Arf6

Summary

Gene Symbol: Arf6
Description: ADP-ribosylation factor 6
Alias: AI788669, AW496366, ADP-ribosylation factor 6
Species: mouse
Products:     Arf6

Top Publications

  1. Ikeda S, Ushio Fukai M, Zuo L, Tojo T, Dikalov S, Patrushev N, et al. Novel role of ARF6 in vascular endothelial growth factor-induced signaling and angiogenesis. Circ Res. 2005;96:467-75 pubmed
    ..The small GTPase ARF6 is involved in membrane trafficking and cell motility; however, its roles in VEGF signaling and physiological ..
  2. Hurtado Lorenzo A, Skinner M, El Annan J, Futai M, Sun Wada G, Bourgoin S, et al. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol. 2006;8:124-36 pubmed
    The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification...
  3. Akiyama M, Zhou M, Sugimoto R, Hongu T, Furuya M, Funakoshi Y, et al. Tissue- and development-dependent expression of the small GTPase Arf6 in mice. Dev Dyn. 2010;239:3416-35 pubmed publisher
    The small GTPase Arf6 is a member of the Arf (ADP-ribosylation factor) family. Although the function of Arf6 has been heavily studied at the cellular level, its physiological function at the whole animal level is largely unknown...
  4. Karim Z, Choi W, Whiteheart S. Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. J Biol Chem. 2008;283:11995-2003 pubmed publisher
    Previous studies showed that ADP-ribosylation factor 6 (Arf6) is important for platelet function; however, little is known about which signaling events regulate this small GTP-binding protein...
  5. Balasubramanian N, Scott D, Castle J, Casanova J, Schwartz M. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nat Cell Biol. 2007;9:1381-91 pubmed
    ..The small GTPase Arf6 and microtubules also regulate Rac-dependent cell spreading and migration, but the mechanisms are poorly understood...
  6. Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, et al. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol. 2006;26:6149-56 pubmed
    The mammalian small GTPase ADP-ribosylation factor 6 (ARF6) plays important roles in a wide variety of cellular events, including endocytosis, actin cytoskeletal reorganization, and phosphoinositide metabolism...
  7. Lee S, Wurtzel J, Goldfinger L. The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration. Biochem Biophys Res Commun. 2014;454:560-5 pubmed publisher
    ..sites for many proteins, and we have found that it interacts with ARNO, a guanine nucleotide exchange factor for Arf6, and that RLIP76 regulates activation of Rac1 via Arf6, and regulates cell spreading and migration in an ARNO and ..
  8. Mukhamedova N, Hoang A, Cui H, Carmichael I, Fu Y, Bukrinsky M, et al. Small GTPase ARF6 Regulates Endocytic Pathway Leading to Degradation of ATP-Binding Cassette Transporter A1. Arterioscler Thromb Vasc Biol. 2016;36:2292-2303 pubmed
    ..the principal pathway responsible for the internalization of ABCA1 leading to its degradation in macrophages is ARF6-dependent endocytic pathway...
  9. Lin J, Jeon J, Fan Q, Wong H, Palmer M, Holzman L. ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics. PLoS ONE. 2017;12:e0184575 pubmed publisher
    ADP-ribosylation factor 6 (ARF6) is a small GTPase necessary for regulating cellular structure, motility, and vesicle trafficking...

More Information

Publications77

  1. Yamaoka M, Ando T, Terabayashi T, Okamoto M, Takei M, Nishioka T, et al. PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. J Cell Sci. 2016;129:637-49 pubmed publisher
    ..that interacted with the Rab27a GTPase-activating protein (GAP) EPI64 (also known as TBC1D10A) and identified the Arf6 guanine-nucleotide-exchange factor (GEF) ARNO (also known as CYTH2) in pancreatic β-cells...
  2. Kon S, Tanabe K, Watanabe T, Sabe H, Satake M. Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. Exp Cell Res. 2008;314:1415-28 pubmed publisher
    ..the role of SMAP1, a clathrin-interacting GTPase-activating protein (GAP) for the ADP-ribosylation factor 6 (Arf6) GTPase, in E-cadherin endocytosis...
  3. Clarke M, Ewart M, Santy L, Prekeris R, Gould G. ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochem Biophys Res Commun. 2006;342:1361-7 pubmed
    ..We also demonstrate that Arf6 also plays a role in the secretion of ACRP30...
  4. Miyamoto Y, Torii T, Nakamura K, Takashima S, Sanbe A, Tanoue A, et al. Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells. Cell Signal. 2013;25:1379-87 pubmed publisher
    ..Here, we show that cytohesin-1, a guanine-nucleotide exchange factor (GEF), and the effector Arf6 are required for migration of primary Schwann cells...
  5. Anthonio E, Brees C, Baumgart Vogt E, Hongu T, Huybrechts S, Van Dijck P, et al. Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6. BMC Cell Biol. 2009;10:58 pubmed publisher
    ..In addition, we provide evidence that a portion of endogenous Arf6, the mammalian orthologue of yeast Arf3, is associated with the cytoplasmic face of rat liver peroxisomes...
  6. Torii T, Miyamoto Y, Nakamura K, Maeda M, Yamauchi J, Tanoue A. Arf6 guanine-nucleotide exchange factor, cytohesin-2, interacts with actinin-1 to regulate neurite extension. Cell Signal. 2012;24:1872-82 pubmed publisher
    ..However, their regulatory mechanisms remain to be fully understood. Here, we show that the Arf6 guanine-nucleotide exchange factor (GEF), cytohesin-2 (CYTH2), interacts with the cytoskeletal protein actinin-1 (..
  7. Bach A, Enjalbert S, Comunale F, Bodin S, Vitale N, Charrasse S, et al. ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways. Mol Biol Cell. 2010;21:2412-24 pubmed publisher
    ..Moreover, Loner/GEP(100)/BRAG2, a GEF of ARF6, has been involved in mammalian and Drosophila myoblast fusion, but the specific role of ARF6 has been not fully ..
  8. Miura Y, Hongu T, Yamauchi Y, Funakoshi Y, Katagiri N, Ohbayashi N, et al. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Biochem J. 2016;473:2591-602 pubmed publisher
    ..plays an important role in neurite outgrowth of mouse hippocampal neurons through its GAP activity specific to Arf6. In primary cultured mouse hippocampal neurons, knockdown of ACAP3 abrogated neurite outgrowth, which was rescued ..
  9. Pawar A, Meier J, Dasgupta A, Diwanji N, Deshpande N, Saxena K, et al. Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling. Cell Signal. 2016;28:1225-36 pubmed publisher
    ..This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells...
  10. Miura K, Nam J, Kojima C, Mochizuki N, Sabe H. EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Mol Biol Cell. 2009;20:1949-59 pubmed publisher
    ..Here, we found that Arf6 activity is down-regulated in Madin-Darby canine kidney cells, which is dependent on cell density and calcium ion ..
  11. Rothmeier A, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, et al. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arterioscler Thromb Vasc Biol. 2017;37:1323-1331 pubmed publisher
    ..TF cell surface availability for release onto microvesicles is regulated by the GTPase arf6 associated with integrin ?4?1...
  12. Huang Y, Joshi S, Xiang B, Kanaho Y, Li Z, Bouchard B, et al. Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking. Blood. 2016;127:1459-67 pubmed publisher
    ..Adenosine 5'-diphosphate-ribosylation factor 6 (Arf6) is a small guanosine triphosphate-binding protein that regulates endocytic trafficking, especially of integrins...
  13. Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, et al. IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses. Neurosci Res. 2008;60:199-212 pubmed publisher
    b>ADP ribosylation factor 6 (Arf6) is a small GTPase that regulates dendritic differentiation possibly through the organization of actin cytoskeleton and membrane traffic...
  14. Torii T, Miyamoto Y, Yamamoto M, Ohbuchi K, Tsumura H, Kawahara K, et al. Arf6 mediates Schwann cell differentiation and myelination. Biochem Biophys Res Commun. 2015;465:450-7 pubmed publisher
    ..Here, we show that Arf6, an Arf protein of the small GTPase family, is involved in promoting the myelination process...
  15. Hara Y, Fukaya M, Hayashi K, Kawauchi T, Nakajima K, Sakagami H. ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin. Eneuro. 2016;3: pubmed publisher
    ..b>ADP ribosylation factor 6 (Arf6) is a critical small GTPase that regulates membrane trafficking between the plasma membrane and ..
  16. Wurtzel J, Lee S, Singhal S, Awasthi S, Ginsberg M, Goldfinger L. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochem Biophys Res Commun. 2015;467:785-91 pubmed publisher
    ..enhances cell spreading and motility via RalBP1/RLIP76, an R-Ras effector that links GTP-R-Ras to activation of Arf6 and Rac1 GTPases...
  17. Sakurai A, Gavard J, Annas Linhares Y, Basile J, Amornphimoltham P, Palmby T, et al. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol. 2010;30:3086-98 pubmed publisher
    ..Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively...
  18. Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, et al. ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep. 2004;5:1171-5 pubmed
    ..We identified EFA6, an exchange factor for the small G protein ADP-ribosylation factor 6 (ARF6), as a protein binding to TWIK1. EFA6 interacts with TWIK1 only when it is bound to ARF6...
  19. Kang Y, Zhao X, Lovaas J, Eisenberg E, Greene L. Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway. J Cell Sci. 2009;122:4062-9 pubmed publisher
    ..The internalized PrP(c) was found to colocalize with cargo that traffic in the Arf6 pathway and in large vacuoles in cells expressing the Arf6 dominant-active mutant...
  20. Shteyn E, Pigati L, FOLSCH H. Arf6 regulates AP-1B-dependent sorting in polarized epithelial cells. J Cell Biol. 2011;194:873-87 pubmed publisher
    ..Here we identify the ADP-ribosylation factor 6 (Arf6) as an important regulator of AP-1B. We show that activated Arf6 pulled down AP-1B in vitro...
  21. Duan X, Zhang H, Pan M, Zhang Y, Sun S. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. Biochim Biophys Acta Mol Cell Res. 2018;1865:455-462 pubmed publisher
    b>Arf6 (ADP-ribosylation factor 6) is known to play important roles in membrane dynamics through the regulation of actin filament reorganization for multiple cellular processes such as cytokinesis, phagocytosis, cell migration and tumor ..
  22. Yamauchi J, Miyamoto Y, Torii T, Mizutani R, Nakamura K, Sanbe A, et al. Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells. Exp Cell Res. 2009;315:2043-52 pubmed publisher
    ..The outgrowth is specifically inhibited by siRNA knockdown of Arf6, but not by that of Arf1...
  23. Liu Y, Zhou D, Abumrad N, Su X. ADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes. Am J Physiol Cell Physiol. 2010;298:C921-8 pubmed publisher
    ADP-ribosylation factor 6 (Arf6) is a small GTPase that influences membrane receptor trafficking and the actin cytoskeleton...
  24. Matsuya S, Sakagami H, Tohgo A, Owada Y, Shin H, Takeshima H, et al. Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells. J Neurochem. 2005;93:674-85 pubmed
    ..is a third member of the EFA6 family of guanine nucleotide exchange factors (GEFs) for ADP-ribosylation factor 6 (ARF6)...
  25. Kim W, Kim S, Kim T, Kim M, Bae D, Choi H, et al. ADP-ribosylation factors 1 and 6 regulate Wnt/?-catenin signaling via control of LRP6 phosphorylation. Oncogene. 2013;32:3390-6 pubmed publisher
    ..Overall, our data suggest that transient activation of Arf modulates LRP6 phosphorylation for the transduction of Wnt/?-catenin signaling. ..
  26. Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, et al. The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling. J Biol Chem. 2014;289:1364-76 pubmed publisher
    ..The small GTPase ADP-ribosylation factor 6 (Arf6) was shown to regulate the plasma membrane association of Mal...
  27. Falace A, Filipello F, La Padula V, Vanni N, Madia F, De Pietri Tonelli D, et al. TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy. Am J Hum Genet. 2010;87:365-70 pubmed publisher
    ..By coimmunoprecipitation assay we found that TBC1D24 binds ARF6, a Ras-related family of small GTPases regulating exo-endocytosis dynamics...
  28. Scholz R, Berberich S, Rathgeber L, Kolleker A, Köhr G, Kornau H. AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression. Neuron. 2010;66:768-80 pubmed publisher
    ..protein BRAG2, which functions as a guanine-nucleotide exchange factor (GEF) for the coat-recruitment GTPase Arf6. BRAG2-mediated catalysis, controlled by ligand-binding and tyrosine phosphorylation of GluA2, activates Arf6 to ..
  29. Sakagami H, Hara Y, Fukaya M. Interaction of serologically defined colon cancer antigen-3 with Arf6 and its predominant expression in the mouse testis. Biochem Biophys Res Commun. 2016;477:868-873 pubmed publisher
    b>ADP ribosylation factor 6 (Arf6) is a small GTPase that regulates endosomal trafficking and actin cytoskeleton remodeling...
  30. Egami Y, Fujii M, Kawai K, Ishikawa Y, Fukuda M, Araki N. Activation-Inactivation Cycling of Rab35 and ARF6 Is Required for Phagocytosis of Zymosan in RAW264 Macrophages. J Immunol Res. 2015;2015:429439 pubmed publisher
    ..Rab35 or the expression of plasma membrane-targeted ACAP2 showed a marked inhibitory effect on phagocytosis through ARF6 inactivation by the GAP activity of ACAP2...
  31. Davies J, Bain S, Kanamarlapudi V. ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes. Biochem Pharmacol. 2014;90:406-13 pubmed publisher
    ..b>ARF6 small GTPase, which plays a vital role in cell surface receptors trafficking, has previously been shown to regulate ..
  32. Vidal Quadras M, Gelabert Baldrich M, Soriano Castell D, Lladó A, Rentero C, Calvo M, et al. Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis. Traffic. 2011;12:1879-96 pubmed publisher
    ..demonstrated that the tubules were plasma membrane invaginations resulting from an ADP-ribosylation factor 6 (ARF6)-dependent and clathrin-independent pathway...
  33. Suzuki A, Arikawa C, Kuwahara Y, Itoh K, Watanabe M, Watanabe H, et al. The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons. FEBS Lett. 2010;584:2801-6 pubmed publisher
    The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions...
  34. Fukaya M, Fukushima D, Hara Y, Sakagami H. EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth. J Neurochem. 2014;129:21-36 pubmed publisher
    The membrane trafficking and actin cytoskeleton remodeling mediated by ADP ribosylation factor 6 (Arf6) are functionally linked to various neuronal processes including neurite formation and maintenance, neurotransmitter release, and ..
  35. Hall B, McLean M, Davis K, Casanova J, Sligar S, Schwartz M. A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem. 2008;374:243-9 pubmed
    The involvement of the small GTPase Arf6 in Rac activation, cell migration, and cancer invasiveness suggests that it is activated in a spatially and temporally regulated manner...
  36. Ikenouchi J, Umeda M. FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A. 2010;107:748-53 pubmed publisher
    ..In the present study, we found that activation of Arf6 is spatiotemporally regulated as a downstream signaling pathway of the Par protein complex...
  37. Wu J, Kuo C. Pivotal role of ADP-ribosylation factor 6 in Toll-like receptor 9-mediated immune signaling. J Biol Chem. 2012;287:4323-34 pubmed publisher
    ..ADP-ribosylation factor 6 (ARF6) is a member of the Ras superfamily, which is critical to a wide variety of cellular events including endocytosis...
  38. Tamaki H, Sanda M, Katsumata O, Hara Y, Fukaya M, Sakagami H. Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure. FEBS Lett. 2012;586:3064-70 pubmed publisher
    ..In this study, we identified Pilt as an Arf6-binding protein by yeast two-hybrid screening...
  39. Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M. BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal. Invest Ophthalmol Vis Sci. 2017;58:3795-3803 pubmed publisher
    ..Arf-GEF 2 (BRAG2), also known as IQSEC1, is a guanine nucleotide exchange factor for ADP-ribosylation factor 6 (Arf6), a critical GTPase that regulates endosomal trafficking and actin cytoskeleton remodeling...
  40. Arvanitis D, Behar A, Tryoen Toth P, Bush J, Jungas T, Vitale N, et al. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013;140:2082-92 pubmed publisher
    ..cell-ECM adhesion by promoting apical localization of integrin ?1 and we identify ADP-ribosylation factor 6 (Arf6) as an important effector of ephrin B1 reverse signaling in apical adhesion of APs...
  41. Repella T, Ho M, Chong T, Bannai Y, Wilson B. Arf6-dependent intracellular trafficking of Pasteurella multocida toxin and pH-dependent translocation from late endosomes. Toxins (Basel). 2011;3:218-41 pubmed publisher
    ..Our studies implicate the small regulatory GTPase Arf6 in the endocytic trafficking of PMT...
  42. Martinu L, Masuda Robens J, Robertson S, Santy L, Casanova J, Chou M. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Mol Cell Biol. 2004;24:9752-62 pubmed
    ..we show that TRE17 (also called Tre-2 and USP6), a founding member of the TBC family, targets the Arf family GTPase Arf6, which regulates plasma membrane-endosome trafficking...
  43. Svensson H, West M, Mollahan P, Prescott A, Zaru R, Watts C. A role for ARF6 in dendritic cell podosome formation and migration. Eur J Immunol. 2008;38:818-28 pubmed publisher
    ADP-ribosylation factor 6 (ARF6) is a widely expressed GTPase that influences both membrane traffic and actin cytoskeleton function. Its role in dendritic cells (DC) has not previously been investigated...
  44. Marquer C, Tian H, Yi J, Bastien J, Dall Armi C, Yang Klingler Y, et al. Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun. 2016;7:11919 pubmed publisher
    Small GTPases play a critical role in membrane traffic. Among them, Arf6 mediates transport to and from the plasma membrane, as well as phosphoinositide signalling and cholesterol homeostasis...
  45. Krey J, Dumont R, Wilmarth P, David L, Johnson K, Barr Gillespie P. ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci. 2018;38:843-857 pubmed publisher
    ..ELMO domain-containing protein 1 (ELMOD1), a guanine nucleoside triphosphatase activating protein (GAP) for ARF6, as the most highly enriched ARF regulator in hair cells...
  46. Schurmann A, Breiner M, Becker W, Huppertz C, Kainulainen H, Kentrup H, et al. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994;269:15683-8 pubmed
    ..It is suggested that the function of ARL 4 is related to the adipocyte-like phenotype of 3T3-L1 cells. ..
  47. Mohanan V, Nakata T, Desch A, Lévesque C, Boroughs A, Guzman G, et al. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018;359:1161-1166 pubmed publisher
    ..by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. By limiting cytohesin-1-dependent ARF6 activation, C1orf106 stabilizes adherens junctions...
  48. Makyio H, Ohgi M, Takei T, Takahashi S, Takatsu H, Katoh Y, et al. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. EMBO J. 2012;31:2590-603 pubmed publisher
    A small GTPase, Arf6, is involved in cytokinesis by localizing to the Flemming body (the midbody). However, it remains unknown how Arf6 contributes to cytokinesis...
  49. Niedergang F, Colucci Guyon E, Dubois T, Raposo G, Chavrier P. ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J Cell Biol. 2003;161:1143-50 pubmed
    ..Here, we report that endogenous ADP ribosylation factor 6 (ARF6), a small GTP-binding protein, undergoes a sharp and transient activation in macrophages when ..
  50. Davis C, Zhu W, Gibson C, Bowman Kirigin J, Sorensen L, Ling J, et al. ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock. J Immunol. 2014;192:6045-52 pubmed publisher
    ..The small GTPase ARF6 is activated by a MyD88-ARNO interaction to induce vascular leak through disruption of endothelial adherens ..
  51. Moreau K, Ravikumar B, Puri C, Rubinsztein D. Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D. J Cell Biol. 2012;196:483-96 pubmed publisher
    ..In this paper, we identify a positive role for the small G protein Arf6 in autophagosome formation...
  52. Sakagami H, Suzuki H, Kamata A, Owada Y, Fukunaga K, Mayanagi H, et al. Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain. Brain Res. 2006;1093:1-11 pubmed
    The EFA6 family is a member of guanine nucleotide exchange factors (GEFs) that can activate ARF6 specifically in vitro...
  53. Heckel T, Czupalla C, Expirto Santo A, Anitei M, Arantzazu Sanchez Fernandez M, Mosch K, et al. Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts. Proc Natl Acad Sci U S A. 2009;106:1451-6 pubmed publisher
    ..protein GIT2, which localizes to sealing zones upon Src phosphorylation, or a lack of GTP hydrolysis on ARF6 impairs sealing zone formation and polarized membrane traffic...
  54. Teixeira T, Cruz L, Mortara R, da Silva C. Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction. Parasit Vectors. 2015;8:493 pubmed publisher
    ..ARF-6 and Annexin A2 are involved in invasion of mammalian cells by T. cruzi amastigotes. ..
  55. Miyazaki H, Yamazaki M, Watanabe H, Maehama T, Yokozeki T, Kanaho Y. The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. FEBS Lett. 2005;579:6834-8 pubmed
    ..Here we investigated whether the small GTPase, ADP-ribosylation factor 6 (ARF6), which regulates actin dynamics and peripheral vesicular trafficking, is involved in the regulation of spine ..
  56. Kagan J, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006;125:943-55 pubmed
    ..TIRAP then functions to facilitate MyD88 delivery to activated TLR4 to initiate signal transduction. These results establish that phosphoinositide-mediated adaptor recruitment initiates a specific signal-transduction pathway. ..
  57. Katsumata O, Honma T, Sanda M, Kamata A, Takeda S, Kondo H, et al. Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes. Brain Res. 2008;1234:44-9 pubmed publisher
    ..nucleotide exchange factor that is highly expressed in the nervous system with the ability to activate ADP ribosylation factor 6 (ARF6)...
  58. Borroni V, Barrantes F. Cholesterol modulates the rate and mechanism of acetylcholine receptor internalization. J Biol Chem. 2011;286:17122-32 pubmed publisher
    ..Under Chol(-) conditions, AChR internalization is furthermore found to require the activity of Arf6 and its effectors Rac1 and phospholipase D...
  59. Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem. 1996;120:813-9 pubmed
    ..These results suggest that although all the ARF proteins play fundamental and critical roles in cellular function, they are involved in different vesicular transport processes. ..
  60. Lawrence J, Birnbaum M. ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2003;100:13320-5 pubmed
    ADP-ribosylation factor 6 (ARF6) is a small GTP-binding protein that regulates peripheral vesicular trafficking and actin cytoskeletal dynamics, and it has been implicated as critical to regulated secretion...
  61. Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, et al. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A. 2011;108:E559-68 pubmed publisher
    ..we demonstrate that BACE1 is sorted to early endosomes via a route controlled by the small GTPase ADP ribosylation factor 6 (ARF6)...
  62. Schultz N, Ingels J, Hillhouse A, Wardwell K, Chang P, Cheverud J, et al. The Genetic Basis of Baculum Size and Shape Variation in Mice. G3 (Bethesda). 2016;6:1141-51 pubmed publisher
  63. Akiyama M, Hasegawa H, Hongu T, Frohman M, Harada A, Sakagami H, et al. Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth factor-2. Nat Commun. 2014;5:4744 pubmed publisher
    The small G protein ADP-ribosylation factor 6 (Arf6) plays important roles in a wide variety of membrane dynamics-based cellular events such as neurite outgrowth and spine formation in vitro...
  64. Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A. Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6. J Biol Chem. 2010;285:24270-81 pubmed publisher
    ..factor for the Arf family GTP-binding proteins, regulates migration of mouse preadipocyte 3T3-L1 cells through Arf6. SecinH3, a specific inhibitor of the cytohesin family, markedly inhibits migration of 3T3-L1 cells...
  65. Davies J, Tamaddon Jahromi S, Jannoo R, Kanamarlapudi V. Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2. Biochem Pharmacol. 2014;92:651-60 pubmed publisher
    ..ADP-ribosylation factor 6 (ARF6) small GTPase, which regulates membrane trafficking, is activated by GTP-exchange factors (GEFs) such as cytohesin ..
  66. Miura Y, Kanaho Y. ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex. Biochem Biophys Res Commun. 2017;493:1089-1094 pubmed publisher
    The GTPase-activating protein (GAP) specific to the small GTPase Arf6, ACAP3, is known to regulate morphogenesis of neurons in vitro. However, physiological significance of ACAP3 in the brain development in vivo remains unclear...
  67. Mitrea D, Grace C, Buljan M, Yun M, Pytel N, Satumba J, et al. Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc Natl Acad Sci U S A. 2014;111:4466-71 pubmed publisher
    ..We propose that the diverse functional repertoire associated with NPM1 is controlled through a regulated unfolding mechanism signaled through posttranslational modifications and intermolecular interactions...
  68. Tuvshintugs B, Sato T, Enkhtuya R, Yamashita K, Yoshioka K. JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis. Genes Cells. 2014;19:692-703 pubmed publisher
    The ADP-ribosylation factor 6 (ARF6) GTPase is important in cytokinesis and localizes to the midbody. However, the mechanism and regulation of ARF6's recruitment to the midbody are largely unknown...