Apoe

Summary

Gene Symbol: Apoe
Description: apolipoprotein E
Alias: AI255918, Apo-E, apolipoprotein E
Species: mouse
Products:     Apoe

Top Publications

  1. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim H, Bennett B, et al. Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS ONE. 2014;9:e88274 pubmed publisher
    b>Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6 background (129-apoE)...
  2. Zhou C, Liu L, Liu L, Zhang M, Guo H, Pan J, et al. Salusin-? not salusin-? promotes vascular inflammation in ApoE-deficient mice via the I-?B?/NF-?B pathway. PLoS ONE. 2014;9:e91468 pubmed publisher
    ..In this study, we observed the effects of salusins on vascular inflammation in apoE-deficient (apoE-/-) mice...
  3. Tsiantoulas D, Diehl C, Witztum J, Binder C. B cells and humoral immunity in atherosclerosis. Circ Res. 2014;114:1743-56 pubmed publisher
    ..Moreover, we will highlight potential therapeutic approaches focusing on B-cell depletion that could be used to translate experimental evidence to human disease...
  4. Merkel M, Velez Carrasco W, Hudgins L, Breslow J. Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A. 2001;98:13294-9 pubmed
    ..We have used two mouse models of atherosclerosis, low density lipoprotein receptor-deficient (LDLRKO) and apolipoprotein E-deficient (apoEKO) mice to measure the effects of four isocaloric diets enriched with either SFA, MUFA, PUFA, ..
  5. Fukumoto Y, Deguchi J, Libby P, Rabkin Aikawa E, Sakata Y, Chin M, et al. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004;110:1953-9 pubmed
    ..influence the structure of atheromata, we examined collagen accumulation in atherosclerotic lesions of apolipoprotein E-deficient mice (apoE-/-) that express collagenase-resistant collagen-I (ColR/R/apoE-/-, n=12) or wild-type ..
  6. Saederup N, Chan L, Lira S, Charo I. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation. 2008;117:1642-8 pubmed publisher
    ..We crossed CX3CL1(-/-)ApoE(-/-) and CCR2(-/-)ApoE(-/-) mice to create CX3CL1(-/-)CCR2(-/-)ApoE(-/-) triple knockouts and performed a 4-arm ..
  7. Stewart Phillips J, Lough J, Skamene E. ATH-3, a new gene for atherosclerosis in the mouse. Clin Invest Med. 1989;12:121-6 pubmed
  8. Wang J, Cheng X, Xiang M, Alanne Kinnunen M, Wang J, Chen H, et al. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011;121:3564-77 pubmed publisher
    ..This study reveals what we believe to be several previously unrecognized IgE activities that affect arterial cell biology and likely other IgE-associated pathologies in human diseases. ..
  9. Moreau P, Bott J, Zerbinatti C, Renger J, Kelche C, Cassel J, et al. ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice. Behav Brain Res. 2013;243:1-5 pubmed publisher
    The APOE-?4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-?4 carriers...
  10. Mita T, Otsuka A, Azuma K, Uchida T, Ogihara T, Fujitani Y, et al. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 2007;358:679-85 pubmed
    ..This was independent of changes in serum cholesterol level in vivo. Reduction of glucose fluctuation by alpha-glucosidase inhibitor efficiently controlled the progression of atherosclerosis. ..

Detail Information

Publications114 found, 100 shown here

  1. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim H, Bennett B, et al. Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS ONE. 2014;9:e88274 pubmed publisher
    b>Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6 background (129-apoE)...
  2. Zhou C, Liu L, Liu L, Zhang M, Guo H, Pan J, et al. Salusin-? not salusin-? promotes vascular inflammation in ApoE-deficient mice via the I-?B?/NF-?B pathway. PLoS ONE. 2014;9:e91468 pubmed publisher
    ..In this study, we observed the effects of salusins on vascular inflammation in apoE-deficient (apoE-/-) mice...
  3. Tsiantoulas D, Diehl C, Witztum J, Binder C. B cells and humoral immunity in atherosclerosis. Circ Res. 2014;114:1743-56 pubmed publisher
    ..Moreover, we will highlight potential therapeutic approaches focusing on B-cell depletion that could be used to translate experimental evidence to human disease...
  4. Merkel M, Velez Carrasco W, Hudgins L, Breslow J. Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A. 2001;98:13294-9 pubmed
    ..We have used two mouse models of atherosclerosis, low density lipoprotein receptor-deficient (LDLRKO) and apolipoprotein E-deficient (apoEKO) mice to measure the effects of four isocaloric diets enriched with either SFA, MUFA, PUFA, ..
  5. Fukumoto Y, Deguchi J, Libby P, Rabkin Aikawa E, Sakata Y, Chin M, et al. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004;110:1953-9 pubmed
    ..influence the structure of atheromata, we examined collagen accumulation in atherosclerotic lesions of apolipoprotein E-deficient mice (apoE-/-) that express collagenase-resistant collagen-I (ColR/R/apoE-/-, n=12) or wild-type ..
  6. Saederup N, Chan L, Lira S, Charo I. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation. 2008;117:1642-8 pubmed publisher
    ..We crossed CX3CL1(-/-)ApoE(-/-) and CCR2(-/-)ApoE(-/-) mice to create CX3CL1(-/-)CCR2(-/-)ApoE(-/-) triple knockouts and performed a 4-arm ..
  7. Stewart Phillips J, Lough J, Skamene E. ATH-3, a new gene for atherosclerosis in the mouse. Clin Invest Med. 1989;12:121-6 pubmed
  8. Wang J, Cheng X, Xiang M, Alanne Kinnunen M, Wang J, Chen H, et al. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011;121:3564-77 pubmed publisher
    ..This study reveals what we believe to be several previously unrecognized IgE activities that affect arterial cell biology and likely other IgE-associated pathologies in human diseases. ..
  9. Moreau P, Bott J, Zerbinatti C, Renger J, Kelche C, Cassel J, et al. ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice. Behav Brain Res. 2013;243:1-5 pubmed publisher
    The APOE-?4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-?4 carriers...
  10. Mita T, Otsuka A, Azuma K, Uchida T, Ogihara T, Fujitani Y, et al. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 2007;358:679-85 pubmed
    ..This was independent of changes in serum cholesterol level in vivo. Reduction of glucose fluctuation by alpha-glucosidase inhibitor efficiently controlled the progression of atherosclerosis. ..
  11. Gustavsson C, Agardh C, Zetterqvist A, Nilsson J, Agardh E, Gomez M. Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia. PLoS ONE. 2010;5:e12699 pubmed publisher
    ..of VCAM-1 was examined by confocal immunofluorescence microscopy in vessels of wild type (wt), hyperlipidemic (ApoE(-/-)) and TNF? deficient (TNF?(-/-), ApoE(-/-)/TNF?(-/-)) mice...
  12. Billon Gales A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, et al. Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A. 2011;108:13311-6 pubmed publisher
    ..Thus, whereas ER?AF1 and ER?AF2 are both required for the uterotrophic action of E2, we show that only ER?AF2 is necessary for its atheroprotective effect. ..
  13. Hanna R, Shaked I, Hubbeling H, Punt J, Wu R, Herrley E, et al. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res. 2012;110:416-27 pubmed publisher
    ..In a second model, mice deficient in both Nur77 and ApoE (ApoE(-/-)Nur77(-/-)) also showed increased atherosclerosis after 11 weeks of Western diet...
  14. Ophir G, Amariglio N, Jacob Hirsch J, Elkon R, Rechavi G, Michaelson D. Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade. Neurobiol Dis. 2005;20:709-18 pubmed
    ..Genome-wide gene expression profiling was employed to study the effects of apoE genotype on hippocampal gene expression in LPS-treated mice, transgenic for either apoE4 or the AD benign allele, ..
  15. Mani S, Li H, Untereiner A, Wu L, Yang G, Austin R, et al. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation. 2013;127:2523-34 pubmed publisher
    ..To date, there is no direct evidence for a causative role of altered metabolism of endogenous H2S in atherosclerosis development...
  16. Dansky H, Barlow C, Lominska C, Sikes J, Kao C, Weinsaft J, et al. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol. 2001;21:1662-7 pubmed
    ..domain 4-deficient (D4D) mice, which partially circumvent the embryonic lethality of Vcam1 null mice, with apolipoprotein E null (Apoe(-/-)) mice, which spontaneously develop hypercholesterolemia and atherosclerosis...
  17. Erdely A, Kepka Lenhart D, Salmen Muniz R, Chapman R, Hulderman T, Kashon M, et al. Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. PLoS ONE. 2010;5:e15253 pubmed publisher
    ..and on global arginine bioavailability (defined as the ratio of plasma arginine to ornithine + citrulline) in apoE(-/-) and wild-type C57BL/6J mice. HC and HF diets led to reduced global arginine bioavailability in both strains...
  18. van Ree J, Gijbels M, van den Broek W, Hofker M, Havekes L. Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding. Atherosclerosis. 1995;112:237-43 pubmed
    ..4 mM serum cholesterol) and apo E-deficient mice on a regular chow diet (20 mM serum cholesterol) did not show such lesions...
  19. Idel S, Dansky H, Breslow J. A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains. Proc Natl Acad Sci U S A. 2003;100:14235-40 pubmed
  20. Schulte S, Sukhova G, Libby P. Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am J Pathol. 2008;172:1500-8 pubmed publisher
    ..This study examined the influence of Th1 and Th2 helper cell subsets on atherogenesis in two ApoE(-/-) mouse strains, C57BL/6 and BALB/c, which display opposite T-cell subset polarizations...
  21. Yesilaltay A, Daniels K, Pal R, Krieger M, Kocher O. Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice. PLoS ONE. 2009;4:e8103 pubmed publisher
    ..PDZK1 has been shown to be atheroprotective using the high fat/high cholesterol ('Western') diet-fed murine apolipoprotein E (apoE) KO model of atherosclerosis, presumably because of its role in promoting reverse cholesterol transport ..
  22. Chamberlain C, Ang L, Boivin W, Cooper D, Williams S, Zhao H, et al. Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol. 2010;176:1038-49 pubmed publisher
    ..In the current study, the role of GZMB in abdominal aortic aneurysm (AAA) was assessed. Apolipoprotein E (APOE)(-/-) x GZMB(-/-) and APOE(-/-) x perforin(-/-) double knockout (GDKO, PDKO) mice were generated to ..
  23. Ng H, Burris R, Nagarajan S. Attenuated atherosclerotic lesions in apoE-Fc?-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cells. J Immunol. 2011;187:6082-93 pubmed publisher
    ..the current study, we investigated the role for activating Fc?R in the progression of atherosclerosis using apolipoprotein E (apoE)-Fc?-chain double-knockout (DKO) mice...
  24. Galkina E, Kadl A, Sanders J, Varughese D, Sarembock I, Ley K. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med. 2006;203:1273-82 pubmed
    ..Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation. ..
  25. Hansmann G, de Jesus Perez V, Alastalo T, Alvira C, Guignabert C, Bekker J, et al. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest. 2008;118:1846-57 pubmed publisher
    ..Here, we report an interplay between PPARgamma and its transcriptional target apoE downstream of BMP-2 signaling...
  26. Wigren M, Bengtsson D, Dunér P, Olofsson K, Bjorkbacka H, Bengtsson E, et al. Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells. Circ Res. 2009;104:e62-70 pubmed publisher
    ..To characterize the immune pathways mediating this protection, we treated wild-type C57BL/6 and Apoe(-)(/)(-) mice with Alum or PBS...
  27. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
  28. Kamari Y, Shaish A, Shemesh S, Vax E, Grosskopf I, Dotan S, et al. Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1?. Biochem Biophys Res Commun. 2011;405:197-203 pubmed publisher
    ..resident vascular cells or emigrating bone marrow-derived cells promote the development of atherosclerosis in apoE-/- mice and determined the effect of selective macrophage IL-1? or IL-1? deficiency on degradation of LDL and ..
  29. Johansson M, Wickman A, Fitzgerald S, Gan L, Bergstrom G. Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice. J Hypertens. 2005;23:1541-9 pubmed
    Angiotensin II (Ang II) accelerates atherogenesis in ApoE mice via the angiotensin II, type 1 receptor (AT1) while the type 2 receptor (AT2) is suggested to counteract atherogenesis...
  30. Blain J, Sullivan P, Poirier J. A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. Neurobiol Dis. 2006;21:505-14 pubmed
    ..However, the exact mechanisms by which apoE4 confers such susceptibility is currently unknown. We used a human apoE targeted replacement (hE-TR) mouse model to investigate the allele-specific response to entorhinal cortex lesion (..
  31. Maeda N, Johnson L, Kim S, Hagaman J, Friedman M, Reddick R. Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds. Atherosclerosis. 2007;195:75-82 pubmed
    ..To study the basis of these effects, we have generated the apolipoprotein E-null mutation in mouse embryonic stem cells of 129/SvEv origin, maintained it in the inbred strain (129-apoE),..
  32. Wang K, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, et al. Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level. Arterioscler Thromb Vasc Biol. 2011;31:800-7 pubmed publisher
    ..In the present study, we generated apolipoprotein E (apoE) and histamine synthesizing histidine decarboxylase double knockout (DKO) mice on a C57BL/6J (wild-type ..
  33. Xu S, Little P, Lan T, Huang Y, Le K, Wu X, et al. Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet. Arch Biochem Biophys. 2011;515:72-9 pubmed publisher
    ..study investigated whether Tan can decrease and stabilize atherosclerotic plaques in Apolipoprotein-E knockout (ApoE(-/-)) mice maintained on a high cholesterol diet (HCD)...
  34. Martens G, Arikan M, Lee J, Ren F, Vallerskog T, Kornfeld H. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun. 2008;76:3464-72 pubmed publisher
    We demonstrate that apolipoprotein E -deficient (ApoE(-/-)) mice are highly susceptible to tuberculosis and that their susceptibility depends on the severity of hypercholesterolemia...
  35. Huang Y, Liu X, Rall S, Taylor J, von Eckardstein A, Assmann G, et al. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem. 1998;273:26388-93 pubmed
    ..we found that expressing high plasma levels of human apoE3 in transgenic mice lacking endogenous mouse apoE caused HTG...
  36. Nathan B, Nisar R, Short J, Randall S, Grissom E, Griffin G, et al. Delayed olfactory nerve regeneration in ApoE-deficient mice. Brain Res. 2005;1041:87-94 pubmed
    b>Apolipoprotein E (apoE), a lipid transporting protein, is extensively expressed in the primary olfactory pathway, but its function is unknown...
  37. Secchiero P, Candido R, Corallini F, Zacchigna S, Toffoli B, Rimondi E, et al. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation. 2006;114:1522-30 pubmed
    ..human TRAIL and an adeno-associated virus vector expressing human TRAIL were used to deliver TRAIL in apolipoprotein E (apoE)-null mice in which diabetes mellitus was induced by destruction of islet cells with streptozotocin...
  38. Langheinrich A, Sedding D, Kampschulte M, Moritz R, Wilhelm J, Haberbosch W, et al. 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice. Atherosclerosis. 2009;202:103-10 pubmed publisher
    ..c(3)Ado), an anti-inflammatory and anti-proliferative drug, on plaque progression and VV neovascularization in apoE(-/-)/LDL(-/-) double knockout mice...
  39. Lewis R, Jackson C, Morgan B, Hughes T. The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Mol Immunol. 2010;47:1098-105 pubmed publisher
    ..C6 (C6(-/-)) deficient and CD59a (Cd59a(-/-)) knockout mice were separately crossed onto the apolipoprotein E knockout (apoE(-/-)) background...
  40. Bien Ly N, Gillespie A, Walker D, Yoon S, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent A? accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012;32:4803-11 pubmed publisher
    ..Brain amyloid-? (A?) accumulation depends on age and apoE isoforms (apoE4 > apoE3) both in humans and in transgenic mouse models...
  41. Ervinna N, Mita T, Yasunari E, Azuma K, Tanaka R, Fujimura S, et al. Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. Endocrinology. 2013;154:1260-70 pubmed publisher
    ..To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet...
  42. Reddick R, Zhang S, Maeda N. Aortic atherosclerotic plaque injury in apolipoprotein E deficient mice. Atherosclerosis. 1998;140:297-305 pubmed
    The acute platelet response and chronic smooth muscle cell (SMC) proliferation following aortic injury in apolipoprotein E-deficient mice was investigated...
  43. Malloy S, Altenburg M, Knouff C, Lanningham Foster L, Parks J, Maeda N. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol. 2004;24:91-7 pubmed
    ..hypothesis, doubling Ldlr expression caused severe atherosclerosis with marked accumulation of cholesterol-rich, apoE-poor remnants in mice with human apoE4, but not apoE3, when the animals were fed a Western-type diet...
  44. Rozenberg I, Sluka S, Rohrer L, Hofmann J, Becher B, Akhmedov A, et al. Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arterioscler Thromb Vasc Biol. 2010;30:923-30 pubmed publisher
    ..Whether this affects the formation of atherosclerotic lesions, however, remains elusive. Apolipoprotein E-null (ApoE(-/-)) mice treated with a histamine H1 receptor but not an H2 receptor antagonist developed 40% ..
  45. Di Bartolo B, Cartland S, Harith H, Bobryshev Y, Schoppet M, Kavurma M. TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL. PLoS ONE. 2013;8:e74211 pubmed publisher
    ..isolated from TRAIL(-/-) and wild-type mice, as well as in vivo, in advanced atherosclerotic lesions of TRAIL(-/-)ApoE(-/-) mice. The involvement of OPG and RANKL in this process was also examined...
  46. Smith E, Prasad K, Butcher M, Dobrian A, Kolls J, Ley K, et al. Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2010;121:1746-55 pubmed publisher
    ..IL-17A was found to be elevated in the plasma and tissues of apolipoprotein E-deficient (Apoe(-/-)) mice...
  47. Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS ONE. 2011;6:e20240 pubmed publisher
    ..Although several studies have suggested that certain periodontopathic bacteria accelerate atherogenesis in apolipoprotein E-deficient mice, the mechanistic link between cholesterol accumulation and periodontal infection-induced ..
  48. Wu D, Sharan C, Yang H, Goodwin J, Zhou L, Grabowski G, et al. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res. 2007;48:2571-8 pubmed
    b>Apolipoprotein E (apoE) deficiency has been suggested to induce foam cell formation...
  49. Yu Z, Crichton I, Tang S, Hui Y, Ricciotti E, Levin M, et al. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A. 2012;109:6727-32 pubmed publisher
    ..When crossed into ApoE-deficient hyperlipidemic mice, COX-2 deletion accelerated atherogenesis in both genders, with lesions exhibiting ..
  50. Fryer J, DeMattos R, McCormick L, O Dell M, Spinner M, Bales K, et al. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J Biol Chem. 2005;280:25754-9 pubmed
    b>Apolipoprotein E (apoE), a chaperone for the amyloid beta (Abeta) peptide, regulates the deposition and structure of Abeta that deposits in the brain in Alzheimer disease (AD)...
  51. Ortiz Muñoz G, Martin Ventura J, Hernandez Vargas P, Mallavia B, Lopez Parra V, Lopez Franco O, et al. Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:525-31 pubmed publisher
    ..SOCS were also increased in aortic lesions from apoE(-/-) mice...
  52. Yuan Z, Pei H, Roberts D, Zhang Z, Rowlan J, Matsumoto A, et al. Quantitative trait locus analysis of neointimal formation in an intercross between C57BL/6 and C3H/HeJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2009;2:220-8 pubmed publisher
    ..and C3H/HeJ (C3H) exhibit marked differences in neointimal formation after arterial injury when deficient in apolipoprotein E (apoE(-/-)) and fed a Western diet...
  53. Hans C, Feng Y, Naura A, Zerfaoui M, Rezk B, Xia H, et al. Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. PLoS ONE. 2009;4:e7430 pubmed publisher
    ..Apolipoprotein (ApoE)(-/-) mice fed a high-fat diet were used as a model of atherosclerosis...
  54. Mitchel R, Hasu M, Bugden M, Wyatt H, Hildebrandt G, Chen Y, et al. Low-dose radiation exposure and protection against atherosclerosis in ApoE(-/-) mice: the influence of P53 heterozygosity. Radiat Res. 2013;179:190-9 pubmed publisher
    We recently described the effects of low-dose ?-radiation exposures on atherosclerosis in genetically susceptible (ApoE(-/-)) mice with normal p53 function...
  55. Akiyama T, Sakai S, Lambert G, Nicol C, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002;22:2607-19 pubmed
    ..Reductions in the basal levels of apolipoprotein E (apoE) mRNA in macrophages and apoE protein in total plasma and high-density lipoprotein (HDL) were also ..
  56. Wang C, Wilson W, Moore S, Mace B, Maeda N, Schmechel D, et al. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol Dis. 2005;18:390-8 pubmed
    The human APOE*4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Long before the onset of AD, cognitive deficits can be identified in APOE*4 carriers...
  57. Kunieda T, Minamino T, Nishi J, Tateno K, Oyama T, Katsuno T, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation. 2006;114:953-60 pubmed
    ..Our results suggest a critical role of p21-dependent premature senescence of VSMCs in the pathogenesis of atherosclerosis. ..
  58. Altenburg M, Arbones Mainar J, Johnson L, Wilder J, Maeda N. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol. 2008;28:1104-10 pubmed publisher
    ..Here we investigate the mechanism by which mice expressing human apoE isoforms recapitulate this association when they also express high levels of human low-density lipoprotein receptor ..
  59. Manning Tobin J, Moore K, Seimon T, Bell S, Sharuk M, Alvarez Leite J, et al. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2009;29:19-26 pubmed publisher
    ..To test the impact of deleting these receptors, we generated Apoe(-/-) mice lacking both SR-A and CD36 and fed them a Western diet for 12 weeks...
  60. Thorp E, Li G, Seimon T, Kuriakose G, Ron D, Tabas I. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab. 2009;9:474-81 pubmed publisher
    ..To test the effect of CHOP deficiency in vivo, aortic root lesions of fat-fed Chop+/+;Apoe-/- and Chop-/-;Apoe-/- mice were analyzed for size and morphology...
  61. Bourassa P, Milos P, Gaynor B, Breslow J, Aiello R. Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 1996;93:10022-7 pubmed
    We have studied the effects of endogenous and exogenous estrogen on atherosclerotic lesions in apolipoprotein E-deficient mice. Female mice ovariectomized (OVX) at weaning displayed increases (P < 0...
  62. Massberg S, Brand K, Grüner S, Page S, Müller E, Muller I, et al. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med. 2002;196:887-96 pubmed
    ..Here, we show in vivo that platelets adhere to the vascular endothelium of the carotid artery in ApoE(-)(/)(-) mice before the development of manifest atherosclerotic lesions...
  63. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn M, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008;118:4002-13 pubmed publisher
    ..How apoE isoforms influence Abeta accumulation in the brain has, however, remained unclear...
  64. Lammers B, Out R, Hildebrand R, Quinn C, Williamson D, Hoekstra M, et al. Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development. Atherosclerosis. 2009;205:420-6 pubmed publisher
    ATP-binding cassette transporter G1 (Abcg1) and apolipoprotein E (Apoe) play a role in macrophage cholesterol efflux and consequently the development of atherosclerosis...
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    We have previously shown that expression of the human apo A-I transgene on the apo E-deficient background increases HDL cholesterol and greatly diminishes fatty streak lesion formation...
  67. Moura R, Tjwa M, Vandervoort P, Van Kerckhoven S, Holvoet P, Hoylaerts M. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice. Circ Res. 2008;103:1181-9 pubmed publisher
    ..Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet...
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    ..Loss of Id3 in Apoe(-/-) mice resulted in early and increased atherosclerosis...
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    We have inactivated the endogenous apolipoprotein E (apoE) gene by using gene targeting in mouse embryonic stem (ES) cells...
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    b>Apolipoprotein E (apo E)-deficient mice are severely hypercholesterolemic and develop advanced atheromas independent of diet...
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    ..We crossed eNOS-overexpressing (eNOS-Tg) mice with atherogenic apoE-deficient (apoE-KO) mice to determine whether eNOS overexpression in the endothelium could inhibit the development ..
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    ..Elevations in CCL2 and margination of Ly-6C(hi) cells demonstrate that the role of CCR2 in controlling monocyte levels goes beyond the control of monocyte emigration. ..
  73. Brodbeck J, McGuire J, Liu Z, Meyer Franke A, Balestra M, Jeong D, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011;286:17217-26 pubmed publisher
    ..Correcting the pathological structure of apoE4 by disrupting domain interaction is a potential therapeutic approach to treat or prevent AD related to apoE4. ..
  74. Potteaux S, Gautier E, Hutchison S, Van Rooijen N, Rader D, Thomas M, et al. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest. 2011;121:2025-36 pubmed publisher
    ..Mice lacking the gene Apoe (Apoe-/- mice) have high levels of cholesterol and spontaneously develop atherosclerotic lesions...
  75. Hartley C, Reddy A, Madala S, Martin McNulty B, Vergona R, Sullivan M, et al. Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol Heart Circ Physiol. 2000;279:H2326-34 pubmed
    b>Apolipoprotein E-knockout (ApoE-KO) mice develop advanced atherosclerotic lesions by 1 yr of age and have been well characterized pathologically and morphologically, but little is known regarding their cardiovascular physiology and ..
  76. van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter E, Gumperz J, et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005;437:906-10 pubmed
    ..b>Apolipoprotein E binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 ..
  77. Shamshiev A, Ampenberger F, Ernst B, Rohrer L, Marsland B, Kopf M. Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity. J Exp Med. 2007;204:441-52 pubmed
    ..These results show that a dyslipidemic microenvironment can directly interfere with DC responses to pathogen-derived signals and skew the development of T cell-mediated immunity. ..
  78. Podrez E, Byzova T, Febbraio M, Salomon R, Ma Y, Valiyaveettil M, et al. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med. 2007;13:1086-95 pubmed
    ..Thus, interactions of platelet CD36 with specific endogenous oxidized lipids play a crucial role in the well-known clinical associations between dyslipidemia, oxidant stress and a prothrombotic phenotype. ..
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  80. Xu P, Schmechel D, Rothrock Christian T, Burkhart D, Qiu H, Popko B, et al. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis. 1996;3:229-45 pubmed
    b>Apolipoprotein E (apoE) and its three major alleles (APOE2, E3, and E4) have been implicated in Alzheimer's disease and other neurological disorders. Little is known of the role apoE plays in normal brain function and pathology...