Genomes and Genes
Gene Symbol: Arc
Description: activity regulated cytoskeletal-associated protein
Alias: Arc3.1, C86064, arg3.1, mArc, ARC/ARG3.1, activity-regulated cytoskeleton-associated protein, activity-regulated gene 3.1 protein homolog
- Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptorsJason D Shepherd
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 52:475-84. 2006..Here, we demonstrate that Arc/Arg3...
- Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generationJing Wu
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 147:615-28. 2011..Here, we report that the immediate early gene Arc is required for activity-dependent generation of Aβ...
- Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networksLavinia Alberi
Institute for Cell Engineering, Neuroregeneration Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 69:437-44. 2011..In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3...
- Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβHiroyuki Okuno
Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
Cell 149:886-98. 2012The Arc/Arg3.1 gene product is rapidly upregulated by strong synaptic activity and critically contributes to weakening synapses by promoting AMPA-R endocytosis...
- A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortexMing Gao
Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742, USA
J Neurosci 30:7168-78. 2010..neural activity rapidly upregulates mRNAs of immediate early genes involved in synaptic plasticity, one of which is Arc (activity-regulated cytoskeleton protein or Arg3.1). Cell biological studies indicate that Arc/Arg3...
- In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortexKuan Hong Wang
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 126:389-402. 2006..the mechanisms in mice, we replaced the coding part of the neural activity-regulated immediate early gene Arc with a GFP gene and repeatedly monitored visual experience-induced GFP expression in adult primary visual cortex by ..
- Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neuronsTakashi Kawashima
Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Proc Natl Acad Sci U S A 106:316-21. 2009The neuronal immediate early gene Arc/Arg-3.1 is widely used as one of the most reliable molecular markers for intense synaptic activity in vivo...
- Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 proteinVikas Kumar
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 287:5412-25. 2012..up-regulates genes involved in synaptic plasticity including activity-regulated cytoskeletal-associated protein (Arc/Arg3.1)...
- Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic miceJorge J Palop
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
J Neurosci 25:9686-93. 2005Activity-induced expression of Arc is necessary for maintenance of long-term potentiation and for memory consolidation...
- Independent effects of intra- and extracellular Abeta on learning-related gene expressionBettina M Wegenast-Braun
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tubingen, Germany
Am J Pathol 175:271-82. 2009..of different forms of Abeta on cognitive decline by analyzing the behavioral induction of the learning-related gene Arc/Arg3.1 in three different transgenic mouse models of cerebral amyloidosis (APPPS1, APPDutch, and APP23)...
- Learning-induced arg 3.1/arc mRNA expression in the mouse brainMonique Montag-Sallaz
Neurogenetics Research Group, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
Learn Mem 10:99-107. 2003The effector immediate-early gene (IEG) arg 3.1, also called arc, encodes a protein interacting with the neuronal cytoskeleton. The selective localization of arg 3.1/arc mRNA in activated dendritic segments suggests that the arg 3...
- Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memoriesNiels Plath
Molecular Neurobiology, Department of Biology Chemistry Pharmacy, Freie Universitat Berlin, 14195 Berlin, Germany
Neuron 52:437-44. 2006b>Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3...
- Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteinsEsperanza Fernandez
Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Cambridge, UK
Mol Syst Biol 5:269. 2009..This targeted TAP tagging strategy is generally applicable to mammalian proteomics and systems biology approaches to disease...
- Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1Fuwang Peng
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
J Biol Chem 285:21615-24. 2010..In the present study we demonstrated that in the rat hippocampal neurons PDGF regulated the expression of Arc/Arg3.1 gene that has been implicated in both synapse plasticity and long term potentiation...
- Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrusGiuseppe Gangarossa
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e19415. 2011..SKF 81297 was also able to enhance the levels of Zif268 and Arc/Arg3.1, two immediate early genes involved in transcriptional regulation and synaptic plasticity...
- The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factorsLin Li
Ward 7 110, Department of Pathology, W127, Northwestern University, 393 E Chicago Ave, Chicago, IL 60611, USA
Mol Cell Biol 25:10286-300. 2005..we show that Egr1 and Egr3 directly regulate the plasticity-associated activity-regulated cytoskeletal-related (Arc) gene, a synaptic activity-induced effector molecule which is also required for L-LTP and hippocampus-dependent ..
- Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDSungjin Park
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
Neuron 59:70-83. 2008..Here, we demonstrate that Arc/Arg3...
- Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activationR Waltereit
Institut fuer Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, 20246 Hamburg, Germany
J Neurosci 21:5484-93. 2001..More recently, arg3.1/arc became of interest, because after synaptic stimulation, arg3...
- Off-line Arc transcription in active ensembles during fear memory retrievalYoshiko Yamasaki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Eur J Neurosci 36:3451-7. 2012..b>Arc/Arg3.1 (Arc) expression is regulated by neural activity and is a critical protein for memory reconsolidation...
- Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populationsCasey J Guenthner
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Neuron 78:773-84. 2013..recombinase CreER(T2) is expressed in an activity-dependent manner from the loci of the immediate early genes Arc and Fos...
- Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticityErica Korb
Gladstone Institutes of Neurological Disease, San Francisco, California, USA
Nat Neurosci 16:874-83. 2013The activity-regulated cytoskeletal protein Arc (also known as Arg3.1) is required for long-term memory formation and synaptic plasticity...
- Impairment of TrkB-PSD-95 signaling in Angelman syndromeCong Cao
Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America
PLoS Biol 11:e1001478. 2013..of proteins implicated in synaptic plasticity, such as the activity-regulated cytoskeletal-associated protein (Arc/Arg3.1)...
- Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's diseaseNikita Rudinskiy
Alzheimer s Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Nat Neurosci 15:1422-9. 2012Experience-induced expression of immediate-early gene Arc (also known as Arg3.1) is known to be important for consolidation of memory...
- Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse hippocampusLan Xie
Research Group Structural Plasticity, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany
J Neurochem 125:457-64. 2013..day 14-16 was applied as ELS and two immediate early genes underlying experience-induced synaptic plasticity, Arc and early growth response 1 (Egr1) were analyzed...
- Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesisD Liu
Friedrich Miescher Institute, P O Box 2543, 4002, Basel, Switzerland
Mech Dev 92:207-15. 2000Activity-regulated, cytoskeleton-associated protein (Arc) was first identified as an immediate-early gene regulated by synaptic activity. We have studied its functional role in vivo using a gene-targeting approach...
- Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tailBernhard Maier
Department of Neuroscience Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, Virginia 22903, USA
Biol Reprod 68:67-76. 2003In neurons, arc (activity regulated, cytoskeleton associated) is an immediate early gene (IEG) that is rapidly and transiently induced by excitatory stimulation...
- Preferential Arc transcription at rest in the active ensemble during associative learningKoichi Hashikawa
Laboratory of Chemical Pharmacology Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
Neurobiol Learn Mem 95:498-504. 2011..activity during rest triggers transcription of immediate early genes such as activity regulated cytoskeletal gene (Arc)...
- Arc/Arg3.1 mRNA expression reveals a subcellular trace of prior sound exposure in adult primary auditory cortexT N Ivanova
Department of Biology, Emory University, Atlanta, GA 30322, USA
Neuroscience 181:117-26. 2011..early gene (IEG) with documented roles in synaptic plasticity and memory consolidation in the hippocampus: Arc/Arg3.1...
- The activity-regulated cytoskeleton-associated (Arc) gene is a new light-inducible early gene in the mouse suprachiasmatic nucleusM Nishimura
Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Neuroscience 116:1141-7. 2003..appears in suprachiasmatic nucleus clock cells, and here, we report the expression of a new immediate-early gene Arc (activity-regulated cytoskeleton-associated gene) in mice...
- Arc-dependent synapse-specific homeostatic plasticityJean Claude Beique
The Solomon Snyder Department of Neuroscience, Johns Hopkins University, USA
Proc Natl Acad Sci U S A 108:816-21. 2011..synapse-specific homeostatic plasticity, similar to global synaptic plasticity, requires the immediate early gene Arc. Together, our results document an extra level of regulation of synaptic function that bears important ..
- Arc regulates spine morphology and maintains network stability in vivoCarol L Peebles
Gladstone Institute of Neurological Disease and the Keck Program in Striatal Physiology, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:18173-8. 2010..This plasticity involves trafficking of AMPA receptors (AMPAR) and alteration of spine morphology. Arc, a gene induced by synaptic activity, mediates the endocytosis of AMPA receptors and is required for both long-term ..
- α7 nicotinic receptor agonism mitigates phencyclidine-induced changes in synaptophysin and Arc gene expression in the mouse prefrontal cortexMorten S Thomsen
Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
Neurochem Int 57:756-61. 2010..This effect is accompanied by a normalization of the PCP-induced increase in Arc mRNA expression in the same regions...
- Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic miceJong Ok Pyo
Creative Research Initiative Acceleration Research, Seoul National University, Shillim Dong, Seoul 151 747, Korea
J Biol Chem 283:30707-14. 2008..To examine the function of apoptosis repressor with a caspase recruitment domain (ARC) in the ischemic/hypoxic damage of cardiomyocytes, we generated cardio-specific ARC transgenic mice using a mouse ..
- Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated proteinR Molteni
Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
J Psychopharmacol 24:595-603. 2010..neurotrophic factor (BDNF) and the immediate-early gene activity-regulated cytoskeletal-associated protein (Arc), two closely related molecules that can contribute to neuroplastic and morphological changes observed in ..
- Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expressionMichele P Kelly
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Learn Mem 15:75-83. 2008..and if these memory deficits are associated with PKA-dependent alterations in neuronal activity as mapped by Arc mRNA expression...
- Genetic and physical maps of the stargazer locus on mouse chromosome 15V A Letts
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genomics 43:62-8. 1997..A physical contig of YACs, BACs, and P1s stretching 1.1 Mb from D15Mit30 to the somatostatin receptor 3 gene is reported, and the DNA interval including the stargazer locus has been narrowed to 150 kb...
- Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic conditionNoboru Otsuka
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
Brain Res 1287:136-45. 2009..Two genes, Activity-regulated cytoskeleton-associated protein (Arc) and CUG-binding protein-2 (Cugbp2), showed remarkable and persistent increases in their expression levels in ..
- The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arcPaul L Greer
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Cell 140:704-16. 2010..Ube3A transcription and that Ube3A then regulates excitatory synapse development by controlling the degradation of Arc, a synaptic protein that promotes the internalization of the AMPA subtype of glutamate receptors...
- Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivationCortina L McCurry
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Nat Neurosci 13:450-7. 2010..We found that visual cortex lacking Arc is impervious to the effects of deprivation or experience...
- Altered processing of novel information in N-CAM-deficient miceM Montag-Sallaz
Department of Neurobiology, Swiss Federal Institute of Technology ETH, Hoenggerberg, CH 8093 Zurich, Switzerland
Neuroreport 14:1343-6. 2003..1/arc in N-CAM-deficient mice after presentation of saccharin as novel or familiar and water as neutral gustatory ..
- Rapid induction of Arc is observed in the granule cell dendrites in the accessory olfactory bulb after matingMasato Matsuoka
Division of Neurobiology and Anatomy, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 1 757 Asahimachidori, Niigata 951 8510, Japan
Brain Res 975:189-95. 2003The activity-regulated cytoskeleton-associated protein (Arc), encoded by the immediate early gene arc, is enriched in the brain and is hypothesized to play a role in the activity-dependent neuronal plasticity in the hippocampus...
- Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1Natalia Elizalde
Department of Pharmacology, University of Navarra, Pamplona, Spain
J Neurochem 114:1302-14. 2010..plasticity markers (VGLUT1, synapsin 1, sinaptophysin, rab3A and activity regulated cytoskeletal protein - Arc) but a long-lasting decrease of the brain derived neurotrophic factor as well as depressive-like behaviour...
- Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalinMehdi Hossaini
Dept, of Neuroscience, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Mol Pain 6:43. 2010..The immediate early gene Arc/Arg3...
- SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cellsConstance Smith-Hicks
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 13:1082-9. 2010..the late phase of LTD in mouse cultured cerebellar Purkinje cells, as did deletion of the immediate early gene Arc. Using neuronal bacterial artificial chromosome (BAC) transfection, we found that, in Arc-/- cells transfected with ..
- Persistent neural activity regulates Arc/Arg3.1 transcription in the dentate gyrusTakeshi Toyoda
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan
J Neurosci Res 88:3060-6. 2010The activity-regulated cytoskeleton-associated gene (Arc, also known as Arg3.1) is an effector immediate-early gene rapidly induced by strong neural activity...
- Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neuronsP J Clark
Department of Psychology, The Beckman Institute, 405 N Mathews Avenue, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Neuroscience 184:16-27. 2011..The purpose of this study was three-fold: (1) to determine if Arc and Zif268 expression are also induced from wheel running in both pre-existing and newly formed neurons (2) to ..