Gene Symbol: Aqp7
Description: aquaporin 7
Alias: AQP7L, AQPap, aquaporin-7, AQP-7, aquaglyceroporin-7
Species: mouse
Products:     Aqp7

Top Publications

  1. Verkman A. Role of aquaporin water channels in kidney and lung. Am J Med Sci. 1998;316:310-20 pubmed
    ..The transgenic mouse and mammalian cell models are thus beginning to provide clues about the role of aquaporins in normal physiology and disease. ..
  2. West Farrell E, Xu M, Gomberg M, Chow Y, Woodruff T, Shea L. The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles. Biol Reprod. 2009;80:432-9 pubmed publisher
    ..The expression levels of genes (Star, Cyp11a1, Cyp17a1, Hsd3b1, Cyp19a1, Fshr, Lhcgr, Aqp7, Aqp8, Aqp9, and Hif1a) were measured and correlated to follicle developmental status...
  3. Sohara E, Rai T, Miyazaki J, Verkman A, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005;289:F1195-200 pubmed
    The aquaporin-7 (AQP7) water channel is known as a member of the aquaglyceroporins, which facilitate the transport of glycerol as well as water...
  4. Verkman A. Lessons on renal physiology from transgenic mice lacking aquaporin water channels. J Am Soc Nephrol. 1999;10:1126-35 pubmed
    ..descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule...
  5. Shen F, Gu X, Pan W, Li W, Li W, Ye J, et al. Over-expression of AQP7 contributes to improve insulin resistance in adipocytes. Exp Cell Res. 2012;318:2377-84 pubmed publisher
    b>Aquaglyceroporin 7 (AQP7) is required for efflux of glycerol from adipocytes...
  6. Sohara E, Ueda O, Tachibe T, Hani T, Jishage K, Rai T, et al. Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice. Fertil Steril. 2007;87:671-6 pubmed
    To investigate the functional and morphologic role of Aquaporin 7 (AQP7) in testis and sperm. Experimental laboratory study. University and research institute units. AQP7 knockout mice (C57BL/6J background). None...
  7. Yeung C, Callies C, Rojek A, Nielsen S, Cooper T. Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa. Biol Reprod. 2009;80:350-7 pubmed publisher
    ..b>Aqp7, Aqp8, and Aqp9 mRNAs were identified in spermatozoa by RT-PCR, and the entire open reading frames were sequenced ..
  8. Knoers N, Deen P. Aquaporin molecular biology and clinical abnormalities of the water transport channels. Curr Opin Pediatr. 1998;10:428-34 pubmed
    ..The finding of changed AQP2 expression in several acquired water balance disorders may pave the way toward developing treatments for these clinical problems. ..
  9. Miyauchi T, Yamamoto H, Abe Y, Yoshida G, Rojek A, Sohara E, et al. Dynamic subcellular localization of aquaporin-7 in white adipocytes. FEBS Lett. 2015;589:608-14 pubmed publisher
    Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy...

More Information


  1. Kuriyama H, Shimomura I, Kishida K, Kondo H, Furuyama N, Nishizawa H, et al. Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes. 2002;51:2915-21 pubmed
    Plasma glycerol is a major substrate for hepatic gluconeogenesis. Aquaporin adipose (AQPap/7), an adipose-specific glycerol channel, provides fat-derived glycerol into plasma...
  2. Matsumura K, Chang B, Fujimiya M, Chen W, Kulkarni R, Eguchi Y, et al. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007;27:6026-37 pubmed
    ..cells, we studied the expression of the glycerol channels, or aquaglyceroporins, encoded by the aquaporin 3 (Aqp3), Aqp7, and Aqp9 genes in mouse islets...
  3. Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, et al. Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci U S A. 2005;102:10993-8 pubmed
    In adipocytes, hydrolysis of triglycerides results in the release of free fatty acids and glycerol. Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and water...
  4. Hibuse T, Maeda N, Nakatsuji H, Tochino Y, Fujita K, Kihara S, et al. The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator. Cardiovasc Res. 2009;83:34-41 pubmed publisher
    ..Several reports showed that a moderate expression of aquaporin 7 (AQP7), a member of the aquaglyceroporin family that is permeated by glycerol and water, is observed in heart ..
  5. Peng H, Zhang Y, Lei L, Chen Q, Yue J, Tan Y, et al. Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization. Fertil Steril. 2011;95:1514-7.e1-3 pubmed publisher
    The aquaglyceroporin aquaporin 7 (AQP7) is dynamically expressed in mouse uteri undergoing decidualization after implantation...
  6. Liu Z, Shen J, Carbrey J, Mukhopadhyay R, Agre P, Rosen B. Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A. 2002;99:6053-8 pubmed
    ..encodes a membrane protein homologous to the bacterial aquaglyceroporin GlpF and to mammalian aquaglyceroporins AQP7 and AQP9. Fps1p mediates glycerol uptake and glycerol efflux in response to hypoosmotic shock...
  7. Kishida K, Shimomura I, Kondo H, Kuriyama H, Makino Y, Nishizawa H, et al. Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel. J Biol Chem. 2001;276:36251-60 pubmed
    Aquaporin adipose (AQPap) is a putative glycerol channel in adipocytes (Kishida, K., Kuriyama, H., Funahashi, T., Shimomura, I., Kihara, S., Ouchi, N., Nishida, M., Nishizawa, H., Matsuda, M., Takahashi, M., Hotta, K., Nakamura, T...
  8. Parreira K, Debaix H, Cnops Y, Geffers L, Devuyst O. Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pflugers Arch. 2009;458:745-59 pubmed publisher
  9. Verkman A. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 2005;118:3225-32 pubmed
    ..The many roles of AQPs could be exploited for clinical benefit; for example, treatments that modulate AQP expression/function could be used as diuretics, and in the treatment of brain swelling, glaucoma, epilepsy, obesity and cancer. ..
  10. Shin I, Kim H, Lee J, Gye M. Aquaporin7 expression during perinatal development of mouse brain. Neurosci Lett. 2006;409:106-11 pubmed
    ..However, the expression of AQP7, an aquaglyceroporin associated with brain development, has not been shown...
  11. Walker C, Holness M, Gibbons G, Sugden M. Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency. Int J Obes (Lond). 2007;31:1165-71 pubmed
    ..receptor alpha deficiency on gene expression of adipose triglyceride lipase and the glycerol transporter aquaglyceroporin 7 in white adipose tissue in the fed and fasted states in relation to glycerol release by isolated adipocytes...
  12. Yaba A, Sozen B, Suzen B, Demir N. Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle. Morphologie. 2017;101:39-46 pubmed publisher
  13. Tan Y, Zhang X, Ding G, Li R, Wang L, Jin L, et al. Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation. Sci Rep. 2015;5:17741 pubmed publisher
    ..Knockdown of AQP7 expression by siRNA-injection significantly reduced the survival of oocytes after vitrification...
  14. Hashemolhosseini S, Hadjihannas M, Stolt C, Haas C, Amann K, Wegner M. Restricted expression of mouse GCMa/Gcm1 in kidney and thymus. Mech Dev. 2002;118:175-8 pubmed
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development. ..
  15. Louchami K, Best L, Brown P, Virreira M, Hupkens E, Perret J, et al. A new role for aquaporin 7 in insulin secretion. Cell Physiol Biochem. 2012;29:65-74 pubmed publisher
    ..The possible participation of AQP7 to water transport was investigated in AQP7(+/+) or AQP7(-/-) mice...
  16. Offenberg H, Barcroft L, Caveney A, Viuff D, Thomsen P, Watson A. mRNAs encoding aquaporins are present during murine preimplantation development. Mol Reprod Dev. 2000;57:323-30 pubmed
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation. ..
  17. Kong C, Kim J, Bak S, Byun H, Kim S. Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes. J Nutr Biochem. 2011;22:276-81 pubmed publisher
    ..These results suggest that CM-chitin exerts anti-adipogenic effect on lipid accumulation through modulations of AMPK and aquaporin-7 signal pathways. ..
  18. Hara Chikuma M, Sugiyama Y, Kabashima K, Sohara E, Uchida S, Sasaki S, et al. Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells. FASEB J. 2012;26:211-8 pubmed publisher
    ..Here we show that the water/glycerol channel protein aquaporin 7 (AQP7) is expressed on epidermal and dermal DCs and involved in the initiation of primary immune responses...
  19. Hara Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, et al. Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem. 2005;280:15493-6 pubmed
    Aquaporin-7 (AQP7) is a water/glycerol transporting protein expressed in adipocyte plasma membranes. We report here remarkable age-dependent hypertrophy in adipocytes in AQP7-deficient mice...
  20. Tanahashi H, Tian Q, Hara Y, Sakagami H, Endo S, Suzuki T. Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci Rep. 2016;6:20241 pubmed publisher
    ..Our findings indicate that amniotic fluid removal plays an essential role in regulating the amniotic fluid volume. ..
  21. Huang D, Chen P, Chen S, Nagura M, Lim D, Lin X. Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea. Hear Res. 2002;165:85-95 pubmed
    ..We report here that AQP3, AQP7 and AQP9 were expressed in the inner ear...
  22. Ishibashi K, Yamauchi K, Kageyama Y, Saito Ohara F, Ikeuchi T, Marumo F, et al. Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. Biochim Biophys Acta. 1998;1399:62-6 pubmed
    ..The human AQP7 gene is identical with human adipose AQP (AQPap or AQP7L)...
  23. Skowronski M, Lebeck J, Rojek A, Praetorius J, Füchtbauer E, Frøkiaer J, et al. AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Renal Physiol. 2007;292:F956-65 pubmed
    Aquaporin (AQP7) is expressed in proximal tubules and is involved in glycerol uptake. The cellular expression and physiological function in other organs remain largely undefined...
  24. Edashige K, Tanaka M, Ichimaru N, Ota S, Yazawa K, Higashino Y, et al. Channel-dependent permeation of water and glycerol in mouse morulae. Biol Reprod. 2006;74:625-32 pubmed
    ..In conclusion, water and glycerol appear to move across the plasma membrane mainly by simple diffusion in oocytes but by facilitated diffusion through water channel(s) including aquaporin 3 in morulae...
  25. Maeda N, Funahashi T, Hibuse T, Nagasawa A, Kishida K, Kuriyama H, et al. Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci U S A. 2004;101:17801-6 pubmed
    ..Here, we investigated glycerol and glucose metabolism in mice lacking aquaporin 7 (Aqp7), a member of the aquaglyceroporins expressed in adipose tissue, and demonstrated that Aqp7 functions as ..
  26. Tan Y, Xiong Y, Ding G, Zhang D, Meng Y, Huang H, et al. Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation. Fertil Steril. 2013;99:1428-35 pubmed publisher
    To investigate the effects of cryoprotectants on the expression of AQP7 in oocytes. Experimental animal study. University-based research laboratory. Adult female C57BL/6J mice...
  27. Edashige K, Sakamoto M, Kasai M. Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000;40:171-5 pubmed
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...