Genomes and Genes

Species

Gene Symbol: Aplf

Description: aprataxin and PNKP like factor

Alias: 2010301N04Rik, AI452191, aprataxin and PNK-like factor, apurinic-apyrimidinic endonuclease APLF

Species: mouse

Products: Aplf

Danciger M, Yang H, Ralston R, Liu Y, Matthes M, Peirce J, et al. Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains. Mol Vis. 2007;13:79-85 pubmed
Rulten S, Fisher A, Robert I, Zuma M, Rouleau M, Ju L, et al. PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell. 2011;41:33-45 pubmed publisher

..DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate chromosomal DNA DSB repair...
Syed K, Joseph S, Mukherjee A, Majumder A, TEIXEIRA J, Dutta D, et al. Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts. J Cell Sci. 2016;129:4576-4591 pubmed

..For the first time, we report here that the downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin (Cdh1), which is implicated in the mesenchymal-..