Aqp4

Summary

Gene Symbol: Aqp4
Description: aquaporin 4
Alias: WCH4, aquaporin-4, mercurial-insensitive water channel
Species: mouse
Products:     Aqp4

Top Publications

  1. Amiry Moghaddam M, Xue R, Haug F, Neely J, Bhardwaj A, Agre P, et al. Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J. 2004;18:542-4 pubmed
    ..lethal complication of acute hyponatremia, is delayed following knockout of the water channel aquaporin-4 (AQP4)...
  2. Ma T, Song Y, Yang B, Gillespie A, Carlson E, Epstein C, et al. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000;97:4386-91 pubmed
    ..AQP3 deletion had little effect on AQP1 or AQP4 protein expression but decreased AQP2 protein expression particularly in renal cortex...
  3. Ishida N, Hirai S, Mita S. Immunolocalization of aquaporin homologs in mouse lacrimal glands. Biochem Biophys Res Commun. 1997;238:891-5 pubmed
    ..By immunohistochemistry, aquaporin-4 (AQP4) and aquaporin-5 (AQP5) were found to be the lacrimal glands...
  4. Bai C, Fukuda N, Song Y, Ma T, Matthay M, Verkman A. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999;103:555-61 pubmed
    The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia...
  5. Lu D, Zhang H, Zador Z, Verkman A. Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB J. 2008;22:3216-23 pubmed publisher
    Aquaporin-4 (AQP4) is a water-selective transport protein expressed in glial cells throughout the central nervous system...
  6. Song Y, Fukuda N, Bai C, Ma T, Matthay M, Verkman A. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000;525 Pt 3:771-9 pubmed
    ..We used mice deficient in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung fluid ..
  7. Saadoun S, Tait M, Reza A, Davies D, Bell B, Verkman A, et al. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. 2009;161:764-72 pubmed publisher
    The glial cell water channel aquaporin-4 (AQP4) plays an important role in brain edema, astrocyte migration, and neuronal excitability. Zhou et al...
  8. Li J, Verkman A. Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem. 2001;276:31233-7 pubmed
    ..Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus cells) in the organ of Corti...
  9. Kong H, Fan Y, Xie J, Ding J, Sha L, Shi X, et al. AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells. J Cell Sci. 2008;121:4029-36 pubmed publisher
    Aquaporin-4 (AQP4), a key molecule for maintaining water and ion homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes...
  10. Hsu M, Seldin M, Lee D, Seifert G, Steinhauser C, Binder D. Laminar-specific and developmental expression of aquaporin-4 in the mouse hippocampus. Neuroscience. 2011;178:21-32 pubmed publisher
    Mice deficient in the water channel aquaporin-4 (AQP4) demonstrate increased seizure duration in response to hippocampal stimulation as well as impaired extracellular K+ clearance...

Detail Information

Publications74

  1. Amiry Moghaddam M, Xue R, Haug F, Neely J, Bhardwaj A, Agre P, et al. Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J. 2004;18:542-4 pubmed
    ..lethal complication of acute hyponatremia, is delayed following knockout of the water channel aquaporin-4 (AQP4)...
  2. Ma T, Song Y, Yang B, Gillespie A, Carlson E, Epstein C, et al. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000;97:4386-91 pubmed
    ..AQP3 deletion had little effect on AQP1 or AQP4 protein expression but decreased AQP2 protein expression particularly in renal cortex...
  3. Ishida N, Hirai S, Mita S. Immunolocalization of aquaporin homologs in mouse lacrimal glands. Biochem Biophys Res Commun. 1997;238:891-5 pubmed
    ..By immunohistochemistry, aquaporin-4 (AQP4) and aquaporin-5 (AQP5) were found to be the lacrimal glands...
  4. Bai C, Fukuda N, Song Y, Ma T, Matthay M, Verkman A. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999;103:555-61 pubmed
    The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia...
  5. Lu D, Zhang H, Zador Z, Verkman A. Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB J. 2008;22:3216-23 pubmed publisher
    Aquaporin-4 (AQP4) is a water-selective transport protein expressed in glial cells throughout the central nervous system...
  6. Song Y, Fukuda N, Bai C, Ma T, Matthay M, Verkman A. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000;525 Pt 3:771-9 pubmed
    ..We used mice deficient in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung fluid ..
  7. Saadoun S, Tait M, Reza A, Davies D, Bell B, Verkman A, et al. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience. 2009;161:764-72 pubmed publisher
    The glial cell water channel aquaporin-4 (AQP4) plays an important role in brain edema, astrocyte migration, and neuronal excitability. Zhou et al...
  8. Li J, Verkman A. Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem. 2001;276:31233-7 pubmed
    ..Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus cells) in the organ of Corti...
  9. Kong H, Fan Y, Xie J, Ding J, Sha L, Shi X, et al. AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells. J Cell Sci. 2008;121:4029-36 pubmed publisher
    Aquaporin-4 (AQP4), a key molecule for maintaining water and ion homeostasis in the central nervous system, is expressed in adult neural stem cells (ANSCs) as well as astrocytes...
  10. Hsu M, Seldin M, Lee D, Seifert G, Steinhauser C, Binder D. Laminar-specific and developmental expression of aquaporin-4 in the mouse hippocampus. Neuroscience. 2011;178:21-32 pubmed publisher
    Mice deficient in the water channel aquaporin-4 (AQP4) demonstrate increased seizure duration in response to hippocampal stimulation as well as impaired extracellular K+ clearance...
  11. Saadoun S, Papadopoulos M, Watanabe H, Yan D, Manley G, Verkman A. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005;118:5691-8 pubmed
    ..Our findings provide evidence for the involvement of aquaporin-4 in astroglial cell migration, which occurs during glial scar formation in brain injury, stroke, tumor and focal abscess. ..
  12. Crane J, Bennett J, Verkman A. Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells. J Biol Chem. 2009;284:35850-60 pubmed publisher
    Aquaporin-4 (AQP4) can assemble into supramolecular aggregates called orthogonal arrays of particles (OAPs)...
  13. Yang B, Verbavatz J, Song Y, Vetrivel L, Manley G, Kao W, et al. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000;278:C1108-15 pubmed
    It has been proposed that aquaporin-4 (AQP4), a water channel expressed at the plasmalemma of skeletal muscle cells, is important in normal muscle physiology and in the pathophysiology of Duchenne's muscular dystrophy...
  14. Strohschein S, Hüttmann K, Gabriel S, Binder D, Heinemann U, Steinhäuser C. Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus. Glia. 2011;59:973-80 pubmed publisher
    Aquaporin-4 (AQP4) is the main water channel in the brain and primarily localized to astrocytes where the channels are thought to contribute to water and K(+) homeostasis...
  15. Iliff J, Wang M, Liao Y, Plogg B, Peng W, Gundersen G, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid ?. Sci Transl Med. 2012;4:147ra111 pubmed publisher
    ..Animals lacking the water channel aquaporin-4 (AQP4) in astrocytes exhibit slowed CSF influx through this system and a ~70% reduction in interstitial solute clearance, ..
  16. Bao F, Chen M, Zhang Y, Zhao Z. Hypoalgesia in mice lacking aquaporin-4 water channels. Brain Res Bull. 2010;83:298-303 pubmed publisher
    ..Moreover, latencies to thermal stimuli were significantly prolonged in a subset of dorsal horn wide-dynamic-range neurons. Taken together, these results suggest that aquaporin-4 plays a role in the processing of nociception. ..
  17. Zhou J, Kong H, Hua X, Xiao M, Ding J, Hu G. Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice. Neuroreport. 2008;19:1-5 pubmed publisher
    To investigate the role of astroglial water channel aquaporin-4 (AQP4) in maintaining blood-brain barrier integrity, structure and permeability of the brain microvessels were investigated in adult AQP4 knockout mice...
  18. Li L, Zhang H, Varrin Doyer M, Zamvil S, Verkman A. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J. 2011;25:1556-66 pubmed publisher
    Aquaporin-4 (AQP4) deficiency in mice reduces neuroinflammation in experimental autoimmune encephalomyelitis (EAE) produced by active immunization with myelin oligodendrocyte glycoprotein peptide (MOG)...
  19. Saadoun S, Waters P, Leite M, Bennett J, Vincent A, Papadopoulos M. Neuromyelitis optica IgG causes placental inflammation and fetal death. J Immunol. 2013;191:2999-3005 pubmed publisher
    ..Our data suggest that NMO-IgG can cause miscarriage, thus challenging the concept that NMO affects only the CNS. These findings have implications for the management of NMO during pregnancy. ..
  20. Chen M, Bao F, Zhang Y, Zhao Z. Effects of aquaporin 4 deficiency on morphine analgesia and chronic tolerance: a study at spinal level. J Mol Neurosci. 2010;42:140-4 pubmed publisher
    Recent reports showed that aquaporin 4 (AQP4) deficiency potentiated morphine analgesia but attenuated chronic morphine-induced tolerance in hot-plate test, predominantly reflecting supraspinal pain response...
  21. Amiry Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle N, Nagelhus E, et al. Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proc Natl Acad Sci U S A. 2003;100:13615-20 pubmed
    ..The predominant water channel protein in brain, aquaporin-4 (AQP4), is concentrated in the astrocyte end-feet membranes adjacent to blood vessels in neocortex and cerebellum by ..
  22. Kalluri S, Rothhammer V, Staszewski O, Srivastava R, Petermann F, Prinz M, et al. Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica. PLoS ONE. 2011;6:e16083 pubmed publisher
    Antibodies to the water channel protein aquaporin-4 (AQP4), which is expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum of Neuromyelitis optica (NMO) patients and are believed to induce damage to ..
  23. Zhang H, Verkman A. Evidence against involvement of aquaporin-4 in cell-cell adhesion. J Mol Biol. 2008;382:1136-43 pubmed publisher
    Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, where they play a role in brain water balance, neuroexcitation, and glial cell migration...
  24. Ma T, Song Y, Gillespie A, Carlson E, Epstein C, Verkman A. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999;274:20071-4 pubmed
    ..Water channels AQP1 and AQP4 have also been localized to salivary gland; however, pilocarpine stimulation studies showed no defect in the volume ..
  25. Lee M, Ruby C, Hinton D, Choi S, Adams C, Young Kang N, et al. Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. Neuropsychopharmacology. 2013;38:437-45 pubmed publisher
    ..the expression of type 2 excitatory amino-acid transporter (EAAT2) and the astrocyte-specific water channel, aquaporin 4 (AQP4). EAAT2 and AQP4 colocalization was also reduced in the striatum of ENT1 null mice...
  26. Fan Y, Zhang J, Sun X, Gao L, Zeng X, Ding J, et al. Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice. J Neurosci Res. 2005;82:458-64 pubmed
    Aquaporin-4 (AQP4), a predominant water channel of the brain, mediates transmembrane water movement at the blood-brain barrier and brain-cerebrospinal fluid interface...
  27. Costa C, Tortosa R, Domènech A, Vidal E, Pumarola M, Bassols A. Mapping of aggrecan, hyaluronic acid, heparan sulphate proteoglycans and aquaporin 4 in the central nervous system of the mouse. J Chem Neuroanat. 2007;33:111-23 pubmed
    ..AQP are a family of membrane proteins which acts as a water channel and AQP4 is the most abundant isoform in the brain...
  28. Vajda Z, Pedersen M, Füchtbauer E, Wertz K, Stødkilde Jørgensen H, Sulyok E, et al. Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci U S A. 2002;99:13131-6 pubmed
    ..and immunoelectron microscopic analyses of dystrophin-null brains revealed a dramatic reduction of AQP4 (aquaporin-4) in astroglial end-feet surrounding capillaries (blood-brain barrier) and at the glia limitans (..
  29. Ma T, Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998;273:4296-9 pubmed
    ..The grossly normal phenotype in human subjects deficient in AQP1 (Colton null blood group) and in AQP4 knockout mice has suggested that aquaporins (other than the vasopressin-regulated water channel AQP2) may not be ..
  30. Song Y, Verkman A. Aquaporin-5 dependent fluid secretion in airway submucosal glands. J Biol Chem. 2001;276:41288-92 pubmed
    ..membrane of serous epithelial cells in submucosal glands throughout the mouse nasopharynx and upper airways and AQP4 at the contralateral basolateral membrane in some glands...
  31. Binder D, Papadopoulos M, Haggie P, Verkman A. In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci. 2004;24:8049-56 pubmed
    ..produced by brain edema and seizure activity, diffusion in the ECS was faster in mice lacking aquaporin-4 (AQP4), an astroglial water channel that facilitates fluid movement between cells and the ECS...
  32. Da T, Verkman A. Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Invest Ophthalmol Vis Sci. 2004;45:4477-83 pubmed
    ..is expressed in Muller cells in retina, which are similar to astroglial cells in the central nervous system, where AQP4 deletion protects against cytotoxic brain edema after cerebral ischemia...
  33. Vitellaro Zuccarello L, Mazzetti S, Bosisio P, Monti C, De Biasi S. Distribution of Aquaporin 4 in rodent spinal cord: relationship with astrocyte markers and chondroitin sulfate proteoglycans. Glia. 2005;51:148-59 pubmed
    ..b>Aquaporin 4 (AQP4) is the predominant water channel in brain and spinal cord, where it is present mainly on astrocytic ..
  34. Papadopoulos M, Manley G, Krishna S, Verkman A. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004;18:1291-3 pubmed
    Aquaporin-4 (AQP4) is the major water channel in the brain, expressed predominantly in astroglial cell membranes. Initial studies in AQP4-deficient mice showed reduced cellular brain edema following water intoxication and ischemic stroke...
  35. Thrane A, Rappold P, Fujita T, Torres A, Bekar L, Takano T, et al. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011;108:846-51 pubmed publisher
    Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation...
  36. Moore M, Ma T, Yang B, Verkman A. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000;70:557-62 pubmed
    ..water channels has been reported in the lacrimal gland: AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia...
  37. Rossi A, Moritz T, Ratelade J, Verkman A. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes. J Cell Sci. 2012;125:4405-12 pubmed publisher
    Aquaporin-4 (AQP4) is a water channel expressed in astrocytes, skeletal muscle and epithelial cells that forms supramolecular aggregates in plasma membranes called orthogonal arrays of particles (OAPs)...
  38. Zeng X, Sun X, Gao L, Fan Y, Ding J, Hu G. Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes. Mol Cell Neurosci. 2007;34:34-9 pubmed
    ..regulative role of aquporin-4 on glutamate transporter using primary cultured astrocytes from aquaporin-4 knockout (AQP4(-/-)) mice...
  39. Li Z, Gao L, Liu Q, Cao C, Sun X, Ding J, et al. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neurosci Lett. 2006;403:294-8 pubmed
    Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface...
  40. Haj Yasein N, Jensen V, Østby I, Omholt S, Voipio J, Kaila K, et al. Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus. Glia. 2012;60:867-74 pubmed publisher
    Little is known about the physiological roles of aquaporin-4 (AQP4) in the central nervous system...
  41. Silberstein C, Bouley R, Huang Y, Fang P, Pastor Soler N, Brown D, et al. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004;287:F501-11 pubmed
    Aquaporin-4 (AQP4) water channels exist as heterotetramers of M1 and M23 splice variants and appear to be present in orthogonal arrays of intramembraneous particles (OAPs) visualized by freeze-fracture microscopy...
  42. McCoy E, Haas B, Sontheimer H. Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion. Neuroscience. 2010;168:971-81 pubmed publisher
    ..Two members of this family, AQP1 and AQP4 are highly expressed in primary brain tumor biopsies and both have a consensus phosphorylation site for protein ..
  43. Skucas V, Mathews I, Yang J, Cheng Q, Treister A, Duffy A, et al. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci. 2011;31:6392-7 pubmed publisher
    Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in astrocytes...
  44. Chou C, Ma T, Yang B, Knepper M, Verkman A. Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Am J Physiol. 1998;274:C549-54 pubmed
    Aquaporin (AQP)-3 and AQP4 water channels are expressed at the basolateral membrane of mammalian collecting duct epithelium...
  45. Solenov E, Watanabe H, Manley G, Verkman A. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol. 2004;286:C426-32 pubmed
    ..3 +/- 0.5 vs. 5.5 +/- 0.4 kcal/mol). Our studies establish a calcein quenching method for measurement of cell membrane water permeability and indicate that AQP-4 provides the principal route for water transport in astrocytes. ..
  46. Kitaura H, Tsujita M, Huber V, Kakita A, Shibuki K, Sakimura K, et al. Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res. 2009;64:208-12 pubmed publisher
    We investigated the role of aquaporin-4 (AQP4), a water channel expressed in glial cells, in neural activity mediated morphological changes observed in brain slice preparation...
  47. Benfenati V, Caprini M, Dovizio M, Mylonakou M, Ferroni S, Ottersen O, et al. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc Natl Acad Sci U S A. 2011;108:2563-8 pubmed publisher
    ..The molecular basis of RVD is not understood. Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes...
  48. Ma T, Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997;100:957-62 pubmed
    Aquaporin-4 (AQP4) is a mercurial-insensitive, water-selective channel that is expressed in astroglia and basolateral plasma membranes of epithelia in the kidney collecting duct, airways, stomach, and colon...
  49. Fan Y, Kong H, Shi X, Sun X, Ding J, Wu J, et al. Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. Neurobiol Aging. 2008;29:1226-36 pubmed
    b>Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, which is localized in the astrocyte plasma membrane...
  50. Kuppers E, Gleiser C, Brito V, Wachter B, Pauly T, Hirt B, et al. AQP4 expression in striatal primary cultures is regulated by dopamine--implications for proliferation of astrocytes. Eur J Neurosci. 2008;28:2173-82 pubmed publisher
    ..Therefore we studied the effect of dopamine on aquaporin 4 (AQP4) expression, the main aquaporin subtype expressed in glial cells, and observed a down-regulation of the ..
  51. Verkman A, Binder D, Bloch O, Auguste K, Papadopoulos M. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochim Biophys Acta. 2006;1758:1085-93 pubmed
    Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system, particularly at the blood-brain and brain-cerebrospinal fluid barriers...
  52. Papadopoulos M, Verkman A. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem. 2005;280:13906-12 pubmed
    The astroglial water channel aquaporin-4 (AQP4) facilitates water movement into and out of brain parenchyma...
  53. Manley G, Fujimura M, Ma T, Noshita N, Filiz F, Bollen A, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000;6:159-63 pubmed
    ..Here we show that mice deficient in aquaporin-4 (AQP4), a glial membrane water channel, have much better survival than wild-type mice in a model of brain edema caused by ..
  54. Wu N, Lu X, Yan H, Su R, Wang J, Liu Y, et al. Aquaporin 4 deficiency modulates morphine pharmacological actions. Neurosci Lett. 2008;448:221-5 pubmed publisher
    ..b>Aquaporin 4 (AQP4) is most strongly expressed in astrocytes throughout central nervous system, and plays an important role ..
  55. Nicchia G, Rossi A, Mola M, Pisani F, Stigliano C, Basco D, et al. Higher order structure of aquaporin-4. Neuroscience. 2010;168:903-14 pubmed publisher
    Unlike other mammalian AQPs, multiple tetramers of AQP4 associate in the plasma membrane to form peculiar structures called Orthogonal Arrays of Particles (OAPs), that are observable by freeze-fracture electron microscopy (FFEM)...
  56. Nelson P, Khodadoust M, Prodhomme T, Spencer C, Patarroyo J, Varrin Doyer M, et al. Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. PLoS ONE. 2010;5:e15050 pubmed publisher
    Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass. However, a role for AQP4-specific T cells in this CNS inflammatory disease is not known...
  57. Ding J, Sha L, Chang J, Zhou X, Fan Y, Hu G. Alterations of striatal neurotransmitter release in aquaporin-4 deficient mice: An in vivo microdialysis study. Neurosci Lett. 2007;422:175-80 pubmed
    Our previous investigation has demonstrated that the lack of aquaporin-4 (AQP4) expressions in mice is paralleled by sex- and region-specific abnormalities in neurotransmission...
  58. Basco D, Nicchia G, D Alessandro A, Zolla L, Svelto M, Frigeri A. Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. PLoS ONE. 2011;6:e19225 pubmed publisher
    Aquaporin-4 (AQP4) is a water channel expressed at the sarcolemma of fast-twitch skeletal muscle fibers, whose expression is altered in several forms of muscular dystrophies...
  59. Hinson S, Romero M, Popescu B, Lucchinetti C, Fryer J, Wolburg H, et al. Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A. 2012;109:1245-50 pubmed publisher
    The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying severity that is unified by detection of the serum ..
  60. Frigeri A, Nicchia G, Balena R, Nico B, Svelto M. Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin-4. FASEB J. 2004;18:905-7 pubmed
    Aquaporin-4 (AQP4) is the major water channel of the neuromuscular system, but its physiological function in both perivascular astrocytes and skeletal muscle sarcolemma is unclear...
  61. Graber D, Levy M, Kerr D, Wade W. Neuromyelitis optica pathogenesis and aquaporin 4. J Neuroinflammation. 2008;5:22 pubmed publisher
    ..An IgG1 autoantibody (NMO-IgG) that binds aquaporin 4 (AQP4) has been identified in the sera of a significant number of NMO patients, as well as in patients with two ..
  62. Nicchia G, Srinivas M, Li W, Brosnan C, Frigeri A, Spray D. New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J. 2005;19:1674-6 pubmed
    Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes of mouse, rat, and human astrocytes...
  63. Turtzo L, Lee M, Lu M, Smith B, Copeland N, Gilbert D, et al. Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia. Genomics. 1997;41:267-70 pubmed
    ..Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18...
  64. Rossi A, Crane J, Verkman A. Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding. Glia. 2011;59:1056-63 pubmed publisher
    Water channel aquaporin-4 (AQP4) is expressed in astrocytes throughout brain and spinal cord. Two major AQP4 isoforms are expressed, M1 and M23, having different translation initiation sites...
  65. Noell S, Fallier Becker P, Deutsch U, Mack A, Wolburg H. Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes. Cell Tissue Res. 2009;337:185-95 pubmed publisher
    ..effects of agrin isoforms on the expression and distribution of the water channel protein, aquaporin-4 (AQP4), on the swelling capacity of cultured astrocytes of neonatal mice and on freeze-fracture data revealing an agrin-..
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    Neuromyelitis optica (NMO) is an autoimmune demyelinating disease characterized by the presence of anti-aquaporin-4 (AQP4) antibodies in the patient sera...