Aqp1

Summary

Gene Symbol: Aqp1
Description: aquaporin 1
Alias: CHIP28, aquaporin-1, AQP-1, DER2, aquaporin-CHIP, delayed early response protein 2, growth factor-induced delayed early response protein, water channel protein for red blood cells and kidney proximal tubule
Species: mouse
Products:     Aqp1

Top Publications

  1. Oshio K, Watanabe H, Yan D, Verkman A, Manley G. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006;341:1022-8 pubmed
    Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production...
  2. Saadoun S, Papadopoulos M, Hara Chikuma M, Verkman A. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92 pubmed
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  3. Larsen H, Ruus A, Galtung H. Aquaporin expression patterns in the developing mouse salivary gland. Eur J Oral Sci. 2009;117:655-62 pubmed publisher
    ..Overall, this study demonstrates that AQP presentation varies and has a specific expression pattern during the development of mouse SMG. This feature may be important for glandular anatomical and physiological development. ..
  4. Moore M, Ma T, Yang B, Verkman A. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000;70:557-62 pubmed
    ..AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia...
  5. Shields S, Mazario J, Skinner K, Basbaum A. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007;131:8-20 pubmed
    b>Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues...
  6. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..
  7. Chou C, Knepper M, Hoek A, Brown D, Yang B, Ma T, et al. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999;103:491-6 pubmed
    ..high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels...
  8. Verkman A, Yang B, Song Y, Manley G, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000;85 Spec No:233S-241S pubmed
    ..Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect...
  9. Monzani E, Bazzotti R, Perego C, La Porta C. AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS ONE. 2009;4:e6167 pubmed publisher
    b>AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues...
  10. Sohara E, Rai T, Miyazaki J, Verkman A, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005;289:F1195-200 pubmed
    ..0 +/- 0.3 x 10(-3) cm/s). Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, ..

Detail Information

Publications91

  1. Oshio K, Watanabe H, Yan D, Verkman A, Manley G. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006;341:1022-8 pubmed
    Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production...
  2. Saadoun S, Papadopoulos M, Hara Chikuma M, Verkman A. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92 pubmed
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  3. Larsen H, Ruus A, Galtung H. Aquaporin expression patterns in the developing mouse salivary gland. Eur J Oral Sci. 2009;117:655-62 pubmed publisher
    ..Overall, this study demonstrates that AQP presentation varies and has a specific expression pattern during the development of mouse SMG. This feature may be important for glandular anatomical and physiological development. ..
  4. Moore M, Ma T, Yang B, Verkman A. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000;70:557-62 pubmed
    ..AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia...
  5. Shields S, Mazario J, Skinner K, Basbaum A. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007;131:8-20 pubmed
    b>Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues...
  6. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..
  7. Chou C, Knepper M, Hoek A, Brown D, Yang B, Ma T, et al. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999;103:491-6 pubmed
    ..high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels...
  8. Verkman A, Yang B, Song Y, Manley G, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000;85 Spec No:233S-241S pubmed
    ..Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect...
  9. Monzani E, Bazzotti R, Perego C, La Porta C. AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS ONE. 2009;4:e6167 pubmed publisher
    b>AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues...
  10. Sohara E, Rai T, Miyazaki J, Verkman A, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005;289:F1195-200 pubmed
    ..0 +/- 0.3 x 10(-3) cm/s). Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, ..
  11. Song Y, Ma T, Matthay M, Verkman A. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000;115:17-27 pubmed
    The mammalian peripheral lung contains at least three aquaporin (AQP) water channels: AQP1 in microvascular endothelia, AQP4 in airway epithelia, and AQP5 in alveolar epithelia...
  12. Verkman A. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 2005;118:3225-32 pubmed
    ..AQPs facilitate cell migration, as manifested by reduced tumor angiogenesis in AQP1-knockout mice, by a mechanism that might involve facilitated water transport in lamellipodia of migrating cells...
  13. Schnermann J, Chou C, Ma T, Traynor T, Knepper M, Verkman A. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A. 1998;95:9660-4 pubmed
    To investigate the role of aquaporin-1 (AQP1) water channels in proximal tubule function, in vitro proximal tubule microperfusion and in vivo micropuncture measurements were done on AQP1 knockout mice...
  14. Iandiev I, Pannicke T, Reichel M, Wiedemann P, Reichenbach A, Bringmann A. Expression of aquaporin-1 immunoreactivity by photoreceptor cells in the mouse retina. Neurosci Lett. 2005;388:96-9 pubmed
    ..The data suggest that photoreceptor cells, but not Müller cells, express aquaporin-1 in the murine retina. ..
  15. Song Y, Fukuda N, Bai C, Ma T, Matthay M, Verkman A. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000;525 Pt 3:771-9 pubmed
    ..We used mice deficient in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung ..
  16. Yang B, Ma T, Verkman A. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001;276:624-8 pubmed
    Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes...
  17. Bai C, Fukuda N, Song Y, Ma T, Matthay M, Verkman A. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999;103:555-61 pubmed
    The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia...
  18. Shields S, Moore K, Phelps P, Basbaum A. Olfactory ensheathing glia express aquaporin 1. J Comp Neurol. 2010;518:4329-41 pubmed publisher
    ..Here we provide evidence through anatomical colocalization studies that OEG express the water channel aquaporin 1 (AQP1), both in vivo and in vitro...
  19. Ma T, Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998;273:4296-9 pubmed
    Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia...
  20. Jouret F, Igarashi T, Gofflot F, Wilson P, Karet F, Thakker R, et al. Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int. 2004;65:198-208 pubmed
    ..mouse and human nephrogenesis, in comparison with H+-ATPase, type II carbonic anhydrase (CAII), and aquaporin-1 (AQP1). An early induction (E13.5-E14...
  21. Zhang H, Verkman A. Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. J Biol Chem. 2010;285:5896-906 pubmed publisher
    Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of dorsal root ganglion (DRG) neurons. We found reduced osmotic water permeability in freshly isolated DRG neurons from AQP1(-/-) versus AQP1(+/+) mice...
  22. Li J, Verkman A. Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem. 2001;276:31233-7 pubmed
    ..Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus ..
  23. Ni J, Verbavatz J, Rippe A, Boisdé I, Moulin P, Rippe B, et al. Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int. 2006;69:1518-25 pubmed
    The water channel aquaporin-1 (AQP1) is considered as the molecular counterpart of the ultrasmall pore predicted by the three-pore model of fluid transport across the peritoneal membrane...
  24. Ma T, Song Y, Gillespie A, Carlson E, Epstein C, Verkman A. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999;274:20071-4 pubmed
    ..Water channels AQP1 and AQP4 have also been localized to salivary gland; however, pilocarpine stimulation studies showed no defect in ..
  25. Pallone T, Edwards A, Ma T, Silldorff E, Verkman A. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest. 2000;105:215-22 pubmed
    Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasa recta (OMDVR)...
  26. Yang B, Fukuda N, van Hoek A, Matthay M, Ma T, Verkman A. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000;275:2686-92 pubmed
    Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2)...
  27. Umenishi F, Yoshihara S, Narikiyo T, Schrier R. Modulation of hypertonicity-induced aquaporin-1 by sodium chloride, urea, betaine, and heat shock in murine renal medullary cells. J Am Soc Nephrol. 2005;16:600-7 pubmed
    Aquaporin-1 (AQP1) expression is induced by hypertonicity in renal medullary cells...
  28. Wintmo P, Johansen S, Hansen P, Lindholt J, Urbonavicius S, Rasmussen L, et al. The water channel AQP1 is expressed in human atherosclerotic vascular lesions and AQP1 deficiency augments angiotensin II-induced atherosclerosis in mice. Acta Physiol (Oxf). 2017;220:446-460 pubmed publisher
    The water channel aquaporin 1 (AQP1) promotes endothelial cell migration. It was hypothesized that AQP1 promotes neovascularization and growth of atherosclerotic plaques...
  29. Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N kuli F, Hoffmann D, et al. Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch. PLoS ONE. 2015;10:e0117398 pubmed publisher
    The water channel aquaporin-1 (AQP1) promotes migration of many cell types. Although AQP1 is expressed in macrophages, its potential role in macrophage motility, particularly in relation with phenotype polarization, remains unknown...
  30. Mahendrasingam S, Bebb C, Shepard E, Furness D. Subcellular distribution and relative expression of fibrocyte markers in the CD/1 mouse cochlea assessed by semiquantitative immunogold electron microscopy. J Histochem Cytochem. 2011;59:984-1000 pubmed publisher
    ..Caldesmon and aquaporin 1 are expressed more in type III fibrocytes than any other type...
  31. Shekarabi M, Salin Cantegrel A, Laganiere J, Gaudet R, Dion P, Rouleau G. Cellular expression of the K+-Cl- cotransporter KCC3 in the central nervous system of mouse. Brain Res. 2011;1374:15-26 pubmed publisher
    ..Finally, we showed that some non-neuronal cells, such as radial glial-like cells in the spinal cord, also express KCC3. ..
  32. Gabbi C, Kim H, Hultenby K, Bouton D, Toresson G, Warner M, et al. Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. Proc Natl Acad Sci U S A. 2008;105:15052-7 pubmed publisher
    ..between LXRbeta and pancreatic secretion, we studied the expression of LXRbeta and the water channel, aquaporin-1 (AQP1), in the ductal epithelium of the pancreas...
  33. Kingsley P, Greenfest Allen E, Frame J, Bushnell T, Malik J, McGrath K, et al. Ontogeny of erythroid gene expression. Blood. 2013;121:e5-e13 pubmed publisher
    ..We have created a user-friendly Web site (http://www.cbil.upenn.edu/ErythronDB) to make these global expression data readily accessible and amenable to complex search strategies by the scientific community. ..
  34. Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, et al. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol. 2008;294:F542-53 pubmed publisher
    ..Thus TAZ is essential for developmental mechanisms involved in kidney and lung organogenesis, whose disturbance may lead to the pathogenesis of common human diseases. ..
  35. Solenov E, Vetrivel L, Oshio K, Manley G, Verkman A. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J Neurosci Methods. 2002;113:85-90 pubmed
    ..At least two aquaporin-type water channels are expressed in spinal cord: AQP1 in afferent sensory nerve fibers in the superficial layers of the dorsal horn, and AQP4 in glial cells throughout ..
  36. Ma T, Jayaraman S, Wang K, Song Y, Yang B, Li J, et al. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001;280:C126-34 pubmed
    Immunocytochemistry showed expression of aquaporin-1 (AQP1) water channels at sites involved in dietary fat processing, including intrahepatic cholangiocytes, gallbladder, pancreatic microvascular endothelium, and intestinal lacteals...
  37. Bates C, Kegg H, Grady S. Expression of somatostatin in the adult and developing mouse kidney. Kidney Int. 2004;66:1785-93 pubmed
    ..Expression in the thin descending limb persists in the adult kidney. ..
  38. Parreira K, Debaix H, Cnops Y, Geffers L, Devuyst O. Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pflugers Arch. 2009;458:745-59 pubmed publisher
  39. Jiang Y, Wang H, Zheng S, Mu S, Ma M, Xie X, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015;24:224-9 pubmed publisher
    ..In the current study, we aim to elucidate the role of aquaporin 1 in high-salt-induced hypertension and cardiac injuries and whether angiotensin II receptor blocker valsartan ..
  40. Srichai M, Colleta H, Gewin L, Matrisian L, Abel T, Koshikawa N, et al. Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. PLoS ONE. 2011;6:e17099 pubmed publisher
    ..Thus, our results show that although MT4-MMP is expressed in the kidney, this metalloproteinase does not play a major role in renal development or function; however it does appear to modify the neural stimuli that modulate thirst. ..
  41. Zhu J, Wu M, Liu Y, Zhao D. [Expressions of aquaporins 1 and 3 in the mouse prostate and their significance]. Zhonghua Nan Ke Xue. 2011;17:483-7 pubmed
    ..of AQP0 - 4 in the mouse prostatic tissue were determined by RT-PCR, and the expressions and localizations of AQP1 and AQP3 proteins were characterized by Western blot and immunohistochemistry...
  42. Gao J, Tan M, Gu M, Marshall C, Ding J, Hu G, et al. Cellular localization of aquaporin-1 in the human and mouse trigeminal systems. PLoS ONE. 2012;7:e46379 pubmed publisher
    ..Previous studies reported that a subpopulation of mouse and rat trigeminal neurons express water channel aquaporin-1 (AQP1). In this study we make a comparative investigation of AQP1 localization in the human and mouse trigeminal systems...
  43. Offenberg H, Barcroft L, Caveney A, Viuff D, Thomsen P, Watson A. mRNAs encoding aquaporins are present during murine preimplantation development. Mol Reprod Dev. 2000;57:323-30 pubmed
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation. ..
  44. Johansson P, Dziegielewska K, Ek C, Habgood M, Møllgård K, Potter A, et al. Aquaporin-1 in the choroid plexuses of developing mammalian brain. Cell Tissue Res. 2005;322:353-64 pubmed
    ..We describe the temporal expression and appearance of aquaporin-1 (AQP1) which is important for water transfer across adult choroid plexuses...
  45. Bélanger M, Robert B, Cayouette M. Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals. Dev Cell. 2017;40:137-150 pubmed publisher
    ..These results uncover a population of CMZ progenitors, distinct from classical RPCs, that also contributes to mammalian retinogenesis. ..
  46. Herriges M, Swarr D, Morley M, Rathi K, Peng T, Stewart K, et al. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014;28:1363-79 pubmed publisher
    ..These studies reveal that lncRNAs play an important role in foregut and lung endoderm development by regulating multiple aspects of gene transcription, often through regulation of transcription factor expression. ..
  47. Koshida R, Oishi H, Hamada M, Takei Y, Takahashi S. MafB is required for development of the hindbrain choroid plexus. Biochem Biophys Res Commun. 2017;483:288-293 pubmed publisher
    ..5, an early stage of hChP development. Collectively, our findings reveal that MafB play an important role in promoting hChP development during embryogenesis. ..
  48. Moon C, King L, Agre P. Aqp1 expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction. Am J Physiol. 1997;273:C1562-70 pubmed
    The aquaporin-1 (AQP1) water channel protein is expressed in multiple mammalian tissues by several different developmental programs; however, the genetic regulation is undefined...
  49. Calamita G, Ferri D, Bazzini C, Mazzone A, Botta G, Liquori G, et al. Expression and subcellular localization of the AQP8 and AQP1 water channels in the mouse gall-bladder epithelium. Biol Cell. 2005;97:415-23 pubmed
    ..of subcellular localization were then addressed to the mouse gall-bladder where the transcript of a second AQP, AQP1, was also detected. Immunoblotting experiments confirmed the presence of AQP8 and AQP1 at a protein level...
  50. Varadaraj K, Kumari S, Mathias R. Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Dev Dyn. 2007;236:1319-28 pubmed
    Aquaporin 0 (AQP0) and AQP1 are expressed in the lens, each in a different cell type, and their functional roles are not thoroughly understood. Our previous study showed that these two AQPs function as water transporters...
  51. Kumari S, Gao J, Mathias R, Sun X, Eswaramoorthy A, Browne N, et al. Aquaporin 0 Modulates Lens Gap Junctions in the Presence of Lens-Specific Beaded Filament Proteins. Invest Ophthalmol Vis Sci. 2017;58:6006-6019 pubmed publisher
    ..type (WT), AQP0-Htz lenses showed decreased Pf (approximately 50%), which was restored by transgenic expression of AQP1 (TgAQP1/AQP0-Htz), but the opacities and differences between FVB and C57 persisted...
  52. Zheng Fischhöfer Q, Schnichels M, Dere E, Strotmann J, Loscher N, McCulloch F, et al. Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction. Eur J Cell Biol. 2007;86:683-700 pubmed
    ..Furthermore, they showed normal auditory thresholds as measured by brain stem evoked potentials. These mice did, however, exhibit reduced behavioural responses to a vanilla scent...
  53. Galán Cobo A, Ramírez Lorca R, Toledo Aral J, Echevarría M. Aquaporin-1 plays important role in proliferation by affecting cell cycle progression. J Cell Physiol. 2016;231:243-56 pubmed publisher
    Aquaporin-1 (AQP1) has been associated with tumor development. Here, we investigated how AQP1 may affect cell proliferation...
  54. Vallon V, Verkman A, Schnermann J. Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. Am J Physiol Renal Physiol. 2000;278:F1030-3 pubmed
    To examine the role of aquaporin-1 (AQP1) in near-isosmolar fluid reabsorption in the proximal tubule, we compared osmolalities in micropuncture samples of late proximal tubular fluid and plasma in wild-type (+/+) and AQP1-knockout (-/-) ..
  55. Edashige K, Sakamoto M, Kasai M. Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000;40:171-5 pubmed
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  56. Zhou Q, Clarke L, Nie R, Carnes K, Lai L, Lien Y, et al. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A. 2001;98:14132-7 pubmed
    ..Immunohistochemical staining for NHE3, carbonic anhydrase II (CAII), and aquaporin-I (AQP1) was decreased in ER alpha knockout (alpha ERKO) efferent ductules...
  57. Fotiadis D, Suda K, Tittmann P, Jeno P, Philippsen A, Muller D, et al. Identification and structure of a putative Ca2+-binding domain at the C terminus of AQP1. J Mol Biol. 2002;318:1381-94 pubmed
    Aquaporin-1 (AQP1) is the first functionally identified aquaporin of a growing family of membrane water channels found in all forms of life...
  58. Dong C, Wang G, Li B, Xiao K, Ma Z, Huang H, et al. Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma. Respir Physiol Neurobiol. 2012;181:21-8 pubmed publisher
    ..The influence of these agents on OVA-induced airway inflammation was also evaluated. The mRNA expression levels of AQP1, 4, and 5 were significantly reduced and that of AQP3 was significantly increased 24h after the last OVA exposure...
  59. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..The C57Bl6 Wnt11 (-/-) mouse generated here provides a model for studying the mechanisms behind tubular anomalies and glomerular cyst formation. ..
  60. Huang X, Ketova T, Fleming J, Wang H, Dey S, Litingtung Y, et al. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 2009;136:2535-43 pubmed publisher
  61. Lanaspa M, Andres Hernando A, Li N, Rivard C, Cicerchi C, Roncal Jimenez C, et al. The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. J Biol Chem. 2010;285:31694-703 pubmed publisher
    Expression of aquaporin-1 (AQP1) and -2 (AQP2) channels in the kidney are critical for the maintenance of water homeostasis and the operation of the urinary concentrating mechanism...
  62. Verkman A. Aquaporins in endothelia. Kidney Int. 2006;69:1120-3 pubmed
    Aquaporin-1 (AQP1) water channels are expressed widely in microvascular endothelia outside of the central nervous system, including renal vasa recta and tumor microvessels, as well as in non-vascular endothelia in pleura, peritoneum, ..
  63. Zhang W, Freichel M, van der Hoeven F, Nawroth P, Katus H, Kälble F, et al. Novel Endothelial Cell-Specific AQP1 Knockout Mice Confirm the Crucial Role of Endothelial AQP1 in Ultrafiltration during Peritoneal Dialysis. PLoS ONE. 2016;11:e0145513 pubmed publisher
    The water channel aquaporin-1 (AQP1) mediates about 50% ultrafiltration during a 2-hour hypertonic dwell in global AQP1 knockout (AQP1-/-) mice...
  64. Kumari S, Varadaraj K. Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration. Biochem Biophys Res Commun. 2014;452:986-91 pubmed publisher
    ..of wild type (WT) mouse, AQP0 knockout (heterozygous, AQP0(+/-)) and AQP0 knockout lens transgenically expressing AQP1 (heterozygous AQP0(+/)(-)/AQP1(+/)(-)) mouse models were used for the study...
  65. Felszeghy S, Modis L, Nemeth P, Nagy G, Zelles T, Agre P, et al. Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol. 2004;49:247-57 pubmed
    ..In the present study we have characterised the expression of six different aquaporin isoforms (AQP1-5, AQP-9) in developing human and mouse tooth germs by immunohistochemistry using isoform specific antibodies...
  66. Downes G, Gilbert D, Copeland N, Gautam N, Jenkins N. Chromosomal mapping of five mouse G protein gamma subunits. Genomics. 1999;57:173-6 pubmed
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes. ..
  67. Song Y, Jayaraman S, Yang B, Matthay M, Verkman A. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol. 2001;117:573-82 pubmed
    Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia...
  68. Schweitzer K, Li E, Sidhaye V, Leitch V, Kuznetsov S, King L. Accumulation of aquaporin-1 during hemolysin-induced necrotic cell death. Cell Mol Biol Lett. 2008;13:195-211 pubmed
    ..We observed induction of aquaporin-1 (AQP1) during Staphylococcus aureus infection of cultured cells indicating a potential mechanism underlying altered water ..
  69. Zhang J, Xie C, Zhu Z, Huang H, Zeng Z. Potential role of AQP1 and VEGF in the development of malignant pleural effusion in mice. Med Oncol. 2012;29:656-62 pubmed publisher
    Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized...
  70. Verkman A. Role of aquaporin water channels in eye function. Exp Eye Res. 2003;76:137-43 pubmed
    ..At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary ..
  71. Rutkovskiy A, Bliksøen M, Hillestad V, Amin M, Czibik G, Valen G, et al. Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia. J Mol Cell Cardiol. 2013;56:22-33 pubmed publisher
    Aquaporin-1 (AQP1) is expressed in human and mouse hearts, but little is known about its cellular and subcellular localization and regulation...
  72. Yang B, Ma T, Dong J, Verkman A. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther. 2000;11:567-75 pubmed
    ..channel gene delivery to kidney tubules and microvessels was evaluated by delivery of an adenovirus encoding aquaporin 1 (AQP1-Ad5) to transgenic AQP1 null mice...
  73. Kim J, Lee Y, Park K, Lee W, Lee J. Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J Cereb Blood Flow Metab. 2010;30:943-9 pubmed publisher
    ..It can thus be suggested that agmatine could attenuate brain edema by limiting BBB disruption and blocking the accumulation of brain water content through lessening the expression of AQP-1 after cerebral ischemia. ..
  74. Prows D, Leikauf G. Quantitative trait analysis of nickel-induced acute lung injury in mice. Am J Respir Cell Mol Biol. 2001;24:740-6 pubmed
  75. Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, et al. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development. 2015;142:1193-202 pubmed publisher
  76. Kim W, Lee H, Han K, Nam S, Choi A, Kim Y, et al. Descending thin limb of the intermediate loop expresses both aquaporin 1 and urea transporter A2 in the mouse kidney. Histochem Cell Biol. 2016;146:1-12 pubmed publisher
    ..to identify the descending thin limb (DTL) of the intermediate loop in the adult C57Bl/6 mouse kidney using aquaporin 1 (AQP1) and urea transporter A2 (UT-A2) antibodies...
  77. Yang B, Zhao D, Verkman A. Evidence against functionally significant aquaporin expression in mitochondria. J Biol Chem. 2006;281:16202-6 pubmed
  78. Georgas K, Rumballe B, Wilkinson L, Chiu H, Lesieur E, Gilbert T, et al. Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem Cell Biol. 2008;130:927-42 pubmed publisher
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
  79. Guo J, He H, Liu H, Liu Q, Zhang L, Liu B, et al. Aquaporin-1, a New Maternally Expressed Gene, Regulates Placental Development in the Mouse. Biol Reprod. 2016;95:40 pubmed publisher
    ..The imprinting state, expression, and function of aquaporin-1 (Aqp1) were explored in knockout mice by imprinting analysis, real-time PCR, and immunohistochemistry...
  80. Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode Shakked N, et al. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development. 2010;137:3835-45 pubmed publisher
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation. ..
  81. Radtke A, O Riordan M. Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell Microbiol. 2008;10:2197-207 pubmed publisher
    ..We found that Aquaporin-1 (AQP1), a water channel that regulates swelling of secretory vesicles, associated with PCV...
  82. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  83. Buffoli B, Foglio E, Borsani E, Exley C, Rezzani R, Rodella L. Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: an immunohistochemical study. Acta Histochem. 2013;115:418-24 pubmed publisher
  84. Basta J, Robbins L, Denner D, Kolar G, Rauchman M. A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Development. 2017;144:3080-3094 pubmed publisher
    ..These global changes in gene expression were accompanied by a significant decrease in THP-, NKCC2- and AQP1-positive loop of Henle nephron segments in mutant ?SRM kidneys...
  85. Nicchia G, Stigliano C, Sparaneo A, Rossi A, Frigeri A, Svelto M. Inhibition of aquaporin-1 dependent angiogenesis impairs tumour growth in a mouse model of melanoma. J Mol Med (Berl). 2013;91:613-23 pubmed publisher
    ..Aquaporin-1 (AQP1) is a water channel membrane protein that promotes tumour angiogenesis by allowing faster endothelial cell ..