Gene Symbol: Aph2
Description: zinc finger, DHHC domain containing 16
Alias: 1500015N03Rik, Aph2, palmitoyltransferase ZDHHC16, Abl-philin 2, ablphilin-2, zinc finger DHHC domain-containing protein 16
Conibear E, Davis N. Palmitoylation and depalmitoylation dynamics at a glance. J Cell Sci. 2010;123:4007-10 pubmed publisher
Li B, Cong F, Tan C, Wang S, Goff S. Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. J Biol Chem. 2002;277:28870-6 pubmed
..Here we report the identification of Abl-philin 2 (Aph2), encoding a novel protein with a unique cysteine-rich motif (zf-DHHC) and a 53-amino acid stretch sharing homology ..
Blasković S, Adibekian A, Blanc M, van der Goot G. Mechanistic effects of protein palmitoylation and the cellular consequences thereof. Chem Phys Lipids. 2014;180:44-52 pubmed publisher
Fukata Y, Murakami T, Yokoi N, Fukata M. Local Palmitoylation Cycles andÂ Specialized Membrane Domain Organization. Curr Top Membr. 2016;77:97-141 pubmed publisher
..Here, we review the recent progress in protein palmitoylation at the molecular, cellular, and in vivo level and discuss how locally regulated palmitoylation machinery works for dynamic nanoscale organization of membrane domains. ..
Chamberlain L, Lemonidis K, Sanchez Pérez M, Werno M, Gorleku O, Greaves J. Palmitoylation and the trafficking of peripheral membrane proteins. Biochem Soc Trans. 2013;41:62-6 pubmed publisher
..Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems. ..
Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, et al
. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015;112:15666-71 pubmed publisher
..Here we generated mice deficient in the acyl transferase Aph2 (Ablphilin 2 or zf-DHHC16) and demonstrated an essential role for Aph2 in embryonic/postnatal survival, eye development, and ..
Cao N, Li J, Rao Y, Liu H, Wu J, Li B, et al
. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. BMC Mol Biol. 2016;17:12 pubmed publisher
..Our results revealed critical roles for protein palmitoylation and palmitoyltransferase zDHHC16 in early stages of DNA damage responses and in the regulation of Atm activation.