Apc

Summary

Gene Symbol: Apc
Description: adenomatosis polyposis coli
Alias: AI047805, AU020952, AW124434, CC1, Min, mAPC, adenomatous polyposis coli protein, multiple intestinal neoplasia
Species: mouse
Products:     Apc

Top Publications

  1. Angus Hill M, Elbert K, Hidalgo J, Capecchi M. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A. 2011;108:4914-9 pubmed publisher
    ..Taken together, our in vivo studies favor a tumor suppressor function for Tcf4. ..
  2. Schepers A, Snippert H, Stange D, van den Born M, van Es J, van de Wetering M, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science. 2012;337:730-5 pubmed publisher
    ..The Lgr5(+) cells are intermingled with Paneth cells near the adenoma base, a pattern reminiscent of the architecture of the normal crypt niche...
  3. Crist R, Roth J, Lisanti M, Siracusa L, Buchberg A. Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. Cell Cycle. 2011;10:1092-9 pubmed
    ..The C57BL/6J (B6) Apc (Min/+) mouse develops polyps throughout the gastrointestinal tract and has been a valuable model for understanding the ..
  4. Amos Landgraf J, Irving A, Hartman C, Hunter A, Laube B, Chen X, et al. Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. Proc Natl Acad Sci U S A. 2012;109:2060-5 pubmed publisher
    ..In murine models of familial adenomatous polyposis, specifically the multiple intestinal neoplasia mouse (Min) and the polyposis in the rat colon (Pirc) rat, most adenomas have lost their WT copy of ..
  5. Nnadi S, Watson R, Innocent J, Gonye G, Buchberg A, Siracusa L. Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain. Carcinogenesis. 2012;33:1589-97 pubmed publisher
    ..The Apc ( Min ) mouse model carries a point mutation in the Apc gene and develops polyps along the intestinal tract...
  6. Metcalfe C, Kljavin N, Ybarra R, De Sauvage F. Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell. 2014;14:149-59 pubmed publisher
    ..though, we found that crypts deficient for Lgr5(+) cells are competent to undergo hyperplasia upon loss of Apc. These data argue that Lgr5(-) reserve stem cells are radiosensitive and that Lgr5(+) cells are crucial for robust ..
  7. Durand A, Donahue B, Peignon G, Letourneur F, Cagnard N, Slomianny C, et al. Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A. 2012;109:8965-70 pubmed publisher
    ..Finally, CBC stem cells deficient in adenomatous polyposis coli (Apc) and Math1 were able to promote intestinal tumorigenesis...
  8. Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
    ..YAP/TAZ are required for intestinal crypt overgrowth induced by APC deficiency and for crypt regeneration ex vivo...
  9. MacFarlane A, Perry C, McEntee M, Lin D, Stover P. Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk. Cancer Res. 2011;71:2098-107 pubmed publisher
    ..Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc(min)(/+) mice through a gene-by-diet interaction, indicating that the capacity for thymidylate synthesis modifies ..
  10. Starr T, Scott P, Marsh B, Zhao L, Than B, O Sullivan M, et al. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A. 2011;108:5765-70 pubmed publisher
    ..that cooperate with mutant APC, we performed a forward genetic screen in mice carrying a mutant allele of Apc (Apc(Min)) using Sleeping Beauty (SB) transposon-mediated mutagenesis...

Detail Information

Publications86

  1. Angus Hill M, Elbert K, Hidalgo J, Capecchi M. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A. 2011;108:4914-9 pubmed publisher
    ..Taken together, our in vivo studies favor a tumor suppressor function for Tcf4. ..
  2. Schepers A, Snippert H, Stange D, van den Born M, van Es J, van de Wetering M, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science. 2012;337:730-5 pubmed publisher
    ..The Lgr5(+) cells are intermingled with Paneth cells near the adenoma base, a pattern reminiscent of the architecture of the normal crypt niche...
  3. Crist R, Roth J, Lisanti M, Siracusa L, Buchberg A. Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. Cell Cycle. 2011;10:1092-9 pubmed
    ..The C57BL/6J (B6) Apc (Min/+) mouse develops polyps throughout the gastrointestinal tract and has been a valuable model for understanding the ..
  4. Amos Landgraf J, Irving A, Hartman C, Hunter A, Laube B, Chen X, et al. Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. Proc Natl Acad Sci U S A. 2012;109:2060-5 pubmed publisher
    ..In murine models of familial adenomatous polyposis, specifically the multiple intestinal neoplasia mouse (Min) and the polyposis in the rat colon (Pirc) rat, most adenomas have lost their WT copy of ..
  5. Nnadi S, Watson R, Innocent J, Gonye G, Buchberg A, Siracusa L. Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain. Carcinogenesis. 2012;33:1589-97 pubmed publisher
    ..The Apc ( Min ) mouse model carries a point mutation in the Apc gene and develops polyps along the intestinal tract...
  6. Metcalfe C, Kljavin N, Ybarra R, De Sauvage F. Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell. 2014;14:149-59 pubmed publisher
    ..though, we found that crypts deficient for Lgr5(+) cells are competent to undergo hyperplasia upon loss of Apc. These data argue that Lgr5(-) reserve stem cells are radiosensitive and that Lgr5(+) cells are crucial for robust ..
  7. Durand A, Donahue B, Peignon G, Letourneur F, Cagnard N, Slomianny C, et al. Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A. 2012;109:8965-70 pubmed publisher
    ..Finally, CBC stem cells deficient in adenomatous polyposis coli (Apc) and Math1 were able to promote intestinal tumorigenesis...
  8. Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
    ..YAP/TAZ are required for intestinal crypt overgrowth induced by APC deficiency and for crypt regeneration ex vivo...
  9. MacFarlane A, Perry C, McEntee M, Lin D, Stover P. Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk. Cancer Res. 2011;71:2098-107 pubmed publisher
    ..Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc(min)(/+) mice through a gene-by-diet interaction, indicating that the capacity for thymidylate synthesis modifies ..
  10. Starr T, Scott P, Marsh B, Zhao L, Than B, O Sullivan M, et al. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A. 2011;108:5765-70 pubmed publisher
    ..that cooperate with mutant APC, we performed a forward genetic screen in mice carrying a mutant allele of Apc (Apc(Min)) using Sleeping Beauty (SB) transposon-mediated mutagenesis...
  11. March H, Rust A, Wright N, Ten Hoeve J, de Ridder J, Eldridge M, et al. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet. 2011;43:1202-9 pubmed publisher
    ..performed insertional mutagenesis using the Sleeping Beauty transposon system in mice carrying germline or somatic Apc mutations...
  12. Grivennikov S, Wang K, Mucida D, Stewart C, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491:254-8 pubmed publisher
    ..Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and activation of ?-catenin are followed by mutations in K-Ras, PIK3CA and TP53, as the tumour ..
  13. McClellan J, Davis J, Steiner J, Enos R, Jung S, Carson J, et al. Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1087-95 pubmed publisher
    ..Male Apc(Min/+), Apc(Min/+)/MCP-1(-/-) or wild-type mice were euthanized at 18 wk of age and intestines were analyzed for polyp ..
  14. McClellan J, Davis J, Steiner J, Day S, Steck S, Carmichael M, et al. Intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse. Cytokine. 2012;57:113-9 pubmed publisher
    ..the timing and magnitude of the intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse...
  15. Xia D, Wang D, Kim S, Katoh H, DuBois R. Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med. 2012;18:224-6 pubmed publisher
    ..These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression. ..
  16. Zhou W, Geng Z, Spence J, Geng J. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature. 2013;501:107-11 pubmed publisher
    ..Therefore Rspo1 and Slit2 may act as therapeutic adjuvants to enhance host tolerance to aggressive chemoradiotherapy for eradicating metastatic cancers. ..
  17. Castets M, Broutier L, Molin Y, Brevet M, Chazot G, Gadot N, et al. DCC constrains tumour progression via its dependence receptor activity. Nature. 2011;482:534-7 pubmed publisher
    ..is also associated with an increase in the number and aggressiveness of intestinal tumours in a predisposing APC mutant context, resulting in the development of highly invasive adenocarcinomas...
  18. Li A, Chan B, Felix J, Xing Y, Li M, Brody S, et al. Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS ONE. 2013;8:e62215 pubmed publisher
    ..Adenomatous Polyposis Coli, Apc is a negative regulator of the Wnt pathway and a well known multifunctional protein...
  19. Miclea R, van der Horst G, Robanus Maandag E, Lowik C, Oostdijk W, Wit J, et al. Apc bridges Wnt/?-catenin and BMP signaling during osteoblast differentiation of KS483 cells. Exp Cell Res. 2011;317:1411-21 pubmed publisher
    ..Adenomatous polyposis coli (Apc) is the critical intracellular regulator of ?-catenin turnover...
  20. Ittmann M, Huang J, Radaelli E, Martin P, Signoretti S, Sullivan R, et al. Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res. 2013;73:2718-36 pubmed publisher
  21. Necela B, Carr J, Asmann Y, Thompson E. Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer. PLoS ONE. 2011;6:e18501 pubmed publisher
    ..in tumors and control colonic epithelial cells isolated from distal colons of chronically inflamed mice and APC(Min/+) mice...
  22. Vlantis K, Wullaert A, Sasaki Y, Schmidt Supprian M, Rajewsky K, Roskams T, et al. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest. 2011;121:2781-93 pubmed publisher
    ..intestinal epithelial cells (IECs) induced spontaneous tumors in aged mice and also strongly enhanced chemical- and Apc mutation-mediated carcinogenesis...
  23. de Lau W, Barker N, Low T, Koo B, Li V, Teunissen H, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011;476:293-7 pubmed publisher
    ..These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues. ..
  24. Schwitalla S, Fingerle A, Cammareri P, Nebelsiek T, Göktuna S, Ziegler P, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013;152:25-38 pubmed publisher
    ..Thus, our data support the concept of bidirectional conversion and highlight the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo. ..
  25. Azzolin L, Zanconato F, Bresolin S, Forcato M, Basso G, Bicciato S, et al. Role of TAZ as mediator of Wnt signaling. Cell. 2012;151:1443-56 pubmed publisher
    ..In the absence of Wnt activity, the components of the ?-catenin destruction complex--APC, Axin, and GSK3--are also required to keep TAZ at low levels...
  26. Koshimizu H, Fukui Y, Takao K, Ohira K, Tanda K, Nakanishi K, et al. Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Front Behav Neurosci. 2011;5:85 pubmed publisher
    A tumor suppressor gene, Adenomatous polyposis coli (Apc), is expressed in the nervous system from embryonic to adulthood stages, and transmits the Wnt signaling pathway in which schizophrenia susceptibility genes, including T-cell ..
  27. de la Roche M, Ibrahim A, Mieszczanek J, Bienz M. LEF1 and B9L shield ?-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res. 2014;74:1495-505 pubmed publisher
    ..the transcriptional activity of ?-catenin by blocking its binding to BCL9, and attenuates intestinal tumors in Apc(Min) mice...
  28. Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, et al. Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice. Mol Cancer Res. 2012;10:66-74 pubmed publisher
  29. Sebastian C, Zwaans B, Silberman D, Gymrek M, Goren A, Zhong L, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012;151:1185-99 pubmed publisher
    ..Our studies reveal SIRT6 to be a potent tumor suppressor acting to suppress cancer metabolism. ..
  30. White J, Puppa M, Gao S, Sato S, Welle S, Carson J. Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. Am J Physiol Endocrinol Metab. 2013;304:E1042-52 pubmed publisher
    ..IL-6 effects on mTOR activation were examined in Apc(Min/+) mouse skeletal muscle and C2C12 myotubes...
  31. Luis T, Naber B, Roozen P, Brugman M, de Haas E, Ghazvini M, et al. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell. 2011;9:345-56 pubmed publisher
    ..dosage-dependent fashion, we analyzed the effect of different mutations in the Adenomatous polyposis coli gene (Apc), a negative modulator of the canonical Wnt pathway...
  32. Jamieson T, Clarke M, Steele C, Samuel M, Neumann J, Jung A, et al. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest. 2012;122:3127-44 pubmed publisher
    ..Similar leukocyte populations were also found in human intestinal adenomas, which suggests that CXCR2 antagonists may have therapeutic and prophylactic potential in the treatment of cancer. ..
  33. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus Hock V, et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014;25:469-83 pubmed publisher
    ..We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression...
  34. Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, et al. Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci. 2013;33:3113-30 pubmed publisher
    The expression of the gut tumor suppressor gene adenomatous polyposis coli (Apc) and its role in the oligodendroglial lineage are poorly understood...
  35. Tanwar P, Zhang L, TEIXEIRA J. Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium. Mol Endocrinol. 2011;25:1725-39 pubmed publisher
    ..Mutation of the adenomatous polyposis coli (APC) gene has been associated with various human cancers, including testicular cancer, but its involvement in ..
  36. Shaked H, Hofseth L, Chumanevich A, Chumanevich A, Wang J, Wang Y, et al. Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012;109:14007-12 pubmed publisher
    ..However, when crossed to mice with IEC-specific allelic deletion of the adenomatous polyposis coli (Apc) tumor suppressor locus, Ikk?(EE)(IEC) mice exhibited more ?-catenin(+) early lesions and visible small intestinal ..
  37. Zeilstra J, Joosten S, Dokter M, Verwiel E, Spaargaren M, Pals S. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res. 2008;68:3655-61 pubmed publisher
    ..The expression of CD44 is dramatically increased in aberrant crypt foci in both humans and tumor-susceptible Apc(Min/+) mice, suggesting a role for CD44 in intestinal tumorigenesis...
  38. Wilding J, Straub J, Bee J, Churchman M, Bodmer W, Dickson C, et al. Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Cancer Res. 2002;62:4562-5 pubmed
    ..We tested the hypothesis that cyclin D1 gene activation is important for intestinal tumorigenesis. Multiple intestinal neoplasia mice (a model for human familial adenomatous polyposis) were crossed with cyclin D1 knockout (Ccnd1(-/-..
  39. Smits R, Kielman M, Breukel C, Zurcher C, Neufeld K, Jagmohan Changur S, et al. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 1999;13:1309-21 pubmed
    The adenomatous polyposis coli (APC) gene is considered as the true gatekeeper of colonic epithelial proliferation: It is mutated in the majority of colorectal tumors, and mutations occur at early stages of tumor development in mouse and ..
  40. Purro S, Ciani L, Hoyos Flight M, Stamatakou E, Siomou E, Salinas P. Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci. 2008;28:8644-54 pubmed publisher
    ..Wnt signaling directly affects the microtubule cytoskeleton by unexpectedly inducing adenomatous polyposis coli (APC) loss from microtubule plus-ends. Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function...
  41. Gutierrez L, Suckow M, Lawler J, Ploplis V, Castellino F. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis. 2003;24:199-207 pubmed
    ..TSP-1 on adenoma formation and development into cancerous lesions has been evaluated in the Min(/+) (multiple intestinal neoplasia) mouse model...
  42. Halberg R, Katzung D, Hoff P, Moser A, Cole C, Lubet R, et al. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A. 2000;97:3461-6 pubmed
    The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers...
  43. Boily G, He X, Pearce B, Jardine K, McBurney M. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene. 2009;28:2882-93 pubmed publisher
    ..The number of intestinal polyps induced in mice carrying the Apc(min) mutation was unaffected by the SirT1 genotype although the average polyp size was slightly smaller in the ..
  44. Baker S, Harris A, Tsao J, Flath T, Bronner C, Gordon M, et al. Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res. 1998;58:1087-9 pubmed
    ..Whereas Pms2-deficient mice do not develop intestinal tumors, mice deficient in Pms2 and heterozygous for Min, an allele of Apc, develop approximately three times the number of small intestinal adenomas and four times the ..
  45. Silverman K, Koratkar R, Siracusa L, Buchberg A. Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res. 2002;12:88-97 pubmed
    Min (Multiple intestinal neoplasia) mice carry a dominant mutation in the adenomatous polyposis coli (Apc) gene and develop multiple adenomas throughout their intestinal tract (Moser et al. 1990; Su et al 1992)...
  46. Eads C, Nickel A, Laird P. Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res. 2002;62:1296-9 pubmed
    ..In this study, we show that low levels of CpG island methylation occur in the normal intestinal mucosa of Apc(Min/+) mice and are increased in Multiple Intestinal Metaplasia (Min) polyps...
  47. Hulit J, Wang C, Li Z, Albanese C, Rao M, Di Vizio D, et al. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol. 2004;24:7598-611 pubmed
    ..activity, the primary transforming events in colorectal carcinoma, occurs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyposis...
  48. Petrova T, Nykänen A, Norrmen C, Ivanov K, Andersson L, Haglund C, et al. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell. 2008;13:407-19 pubmed publisher
    ..to carcinoma in situ, and its loss inhibits growth of human colorectal tumor xenografts and intestinal adenomas in Apc(min/+) mice, while its transgenic overexpression promotes colorectal tumorigenesis...
  49. Guillen Ahlers H, Buechler S, Suckow M, Castellino F, Ploplis V. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis. 2008;29:1421-7 pubmed publisher
    ..However, the mechanisms by which these drugs act are not fully understood. In this study, Apc(Min/+) mice, a genetic model of human familial adenomatous polyposis, were treated with sulindac, and these mice ..
  50. Cheung A, Carter A, Kostova K, Woodruff J, Crowley D, Bronson R, et al. Complete deletion of Apc results in severe polyposis in mice. Oncogene. 2010;29:1857-64 pubmed publisher
    ..studies reveal that whole-gene deletion of Apc results in more rapid tumor development than the APC multiple intestinal neoplasia (Apc(Min)) truncation...
  51. Jacoby R, Marshall D, Newton M, Novakovic K, Tutsch K, Cole C, et al. Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam. Cancer Res. 1996;56:710-4 pubmed
    C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet...
  52. Dove W, Clipson L, Gould K, Luongo C, Marshall D, Moser A, et al. Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res. 1997;57:812-4 pubmed
    ..In parallel, we have found that C57BL/6-ApcMin/+ mice mutated at the beige locus, which controls natural killer activity, are also unaltered in adenoma multiplicity. ..
  53. Harper J, Burns J, Foulstone E, Pignatelli M, Zaina S, Hassan A. Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res. 2006;66:1940-8 pubmed
    ..paternally expressed) mouse (Igf2) and human (IGF2) genes modify progression of intestinal adenoma in the Apc(Min/+) mouse and correlate with a high relative risk of human colorectal cancer susceptibility, respectively...
  54. Yekkala K, Baudino T. Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. Mol Cancer Res. 2007;5:1296-303 pubmed publisher
    ..In humans, mutations of the adenomatous polyposis coli (Apc) tumor suppressor gene occur in most colorectal cancers...
  55. Fancy S, Baranzini S, Zhao C, Yuk D, Irvine K, Kaing S, et al. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 2009;23:1571-85 pubmed publisher
    ..on (1) conditional activation of beta-catenin in the oligodendrocyte lineage in vivo and (2) findings from APC(Min) mice, which lack one functional copy of the endogenous Wnt pathway inhibitor APC...
  56. Lewis A, Segditsas S, Deheragoda M, Pollard P, Jeffery R, Nye E, et al. Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5. Gut. 2010;59:1680-6 pubmed publisher
    Adenomatous polyposis coli (APC) is a tumour suppressor gene mutated in the germline of patients with familial adenomatous polyposis (FAP) and somatically in most colorectal cancers...
  57. Tanaka T, Kohno H, Suzuki R, Hata K, Sugie S, Niho N, et al. Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. Int J Cancer. 2006;118:25-34 pubmed
    The mouse model for familial adenomatous polyposis, Apc(Min/+) mouse, contains a truncating mutation in the Apc gene and spontaneously develops numerous adenomas in the small intestine but few in the large bowel...
  58. Linhart H, Lin H, Yamada Y, Moran E, Steine E, Gokhale S, et al. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev. 2007;21:3110-22 pubmed
    ..novo methylation in tumor development, we overexpressed the de novo DNA methyltransferases Dnmt3a1 and Dnmt3b1 in Apc Min/+ mice...
  59. Qiu W, Carson Walter E, Kuan S, Zhang L, Yu J. PUMA suppresses intestinal tumorigenesis in mice. Cancer Res. 2009;69:4999-5006 pubmed publisher
    ..enhanced the formation of spontaneous macroadenomas and microadenomas in the distal small intestine and colon of APC(Min/+) mice...
  60. Oshima H, Oshima M, Kobayashi M, Tsutsumi M, Taketo M. Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice. Cancer Res. 1997;57:1644-9 pubmed
    Mutations in the human adenomatous polyposis coli (APC) gene are responsible for not only familial adenomatous polyposis but also many sporadic cancers of the digestive tract...
  61. Rosner A, Miyoshi K, Landesman Bollag E, Xu X, Seldin D, Moser A, et al. Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol. 2002;161:1087-97 pubmed
    ..glycogen synthase kinase 3-beta, beta-Catenin, and spontaneous mutants of adenomatous polyposis coli gene (Apc)]...
  62. Wong E, Yang K, Kuraguchi M, Werling U, Avdievich E, Fan K, et al. Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci U S A. 2002;99:14937-42 pubmed
    ..The combination of Mbd4 deficiency with a germ line mutation in the adenomatous polyposis coli (Apc) gene increased the tumor number in the GI tract and accelerated tumor progression...
  63. Barker N, Ridgway R, van Es J, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608-11 pubmed publisher
    Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin has remained elusive...
  64. You S, Ohmori M, Pena M, Nassri B, Quiton J, Al Assad Z, et al. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol. 2006;87:227-36 pubmed
    ..Apc(Min/+) mice, heterozygous for the Apc gene mutation, progressively develop small intestinal tumours in a manner that is ..
  65. Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A. 1994;91:8969-73 pubmed
    ..observed in patients with familial adenomatous polyposis and in mice which carry a mutation called multiple intestinal neoplasia (Min)...
  66. Marsh V, Winton D, Williams G, Dubois N, Trumpp A, Sansom O, et al. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet. 2008;40:1436-44 pubmed publisher
    ..However, loss of Pten in the context of Apc deficiency accelerates tumorigenesis through increased activation of Akt, leading to rapid development of ..
  67. Shibata H, Toyama K, Shioya H, Ito M, Hirota M, Hasegawa S, et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science. 1997;278:120-3 pubmed
    ..by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene...
  68. Lane S, Sykes S, Al Shahrour F, Shterental S, Paktinat M, Lo Celso C, et al. The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood. 2010;115:3489-97 pubmed publisher
    b>Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis...
  69. Kuraguchi M, Wang X, Bronson R, Rothenberg R, Ohene Baah N, Lund J, et al. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2:e146 pubmed
    The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis...
  70. Xu H, Posner G, Stevenson M, Campbell F. Apc(MIN) modulation of vitamin D secosteroid growth control. Carcinogenesis. 2010;31:1434-41 pubmed publisher
    ..Most sporadic CRCs arise from adenomatous polyposis coli (APC) gene mutation but understanding of its effects on vitamin D growth control is limited...
  71. van der Houven van Oordt C, Smits R, Schouten T, Houwing Duistermaat J, Williamson S, Luz A, et al. The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer. 1999;24:191-8 pubmed
    ..The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.
  72. Barnes C, Lee M. Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin. Gastroenterology. 1998;114:873-7 pubmed
    ..Six-week-old male and female C57BL/6J +/+ (control) and C57BL/6J ApcMin/+ (Min) mice were fed either a control AIN-76A diet or one supplemented with 250 or 500 parts per million (ppm) aspirin (n ..
  73. Mahmoud N, Dannenberg A, Bilinski R, Mestre J, Chadburn A, Churchill M, et al. Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis. Carcinogenesis. 1999;20:299-303 pubmed
    ..Mice susceptible to intestinal tumors as a result of a germline mutation in Apc (Min/+ mice) were given a 10 week dietary treatment with 0.5% chenodeoxycholate...
  74. Behrens J, Jerchow B, Würtele M, Grimm J, Asbrand C, Wirtz R, et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science. 1998;280:596-9 pubmed
    ..found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC)...
  75. Colnot S, Decaens T, Niwa Kawakita M, Godard C, Hamard G, Kahn A, et al. Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A. 2004;101:17216-21 pubmed
    ..To investigate this issue, we constructed a mutant mouse strain, Apc(lox/lox), in which exon 14 of the tumor-suppressor gene adenomatous polyposis coli (Apc) is flanked by loxP ..
  76. Steffensen I, Alexander J. Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice. Cancer Lett. 2006;240:289-96 pubmed
    ..8- and 3.7-fold above the spontaneous levels in multiple intestinal neoplasia (Min)/+ F1 mice with AKR/J and A/J backgrounds, respectively, compared with only 3-fold in C57BL/6J ..
  77. Athineos D, Sansom O. Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine. Oncogene. 2010;29:2585-90 pubmed publisher
    The adenomatous polyposis coli (APC) gene encodes APC tumour suppressor protein, germline mutation of which causes familial adenomatous polyposis, an autosomal intestinal cancer syndrome...
  78. Haigis K, Kendall K, Wang Y, Cheung A, Haigis M, Glickman J, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008;40:600-8 pubmed publisher
    ..In the context of an Apc-mutant colonic tumor, activation of K-Ras led to defects in terminal differentiation and expansion of putative stem ..
  79. Corpet D, Pierre F. Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev. 2003;12:391-400 pubmed
    The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer...
  80. Coletta P, Müller A, Jones E, Mühl B, Holwell S, Clarke D, et al. Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis. Blood. 2004;103:1050-8 pubmed
    ..Here we show that in Apc(Min/+) mice, which carry a heterozygous germ line mutation at codon 850 of Apc, there is progressive loss of immature ..
  81. Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, et al. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A. 2002;99:9924-9 pubmed
    ..However, when combined with a mutation in the adenomatous polyposis coli (Apc) gene, double heterozygous animals have increased numbers of adenocarcinomas and decreased survival...
  82. Buxton R, Wheeler G, Pidsley S, Marsden M, Adams M, Jenkins N, et al. Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 1994;21:510-6 pubmed
    ..We further show that the human DSC3 gene, previously reported to be located on chromosome 9, also maps to human chromosome 18. ..
  83. Rotte A, Bhandaru M, Foller M, Biswas R, Mack A, Friedrich B, et al. APC sensitive gastric acid secretion. Cell Physiol Biochem. 2009;23:133-42 pubmed publisher
    ..Mice carrying a loss-of-function mutation in the apc gene (apc(Min/+)) spontaneously develop gastrointestinal tumors...
  84. Mutanen M, Pajari A, Oikarinen S. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Carcinogenesis. 2000;21:1167-73 pubmed
    ..fibers as well as inulin, polydisperse beta(2-->1) fructan, could affect the formation of intestinal polyps in Apc(Min) mice...