Gene Symbol: Arf4
Description: ADP-ribosylation factor 4
Alias: AA407803, ADP-ribosylation factor 4
Species: mouse
Products:     Arf4

Top Publications

  1. Sadakata T, Shinoda Y, Sekine Y, Saruta C, Itakura M, Takahashi M, et al. Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. J Biol Chem. 2010;285:38710-9 pubmed publisher
    ..Biochemical analyses of the protein-protein interaction showed that CAPS1 interacted specifically with the class II ARF4/ARF5, but not with other classes of ARFs, via the pleckstrin homology domain in a GDP-bound ARF form-specific ..
  2. Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 2012;279:384-94 pubmed publisher
    ..somal CAPS2 is associated with the Golgi membrane, and mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (members of the membrane-trafficking small GTPase family) to the Golgi membrane...
  3. Jain S, Yoon S, Zhu L, Brodbeck J, Dai J, Walker D, et al. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS ONE. 2012;7:e46340 pubmed publisher
    ..We report a novel role for the small GTPase ADP ribosylation factor 4 (Arf4) in controlling pattern separation by regulating dendritic spine development...
  4. Wang J, Morita Y, Mazelova J, Deretic D. The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting. EMBO J. 2012;31:4057-71 pubmed publisher
    ..a scaffold that brings together the proteins necessary for transport to the cilia including the GTP-binding protein Arf4 and the two G proteins of the Rab family--Rab11 and Rab8--linked by the Rab8 guanine nucleotide exchange factor ..
  5. Ezratty E, Pasolli H, Fuchs E. A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. J Cell Biol. 2016;214:89-101 pubmed publisher
    ..components implicated in ciliary targeting and polarized exocytosis, we provide evidence that the small GTPase ARF4 is required for Presenilin basal body localization, Notch signaling, and subsequent epidermal differentiation...
  6. Schurmann A, Breiner M, Becker W, Huppertz C, Kainulainen H, Kentrup H, et al. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994;269:15683-8 pubmed
    ..It is suggested that the function of ARL 4 is related to the adipocyte-like phenotype of 3T3-L1 cells. ..
  7. Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem. 1996;120:813-9 pubmed
    ..These results suggest that although all the ARF proteins play fundamental and critical roles in cellular function, they are involved in different vesicular transport processes. ..
  8. Almind K, Kulkarni R, Lannon S, Kahn C. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes. 2003;52:1535-43 pubmed
  9. Follit J, San Agustin J, Jonassen J, Huang T, Rivera Perez J, Tremblay K, et al. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014;10:e1004170 pubmed publisher
    ..b>Arf4 has been proposed to sort cargo destined for the cilium at the Golgi complex and deemed a key regulator of ciliary ..

More Information


  1. Nakata K, Sugi Y, Narabayashi H, Kobayakawa T, Nakanishi Y, Tsuda M, et al. Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. J Biol Chem. 2017;292:15426-15433 pubmed publisher
    ..miR-21-5p increased intestinal epithelial permeability and up-regulated ADP ribosylation factor 4 (ARF4), a small GTPase, in the IEC line Caco-2...
  2. Pearring J, San Agustin J, Lobanova E, Gabriel C, Lieu E, Monis W, et al. Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. PLoS Genet. 2017;13:e1006740 pubmed publisher
    b>Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating ciliary trafficking, however, this has not been comprehensively tested in vivo...