Aqp1

Summary

Gene Symbol: Aqp1
Description: aquaporin 1
Alias: CHIP28, aquaporin-1, AQP-1, DER2, aquaporin-CHIP, delayed early response protein 2, growth factor-induced delayed early response protein, water channel protein for red blood cells and kidney proximal tubule
Species: mouse

Top Publications

  1. pmc Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure
    Marianne Skals
    Department of Physiology and Biophysics, Aarhus University, 8000 Aarhus, Denmark
    J Biol Chem 285:15557-65. 2010
  2. ncbi Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium
    A Ruiz
    Department of Neurobiology, School of Medicine, University of California, Los Angeles 90024, USA
    Biochim Biophys Acta 1282:174-8. 1996
  3. pmc Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function
    Q Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 98:14132-7. 2001
  4. ncbi Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
    T Ma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 273:4296-9. 1998
  5. pmc Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
    J Schnermann
    Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Proc Natl Acad Sci U S A 95:9660-4. 1998
  6. pmc Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice
    C L Chou
    Laboratory of Kidney and Electrolyte Metabolism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 103:491-6. 1999
  7. pmc Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice
    C Bai
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143 0521, USA
    J Clin Invest 103:555-61. 1999
  8. ncbi Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
    T Ma
    Departments of Medicine, Physiology, and Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 274:20071-4. 1999
  9. pmc Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method
    Y Song
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, USA
    J Gen Physiol 115:17-27. 2000
  10. pmc Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta
    T L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 105:215-22. 2000

Research Grants

  1. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007
  2. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2001
  3. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2006
  4. PHYSIOLOGY AND MOLECULAR BIOLOGY OF LUNG WATER TRANSPORT
    Alan Verkman; Fiscal Year: 2007
  5. MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    Alan Verkman; Fiscal Year: 2008
  6. Role of airway submucosal glands in CF lung disease
    Alan S Verkman; Fiscal Year: 2010
  7. INSULIN RECEPTOR RELATED AND THE KIDNEY
    Carlton Bates; Fiscal Year: 2002
  8. Thomas L Pallone; Fiscal Year: 2016
  9. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    THOMAS PALLONE; Fiscal Year: 2003
  10. Calcium Signaling in Vasa Recta Endothelium
    THOMAS PALLONE; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. pmc Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure
    Marianne Skals
    Department of Physiology and Biophysics, Aarhus University, 8000 Aarhus, Denmark
    J Biol Chem 285:15557-65. 2010
    ..This mechanism might potentially allow HlyA-damaged erythrocytes to be removed from the bloodstream by macrophages and thereby reduce the risk of intravascular hemolysis...
  2. ncbi Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium
    A Ruiz
    Department of Neurobiology, School of Medicine, University of California, Los Angeles 90024, USA
    Biochim Biophys Acta 1282:174-8. 1996
    ..Northern blot analysis of several human tissues revealed a 2.8 kbp transcript. These data confirm the existence of water channels in the human retinal pigment epithelium...
  3. pmc Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function
    Q Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 98:14132-7. 2001
    ..Immunohistochemical staining for NHE3, carbonic anhydrase II (CAII), and aquaporin-I (AQP1) was decreased in ER alpha knockout (alpha ERKO) efferent ductules...
  4. ncbi Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
    T Ma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 273:4296-9. 1998
    Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia...
  5. pmc Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
    J Schnermann
    Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Proc Natl Acad Sci U S A 95:9660-4. 1998
    To investigate the role of aquaporin-1 (AQP1) water channels in proximal tubule function, in vitro proximal tubule microperfusion and in vivo micropuncture measurements were done on AQP1 knockout mice...
  6. pmc Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice
    C L Chou
    Laboratory of Kidney and Electrolyte Metabolism, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 103:491-6. 1999
    ..high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels...
  7. pmc Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice
    C Bai
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143 0521, USA
    J Clin Invest 103:555-61. 1999
    The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia...
  8. ncbi Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
    T Ma
    Departments of Medicine, Physiology, and Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 274:20071-4. 1999
    ..Water channels AQP1 and AQP4 have also been localized to salivary gland; however, pilocarpine stimulation studies showed no defect in ..
  9. pmc Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method
    Y Song
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, USA
    J Gen Physiol 115:17-27. 2000
    The mammalian peripheral lung contains at least three aquaporin (AQP) water channels: AQP1 in microvascular endothelia, AQP4 in airway epithelia, and AQP5 in alveolar epithelia...
  10. pmc Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta
    T L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 105:215-22. 2000
    Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasa recta (OMDVR)...
  11. ncbi Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes
    B Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 275:2686-92. 2000
    Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2)...
  12. pmc Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice
    Y Song
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Physiol 525:771-9. 2000
    ..We used mice deficient in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung ..
  13. ncbi Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5
    M Moore
    Department of Medicine, University of California, San Francisco 94143 0521, USA
    Exp Eye Res 70:557-62. 2000
    ..AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia...
  14. ncbi Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
    B Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, 94143 0521, USA
    J Biol Chem 276:624-8. 2001
    Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes...
  15. ncbi Impaired hearing in mice lacking aquaporin-4 water channels
    J Li
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 276:31233-7. 2001
    ..Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus ..
  16. ncbi Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5
    Francois Jouret
    Division of Nephrology and Laboratory of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 65:198-208. 2004
    ..However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown...
  17. ncbi Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
    Samira Saadoun
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 434:786-92. 2005
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  18. ncbi Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Am J Physiol Renal Physiol 289:F1195-200. 2005
    ..0 +/- 0.3 x 10(-3) cm/s). Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, ..
  19. ncbi Expression of aquaporin-1 immunoreactivity by photoreceptor cells in the mouse retina
    Ianors Iandiev
    Department of Ophthalmology and Eye Clinic, University of Leipzig Medical Faculty, D 04103 Leipzig, Germany
    Neurosci Lett 388:96-9. 2005
    ..The data suggest that photoreceptor cells, but not Müller cells, express aquaporin-1 in the murine retina...
  20. ncbi More than just water channels: unexpected cellular roles of aquaporins
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, Room 1246, Box 0521 University of California San Francisco, San Francisco, CA 94143 0521, USA
    J Cell Sci 118:3225-32. 2005
    ..AQPs facilitate cell migration, as manifested by reduced tumor angiogenesis in AQP1-knockout mice, by a mechanism that might involve facilitated water transport in lamellipodia of migrating cells...
  21. ncbi Impaired pain sensation in mice lacking Aquaporin-1 water channels
    Kotaro Oshio
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 341:1022-8. 2006
    Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production...
  22. ncbi Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis
    J Ni
    Division of Nephrology and Department of Pathology, UCL Medical School, Brussels, Belgium
    Kidney Int 69:1518-25. 2006
    The water channel aquaporin-1 (AQP1) is considered as the molecular counterpart of the ultrasmall pore predicted by the three-pore model of fluid transport across the peritoneal membrane...
  23. ncbi Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons
    Shannon D Shields
    Departments of Anatomy and Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Pain 131:8-20. 2007
    b>Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues...
  24. pmc AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin
    Elena Monzani
    Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy
    PLoS ONE 4:e6167. 2009
    b>AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues...
  25. doi Aquaporin expression patterns in the developing mouse salivary gland
    Helga S Larsen
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Eur J Oral Sci 117:655-62. 2009
    ..Overall, this study demonstrates that AQP presentation varies and has a specific expression pattern during the development of mouse SMG. This feature may be important for glandular anatomical and physiological development...
  26. pmc Olfactory ensheathing glia express aquaporin 1
    Shannon D Shields
    Department of Anatomy and Physiology, WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94158, USA
    J Comp Neurol 518:4329-41. 2010
    ..Here we provide evidence through anatomical colocalization studies that OEG express the water channel aquaporin 1 (AQP1), both in vivo and in vitro...
  27. pmc Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons
    Hua Zhang
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 285:5896-906. 2010
    Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of dorsal root ganglion (DRG) neurons. We found reduced osmotic water permeability in freshly isolated DRG neurons from AQP1(-/-) versus AQP1(+/+) mice...
  28. ncbi Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Exp Physiol 85:233S-241S. 2000
    ..Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect...
  29. ncbi The mouse aquaporin-1 gene
    C Moon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Genomics 30:354-7. 1995
    ..Using a cDNA for mouse Aqp1, the structural gene was isolated and a restriction map was constructed...
  30. ncbi Expression of mRNAs of the aquaporin family in mouse oocytes and embryos
    K Edashige
    Laboratory of Animal Science, College of Agriculture, Kochi University, Nankoku, Kochi, 783 8502, Japan
    Cryobiology 40:171-5. 2000
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  31. pmc Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration
    Y Song
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Gen Physiol 117:573-82. 2001
    Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia...
  32. pmc Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutant
    Michele Merves
    Department of Pediatric Otolaryngology, Center for Hearing and Deafness Research, Cincinnati, OH 45229, USA
    J Assoc Res Otolaryngol 4:264-75. 2003
    To examine the potential roles of aquaporins 1 and 5 (AQP1 and AQP5, respectively) in inner ear development and function, we defined their spatial and temporal expression patterns in the developing mouse inner ear and examined the ..
  33. pmc Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation
    Evan M Braunstein
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Assoc Res Otolaryngol 9:33-43. 2008
    ....
  34. pmc A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus
    Claas Wodarczyk
    Dulbecco Telethon Institute DTI at Dibit, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 4:e7137. 2009
    ..We propose that the role of PC-1 in the brain cilia might be to prevent hydrocephalus, a previously unrecognized role for this receptor and one that might have important implications for other genetic or sporadic diseases...
  35. pmc Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia
    Jae Hwan Kim
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    J Cereb Blood Flow Metab 30:943-9. 2010
    ..It can thus be suggested that agmatine could attenuate brain edema by limiting BBB disruption and blocking the accumulation of brain water content through lessening the expression of AQP-1 after cerebral ischemia...
  36. doi Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney
    Tomonori Kanazawa
    Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Dev Dyn 239:1145-54. 2010
    ..These results suggest the possibility that Hnf4alpha plays an important role in the regulation of the cell survival at the CM stage in nephrogenesis...
  37. doi Cellular and subcellular localization of aquaporins 1, 3, 8, and 9 in amniotic membranes during pregnancy in mice
    Ken Kobayashi
    Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku ku, Tokyo, 160 8582, Japan
    Cell Tissue Res 342:307-16. 2010
    ..After embryonic day 12 (E12), AQP1 was distributed in the plasma membrane of finely branched cell processes in the amniotic fibroblasts...
  38. doi The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
    Max Werth
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 137:3835-45. 2010
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation...
  39. ncbi [Iodoacetamide-induced aquaporin 1 expression in fibroblasts is energy-dependent]
    Er ran Li
    Institute of Respiratory Diseases, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:28-32. 2011
    To investigate the impact of energy metabolism at the cellular level on the expression of the water channel protein aquaporin 1 (AQP1).
  40. pmc Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)
    Liyo Kao
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 286:32563-74. 2011
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system...
  41. pmc Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β
    Chiara Gabbi
    Department of Biosciences and Nutrition, Karolinska Institutet, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 109:3030-4. 2012
    ....
  42. doi Genetic ablation of Slc4a10 alters the expression pattern of transporters involved in solute movement in the mouse choroid plexus
    Helle Hasager Damkier
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 3, Bldg 1233 1234, DK 8000 Aarhus C, Denmark
    Am J Physiol Cell Physiol 302:C1452-9. 2012
    ..Aquaporin-1 (AQP1) abundance was 42.7% lower and Na,K-ATPase 36.4% lower in the CPE of Slc4a10 knockout mice, respectively...
  43. doi Inhibition of aquaporin-1 dependent angiogenesis impairs tumour growth in a mouse model of melanoma
    Grazia P Nicchia
    Department of Bioscience, Biotechnology and Pharmacological Sciences and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Via Amendola 165 A, 70126, Bari, Italy
    J Mol Med (Berl) 91:613-23. 2013
    ..Aquaporin-1 (AQP1) is a water channel membrane protein that promotes tumour angiogenesis by allowing faster endothelial cell ..
  44. doi Role of aquaporin 1 in fetal fluid homeostasis
    Zheng Zheng
    Department of Obstetrics, Guangzhou Women and Children s Medical Centre, Guangzhou Medical College, Guangzhou, China
    J Matern Fetal Neonatal Med 27:505-10. 2014
    The homeostasis of maternal-fetal fluid exchange is critically important in pregnancy. We sought to investigate the function of aquaporin 1 (AQP1) during pregnancy by examining fluid compartments of AQP1 knockout (AQP1-KO) mice.
  45. pmc Fluid reabsorption in proximal convoluted tubules of mice with gene deletions of claudin-2 and/or aquaporin1
    Jurgen Schnermann
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg 10, Rm 4D51, 9000 Rockville Pike, Bethesda, MD 20892
    Am J Physiol Renal Physiol 305:F1352-64. 2013
    Deletions of claudin-2 (Cldn2) and aquaporin1 (AQP1) reduce proximal fluid reabsorption (PFR) by about 30% and 50%, respectively...
  46. pmc Crumbs3 is essential for proper epithelial development and viability
    Eileen L Whiteman
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Mol Cell Biol 34:43-56. 2014
    ..Taken together, our data indicate that Crumbs3 is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. ..
  47. doi Temporal and spatial distribution of the aquaporin 1 in spinal cord and dorsal root ganglia after traumatic injuries of the sciatic nerve
    Yasemin Kaya
    Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, 07070, Turkey
    Childs Nerv Syst 30:1679-86. 2014
    ..and mechanism of aquaporins in central nervous system injury have been reported, the pathophysiologic role of aquaporin 1 (AQP1) in peripheral nerve has not been extensively documented...
  48. pmc Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons
    Hua Zhang
    Departments of Medicine and Physiology, University of California, San Francisco, CA, USA
    Exp Neurol 265:152-9. 2015
    ..Water channel aquaporin-1 (AQP1) is expressed at the plasma membrane of cell bodies and axons of DRG neurons, where it modulates the sensing of ..
  49. doi Aquaporin-1 plays important role in proliferation by affecting cell cycle progression
    Ana Galán-Cobo
    Institute of Biomedicine of Seville IBIS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla Departamento de Fisiología Médica y Biofísica, Seville, Spain
    J Cell Physiol 231:243-56. 2016
    Aquaporin-1 (AQP1) has been associated with tumor development. Here, we investigated how AQP1 may affect cell proliferation...
  50. pmc Aquaporin-1 Deficiency Protects Against Myocardial Infarction by Reducing Both Edema and Apoptosis in Mice
    Lihua Li
    Liaoning Medical University, Department of Cell Biology, Jinzhou, PR China
    Sci Rep 5:13807. 2015
    Many studies have determined that AQP1 plays an important role in edema formation and resolution in various tissues via water transport across the cell membrane...
  51. pmc Novel Endothelial Cell-Specific AQP1 Knockout Mice Confirm the Crucial Role of Endothelial AQP1 in Ultrafiltration during Peritoneal Dialysis
    Wei Zhang
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 11:e0145513. 2016
    The water channel aquaporin-1 (AQP1) mediates about 50% ultrafiltration during a 2-hour hypertonic dwell in global AQP1 knockout (AQP1-/-) mice...
  52. doi Aquaporin-1, a New Maternally Expressed Gene, Regulates Placental Development in the Mouse
    Jing Guo
    School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Heilongjiang, China
    Biol Reprod 95:40. 2016
    ..The imprinting state, expression, and function of aquaporin-1 (Aqp1) were explored in knockout mice by imprinting analysis, real-time PCR, and immunohistochemistry...
  53. pmc Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis
    Irina I Nagy
    Biocenter Oulu, Laboratory of Developmental Biology, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell Matrix Research, University of Oulu, Aapistie 5A, Oulu, 90014, Finland
    BMC Dev Biol 16:30. 2016
    ..The presence of Wnt11 in the emerging tubular system suggests that it may have certain roles later in the development of the epithelial ductal system...
  54. pmc ErbB4 modulates tubular cell polarity and lumen diameter during kidney development
    Ville Veikkolainen
    Department of Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    J Am Soc Nephrol 23:112-22. 2012
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney...
  55. pmc Functional and transcriptional induction of aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α
    Irene Abreu-Rodríguez
    Departamento de Fisiologia Medica y Biofisica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, CSIC, Universidad de Sevilla, Seville, Spain
    PLoS ONE 6:e28385. 2011
    Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O(2) transport. It has been reported that this protein contributes to gas permeation (CO(2), NO and O(2)) through the plasma membrane...
  56. pmc Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice
    Yu May Soh
    Department of Zoology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Endocrinology 153:6054-64. 2012
    ..We suggest these actions of relaxin collectively promote water recruitment into the extracellular matrix to loosen the dense collagen fiber network...
  57. doi Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia
    Arkady Rutkovskiy
    Department of Emergency and Intensive Care at the Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern, 0318 Oslo, Norway
    J Mol Cell Cardiol 56:22-33. 2013
    Aquaporin-1 (AQP1) is expressed in human and mouse hearts, but little is known about its cellular and subcellular localization and regulation...
  58. ncbi Role of aquaporin water channels in kidney and lung
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Am J Med Sci 316:310-20. 1998
    Several aquaporin-type water channels are expressed in mammalian kidney and lung: AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 in apical membrane of collecting duct epithelium; ..
  59. ncbi Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice
    B Yang
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol 276:C76-81. 1999
    Aquaporin-1 (AQP1) water channels are expressed widely in epithelia and capillary endothelia involved in fluid transport...
  60. ncbi Chromosomal mapping of five mouse G protein gamma subunits
    G B Downes
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Genomics 57:173-6. 1999
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes...
  61. ncbi mRNAs encoding aquaporins are present during murine preimplantation development
    H Offenberg
    Department of Clinical Studies, Reproduction, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Mol Reprod Dev 57:323-30. 2000
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation...
  62. ncbi Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling
    Jay R Thiagarajah
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:19139-44. 2002
    Two aquaporin (AQP)-type water channels are expressed in mammalian cornea, AQP1 in endothelial cells and AQP5 in epithelial cells...
  63. ncbi Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice
    G D Leikauf
    Department of Environmental Health, University of Cincinnati, OH 45267 0056, USA
    Res Rep Health Eff Inst . 2001
    ..Positional candidate genes for Aliq4 include aquaporin-1 (Aqp1), SP-B, and transforming growth factor-alpha (TGF-alpha)...
  64. ncbi Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes
    Baoxue Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:36782-6. 2002
    ..transport, we generated double knockout mice lacking UT-B and the major erythrocyte water channel, aquaporin-1 (AQP1). The mice had reduced survival, retarded growth, and defective urinary concentrating ability...
  65. ncbi Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice
    Albert Mennone
    Liver Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 283:G739-46. 2002
    ..Previous studies suggested that aquaporin-1 (AQP1) is an important determinant of water movement in rat cholangiocytes and that cyclic AMP mediates the movement of ..
  66. ncbi Role of aquaporin water channels in eye function
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    Exp Eye Res 76:137-43. 2003
    ..At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary ..
  67. ncbi Effect of aquaporin-1 deletion on pleural fluid transport
    Jin Jun Jiang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Acta Pharmacol Sin 24:301-5. 2003
    To investigate the role of aquaporin-1 (AQP1) and sodium channel on pleural fluid transport.
  68. ncbi Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR
    S Hashimoto
    National Institute of Diabetes, and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Acta Physiol Scand 181:455-62. 2004
    By crossing aquaporin 1 (AQP1)-/- and adenosine 1 receptor (A1AR)-/- mice, we generated an animal model that combines a proximal tubular absorption defect with absence of tubuloglomerular feedback (TGF) regulation of glomerular ..
  69. ncbi Expression of somatostatin in the adult and developing mouse kidney
    Carlton M Bates
    Center for Human and Molecular Genetics, Children s Research Institute, Columbus, Ohio 43205, USA
    Kidney Int 66:1785-93. 2004
    ..Our objective was to determine the expression pattern of SRIF in both the adult and embryonic mouse kidney...
  70. ncbi Renal medullary gene expression in aquaporin-1 null mice
    Matthew R McReynolds
    Department of Physiology, College of Medicine, 1501 N Campbell Ave, University of Arizona, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 288:F315-21. 2005
    Mice that lack the aquaporin-1 gene (AQP1) lack a functional countercurrent multiplier mechanism, fail to concentrate the inner medullary (IM) interstitium, and present with a urinary concentrating defect...
  71. ncbi Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva
    Marc H Levin
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0521, USA
    Invest Ophthalmol Vis Sci 45:4423-32. 2004
    ....
  72. ncbi Modulation of hypertonicity-induced aquaporin-1 by sodium chloride, urea, betaine, and heat shock in murine renal medullary cells
    Fuminori Umenishi
    Address correspondence to Dr Fuminori Umenishi, Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C281, Denver, CO 80262, USA
    J Am Soc Nephrol 16:600-7. 2005
    Aquaporin-1 (AQP1) expression is induced by hypertonicity in renal medullary cells...
  73. ncbi Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice
    Ryan G Morris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 289:F194-9. 2005
    ..Therefore, urinary concentrating capacity is severely impaired in aquaporin-1 knockout (AQP1 -/-) mice...
  74. ncbi Identification and characterization of an aquaporin 1 immunoreactive amacrine-type cell of the mouse retina
    Tae Hoon Kang
    Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    J Comp Neurol 488:352-67. 2005
    Using immunocytochemistry, a type of amacrine cell that is immunoreactive for aquaporin 1 was identified in the mouse retina...
  75. ncbi Aquaporin-1 in the choroid plexuses of developing mammalian brain
    P A Johansson
    Department of Pharmacology and Centre for Neuroscience, University of Melbourne, Parkville, Victoria, 3010, Australia
    Cell Tissue Res 322:353-64. 2005
    ..We describe the temporal expression and appearance of aquaporin-1 (AQP1) which is important for water transfer across adult choroid plexuses...
  76. ncbi Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease
    Nikki P Y Lee
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    FEBS Lett 580:923-31. 2006
    ..Taken together, claudin-19 is a claudin isoform that is highly and specifically expressed in renal tubules with a putative role in TJ homeostasis in renal physiology...
  77. ncbi Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice
    Agustin Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 112:573-85. 2006
    ..study examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex (area 8) homogenates of sporadic CJD cases (six men, four ..
  78. ncbi Expression of TM4SF10, a Claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation
    Leslie A Bruggeman
    Rammelkamp Center for Education and Research Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    Dev Dyn 236:596-605. 2007
    ..TM4SF10 may define a new class of Claudin-like proteins that function during junctional development...
  79. pmc Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
    Zakir Hossain
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Republic of Singapore 138673
    Proc Natl Acad Sci U S A 104:1631-6. 2007
    ..Thus, Wwtr1 is critical for the integrity of renal cilia and its absence in mice leads to the development of renal cysts, indicating that Wwtr1 may represent a candidate gene for polycystic kidney disease in humans...
  80. ncbi Aquaporin 1 and aquaporin 4 overexpression in bovine spongiform encephalopathy in a transgenic murine model and in cattle field cases
    Carme Costa
    Departament de Medicina i Cirurgia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra Cerdanyola del Valles, Barcelona, Spain
    Brain Res 1175:96-106. 2007
    Aquaporins (AQP) are a family of transmembrane proteins that act as water selective channels. AQP1 and AQP4 are widely expressed in the central nervous system where they play several roles...
  81. ncbi Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy
    Javier Ruiz-Ederra
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Invest Ophthalmol Vis Sci 48:4802-10. 2007
    Aquaporin-1 (AQP1) water channels are expressed widely in organ and tumor microvascular endothelia. Rapid microvessel proliferation occurs in growing tumors, diabetic and other retinopathies, and prenatal development...
  82. doi Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
    Ryosuke Makita
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Renal Physiol 294:F542-53. 2008
    ..Thus TAZ is essential for developmental mechanisms involved in kidney and lung organogenesis, whose disturbance may lead to the pathogenesis of common human diseases...
  83. doi Aquaporin 1 expression in the testis, epididymis and vas deferens of postnatal ICR mice
    Lu Danyu
    Department of Anatomy and Histology and Embryology, Peking University Health Science Center, Beijing 100083, China
    Cell Biol Int 32:532-41. 2008
    b>Aquaporin 1 (AQP1) is one of the water channels involved in water transfer and reabsorption...
  84. doi Role of AQP1 in endotoxemia-induced acute kidney injury
    Weidong Wang
    Department of Medicine, Division of Renal Diseases and Hypertension, Univ of Colorado Health Sciences Center, 4200 East 9Ave, Box B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 294:F1473-80. 2008
    ..The higher serum osmolality in AQP1-KO mice during endotoxemia was associated with higher AQP2 (133 +/- 8 vs. 100 +/- 3%, P < 0...
  85. doi Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney
    Britta Walter
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Histochem Cell Biol 130:943-56. 2008
    ..This prominent cytoplasmic localization of ARVCF in cultured cells and its occurrence in proximal tubules implies an involvement of ARVCF in specific functional processes of proximal tubules of kidney...
  86. doi Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney
    Kylie Georgas
    Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, 4072, Australia
    Histochem Cell Biol 130:927-42. 2008
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
  87. pmc Very high aquaporin-1 facilitated water permeability in mouse gallbladder
    Lihua Li
    Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, PR China
    Am J Physiol Gastrointest Liver Physiol 296:G816-22. 2009
    ..We found strong AQP1 immunofluorescence at the apical membrane of mouse gallbladder epithelium...
  88. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells...
  89. pmc The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP
    Miguel A Lanaspa
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado 80045, USA
    J Biol Chem 285:31694-703. 2010
    Expression of aquaporin-1 (AQP1) and -2 (AQP2) channels in the kidney are critical for the maintenance of water homeostasis and the operation of the urinary concentrating mechanism...
  90. doi Brain expression of the water channels aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema
    Martin Eefsen
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
    Metab Brain Dis 25:315-23. 2010
    ..The water channels Aquaporin-1 (Aqp1) and -4 (Aqp4) has been associated with brain edema formation in several neuropathological conditions, indicating a ..
  91. doi Cellular expression of the K+-Cl- cotransporter KCC3 in the central nervous system of mouse
    Masoud Shekarabi
    Centre of Excellence in Neuromics, CHUM Research Center and Department of Medicine, University of Montreal, Notre Dame Hospital, 1560 Sherbrooke East, De Seve Pavillion, room Y 3616 2, Montreal, QC, H2L 4M1, Canada
    Brain Res 1374:15-26. 2011
    ..Finally, we showed that some non-neuronal cells, such as radial glial-like cells in the spinal cord, also express KCC3...
  92. doi Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney
    Hyun Wook Lee
    Department of Anatomy and MRC for Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 505, Banpo dong, Seocho Ku, Seoul, 137 701, Korea
    Cell Tissue Res 343:429-44. 2011
    ..Thus, lymphatic vessels of the kidney might originate by extension of extra-renal lymphatics through an active branching process possibly associated with F4/80(+)/CD11b(-)/LYVE-1(+) macrophages/dendritic cells...
  93. doi Aquaporin-1: a potential membrane channel for facilitating the adaptability of rabbit nucleus pulposus cells to an extracellular matrix environment
    Feng Wang
    Department of Orthopaedics, The First Hospital of China Medical University, No 155 Nanjingbei Road, Heping District, Shenyang 110001, People s Republic of China
    J Orthop Sci 16:304-12. 2011
    ..One hypothesis is that AQP-1 has potential roles in aging degeneration of IVDs...
  94. ncbi [Expressions of aquaporins 1 and 3 in the mouse prostate and their significance]
    Jian Guo Zhu
    Department of Distinguished Professor Tang Ao qing Laboratory, China Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
    Zhonghua Nan Ke Xue 17:483-7. 2011
    ....
  95. pmc Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs
    Robert C Huebert
    Gastroenterology Research Unit, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Am J Pathol 179:1851-60. 2011
    ..Aquaporin-1 (AQP1) is a water channel, overexpressed in cirrhosis, that promotes angiogenesis by enhancing endothelial invasion...
  96. doi Impaired stria vascularis integrity upon loss of E-cadherin in basal cells
    Mark Oliver Trowe
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 359:95-107. 2011
    ....
  97. ncbi Aquaporin molecular biology and clinical abnormalities of the water transport channels
    N V Knoers
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Curr Opin Pediatr 10:428-34. 1998
    ..in identifying the aqueous pore in AQP molecules was the determination of the three-dimensional structure of AQP1. The expression pattern of individual AQPs in different tissues was determined in more detail and AQP-knockout mice ..
  98. ncbi Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice
    E I Solenov
    Departments of Medicine and Physiology, 1246 Health Sciences East Tower, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Neurosci Methods 113:85-90. 2002
    ..At least two aquaporin-type water channels are expressed in spinal cord: AQP1 in afferent sensory nerve fibers in the superficial layers of the dorsal horn, and AQP4 in glial cells throughout ..
  99. ncbi Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea
    Deliang Huang
    Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, 2100 West Third Street, House Ear Institute, Los Angeles, CA 90057, USA
    Hear Res 165:85-95. 2002
    ..Semi-quantitative measurements showed that AQP4 and AQP1 were the two most abundantly expressed AQP subtypes in the inner ear, and their expressions were dramatically ..
  100. ncbi Identification and structure of a putative Ca2+-binding domain at the C terminus of AQP1
    Dimitrios Fotiadis
    M E Müller Institute for Microscopy, Biozentrum of the University of Basel, Switzerland
    J Mol Biol 318:1381-94. 2002
    Aquaporin-1 (AQP1) is the first functionally identified aquaporin of a growing family of membrane water channels found in all forms of life...
  101. pmc Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney
    Xiaohui Fang
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Physiol 542:63-9. 2002
    b>AQP1-dependent CO2 transport has been suggested from the increased CO2 permeability in Xenopus oocytes expressing AQP1...

Research Grants10

  1. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007
    ..Attendance of young scientists insures that the information will be translated into future studies that elucidate the role of ROS in kidney diseases and treatment thereof. [unreadable] [unreadable] [unreadable]..
  2. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2001
    ..These studies will address the hypothesis that the membrane skeleton of these cells is a mobile, dynamic structure. ..
  3. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2006
    ..abstract_text> ..
  4. PHYSIOLOGY AND MOLECULAR BIOLOGY OF LUNG WATER TRANSPORT
    Alan Verkman; Fiscal Year: 2007
    ..Aquaporins (AQPs) are water-transporting proteins expressed in lung microvasculature (AQP1), airways (AQP3 and AQP4), alveolar epithelium (AQP5) and submucosal gland epithelium (AQP5)...
  5. MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    Alan Verkman; Fiscal Year: 2008
    ..The kidney expresses at least four aquaporins: AQP1 in proximal tubule, TDLH and vasa recta; AQP2 in apical membrane of principal cells in collecting duct; and AQP3 ..
  6. Role of airway submucosal glands in CF lung disease
    Alan S Verkman; Fiscal Year: 2010
    ..The data will provide a rigorous scientific rationale for use of small-molecules in CF therapy, and establish widely useful assays to prioritize small molecules for clinical development. ..
  7. INSULIN RECEPTOR RELATED AND THE KIDNEY
    Carlton Bates; Fiscal Year: 2002
    ..After being subjected to systemic alkalosis, IRR-null mouse kidneys will be examined to determine if the intercalated cells have appropriately altered their morphology and intracellular distribution of proton transporters. ..
  8. Thomas L Pallone; Fiscal Year: 2016
    ..vasa recta (AVR) have markedly different transport properties and that DVR express the aquaporin-1 water channel (AQP1) and a urea transporter (UT3)...
  9. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    THOMAS PALLONE; Fiscal Year: 2003
    ....
  10. Calcium Signaling in Vasa Recta Endothelium
    THOMAS PALLONE; Fiscal Year: 2004
    ..We will test whether DVR contractions to norepinephrine, Angll and KCI are increased, measure NO production and assess effects of OH on endothelial and pericyte Ca2+ signaling. ..