Gene Symbol: Arap1
Description: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Alias: 2410002L19Rik, Centd2, mKIAA0782, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, arap1, centaurin, delta 2, cnt-d2
Hasegawa J, Tsujita K, Takenawa T, Itoh T. ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Mol Biol Cell. 2012;23:2481-9 pubmed publisher
..b>ARAP1 (Arf GAP with Rho GAP domain, ankyrin repeat, and PH domain 1) is an Arf GAP molecule with multiple PH domains ..
Guo D, Chenier I, Tardif V, Orlov S, Inagami T. Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Biochem Biophys Res Commun. 2003;310:1254-65 pubmed
..In the present study, we report the isolation of a novel protein, ARAP1, which promotes recycling of AT(1A) to the plasma membrane in HEK-293 cells...
Miyata M, Rikitake Y, Takahashi M, Nagamatsu Y, Yamauchi Y, Ogita H, et al
. Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells. J Biol Chem. 2009;284:24595-609 pubmed publisher
..of the formation of leading edge structures and RhoA inactivation was diminished by additional knockdown of ARAP1, a Rap-activated Rho GAP, which localized at the leading edges of moving NIH3T3 cells...
Kulzer J, Stitzel M, Morken M, Huyghe J, Fuchsberger C, Kuusisto J, et al
. A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. Am J Hum Genet. 2014;94:186-97 pubmed publisher
..for rs11603334 showed that the T2D-risk and proinsulin-decreasing allele (C) is associated with increased ARAP1 expression (p < 0.02)...
Kirov J, Adkisson M, Nava A, Cipollone A, Willis B, Engelhard E, et al
. Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation. PLoS ONE. 2015;10:e0134155 pubmed publisher
..The results support the conclusion that there is promoter silencing in a subset of mutants carrying the tm1a allele. The features of targeted genes which promote local silencing when targeted remain unknown. ..
Moshiri A, Humpal D, Leonard B, Imai D, Tham A, Bower L, et al
. Arap1 Deficiency Causes Photoreceptor Degeneration in Mice. Invest Ophthalmol Vis Sci. 2017;58:1709-1718 pubmed publisher
..b>Arap1 is an Arf-directed GAP that inhibits the trafficking of epidermal growth factor receptor (EGFR) to the early ..
Gambardella L, Hemberger M, Hughes B, Zudaire E, Andrews S, Vermeren S. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Sci Signal. 2010;3:ra76 pubmed publisher
..Our work delineates a previously unknown signaling pathway that controls angiogenesis immediately downstream of PI3K? through ARAP3 to the Rho and Arf family of small GTPases. ..
Doblinger E, Hocherl K, Mederle K, Kattler V, Walter S, Hansen P, et al
. Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II. Am J Physiol Renal Physiol. 2012;302:F1313-24 pubmed publisher
b>Arap1 is a protein that interacts with angiotensin II type 1 (AT(1)) receptors and facilitates increased AT(1) receptor surface expression in vitro...
Carrat G, Hu M, Nguyen Tu M, Chabosseau P, Gaulton K, van de Bunt M, et al
. Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. Am J Hum Genet. 2017;100:238-256 pubmed publisher
Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk...