Aqp2

Summary

Gene Symbol: Aqp2
Description: aquaporin 2
Alias: AQP-CD, WCH-CD, cph, jpk, aquaporin-2, ADH water channel, AQP-2, aquaporin-CD, collecting duct water channel protein, water channel protein for renal collecting duct
Species: mouse
Products:     Aqp2

Top Publications

  1. Moeller H, Praetorius J, Rützler M, Fenton R. Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions. Proc Natl Acad Sci U S A. 2010;107:424-9 pubmed publisher
    The water channel aquaporin-2 (AQP2) is essential for urine concentration. Vasopressin regulates phosphorylation of AQP2 at four conserved serine residues at the COOH-terminal tail (S256, S261, S264, and S269)...
  2. Moeller H, Knepper M, Fenton R. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int. 2009;75:295-303 pubmed publisher
    ..We recently identified a novel form of aquaporin-2 that is phosphorylated at serine-269 (pS269-AQP2)...
  3. Ge Y, Ahn D, Stricklett P, Hughes A, Yanagisawa M, Verbalis J, et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005;288:F912-20 pubmed
    ..normal water intake, urinary osmolality (Uosm), plasma Na concentration, urine volume, and renal aquaporin-2 (AQP2) levels were unchanged, but plasma AVP concentration was reduced in CD ET-1 KO animals...
  4. Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001;276:2775-9 pubmed
    Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel...
  5. Nedvetsky P, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, et al. Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 2010;21:1645-56 pubmed publisher
    Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water...
  6. Rojek A, Füchtbauer E, Kwon T, Frøkiaer J, Nielsen S. Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A. 2006;103:6037-42 pubmed
    Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel in kidney connecting tubule (CNT) and collecting duct (CD) and is essential for renal regulation of body water balance...
  7. Gattone V, Maser R, Tian C, Rosenberg J, Branden M. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev Genet. 1999;24:309-18 pubmed
    ..arginine vasopressin V2 receptors (AVP-V2R), and 3) the presence of appropriate CD water channels (aquaporins, AQP 2 and 3). An increase in urine osmolarity, normally seen between 1 and 3 weeks of age, was absent in cpk cystic mice...
  8. Krane C, Towne J, Menon A. Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster. Mamm Genome. 1999;10:498-505 pubmed
    ..and physical mapping genomic fragments contiguous with Aqp5 revealed two other members of the aquaporin family: Aqp2 and Aqp6, arrayed head to tail in the order Aqp2-Aqp5-Aqp6, and provides evidence of a gene cluster conserved in ..
  9. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
  10. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..

Detail Information

Publications95

  1. Moeller H, Praetorius J, Rützler M, Fenton R. Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions. Proc Natl Acad Sci U S A. 2010;107:424-9 pubmed publisher
    The water channel aquaporin-2 (AQP2) is essential for urine concentration. Vasopressin regulates phosphorylation of AQP2 at four conserved serine residues at the COOH-terminal tail (S256, S261, S264, and S269)...
  2. Moeller H, Knepper M, Fenton R. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int. 2009;75:295-303 pubmed publisher
    ..We recently identified a novel form of aquaporin-2 that is phosphorylated at serine-269 (pS269-AQP2)...
  3. Ge Y, Ahn D, Stricklett P, Hughes A, Yanagisawa M, Verbalis J, et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005;288:F912-20 pubmed
    ..normal water intake, urinary osmolality (Uosm), plasma Na concentration, urine volume, and renal aquaporin-2 (AQP2) levels were unchanged, but plasma AVP concentration was reduced in CD ET-1 KO animals...
  4. Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001;276:2775-9 pubmed
    Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel...
  5. Nedvetsky P, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, et al. Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 2010;21:1645-56 pubmed publisher
    Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water...
  6. Rojek A, Füchtbauer E, Kwon T, Frøkiaer J, Nielsen S. Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A. 2006;103:6037-42 pubmed
    Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel in kidney connecting tubule (CNT) and collecting duct (CD) and is essential for renal regulation of body water balance...
  7. Gattone V, Maser R, Tian C, Rosenberg J, Branden M. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev Genet. 1999;24:309-18 pubmed
    ..arginine vasopressin V2 receptors (AVP-V2R), and 3) the presence of appropriate CD water channels (aquaporins, AQP 2 and 3). An increase in urine osmolarity, normally seen between 1 and 3 weeks of age, was absent in cpk cystic mice...
  8. Krane C, Towne J, Menon A. Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster. Mamm Genome. 1999;10:498-505 pubmed
    ..and physical mapping genomic fragments contiguous with Aqp5 revealed two other members of the aquaporin family: Aqp2 and Aqp6, arrayed head to tail in the order Aqp2-Aqp5-Aqp6, and provides evidence of a gene cluster conserved in ..
  9. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
  10. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..
  11. Jouret F, Auzanneau C, Debaix H, Wada G, Pretto C, Marbaix E, et al. Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005;16:3235-46 pubmed
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA. ..
  12. Guttman J, Samji F, Li Y, Deng W, Lin A, Finlay B. Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol. 2007;9:131-41 pubmed
    ..rodentium infection may alter AQP localization in colonocytes. We demonstrate that during infection, AQP2 and AQP3 are mislocalized from their normal location along cell membranes to the cell cytoplasm...
  13. Bruggeman L, Martinka S, Simske J. Expression of TM4SF10, a Claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation. Dev Dyn. 2007;236:596-605 pubmed
    ..TM4SF10 may define a new class of Claudin-like proteins that function during junctional development. ..
  14. Satake M, Ikarashi N, Ichikawa Y, Maniwa A, Toda T, Ito K, et al. The role of renal aquaporin 2 in the alleviation of dehydration associated with diabetic polyuria in KKAy mice. Life Sci. 2010;87:475-80 pubmed publisher
    ..In the present study, the role of renal aquaporin 2 (AQP2) in the compensating mechanism was investigated in KKAy mice, a type 2 diabetes model.
  15. Knoers N, Deen P. Aquaporin molecular biology and clinical abnormalities of the water transport channels. Curr Opin Pediatr. 1998;10:428-34 pubmed
    ..The discovery of a severe urinary concentrating defect in AQP1-knockout mice was remarkable. Only AQP2, the vasopressin-sensitive water channel in the kidney, which is mutated in autosomal recessive and dominant cases ..
  16. Boone M, Kortenoeven M, Robben J, Deen P. Effect of the cGMP pathway on AQP2 expression and translocation: potential implications for nephrogenic diabetes insipidus. Nephrol Dial Transplant. 2010;25:48-54 pubmed publisher
    ..a cAMP signalling cascade resulting in the activation of protein kinase A (PKA), translocation of aquaporin-2 (AQP2) to the apical membrane and an increase in AQP2 expression. Consequently, concentration of urine is initiated...
  17. Cui J, Li X, Duan Z, Xue W, Wang Z, Lu S, et al. Analysis of Kif5b expression during mouse kidney development. PLoS ONE. 2015;10:e0126002 pubmed publisher
  18. Wang P, Lin S, Liu S, Kuo K, Hsu C, Knepper M, et al. Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1 (signal-induced proliferation-associated 1 like 1)-mediated aquaporin-2 endocytosis. J Biol Chem. 2017;292:7984-7993 pubmed publisher
  19. Garcia Gonzalez M, Outeda P, Zhou Q, Zhou F, Menezes L, Qian F, et al. Pkd1 and Pkd2 are required for normal placental development. PLoS ONE. 2010;5: pubmed publisher
    ..Endothelial cell specific deletion of Pkd1 or Pkd2 recapitulates a subset of findings seen in Pkd null animals. Our studies reveal a complex role for polycystins in maintaining vascular integrity. ..
  20. Fenton R, Moeller H, Hoffert J, Yu M, Nielsen S, Knepper M. Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc Natl Acad Sci U S A. 2008;105:3134-9 pubmed publisher
    ..site, serine 264 (pS264), in the COOH terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2)...
  21. Tanaka M, Endo S, Okuda T, Economides A, Valenzuela D, Murphy A, et al. Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int. 2008;73:181-91 pubmed
    ..Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome. ..
  22. Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner M, et al. Aquaporin 2 promotes cell migration and epithelial morphogenesis. J Am Soc Nephrol. 2012;23:1506-17 pubmed publisher
    The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeostasis in mammals...
  23. Renier N, Wu Z, Simon D, Yang J, Ariel P, Tessier Lavigne M. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014;159:896-910 pubmed publisher
    ..iDISCO enables facile volume imaging of immunolabeled structures in complex tissues. PAPERCLIP: ..
  24. Lloyd D, Hall F, Tarantino L, Gekakis N. Diabetes insipidus in mice with a mutation in aquaporin-2. PLoS Genet. 2005;1:e20 pubmed
    ..harbor mutations in the vasopressin receptor 2 (Avpr2) gene or the vasopressin-sensitive water channel aquaporin-2 (Aqp2) gene. Development of a treatment is rendered difficult due to the lack of a viable animal model...
  25. Hasler U, Leroy V, Martin P, Feraille E. Aquaporin-2 abundance in the renal collecting duct: new insights from cultured cell models. Am J Physiol Renal Physiol. 2009;297:F10-8 pubmed publisher
    ..hormone arginine vasopressin (AVP) increases collecting duct water permeability by enhancing aquaporin-2 (AQP2) water channel insertion in the apical membrane of principal cells, allowing water to passively flow along the ..
  26. Yu M, Miller R, Uawithya P, Rinschen M, Khositseth S, Braucht D, et al. Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct. Proc Natl Acad Sci U S A. 2009;106:2441-6 pubmed publisher
    ..biology-based approach to investigate the basis of cell-specific expression of the water channel aquaporin-2 (AQP2) in the renal collecting duct...
  27. Kobayashi K, Uchida S, Mizutani S, Sasaki S, Marumo F. Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol. 2001;12:1327-34 pubmed
    ..These aspects of CLC-K2 localization suggest that CLC-K2 is important in Cl(-) transport in the distal nephron segments. ..
  28. Caubit X, Lye C, Martin E, Coré N, Long D, Vola C, et al. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008;135:3301-10 pubmed publisher
  29. Hoffert J, Fenton R, Moeller H, Simons B, Tchapyjnikov D, McDill B, et al. Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem. 2008;283:24617-27 pubmed publisher
    Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in renal collecting duct cells...
  30. Jin W, Yao X, Wang T, Ji Q, Li Y, Yang X, et al. Effects of hyperosmolality on expression of urea transporter A2 and aquaporin 2 in mouse medullary collecting duct cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:59-64 pubmed publisher
    In this study, the effects of hyperosmolality on the expression of urea transporter A2 (UTA2) and aquaporin 2 (AQP2) were investigated in transfected immortalized mouse medullary collecting duct (mIMCD3) cell line...
  31. Tamma G, Ranieri M, Di Mise A, Centrone M, Svelto M, Valenti G. Glutathionylation of the aquaporin-2 water channel: a novel post-translational modification modulated by the oxidative stress. J Biol Chem. 2014;289:27807-13 pubmed publisher
    Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water reabsorption and urine concentration...
  32. Wu H, Chen L, Zhou Q, Zhang X, Berger S, Bi J, et al. Aqp2-expressing cells give rise to renal intercalated cells. J Am Soc Nephrol. 2013;24:243-52 pubmed publisher
    ..Taking advantage of the distribution of aquaporin 2 (Aqp2), which localizes to principal cells of the collecting duct, we developed mice lacking Dot1l in Aqp2-..
  33. Hasler U, Jeon U, Kim J, Mordasini D, Kwon H, Feraille E, et al. Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells. J Am Soc Nephrol. 2006;17:1521-31 pubmed
    ..reported previously that hypertonicity exerted a dual, time-dependent effect on vasopressin-inducible aquaporin-2 (AQP2) expression in immortalized mouse collecting duct principal cells (mpkCCDcl4)...
  34. Lang S, Benedix J, Fedeles S, Schorr S, Schirra C, Schäuble N, et al. Different effects of Sec61?, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012;125:1958-69 pubmed publisher
    ..By contrast, silencing the SEC62 gene inhibited only post-translational transport of a signal-peptide-containing precursor protein. ..
  35. Garcia Gonzalez M, Menezes L, Piontek K, Kaimori J, Huso D, Watnick T, et al. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007;16:1940-50 pubmed
    ..These studies are the first to show genetic interaction between the major loci responsible for human renal cystic disease in a common PKD pathway...
  36. Horton C, Davisson M, Jacobs J, Bernstein G, Retik A, Mandell J. Congenital progressive hydronephrosis in mice: a new recessive mutation. J Urol. 1988;140:1310-5 pubmed
    We describe a new autosomal recessive mutation, congenital progressive hydronephrosis (cph), that arose in the C57BL/6J inbred mouse strain...
  37. Yamaguchi Y, Yonemura S, Takada S. Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006;133:4737-48 pubmed
    ..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney. ..
  38. Parreira K, Debaix H, Cnops Y, Geffers L, Devuyst O. Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pflugers Arch. 2009;458:745-59 pubmed publisher
    ..Furthermore, adult CD-1 kidneys expressed more AQP2 in the collecting ducts, which was reflected by a significant delay in excreting a water load...
  39. Bates C, Kegg H, Grady S. Expression of somatostatin in the adult and developing mouse kidney. Kidney Int. 2004;66:1785-93 pubmed
    ..Expression in the thin descending limb persists in the adult kidney. ..
  40. Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, et al. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol. 2008;294:F542-53 pubmed publisher
    ..Thus TAZ is essential for developmental mechanisms involved in kidney and lung organogenesis, whose disturbance may lead to the pathogenesis of common human diseases. ..
  41. Gajghate S, Hiyama A, Shah M, Sakai D, Anderson D, Shapiro I, et al. Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res. 2009;24:992-1001 pubmed publisher
    The goal of this study was to examine the expression and regulation of aquaporin2 (AQP2), a tonicity-sensitive water channel in nucleus pulposus cells of the intervertebral disc...
  42. Ranieri M, Tamma G, Di Mise A, Russo A, Centrone M, Svelto M, et al. Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2. J Cell Sci. 2015;128:2350-60 pubmed publisher
    ..that high luminal Ca(2+) in the renal collecting duct attenuates short-term vasopressin-induced aquaporin-2 (AQP2) trafficking through activation of the Ca(2+)-sensing receptor (CaSR)...
  43. Hilliard S, Aboudehen K, Yao X, El Dahr S. Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Dev Biol. 2011;353:354-66 pubmed publisher
    ..These results demonstrate a critical and cell autonomous role for Mdm2 in the UB lineage. Mdm2-mediated inhibition of p53 activity is a prerequisite for renal organogenesis. ..
  44. Hasler U, Nielsen S, Feraille E, Martin P. Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells. Am J Physiol Renal Physiol. 2006;290:F177-87 pubmed
    Prevailing expression levels of aquaporin-2 (AQP2) mRNA play a major role in regulating AQP2 protein abundance. Here, we investigated whether AQP2 protein abundance is regulated at a posttranscriptional level as well...
  45. Saigusa T, Reichert R, Guare J, Siroky B, Gooz M, Steele S, et al. Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors. Am J Physiol Renal Physiol. 2012;302:F801-8 pubmed publisher
    ..This is the site where vasopressin (AVP) stimulates vasopressin-2 receptor (V2R)-mediated aquaporin-2 (AQP2) insertion into the apical membrane...
  46. Lee S, Lee Y, Yoon J, Kang D, Lee H. Effect of Poria cocos on hypertonic stress-induced water channel expression and apoptosis in renal collecting duct cells. J Ethnopharmacol. 2012;141:368-76 pubmed publisher
    A major physiological role of the kidney is to regulate body water and urine concentration. Aquaporin-2 (AQP2), a family of water channels, plays an important role in the urinary concentrating process and regulation of water balance in ..
  47. Yasuoka Y, Kobayashi M, Sato Y, Nonoguchi H, Tanoue A, Okamoto H, et al. Decreased expression of aquaporin 2 in the collecting duct of mice lacking the vasopressin V1a receptor. Clin Exp Nephrol. 2013;17:183-90 pubmed publisher
    ..Am J Physiol 295: F100-7, 2008). Water balance, plasma vasopressin, plasma and urine osmolality, and aquaporin 2 (AQP2) expression in the kidney of wild-type (WT) and V1aR(-/-) mice were therefore further examined using ..
  48. van Balkom B, Boone M, Hendriks G, Kamsteeg E, Robben J, Stronks H, et al. LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation. J Am Soc Nephrol. 2009;20:990-1001 pubmed publisher
    ..binding to the V2 receptor in renal principal cells leads to activation of protein kinase A, phosphorylation of aquaporin 2 (AQP2) at Ser256, and the translocation of AQP2 to the apical membrane, resulting in concentration of the urine...
  49. Wildman S, Boone M, Peppiatt Wildman C, Contreras Sanz A, King B, Shirley D, et al. Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors. J Am Soc Nephrol. 2009;20:1480-90 pubmed publisher
    ..Basolateral exposure to dDAVP induced AQP2 localization to the apical membrane, but co-treatment with ATP internalized AQP2...
  50. Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, et al. Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol. 2017;424:77-89 pubmed publisher
    ..factors, including Elf5, Elf3 and Ehf, increase the transcriptional activity of the proximal promoters of Aqp2 and Avpr2 in cultured ureteric duct cell lines...
  51. Srichai M, Colleta H, Gewin L, Matrisian L, Abel T, Koshikawa N, et al. Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. PLoS ONE. 2011;6:e17099 pubmed publisher
    ..Thus, our results show that although MT4-MMP is expressed in the kidney, this metalloproteinase does not play a major role in renal development or function; however it does appear to modify the neural stimuli that modulate thirst. ..
  52. Kong K, Park S, Park H, Kim M. A novel gene, Jpk, induces apoptosis in F9 murine teratocarcinoma cell through ROS generation. Ann N Y Acad Sci. 2003;1010:433-6 pubmed
    A novel gene Jpk (Jopock) has been originally isolated through yeast 1 hybridization technique as a trans-acting factor interacting with the position-specific regulatory element of a murine Hoxa-7...
  53. Merves M, Bobbitt B, Parker K, Kishore B, Choo D. Developmental expression of aquaporin 2 in the mouse inner ear. Laryngoscope. 2000;110:1925-30 pubmed
    ..The objective of the present study was to define the developmental temporal and spatial expression pattern of aquaporin 2 (Aqp2) in the developing mouse inner ear...
  54. LeMaire S, Raghuram V, Grady C, Pickering C, Chou C, Umejiego E, et al. Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct. Am J Physiol Renal Physiol. 2017;312:F84-F95 pubmed publisher
    Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct...
  55. Arystarkhova E, Bouley R, Liu Y, Sweadner K. Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport. PLoS ONE. 2017;12:e0188006 pubmed publisher
    ..of urine volume occurs in the inner medullary collecting duct (IMCD), chiefly mediated by the water channel aquaporin 2 (AQP2)...
  56. Gilbert M, Yang L, Su T, McKnight G. Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype. Am J Physiol Renal Physiol. 2015;308:F627-38 pubmed publisher
    ..RI?B mice displayed a marked deficit in urinary concentrating ability and greatly reduced levels of AQP2 and phospho-AQP2...
  57. Yang B, Zhao D, Verkman A. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J. 2009;23:503-12 pubmed publisher
    Mutations in aquaporin-2 (AQP2) that interfere with its cellular processing can produce autosomal recessive nephrogenic diabetes insipidus (NDI)...
  58. Sequeira Lopez M, Nagalakshmi V, Li M, Sigmund C, Gomez R. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015;309:R650-7 pubmed publisher
    ..Further, the main source of circulating renin is the kidney vasculature. ..
  59. Merigo F, Mucignat Caretta C, Cristofoletti M, Zancanaro C. Epithelial membrane transporters expression in the developing to adult mouse vomeronasal organ and olfactory mucosa. Dev Neurobiol. 2011;71:854-69 pubmed publisher
    ..Results showed that CC26, cAMP-activated chloride channel (CFTR), and the water channel protein aquaporin 2, 3, 4, and 5 (AQP2, AQP3, AQP4, and AQP5) are expressed in developing to adult chemosensory epithelia with ..
  60. Tokuda M, Fujisawa M, Miyashita K, Kawakami Y, Morimoto Yamashita Y, Torii M. Involvement of TRPV1 and AQP2 in hypertonic stress by xylitol in odontoblast cells. Connect Tissue Res. 2015;56:44-9 pubmed publisher
    ..OLCs expressed TRPV1, 3 and 4 as well as AQP2. Xylitol inhibited lipopolysaccharide (LPS)-induced IL-6 expression after 3 h of hypertonic stress...
  61. Suda S, Rai T, Sohara E, Sasaki S, Uchida S. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Biochem Biophys Res Commun. 2006;344:246-52 pubmed
    ..By comparing the AQP2 immunolocalization in sequential sections, KLF12 was found to be expressed in the collecting ducts...
  62. Nechiporuk T, Fernandez T, Vasioukhin V. Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev Cell. 2007;13:338-50 pubmed
    ..These findings show that Dlg5 is causally involved in hydrocephalus and renal cysts and reveal that targeted membrane delivery of cadherin-catenin adhesion complexes is critical for cell polarity and epithelial tube maintenance. ..
  63. Moeller H, MacAulay N, Knepper M, Fenton R. Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating. Am J Physiol Renal Physiol. 2009;296:F649-57 pubmed publisher
    Arginine vasopressin (AVP)-regulated phosphorylation of the water channel aquaporin-2 (AQP2) at serine 256 (S256) is essential for its accumulation in the apical plasma membrane of collecting duct principal cells...
  64. Felszeghy S, Modis L, Nemeth P, Nagy G, Zelles T, Agre P, et al. Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol. 2004;49:247-57 pubmed
    ..b>AQP2, AQP3 and AQP9 immunoreactivity was not observed in tooth germs, whereas strong AQP4 and AQP5 expression was ..
  65. Deen P. Mouse models for congenital nephrogenic diabetes insipidus: what can we learn from them?. Nephrol Dial Transplant. 2007;22:1023-6 pubmed
  66. Jung H, Kim S, Choi H, Park E, Lim J, Frøkiaer J, et al. Tankyrase-mediated ?-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells. Am J Physiol Renal Physiol. 2015;308:F473-86 pubmed publisher
    Aquaporin-2 (AQP2) mediates arginine vasopressin (AVP)-induced water reabsorption in the kidney collecting duct. AVP regulates AQP2 expression primarily via Gs?/cAMP/PKA signaling...
  67. Yang B, Zhao D, Qian L, Verkman A. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006;291:F465-72 pubmed
    ..ability produced by deletion of various membrane transport or receptor proteins, including aquaporin-2 (AQP2), are associated with neonatal mortality from polyuria...
  68. Centrone M, Ranieri M, Di Mise A, Berlingerio S, Russo A, Deen P, et al. AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70. Cell Physiol Biochem. 2017;44:515-531 pubmed publisher
    b>AQP2 expression is mainly controlled by vasopressin-dependent changes in protein abundance which is in turn regulated by AQP2 ubiquitylation and degradation, however the proteins involved in these processes are largely unknown...
  69. Hatem Vaquero M, Griera M, Giermakowska W, Luengo A, Calleros L, Gonzalez Bosc L, et al. Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochim Biophys Acta. 2017;1860:922-935 pubmed publisher
    Two processes are associated with progressive loss of renal function: 1) decreased aquaporin-2 (AQP2) expression and urinary concentrating capacity (Nephrogenic Diabetes Insipidus, NDI); and 2) changes in extracellular matrix (ECM) ..
  70. Yang B, Ma T, Xu Z, Verkman A. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999;57:79-83 pubmed
    ..a transgenic mouse model of nephrogenic diabetes insipidus (NDI), we have analyzed the mouse aquaporin-2 (Aqp2) cDNA and gene and generated a mutated Aqp2 orthologous to NDI-causing human AQP2-T126M...
  71. Georgas K, Rumballe B, Wilkinson L, Chiu H, Lesieur E, Gilbert T, et al. Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem Cell Biol. 2008;130:927-42 pubmed publisher
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
  72. Hasler U, Mordasini D, Bianchi M, Vandewalle A, Feraille E, Martin P. Dual influence of aldosterone on AQP2 expression in cultured renal collecting duct principal cells. J Biol Chem. 2003;278:21639-48 pubmed
    ..We have previously shown that endogenous expression of the aquaporin-2 (AQP2) water channel in immortalized mouse cortical CD principal cells (mpkCCDC14) grown on filters is dramatically ..
  73. Rai T, Uchida S, Marumo F, Sasaki S. Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Am J Physiol. 1997;273:F264-73 pubmed
    ..These results indicate that tissue-specific expression of AQP-2 gene may in part be regulated by this novel negative acting cis-element...
  74. Sohara E, Rai T, Yang S, Uchida K, Nitta K, Horita S, et al. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006;103:14217-22 pubmed
    Frame-shift mutations within the C terminus of aquaporin 2 (AQP2) cause autosomal-dominant nephrogenic diabetes insipidus (AD-NDI)...
  75. MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
    ..Taken together, our data show that p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins. ..
  76. Trac D, Liu B, Pao A, Thomas S, Park M, Downs C, et al. Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells. Am J Physiol Renal Physiol. 2013;305:F995-F1005 pubmed publisher
  77. Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode Shakked N, et al. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development. 2010;137:3835-45 pubmed publisher
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation. ..
  78. Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, et al. GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. Mol Cell Biol. 2014;34:1929-41 pubmed publisher
    ..Upon purification of the GFP-positive cells, we found that collecting duct (CD)-specific markers, including aquaporin 2 (Aqp2), an important channel for water reabsorption from urine, were abundantly expressed...
  79. Whiteman E, Fan S, Harder J, Walton K, Liu C, Soofi A, et al. Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014;34:43-56 pubmed publisher
    ..Taken together, our data indicate that Crumbs3 is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. ..
  80. Jiang S, Chiou Y, Wang E, Lin H, Lin Y, Chi Y, et al. Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. Am J Pathol. 2006;168:205-20 pubmed
    ..Abnormalities in Na(+)/K(+)-ATPase, aquaporin-2, and vasopressin V2 receptor expression were also identified. This mouse model may be suitable for further studies of progression and therapeutic interventions of ADPKD. ..
  81. Moeller H, Fuglsang C, Pedersen C, Fenton R. Basolateral cholesterol depletion alters Aquaporin-2 post-translational modifications and disrupts apical plasma membrane targeting. Biochem Biophys Res Commun. 2018;495:157-162 pubmed publisher
    Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis...
  82. Hoffert J, Nielsen J, Yu M, Pisitkun T, Schleicher S, Nielsen S, et al. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol. 2007;292:F691-700 pubmed
    ..site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2)...
  83. Kim D, Wang M, Cai Q, Brooks H, Dressler G. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol. 2007;18:1458-65 pubmed
    ..Furthermore, aquaporin-2 (AQP2) expression in the inner medulla of the ptip knockout mice was decreased approximately 10-fold compared with that ..
  84. Procino G, Barbieri C, Tamma G, De Benedictis L, Pessin J, Svelto M, et al. AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. J Cell Sci. 2008;121:2097-106 pubmed publisher
    Vasopressin regulates the fusion of the water channel aquaporin 2 (AQP2) to the apical membrane of the renal collecting-duct principal cells and several lines of evidence indicate that SNARE proteins mediate this process...
  85. Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan K, Allen S, et al. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011;138:947-57 pubmed publisher
    ..Our analysis implies that Dchs1 and Fat4 function as a ligand-receptor pair during murine development, and identifies novel requirements for Dchs1-Fat4 signaling in multiple organs. ..
  86. Offenberg H, Barcroft L, Caveney A, Viuff D, Thomsen P, Watson A. mRNAs encoding aquaporins are present during murine preimplantation development. Mol Reprod Dev. 2000;57:323-30 pubmed
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation. ..
  87. Edashige K, Sakamoto M, Kasai M. Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000;40:171-5 pubmed
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  88. Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes I, Shan J, et al. Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol. 2011;353:50-60 pubmed publisher
    ..Based on the results, we propose that Dkk1 controls the degree of Wnt-7b signalling in the papilla to coordinate kidney organogenesis. ..
  89. Hashemolhosseini S, Hadjihannas M, Stolt C, Haas C, Amann K, Wegner M. Restricted expression of mouse GCMa/Gcm1 in kidney and thymus. Mech Dev. 2002;118:175-8 pubmed
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development. ..
  90. Guo L, Alli A, Eaton D, Bao H. ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling. Am J Physiol Renal Physiol. 2013;304:F930-7 pubmed publisher
  91. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..The C57Bl6 Wnt11 (-/-) mouse generated here provides a model for studying the mechanisms behind tubular anomalies and glomerular cyst formation. ..
  92. Klein J, Sands J, Qian L, Wang X, Yang B. Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. J Am Soc Nephrol. 2004;15:1161-7 pubmed
    ..reverse transcription-PCR and Northern blot analysis showed upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP...
  93. Hocherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol. 2010;298:F196-204 pubmed publisher
    ..CLP caused a time-dependent downregulation of renal vasopressin V(2) receptor and of AQP2 expression without alterations in plasma vasopressin levels...