediates the development of disease. Infect Immun. 2005;73:6085-90 pubmed
    In a previous work, we demonstrated that the induction of arginase I favored the replication of Leishmania inside macrophages. Now we have analyzed the differential expression of this enzyme in the mouse model of L. major infection...
  22. Zhang W, Baban B, Rojas M, Tofigh S, Virmani S, Patel C, et al. Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. Am J Pathol. 2009;175:891-902 pubmed publisher
    ..Immunofluorescence and flow cytometry confirmed this increase in Arg1, which was localized to glia and microglia...
  23. Iniesta V, Gómez Nieto L, Molano I, Mohedano A, Carcelén J, Mirón C, et al. Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites. Parasite Immunol. 2002;24:113-8 pubmed
    ..BALB/c macrophages with interleukin (IL)-4, IL-10 or transforming growth factor-beta, which are all inducers of arginase I in murine macrophages, led to a proportional increase in the number of intracellular amastigotes...
  24. Chang J, Thangamani S, Kim M, Ulrich B, Morris S, Kim C. Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. Eur J Immunol. 2013;43:967-78 pubmed publisher
    b>Arginase I (Arg1), an enzyme expressed by many cell types including myeloid cells, can regulate immune responses...
  25. Romero M, Iddings J, Platt D, Ali M, Cederbaum S, Stepp D, et al. Diabetes-induced vascular dysfunction involves arginase I. Am J Physiol Heart Circ Physiol. 2012;302:H159-66 pubmed publisher
    ..Here, we examined the roles of the two arginase isoforms, arginase I and II (AI and AII, respectively), in this process...
  26. Pourcet B, Feig J, Vengrenyuk Y, Hobbs A, Kepka Lenhart D, Garabedian M, et al. LXR? regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res. 2011;109:492-501 pubmed publisher
    ..In addition, LXR? levels are high in regressive plaques. Macrophage arginase 1 (Arg1) expression is inversely correlated with atherosclerosis progression and is markedly decreased in foam ..
  27. Biswas A, Bhattacharya A, Kar S, Das P. Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis. Eur J Immunol. 2011;41:992-1003 pubmed publisher
    ..As in CL, BALB/c mice infected with Leishmania donovani showed increased levels of arginase in acute infection. Arginase 1 is the major isoform associated with infection and while the IL-4-induced arginase pathway is operative in CL, ..
  28. Liu Q, Zhang C, Sun A, Zheng Y, Wang L, Cao X. Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. J Immunol. 2009;182:6207-16 pubmed publisher
    ..CD11c(low)CD11b(high)Ia(low) phenotype and high expression of IL-10, NO, vascular endothelial growth factor, and arginase I. Tumor-educated CD11b(high)Ia(low) regulatory DCs inhibited CD4(+) T cell proliferation both in vitro and in ..
  29. Deignan J, Livesay J, Shantz L, Pegg A, O Brien W, Iyer R, et al. Polyamine homeostasis in arginase knockout mice. Am J Physiol Cell Physiol. 2007;293:C1296-301 pubmed
    ..them are still alive, to determine whether tissue polyamine levels were altered in response to a disruption of arginase I (AI) and II (AII) enzymatic activity...
  30. Reese T, Liang H, Tager A, Luster A, Van Rooijen N, Voehringer D, et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007;447:92-6 pubmed
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase. ..
  31. Zimmermann N, King N, Laporte J, Yang M, Mishra A, Pope S, et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest. 2003;111:1863-74 pubmed
    ..Genes related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes...
  32. Heredia J, Mukundan L, Chen F, Mueller A, Deo R, Locksley R, et al. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013;153:376-88 pubmed publisher
    ..Surprisingly, type 2 cytokine signaling is also required in FAPs, but not in myeloid cells, for rapid clearance of necrotic debris, a process that is necessary for timely and complete regeneration of tissues. ..
  33. Hashimoto C, Masuda H, Ayaki M, Suzuki Y, Uenaka A, Seya T, et al. Molecular cloning and sequence analysis of the cDNA for the mouse counterpart to adult hamster liver purified growth inhibitory factor. Biochim Biophys Acta. 1997;1355:205-8 pubmed
    A cDNA clone encoding the mouse counterpart to adult hamster liver purified growth inhibitory factor (PGIF) was isolated from a mouse liver cDNA library by using antibodies raised against PGIF and sequenced...
  34. Schmidt P, Toudjarska I, Sendamarai A, Racie T, Milstein S, Bettencourt B, et al. An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine ?-thalassemia intermedia. Blood. 2013;121:1200-8 pubmed publisher
  35. Toque H, Nunes K, Yao L, Xu Z, Kondrikov D, Su Y, et al. Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function. PLoS ONE. 2013;8:e72277 pubmed publisher
    ..a progressive impairment of vascular endothelial and nitrergic function increased Arg activity and expression (Arg1 in aorta and both Arg1 and Arg2 in CC) compared with that of age-matched WT mice...
  36. Bhatta A, Sangani R, Kolhe R, Toque H, Cain M, Wong A, et al. Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model. Mol Cell Endocrinol. 2016;422:211-220 pubmed publisher
    ..We demonstrated that arginase 1 is abundantly present in the bone and BMSCs...
  37. Ranocchia R, Gorlino C, Crespo M, Harman M, Liscovsky M, Moron G, et al. Arginase-dependent suppression by CpG-ODN plus IFA-induced splenic myeloid CD11b(+)Gr1(+) cells. Immunol Cell Biol. 2012;90:710-21 pubmed publisher
    ..These results underscore a key role of CpG-ODN on ARG activity in vivo and add support to the growing body of evidence in favor of a counter-regulatory role for CpG-ODN in an immune response. ..
  38. Sharda D, Yu S, Ray M, Squadrito M, De Palma M, Wynn T, et al. Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J Immunol. 2011;187:2181-92 pubmed publisher
    ..These divergent phenotypes are characterized, in part, by the expression of inducible NO synthase and arginase I (Arg1) in M1 versus M2 activated macrophages, respectively...
  39. Planas Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, et al. The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016;18:467-79 pubmed publisher
    ..Taken together, our results indicate that the RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration. ..
  40. Yu H, Iyer R, Yoo P, Kern R, Grody W, Cederbaum S. Arginase expression in mouse embryonic development. Mech Dev. 2002;115:151-5 pubmed
    ..mouse embryo to elucidate the pattern of arginase expression in mammalian cells in normal animals and in arginase I (AI) deficiency during development by digoxigenin-labeled RNA in situ hybridization...
  41. Eichin D, Laurila J, Jalkanen S, Salmi M. CD73 Activity is Dispensable for the Polarization of M2 Macrophages. PLoS ONE. 2015;10:e0134721 pubmed publisher
  42. Fu H, Khan A, Coe D, Zaher S, Chai J, Kropf P, et al. Arginine depletion as a mechanism for the immune privilege of corneal allografts. Eur J Immunol. 2011;41:2997-3005 pubmed publisher
    ..We found that both the endothelium and epithelium of murine corneas express functional arginase I, capable of down-regulating T-cell proliferation in an in vitro culture system...
  43. Monticelli L, Buck M, Flamar A, Saenz S, Tait Wojno E, Yudanin N, et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol. 2016;17:656-65 pubmed publisher
    ..Here we demonstrate that expression of the enzyme arginase-1 (Arg1) during acute or chronic lung inflammation is a conserved trait of mouse and human ILC2s...
  44. Badaut J, Copin J, Fukuda A, Gasche Y, Schaller K, da Silva R. Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit. J Neuroinflammation. 2012;9:132 pubmed publisher
    ..aging in this classical mouse model of atherosclerosis induces an increase in the level and activity of arginase I that may impair NO synthesis and contribute to changes in the NVU leading to blood-brain barrier leakage and ..
  45. Trad M, Gautheron A, Fraszczak J, Alizadeh D, Larmonier C, LaCasse C, et al. T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1. Biomed Res Int. 2015;2015:891236 pubmed publisher
  46. Ganji A, Roshan H, Varasteh A, Moghadam M, Sankian M. The effects of WW2/WW3 domains of Smurf2 molecule on TGF-β signaling and arginase I gene expression. Cell Biol Int. 2015;39:690-5 pubmed publisher
    ..b>Arginase I (ArgI) is one of the main products of TGF-β signaling that plays important roles in tumor escape and airway ..
  47. Sathi G, Farahat M, Hara E, Taketa H, Nagatsuka H, Kuboki T, et al. MCSF orchestrates branching morphogenesis in developing submandibular gland tissue. J Cell Sci. 2017;130:1559-1569 pubmed publisher
  48. Bhatt S, Qin J, Bennett C, Qian S, Fung J, Hamilton T, et al. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function. J Immunol. 2014;192:5098-108 pubmed publisher
    ..Thus, we conclude that ATRA enhances both Arg-1 and iNOS expression in IFN-?-treated DCs, resulting in a tolerogenic phenotype. These findings elucidate mechanisms through which ATRA may contribute to liver immune tolerance. ..
  49. Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, et al. Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol. 2014;193:1717-27 pubmed publisher
    ..We observed that Arginase I expression and secretion were markedly induced by PTEN deletion, suggesting PTEN(-/-) macrophages were ..
  50. Abdolazimi Y, Stojanova Z, Segil N. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development. 2016;143:841-50 pubmed publisher
  51. Ren B, Van Kampen E, Van Berkel T, Cruickshank S, Van Eck M. Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis. Atherosclerosis. 2017;256:35-46 pubmed publisher
    Arginase1 (Arg1), an M2 macrophage marker, plays a critical role in a number of immunological functions in macrophages, which are the main cell type facilitating atherosclerotic lesion development...
  52. Morris S, You H, Gao T, Vacher J, Cooper T, Awad A. Distinct roles of arginases 1 and 2 in diabetic nephropathy. Am J Physiol Renal Physiol. 2017;313:F899-F905 pubmed publisher
    ..We therefore generated mice with a macrophage-specific deletion of arginase-1 (CD11bCre /Arg1fl/fl )...
  53. Patnode M, Bando J, Krummel M, Locksley R, Rosen S. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014;211:1281-8 pubmed publisher
    ..The similarity of the eosinophil responses to diverse nematode species suggests that conserved features of nematodes are recognized during parasite infection. ..
  54. Yao L, Bhatta A, Xu Z, Chen J, Toque H, Chen Y, et al. Obesity-induced vascular inflammation involves elevated arginase activity. Am J Physiol Regul Integr Comp Physiol. 2017;313:R560-R571 pubmed publisher
    ..Our previous studies showed that arginase 1 (A1) in endothelial cells (ECs) is critically involved in obesity-induced vascular dysfunction...
  55. Ballantyne L, Sin Y, St Amand T, Si J, Goossens S, Haenebalcke L, et al. Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. PLoS ONE. 2015;10:e0125967 pubmed publisher
  56. Wijnands K, Hoeksema M, Meesters D, Van Den Akker N, Molin D, Briedé J, et al. Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia. PLoS ONE. 2014;9:e86135 pubmed publisher
    ..In this study Arg1(fl/fl)/Tie2-Cre(tg/-) mice were developed to investigate the effect of arginase-1 related arginine depletion on ..
  57. Esser von Bieren J, Mosconi I, Guiet R, Piersgilli A, Volpe B, Chen F, et al. Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4R?-independent alternative differentiation of macrophages. PLoS Pathog. 2013;9:e1003771 pubmed publisher
    ..In summary, we present a novel IL-4R?-independent mechanism of alternative macrophage activation that is antibody-dependent and which both mediates anti-helminth immunity and prevents tissue disruption caused by migrating larvae. ..
  58. Español A, Eijan A, Mazzoni E, Davel L, Jasnis M, Sacerdote De Lustig E, et al. Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines. Int J Mol Med. 2002;9:651-7 pubmed
    ..Moreover, mAchR coupling to distinct effectors might be associated with differences in aggressiveness of tumor cells. ..
  59. Lavulo L, Sossong T, Brigham Burke M, Doyle M, Cox J, Christianson D, et al. Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid. J Biol Chem. 2001;276:14242-8 pubmed
    ..At the high protein concentrations utilized in the crystallizations, this variant exists as a trimer, but weakened salt link interactions are observed for Lys-308. ..
  60. Vannella K, Barron L, Borthwick L, Kindrachuk K, Narasimhan P, Hart K, et al. Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. PLoS Pathog. 2014;10:e1004372 pubmed publisher
    ..We show that in response to IL-4 and IL-13, Lyz2(lo)IL-4Rα(+) macrophages differentiate into an arginase 1-expressing alternatively-activated macrophage (AAM) population, which slows the development of lethal fibrosis ..
  61. Sager H, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, et al. Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015;132:1880-90 pubmed publisher
    ..The presented insight into post-MI bone marrow activation identifies a mechanistic target for muting inflammation in the ischemically damaged heart. ..
  62. Lechner A, Driver I, Lee J, Conroy C, Nagle A, Locksley R, et al. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017;21:120-134.e7 pubmed publisher
    ..Finally, we provide evidence that group 2 innate lymphoid cells are a source of IL-13, which promotes lung regeneration. Together, our data highlight the potential for immunomodulatory therapies to stimulate alveologenesis in adults. ..
  63. Knippenberg S, Brumshagen C, Aschenbrenner F, Welte T, Maus U. Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. Eur J Immunol. 2015;45:1716-26 pubmed publisher
    ..However, the underlying mechanisms are poorly defined. Arginase 1 (Arg1) has been suggested to play an important role in the pathophysiology of asthma, and is rapidly induced in ..
  64. Bak S, Alonso A, Turk M, Berwin B. Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression. Mol Immunol. 2008;46:258-68 pubmed publisher
    ..In accord with their MDSC phenotype, both murine and human VLCs express arginase-1 (ARG1)...
  65. Ckless K, van Der Vliet A, Janssen Heininger Y. Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism. Am J Respir Cell Mol Biol. 2007;36:645-53 pubmed
    ..Conversely, overexpression of arginase I decreased cellular S-nitrosothiol content and enhanced IkappaB kinase activity and NF-kappaB DNA binding, and ..
  66. Sheldon K, Shandilya H, Kepka Lenhart D, Poljakovic M, Ghosh A, Morris S. Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter. J Immunol. 2013;191:2290-8 pubmed publisher
    b>Arginase I is a marker of murine M2 macrophages and is highly expressed in many inflammatory diseases...
  67. Schreiber T, Ehlers S, Heitmann L, Rausch A, Mages J, Murray P, et al. Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity. J Immunol. 2009;183:1301-12 pubmed publisher
    ..Taken together, macrophage-derived IL-10 triggers aspects of alternative macrophage activation and promotes Mtb recrudescence independent of overt effects on anti-TB T cell immunity. ..
  68. Takashima S, Ikejima K, Arai K, Yokokawa J, Kon K, Yamashina S, et al. Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity. Am J Physiol Gastrointest Liver Physiol. 2016;311:G1105-G1113 pubmed publisher
    ..It is proposed that glycine is a promising immunonutrient for prevention and treatment of metabolic syndrome-related nonalcoholic steatohepatitis. ..
  69. Makarenkova V, Bansal V, Matta B, Perez L, Ochoa J. CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol. 2006;176:2085-94 pubmed
    ..markers invade the spleen after traumatic stress and suppress T cell function through the production of arginase 1. We created a consistent model of traumatic stress in C57BL/6 mice to perform this work...
  70. Albina J, Mahoney E, Daley J, Wesche D, Morris S, Reichner J. Macrophage arginase regulation by CCAAT/enhancer-binding protein beta. Shock. 2005;23:168-72 pubmed
    ..and hypoxia (1% O2) induced arginase activity in C/EBPbeta+/+ macrophages, where enzyme activity correlated with arginase I protein. Only rmIL-4 increased arginase activity in C/EBPbeta-/- cells...