Gene Symbol: Apod
Description: apolipoprotein D
Alias: apolipoprotein D
Species: mouse
Products:     Apod

Top Publications

  1. Perdomo G, Kim D, Zhang T, Qu S, Thomas E, Toledo F, et al. A role of apolipoprotein D in triglyceride metabolism. J Lipid Res. 2010;51:1298-311 pubmed publisher
    ..Aberrant expression of apolipoproteins is associated with metabolic abnormalities. Here we characterized apolipoprotein D (apoD) in triglyceride metabolism...
  2. Thomas E, Yao J. Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D. Schizophr Res. 2007;89:147-53 pubmed
    b>Apolipoprotein D (apoD), a member of the lipocalin superfamily of lipid-binding proteins, exhibits abundant expression within the CNS of many species, including humans; however, its physiological role remains unclear...
  3. Cofer S, Ross S. The murine gene encoding apolipoprotein D exhibits a unique expression pattern as compared to other species. Gene. 1996;171:261-3 pubmed
    The ApoD cDNA coding for murine apolipoprotein D (ApoD) was cloned from a mammary gland library and sequenced. The nucleotide sequence and encoded mature protein are highly homologous to those of rabbit and human...
  4. Peters L, Ciciotte S, Lin L, Chishti A. The mouse homolog of the Drosophila discs large tumor suppressor gene maps to chromosome 16. Mamm Genome. 1996;7:619-20 pubmed
  5. Shannon M, Lamerdin J, Richardson L, McCutchen Maloney S, Hwang M, Handel M, et al. Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis. Genomics. 1999;62:427-35 pubmed
    ..These results support a distinct role for the XPF/ERCC1 junction-specific endonuclease during meiosis, most likely in the resolution of heteroduplex intermediates that arise during recombination. ..
  6. Tasheva E, Ke A, Deng Y, Jun C, Takemoto L, Koester A, et al. Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004;10:403-16 pubmed
    ..Our results provide insight into the function of mimecan in the lens and enable further characterization of molecular mechanisms by which this protein exerts its biological roles. ..
  7. Ong W, Hu C, Patel S. Apolipoprotein D in the Niemann-Pick type C disease mouse brain: an ultrastructural immunocytochemical analysis. J Neurocytol. 2002;31:121-9 pubmed
    Enhanced apoD gene expression and abnormally high levels of apoD protein accumulation in the brain have been previously documented as features of the neurodegenerative disorder, Niemann-Pick Type C disease (NP-C)...
  8. Dandoy Dron F, Guillo F, Benboudjema L, Deslys J, Lasmezas C, Dormont D, et al. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. J Biol Chem. 1998;273:7691-7 pubmed
    ..been reported to exhibit increased expression in this disease: cathepsin S, the C1q B-chain of complement, apolipoprotein D, and two previously unidentified genes denominated scrapie-responsive gene (ScRG)-1 and ScRG-2, which are ..
  9. Martinez E, Navarro A, Ordóñez C, Del Valle E, Tolivia J. Amyloid-?25-35 induces apolipoprotein D Synthesis and growth arrest in HT22 hippocampal cells. J Alzheimers Dis. 2012;30:233-44 pubmed publisher
    b>Apolipoprotein D (ApoD) is a secreted glycoprotein that is markedly induced in several pathological and stressful conditions in the nervous system...

More Information


  1. Feenstra J, Kanaya K, Pira C, Hoffman S, Eppey R, Oberg K. Detection of genes regulated by Lmx1b during limb dorsalization. Dev Growth Differ. 2012;54:451-62 pubmed publisher
    ..Our study provides the most comprehensive characterization of genes regulated by Lmx1b during limb development to-date and provides targets for further investigation. ..
  2. Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, et al. Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. PLoS Genet. 2016;12:e1006486 pubmed publisher
    ..Thus, we have identified the molecular pathway that leads to neurodegeneration in FD and have demonstrated that phosphatidylserine treatment has the potential to slow progression of neurodegeneration. ..
  3. Boer S, Sanchez D, Reinieren I, van den Boom T, Udawela M, Scarr E, et al. Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:271-8 pubmed publisher
    b>Apolipoprotein D (ApoD) has many actions critical to maintaining mammalian CNS function...
  4. Kosacka J, Schröder T, Bechmann I, Kloting N, Nowicki M, Mittag A, et al. PACAP up-regulates the expression of apolipoprotein D in 3T3-L1 adipocytes. DRG/3T3-L1 co-cultures study. Neurosci Res. 2011;69:8-16 pubmed publisher
    ..Vice versa, neural cells induced expression of neurotrophic adipokines apolipoprotein D and E (ApoD, ApoE) and angiopoietin-1 (Ang-1) by adipocytes...
  5. Jimenez Palomares M, Cozar Castellano I, Ganfornina M, Sanchez D, Perdomo G. Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. Metabolism. 2011;60:1767-74 pubmed publisher
    b>Apolipoprotein D (ApoD) is an atypical apolipoprotein with an incompletely understood function in the regulation of triglyceride and glucose metabolism...
  6. Carpanini S, McKie L, Thomson D, Wright A, Gordon S, Roche S, et al. A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton. Dis Model Mech. 2014;7:711-22 pubmed publisher
  7. Sanchez D, Ganfornina M, Martinez S. Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis. Mech Dev. 2002;110:225-9 pubmed
    b>Apolipoprotein D (ApoD) is a secreted protein that belongs to the lipocalin family. We describe the expression pattern of ApoD during mouse embryogenesis by in situ hybridization using RNA probes...
  8. Tsukamoto K, Mani D, Shi J, Zhang S, Haagensen D, Otsuka F, et al. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A. 2013;110:17023-8 pubmed publisher
    ..We examined the influence and potential mechanism of action of apolipoprotein D (apoD) whose expression in dKO hearts increased 80-fold by 43 d...
  9. Smallwood P, Munoz Sanjuan I, Tong P, Macke J, Hendry S, Gilbert D, et al. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996;93:9850-7 pubmed
    ..Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function. ..
  10. Flower D. The lipocalin protein family: a role in cell regulation. FEBS Lett. 1994;354:7-11 pubmed
    ..Moreover, many lipocalins have been implicated in the regulation of cell homeostasis: apolipoprotein D, quiescience specific protein, purpurin, alpha-1-microglobulin, and NGAL...
  11. Moore B, Gonzalez Aviles G, Larkins C, Hillman M, Caspary T. Mitochondrial retention of Opa1 is required for mouse embryogenesis. Mamm Genome. 2010;21:350-60 pubmed publisher
    ..Our results define, for the first time, a function of the middle domain of the Opa1 protein and demonstrate that mitochondrial retention of Opa1 protein is essential for normal embryogenesis. ..
  12. Li H, Ruberu K, Muñoz S, Jenner A, Spiro A, Zhao H, et al. Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. Neurobiol Aging. 2015;36:1820-33 pubmed publisher
    b>Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed...
  13. Ganfornina M, Do Carmo S, Martinez E, Tolivia J, Navarro A, Rassart E, et al. ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury. Glia. 2010;58:1320-34 pubmed publisher
    ..In this work we focus on Apolipoprotein D (ApoD), a Lipocalin expressed by glial cells in the PNS and CNS...
  14. Kumar U. Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. J Mol Neurosci. 2012;48:684-95 pubmed
    ..SST) and somatostatin receptor subtypes (SSTR1-5) was determined in the hypothalamus of wild-type (wt) and apolipoprotein D knockout (ApoD(-/-)) mice brain...
  15. Ali K, Abo Ali E, Kabir M, Riggins B, Nguy S, Li L, et al. A Western-fed diet increases plasma HDL and LDL-cholesterol levels in apoD-/- mice. PLoS ONE. 2014;9:e115744 pubmed publisher
    ..According to studies of human genetics and lipid disorders, plasma apoD levels positively correlate with HDL-cholesterol and apoAI levels...
  16. Hildebrand M, de Silva M, Klockars T, Solares C, Hirose K, Smith J, et al. Expression of the carrier protein apolipoprotein D in the mouse inner ear. Hear Res. 2005;200:102-14 pubmed
    ..report that microarray analyses of the Soares NMIE inner ear library revealed cochlear enriched expression of apolipoprotein D (apoD), a glycoprotein and member of the lipocalin family that transport small hydrophobic ligands...
  17. Rajput P, Billova S, Patel S, Kharmate G, Somvanshi R, Kumar U. Expression of somatostatin and somatostatin receptor subtypes in Apolipoprotein D (ApoD) knockout mouse brain: An immunohistochemical analysis. J Chem Neuroanat. 2009;38:20-33 pubmed publisher
    b>Apolipoprotein D (ApoD) is widely distributed in central and peripheral nervous system...
  18. Hummasti S, Laffitte B, Watson M, Galardi C, Chao L, Ramamurthy L, et al. Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res. 2004;45:616-25 pubmed
    ..We identify the multifunction lipid carrier protein apolipoprotein D and the lipogenic protein Spot 14 as LXR responsive genes both in vitro and in vivo...
  19. Verheijen M, Chrast R, Burrola P, Lemke G. Local regulation of fat metabolism in peripheral nerves. Genes Dev. 2003;17:2450-64 pubmed
  20. Burgess D, Rafael J, Meisler M, Chamberlain J. Dlgh1, a mouse homolog of the drosophila discs-large gene, is located on chromosome 16. Mamm Genome. 1996;7:623-4 pubmed
  21. Mehrabian M, Castellani L, Wen P, Wong J, Rithaporn T, Hama S, et al. Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J). J Lipid Res. 2000;41:1936-46 pubmed
    ..Our results suggest that novel genes are likely to be important in the control of HDL metabolism, and they provide evidence of genetic factors influencing the interaction of LCAT with HDL. ..
  22. Rassart E, Bedirian A, Do Carmo S, Guinard O, Sirois J, Terrisse L, et al. Apolipoprotein D. Biochim Biophys Acta. 2000;1482:185-98 pubmed
    b>Apolipoprotein D (apoD) is a 29-kDa glycoprotein that is primarily associated with high density lipoproteins in human plasma...
  23. Salier J. Chromosomal location, exon/intron organization and evolution of lipocalin genes. Biochim Biophys Acta. 2000;1482:25-34 pubmed
  24. de la Brousse F, Birkenmeier E, King D, Rowe L, McKnight S. Molecular and genetic characterization of GABP beta. Genes Dev. 1994;8:1853-65 pubmed
    ..Finally, evidence is presented showing that GABP beta 1-1 and GABP beta 2-1 can heterodimerize through this carboxy-terminal domain, but neither protein can heterodimerize via the dimer-forming region of the bZIP protein C/EBP beta. ..
  25. Warden C, Diep A, Taylor B, Lusis A. Localization of the gene for apolipoprotein D on mouse chromosome 16. Genomics. 1992;12:851-2 pubmed
  26. Kalcheva I, Elliott R, Dalziel M, Lau J. The gene encoding beta-galactoside alpha2,6-sialyltransferase maps to mouse chromosome 16. Mamm Genome. 1997;8:619-20 pubmed
  27. Yoshida K, Cleaveland E, Nagle J, French S, Yaswen L, Ohshima T, et al. Molecular cloning of the mouse apolipoprotein D gene and its upregulated expression in Niemann-Pick disease type C mouse model. DNA Cell Biol. 1996;15:873-82 pubmed
    b>Apolipoprotein D (ApoD) is a member of the lipocalin superfamily. The primary structure and diverse expression of ApoD suggest that this protein is a multiligand, multifunctional glycoprotein...
  28. Li H, Ruberu K, Karl T, Garner B. Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS ONE. 2016;11:e0148238 pubmed publisher
    Recent studies have shown that cerebral apoD levels increase with age and in Alzheimer's disease (AD). In addition, loss of cerebral apoD in the mouse increases sensitivity to lipid peroxidation and accelerates AD pathology...
  29. Ganfornina M, Do Carmo S, Lora J, Torres Schumann S, Vogel M, Allhorn M, et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell. 2008;7:506-15 pubmed publisher
    Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging...
  30. Bajo Grañeras R, Ganfornina M, Martín Tejedor E, Sanchez D. Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems. Glia. 2011;59:1551-66 pubmed publisher
    ..We focus on Apolipoprotein D (ApoD), a Lipocalin expressed by glia and strongly induced upon aging, injury or neurodegeneration...
  31. Seguin D, Desforges M, Rassart E. Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D. Brain Res Mol Brain Res. 1995;30:242-50 pubmed
    The mouse apolipoprotein D gene was isolated from a brain cDNA library. The nucleotide sequence contains a unique reading frame coding for a protein sharing 79.5% homology with human apoD, 86.2% homology with rabbit apoD and 92...