Apc

Summary

Gene Symbol: Apc
Description: adenomatosis polyposis coli
Alias: AI047805, AU020952, AW124434, CC1, Min, mAPC, adenomatous polyposis coli protein, multiple intestinal neoplasia
Species: mouse

Top Publications

  1. ncbi Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition
    Lei Cao
    Department of Molecular Virology, Immunology and Medical Genetics, and Neuroscience and Neurological Surgery and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cell 142:52-64. 2010
  2. ncbi Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 29:824-9. 2008
  3. ncbi Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
    Kenneth E Hung
    Division of Gastroenterology, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:1565-70. 2010
  4. ncbi Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    Randal May
    Department of Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L Young Boulevard, WP 1360, Oklahoma City, Oklahoma 73104, USA
    Stem Cells 26:630-7. 2008
  5. ncbi Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies
    Agnès Bernet
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, CNRS UMR5238, University of Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 133:1840-8. 2007
  6. ncbi Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers
    Sabine Colnot
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM, CNRS UMR 8104, Universite Paris V, Paris, France
    Lab Invest 84:1619-30. 2004
  7. ncbi Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003
  8. ncbi Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA
    Dev Dyn 203:422-33. 1995
  9. ncbi A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    Shaoguang Wu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 15:1016-22. 2009
  10. ncbi ApcMin: a mouse model for intestinal and mammary tumorigenesis
    A R Moser
    McArdle Laboratory, University of Wisconsin, Madison 53706, USA
    Eur J Cancer 31:1061-4. 1995

Research Grants

  1. Transforming Colorectal Cancer Screening through Multimodal Spectral Markers
    Vadim Backman; Fiscal Year: 2011
  2. Spectral Markers for Early Detection of Colon Neoplasia
    Hemant Roy; Fiscal Year: 2007
  3. Improving colonoscopic miss rate by real time microvascular blood analysis
    Hemant Roy; Fiscal Year: 2007
  4. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
  5. HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Chinthalapally V Rao; Fiscal Year: 2010
  6. Role of IL10 and TGFb1 in colon cancer
    SUSAN ERDMAN; Fiscal Year: 2007
  7. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2006
  8. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2007
  9. Role of IL10 and TGFb1 in colon cancer
    Susan E Erdman; Fiscal Year: 2010
  10. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009

Detail Information

Publications112 found, 100 shown here

  1. ncbi Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition
    Lei Cao
    Department of Molecular Virology, Immunology and Medical Genetics, and Neuroscience and Neurological Surgery and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cell 142:52-64. 2010
    ..These results suggest that genetic or environmental activation of this BDNF/leptin axis may have therapeutic significance for cancer...
  2. ncbi Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 29:824-9. 2008
    ..We noticed that Min mice, featuring a defect in the adenomatous polyposis coli (Apc) gene, develop intestinal polyps along with high serum triglyceride (TG) levels up to 10-fold those observed in ..
  3. ncbi Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
    Kenneth E Hung
    Division of Gastroenterology, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:1565-70. 2010
    ..Several of these models involve modification of the adenomatous polyposis coli (Apc) gene and are excellent models for familial cancer predisposition syndromes...
  4. ncbi Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    Randal May
    Department of Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L Young Boulevard, WP 1360, Oklahoma City, Oklahoma 73104, USA
    Stem Cells 26:630-7. 2008
    ..DCAMKL-1) to examine radiation-induced stem cell apoptosis and adenomatous polyposis coli (APC)/multiple intestinal neoplasia (min) mice to determine the effects of APC mutation on DCAMKL-1 expression...
  5. ncbi Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies
    Agnès Bernet
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, CNRS UMR5238, University of Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 133:1840-8. 2007
    ..We investigate here whether UNC5C acts as a tumor suppressor in colorectal malignancies...
  6. ncbi Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers
    Sabine Colnot
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM, CNRS UMR 8104, Universite Paris V, Paris, France
    Lab Invest 84:1619-30. 2004
    Murine models of familial adenomatous polyposis harbor a germinal heterozygous mutation on Apc tumor suppressor gene...
  7. ncbi Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003
  8. ncbi Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA
    Dev Dyn 203:422-33. 1995
    ..Mice carrying Min (multiple intestinal neoplasia), a mutant allele of Apc, develop intestinal and mammary tumors as adults...
  9. ncbi A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    Shaoguang Wu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 15:1016-22. 2009
    ..NTBF) chronically colonize mice, only ETBF triggers colitis and strongly induces colonic tumors in multiple intestinal neoplasia (Min) mice...
  10. ncbi ApcMin: a mouse model for intestinal and mammary tumorigenesis
    A R Moser
    McArdle Laboratory, University of Wisconsin, Madison 53706, USA
    Eur J Cancer 31:1061-4. 1995
    Min (multiple intestinal neoplasia) is a mutant allele of the murine Apc (adenomatous polyposis coli) locus, encoding a nonsense mutation at codon 850...
  11. ncbi Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice
    N Elander
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Biochem Biophys Res Commun 372:249-53. 2008
    ..Here we demonstrate that APC(Min/+) mice with genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), which catalyses the terminal ..
  12. ncbi Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice
    Hector Guillen-Ahlers
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 29:1421-7. 2008
    ..However, the mechanisms by which these drugs act are not fully understood. In this study, Apc(Min/+) mice, a genetic model of human familial adenomatous polyposis, were treated with sulindac, and these mice ..
  13. ncbi Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice
    A R Moser
    Department of Human Oncology, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792, USA
    Cancer Res 61:3480-5. 2001
    Treatment of female C57BL/6J (B6) mice carrying the mutant Min allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approximately 90% of mice developing an average of three mammary tumors within 65 ..
  14. ncbi Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice
    Henrik Oster
    Laboratory for Signal Transduction, Max Planck Institute of Experimental Endocrinology and Department of Nephrology, Hannover Medical School, Hannover, Germany
    Cancer Res 66:6955-63. 2006
    ..Even without an additional Apc mutation, PKCalpha knockout mice showed an elevated tendency to develop spontaneous intestinal tumors...
  15. ncbi Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 437:281-5. 2005
    ..In the Apc(Min) mouse model of intestinal cancer, genetic abrogation of c-Jun N-terminal phosphorylation or gut-specific ..
  16. ncbi Curcumin modifies Apc(min) apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apc(min) mice
    G P Collett
    Department of Surgery, The Cancer Centre, Queen s University Belfast
    Carcinogenesis 22:821-5. 2001
    ..This study investigates the effects of curcumin on apoptosis and tumorigenesis in male Apc(min) mice treated with the human dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)...
  17. ncbi The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus
    Revati Koratkar
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 62:5413-7. 2002
    Intestinal adenoma development in Apc(Min) mice is influenced by genetic background...
  18. ncbi Sulindac suppresses tumorigenesis in the Min mouse
    Y Beazer-Barclay
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Carcinogenesis 17:1757-60. 1996
    The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis...
  19. ncbi Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas
    Harry S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Carcinog 44:31-41. 2005
    The relevance of the Apc(+/Min) mouse model in the study of human colorectal cancer remains uncertain due to the predominance of small intestinal adenomas and few, if any, colorectal adenomas...
  20. ncbi Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice
    Holly Symolon
    Program in Nutrition and Health Science, Emory University, Atlanta, GA 30322, USA
    J Nutr 134:1157-61. 2004
    ..colon tumorigenesis in CF1 mice treated with a colon carcinogen [1,2-dimethylhydrazine (DMH)] and in multiple intestinal neoplasia (Min) mice, which develop intestinal tumors spontaneously...
  21. ncbi Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo
    Tomo o Ishikawa
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, 606 8501, Japan
    Dev Biol 253:230-46. 2003
    Tumor suppressor Apc (adenomatous polyposis coli) is implicated in the Wnt signaling pathway that is involved in the early embryonic development and tumorigenesis in vertebrates...
  22. ncbi Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation
    Takao Hinoi
    Department of Internal Medicine, The Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 2200, USA
    Cancer Res 67:9721-30. 2007
    Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis. Existing mouse intestinal tumor models display mainly small intestinal lesions and carcinomas are rare...
  23. ncbi Atonal homolog 1 is a tumor suppressor gene
    Wouter Bossuyt
    Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
    PLoS Biol 7:e39. 2009
    ..Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation...
  24. ncbi Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene
    Aytekin Akyol
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA
    Nat Methods 5:231-3. 2008
    ..We demonstrated the utility of this approach by inducing colonic polyposis after Cre-mediated bi-allelic inactivation of the Apc gene.
  25. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC)...
  26. ncbi A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    Science 247:322-4. 1990
    ..The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age...
  27. ncbi A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2
    Genzo Iguchi
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, RTP, NC 27709, USA
    Cancer Lett 282:152-8. 2009
    ..NAG-1 expression, we investigated the expression of NAG-1 and COX-2 in normal and tumor tissue from human patients, Apc(Min/+) mice, and COX-2(-/-) mice...
  28. ncbi Apc(MIN) modulation of vitamin D secosteroid growth control
    Haibo Xu
    Centre for Cancer Research and Cell Biology, Queen s University of Belfast, Northern Ireland, UK
    Carcinogenesis 31:1434-41. 2010
    ..Most sporadic CRCs arise from adenomatous polyposis coli (APC) gene mutation but understanding of its effects on vitamin D growth control is limited...
  29. ncbi Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis
    Mi Ni Lee
    Division of Life and Pharmaceutical Sciences, Ewha Women s University, Seoul, Korea
    J Natl Cancer Inst 102:426-42. 2010
    ..Murine arrest-defective protein 1A (mARD1A(225)) acetylates HIF-1alpha, triggering its degradation, and thus may play a role in decreased expression of VEGFA...
  30. ncbi SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
    G Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, and Department of Medicine, University of Ottawa, Ontario, Canada
    Oncogene 28:2882-93. 2009
    ..The number of intestinal polyps induced in mice carrying the Apc(min) mutation was unaffected by the SirT1 genotype although the average polyp size was slightly smaller in the ..
  31. ncbi Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
    Melanie Kucherlapati
    Department of Medicine and Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9924-9. 2002
    ..However, when combined with a mutation in the adenomatous polyposis coli (Apc) gene, double heterozygous animals have increased numbers of adenocarcinomas and decreased survival...
  32. ncbi Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    P C Chulada
    Laboratory of Experimental Carcinogenesis and Mutagenesis, NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:4705-8. 2000
    ..disruption of either Ptgs-1 or Ptgs-2 (genes coding for COX-1 or COX-2, respectively) reduced polyp formation in Min/+ mice by approximately 80%...
  33. ncbi Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
    V J Wielenga
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Pathol 154:515-23. 1999
    ..This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating ..
  34. ncbi 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with ApcMin mutation
    A Andreassen
    Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Mutat Res 604:60-70. 2006
    ..animal studies, spontaneous tumour formation in B6(Min/+) mice was associated with somatic loss of the wild-type Apc+ allele by loss of the entire chromosome 18 or by recombination...
  35. ncbi Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor)
    Catherine Fen Li
    Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Oncogene 24:1615-24. 2005
    ..deletion in Pai-1 was crossed with a mouse that develops aggressive fibromatosis and gastrointestinal tumors (Apc/Apc1638N mouse)...
  36. ncbi Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
    S Colnot
    Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, Universite Paris V, 24 rue du Faubourg St Jacques, 75014 Paris, France
    Proc Natl Acad Sci U S A 101:17216-21. 2004
    ..To investigate this issue, we constructed a mutant mouse strain, Apc(lox/lox), in which exon 14 of the tumor-suppressor gene adenomatous polyposis coli (Apc) is flanked by loxP ..
  37. ncbi Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
    Samira Benhamouche
    Institut Cochin, Département GDPM, INSERM U567, CNRS, UMR S 8104, Paris, F 75014, France
    Dev Cell 10:759-70. 2006
    ..we show the complementary localization of activated beta-catenin in the perivenous area and the negative regulator Apc in periportal hepatocytes...
  38. ncbi EphB receptor activity suppresses colorectal cancer progression
    Eduard Batlle
    Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Nature 435:1126-30. 2005
    ..Furthermore, reduction of EphB activity accelerates tumorigenesis in the colon and rectum of Apc(Min/+) mice, and results in the formation of aggressive adenocarcinomas...
  39. ncbi TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway
    Patty Trobridge
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Gastroenterology 136:1680-8.e7. 2009
    ..The RAS-RAF-ERK pathway is frequently up-regulated in colon cancer via mutational activation of KRAS or BRAF. We assessed how these pathways interact in vivo and affect formation of colorectal tumors...
  40. ncbi Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9
    Nicole M Ramocki
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA or
    Endocrinology 149:261-7. 2008
    ..the hypothesis that reduced IRS-1 expression increases apoptosis of intestinal crypt cells and protects against Apc(min/+) (Min)/beta-catenin-driven intestinal tumors...
  41. ncbi EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells
    Carme Cortina
    Oncology Programme, Institute for Research in Biomedicine IRB, Josep Samitier 1 5, 08028 Barcelona Spain
    Nat Genet 39:1376-83. 2007
    ..Our results indicate that CRC cells must silence EphB expression to avoid repulsive interactions imposed by normal ephrin-B1-expressing intestinal cells at the onset of tumorigenesis...
  42. ncbi Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia
    Francois Boudreau
    Département d Anatomie et de Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, 3001 12e Ave Nord, Fleurimont, QC, Canada, J1H 5N4
    FASEB J 21:3853-65. 2007
    ..Loss of cathepsin L activity leads to a marked increase in tumor multiplicity in the intestine of Apc(Min) mice...
  43. ncbi Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
    ..genetic and pharmacologic studies reveal that loss or inhibition of CB1 accelerated intestinal adenoma growth in Apc(Min/+) mice whereas activation of CB1 attenuated intestinal tumor growth by inducing cell death via down-regulation ..
  44. ncbi APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation
    Miguel Abal
    Morphogenesis and intracellular signalling, UMR 144, Institut Curie CNRS, Paris, France
    Gastroenterology 132:2448-58. 2007
    ..A role for the tumor suppressor gene APC has been proposed in colorectal cancer that leads to compromised chromosome segregation even though the molecular ..
  45. ncbi Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice
    Owen J Sansom
    Beatson Institute of Cancer Research, Glasgow, Scotland, UK
    Gut 56:1410-4. 2007
    ..More recently, it has been shown to be upregulated in human gastric and colorectal cancer. We therefore wished to address the functional importance of SPARC upregulation to intestinal tumorigenesis in vivo...
  46. ncbi Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability
    Karin Kroboth
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 18:910-8. 2007
    Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is involved in many processes that govern gut tissue...
  47. ncbi Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
    Masataka Kohno
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell Biol 26:7211-23. 2006
    ..Here, we show that Sphk1 is expressed and is required for small intestinal tumor cell proliferation in Apc Min/+ mice. Adenoma size but not incidence was dramatically reduced in Apc Min/+ Sphk(-/-) mice...
  48. ncbi Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome
    Thomas E Sussan
    Department of Physiology and The Institute for Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 451:73-5. 2008
    ..b>Apc(Min)-mediated tumour number was determined in aneuploid mouse models Ts65Dn, Ts1Rhr and Ms1Rhr...
  49. ncbi Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
    Owen J Sansom
    Beatson Institute for Cancer Research, Glasgow G61 1BD, United Kingdom
    Proc Natl Acad Sci U S A 103:14122-7. 2006
    ..expressed an oncogenic K-ras(V12) allele in the small intestine of adult mice either alone or in the context of Apc deficiency...
  50. ncbi Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation
    Oronza A Botrugno
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, 67404 Illkirch, France
    Mol Cell 15:499-509. 2004
    ..The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells...
  51. ncbi Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele
    R T Cormier
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA
    Cancer Res 60:3965-70. 2000
    ..5-cytosine DNA methyltransferase gene (Dnmt1(N/+)) diminishes intestinal tumorigenesis in C57BL/6-multiple intestinal neoplasia (Min)/+ mice...
  52. ncbi Aspirin prevents tumors in a murine model of familial adenomatous polyposis
    N N Mahmoud
    New York Hospital Cornell University Medical Center, NY 10021, USA
    Surgery 124:225-31. 1998
    ..Both human and murine studies suggest that anti-inflammatory drugs prevent intestinal neoplasia. The purpose of this study was to investigate the role of aspirin as a chemopreventive agent for colorectal cancer...
  53. ncbi Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency
    M Kuraguchi
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY 10021, USA
    Oncogene 19:5755-63. 2000
    Apc1638N mice, which are heterozygous for a germline mutation in Apc, typically develop three to five spontaneous intestinal tumors per animal. In most cases this is associated with allelic loss of wildtype Apc...
  54. ncbi Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal
    W C Yang
    Albert Einstein Cancer Center, Bronx, New York 10467, USA
    Cancer Res 61:565-9. 2001
    ..increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated...
  55. ncbi Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts
    R Smits
    Medical Genetics Center South West Netherlands, Department of Human Genetics, Leiden University
    Gastroenterology 114:275-83. 1998
    Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant predisposition to the formation of multiple colorectal adenomas...
  56. ncbi Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice
    Jenny Wilding
    Cancer and Immunogenetics Laboratory, Cancer Research UK, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Cancer Res 62:4562-5. 2002
    ..We tested the hypothesis that cyclin D1 gene activation is important for intestinal tumorigenesis. Multiple intestinal neoplasia mice (a model for human familial adenomatous polyposis) were crossed with cyclin D1 knockout (Ccnd1(-/-..
  57. ncbi Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation
    Edmund Wong
    Department of Cell Biology, Biostatistics Core, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:14937-42. 2002
    ..The combination of Mbd4 deficiency with a germ line mutation in the adenomatous polyposis coli (Apc) gene increased the tumor number in the GI tract and accelerated tumor progression...
  58. ncbi Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
    H Shibata
    Department of Cell Biology, Cancer Institute, Toshima ku, Tokyo 170, Japan
    Science 278:120-3. 1997
    ..by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene...
  59. ncbi The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells
    Mutsumi Kanamori
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    J Biol Chem 278:38758-64. 2003
    ..These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway...
  60. ncbi Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac
    N N Mahmoud
    The New York Hospital Cornell Medical Center, New York 10021, USA
    Cancer Res 59:353-9. 1999
    The adenomatous polyposis coli (APC) gene product mediates coordinated cell growth in the intestinal mucosa...
  61. ncbi Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    James Hulit
    The Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Research Building Room E501, 3970 Reservoir Rd, N W, Box 571468, Washington, DC 20057 1468, USA
    Mol Cell Biol 24:7598-611. 2004
    ..activity, the primary transforming events in colorectal carcinoma, occurs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyposis...
  62. ncbi Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model
    Linda S Gutierrez
    Walther Cancer Research Center, W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, Freimann Life Sciences Center University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 24:199-207. 2003
    ..TSP-1 on adenoma formation and development into cancerous lesions has been evaluated in the Min(/+) (multiple intestinal neoplasia) mouse model...
  63. ncbi Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 7:2779-87. 2008
    ..In this study, we explored the antitumorigenic effects of MCC-555 both in cell culture and in Apc-deficient mice, an animal model for human familial adenomatous polyposis...
  64. ncbi The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background
    Richard B Halberg
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 180:601-9. 2008
    ..Afflicted individuals are heterozygous for mutations in the APC gene...
  65. ncbi The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells
    T Senda
    Department of Anatomy I, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 223:329-34. 1996
    The APC gene is mutated in familial adenomatous polyposis and sporadic colorectal tumors. The product of this gene is a 300 kDa cytoplasmic protein associated with catenin...
  66. ncbi Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli
    Silvia A Purro
    Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 28:8644-54. 2008
    ..Wnt signaling directly affects the microtubule cytoskeleton by unexpectedly inducing adenomatous polyposis coli (APC) loss from microtubule plus-ends. Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function...
  67. ncbi A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
    R Fodde
    Department of Genetics, Leiden University, The Netherlands
    Proc Natl Acad Sci U S A 91:8969-73. 1994
    ..observed in patients with familial adenomatous polyposis and in mice which carry a mutation called multiple intestinal neoplasia (Min)...
  68. ncbi Mouse models for hereditary nonpolyposis colorectal cancer
    N de Wind
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 58:248-55. 1998
    ..To develop a model for intestinal tumorigenesis in HNPCC, we introduced the Min allele of the Apc tumor suppressor gene...
  69. ncbi Inactivation of both APC alleles in human and mouse tumors
    D B Levy
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
    Cancer Res 54:5953-8. 1994
    ..coli (APC) gene lead to multiple intestinal tumors in familial adenomatous polyposis patients and in multiple intestinal neoplasia (Min) mice...
  70. ncbi A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation
    Pauline Andreu
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Biol 324:288-96. 2008
    ..de novo specification of Paneth cells in both the small intestine and colon and that colon cancers resulting from Apc mutations expressed many genes involved in Paneth cell differentiation...
  71. ncbi Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions
    Stavroula Mili
    Department of Microbiology, Center for Cell Signaling, University of Virginia, HSC, Charlottesville, Virginia 22908 0577, USA
    Nature 453:115-9. 2008
    ..RNAs in the granules associate with the adenomatous polyposis coli (APC) tumour suppressor and the fragile X mental retardation protein (FMRP)...
  72. ncbi Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation
    Kan Yang
    Strang Cancer Center at New York Blood Bank, New York, USA
    Cancer Res 68:7313-22. 2008
    Somatic mutations of the adenomatous polyposis coli (APC) gene are initiating events in the majority of sporadic colon cancers...
  73. ncbi Dietary induction of colonic tumors in a mouse model of sporadic colon cancer
    Kan Yang
    Strang Cancer Research Laboratory, Department of Medicine, Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10467, USA
    Cancer Res 68:7803-10. 2008
    ..of colonic epithelial cells in the flat mucosa by the NWD was similar to that initiated by inheritance of a mutant Apc allele...
  74. ncbi A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo
    S Hayashi
    Department of Molecular Biology, Princeton University, NJ 08540, USA
    Proc Natl Acad Sci U S A 94:242-7. 1997
    Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers...
  75. ncbi Manipulation of the mouse germline in the study of Min-induced neoplasia
    A Bilger
    Laboratory of Genetics, University of Wisconsin Medical School, Madison 53706, USA
    Semin Cancer Biol 7:249-60. 1996
    The Min mouse, generated by random germline mutagenesis, carries a mutation in the mouse homolog of APC and is a model of inherited human intestinal tumorigenesis...
  76. ncbi PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1
    Marybeth A Pysz
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Exp Cell Res 315:1415-28. 2009
    ..Loss of PKCalpha and effects of its re-expression were independent of the status of the APC/beta-catenin signaling pathway or known genetic alterations, indicating that they are a general characteristic of ..
  77. ncbi Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: an animal model for CEA-directed tumor immunotherapy
    J A Thompson
    Institute of Immunobiology, University of Freiburg, Germany
    Int J Cancer 72:197-202. 1997
    ..As a model for colorectal tumors, mice bearing a mutation in the Apc gene (Min mice) and the CEA transgene developed multiple intestinal adenomas with strong CEA expression in all ..
  78. ncbi Transgenic expression of VEGF in intestinal epithelium drives mesenchymal cell interactions and epithelial neoplasia
    Amelie Boquoi
    Department of Medicine, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Gastroenterology 136:596-606.e4. 2009
    ..We used a transgenic approach to directly test the hypothesis that augmented VEGF expression can drive progression of intestinal neoplasia...
  79. ncbi Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins
    J M Bugni
    Biological Engineering Department and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Oncogene 28:734-41. 2009
    ..AOM and dextran sulfate sodium (DSS)-induced colorectal adenomas and against spontaneous intestinal adenomas in Apc(Min) mice...
  80. ncbi Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway
    Richard B Halberg
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 69:5768-75. 2009
    C57BL/6J mice carrying the Min allele of Adenomatous polyposis coli (Apc) develop numerous adenomas along the entire length of the intestine and consequently die at an early age...
  81. ncbi Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen
    Rinke Bos
    Department of Immunohematology and Blood Transfusion, Tumor Immunology Group, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 68:8446-55. 2008
    ....
  82. ncbi Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences
    W Makałowski
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 6:846-57. 1996
    ..Also, they should prove useful in estimating the additional sampling diversity provided by mouse EST sequencing projects designed to complement the existing human cDNA collection...
  83. ncbi Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells
    Jacqueline A Koehler
    Department of Medicine, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 68:7897-904. 2008
    ..The importance of the GLP-2R for tumor growth was also examined in Apc(Min/+) mice chronically treated with exogenous GLP-2 and in Apc(Min/+):Glp2r(-/-) mice...
  84. ncbi Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice
    Alicia G Cleveland
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Carcinogenesis 30:1581-90. 2009
    ..Through crosses between an ERalpha knockout and Apc(Min) mouse strains, we demonstrate that ERalpha deficiency is associated with a significant increase in intestinal ..
  85. ncbi Pax-2 expression defines a subset of GABAergic interneurons and their precursors in the developing murine cerebellum
    S M Maricich
    Alzheimer Research Laboratory, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Neurobiol 41:281-94. 1999
    ..Finally, our data support the hypothesis that the basket and stellate cells arise from neuronally restricted, migratory precursors located in the early postnatal cerebellar white matter...
  86. ncbi Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice
    A R Shoemaker
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, Wisconsin, WI 53706, USA
    Oncogene 19:2774-9. 2000
    Defects in APC and DNA mismatch repair genes are associated with a strong predisposition to colon cancer in humans, and numerous mouse strains with mutations in these genes have been generated...
  87. ncbi A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity
    Kevin M Haigis
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Madison, 1400 University Avenue, Madison, Wisconsin 53706, USA
    Nat Genet 33:33-9. 2003
    In mammals, loss of APC/Apc gatekeeper function initiates intestinal tumorigenesis...
  88. ncbi Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse
    Nicholas F Paoni
    W M Keck Center for Transgene Research, Walther Cancer Center, and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Physiol Genomics 15:228-35. 2003
    Mutations in the adenomatous polyposis coli (APC) gene that result in excessive beta-catenin-induced cell signaling are implicated in the risk of colon cancer...
  89. ncbi Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice
    Lisa H Colbert
    Department of Kinesiology, University of Wisconsin Madison, WI, USA
    Carcinogenesis 27:2103-7. 2006
    ..9 km/day has had inconsistent effects on spontaneous intestinal polyp development in C57BL/6J-Apc(Min)/J (Min) mice; the amount of energy expenditure and/or a lack of hormonal changes could account for this ..
  90. ncbi Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect
    Jay Whelan
    Department of Nutrition, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996-1900, USA
    Adv Exp Med Biol 507:579-84. 2002
  91. ncbi CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:941-51. 2006
    ..Collectively, our findings show for the first time that CXCL1 is regulated by PGE2 and indicate that CXCL1 inhibitors should be evaluated further as potential anti-angiogenic agents for treatment of CRC...
  92. ncbi The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation
    Anne Maria Pajari
    Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, P O Box 66, 00014 Helsinki, Finland
    Cancer Lett 233:309-14. 2006
    The lignans matairesinol (MAT) and secoisolariciresinol (SECO) were fed to Min mice at 0.02% (w/w) in diet to study their effects on intestinal tumor development. The mean number (67 vs. 51, P=0.052) and size (1.4 vs. 1.2 mm, P=0...
  93. ncbi Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor)
    Cornelia Tolg
    Departments of Oncology and Biochemistry, The University of Western Ontario, Canada
    Oncogene 22:6873-82. 2003
    ..Rhamm-/- mice were crossed with Apc/Apc1638N mice, which harbor a targeted mutation in the Apc gene predisposing animals to gastrointestinal and ..
  94. ncbi CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    Susan E Erdman
    Division of Comparative Medicine and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:3998-4004. 2005
    ..in humans results from sequential genetic changes in intestinal epithelia commencing with inactivation of the APC tumor suppressor gene. Roles for host immunity in epithelial tumorigenesis are poorly understood...
  95. ncbi Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY, USA
    Int J Cancer 116:495-9. 2005
    ..This observation indicates that preexisting mutational events are not necessary for induction of colonic tumors by activated PPAR-gamma in vivo...
  96. ncbi Promotion of colon tumors in C57BL/6J-APC(min)/+ mice by thiazolidinedione PPARgamma agonists and a structurally unrelated PPARgamma agonist
    Michael V Pino
    Aventis Inc, Drug Safety Evaluation, Bridgewater, New Jersey 08807, USA
    Toxicol Pathol 32:58-63. 2004
    ..agonists (troglitazone and rosiglitazone) were previously shown to promote colon tumor formation in C57BL/6J-APC(min)/+ mice, a model for human familial adenomatous polyposis...
  97. ncbi Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice
    Malisetty V Swamy
    Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer Res 66:7370-7. 2006
    ..These observations show that atorvastatin inhibits intestinal tumorigenesis and that, importantly, when given together with low doses of celecoxib, it significantly increases the chemopreventive efficacy in an APC(min) mice.
  98. ncbi Intestinal microbiota: a potential diet-responsive prevention target in ApcMin mice
    Volker Mai
    Department of Epidemiology and Preventive Medicine, The University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Mol Carcinog 46:42-8. 2007
    ..with a freeze-dried fruit and vegetable extract (OFV), reduced the development of intestinal adenomas in Apc(Min) mice by 57% and 33%, respectively, compared to control mice fed a defined diet ad libitum...
  99. ncbi Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac
    Ying Hu
    Department of Medicine, Flinders University of South Australia, Adelaide, Australia
    Cancer Lett 248:234-44. 2007
    The effect of APC loss on azoxymethane (AOM)-induced apoptosis and cell proliferation, as well as their regulation by sulindac was examined in colon and small intestine in APC(Min/+) mice...
  100. ncbi Expression of guanylin is downregulated in mouse and human intestinal adenomas
    K A Steinbrecher
    Division of Pediatric Gastroenterology and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Biochem Biophys Res Commun 273:225-30. 2000
    ..guanylin expression increases adenoma susceptibility in an animal model of intestinal cancer, the multiple intestinal neoplasia (Min) mouse...
  101. ncbi Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse
    Guoxiang Shen
    Center for Cancer Prevention Research, Department of Pharmaceutics, and Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 67:9937-44. 2007
    ..In conclusion, our results showed that both SFN and DBM alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers...

Research Grants68

  1. Transforming Colorectal Cancer Screening through Multimodal Spectral Markers
    Vadim Backman; Fiscal Year: 2011
    ..Our approach is to develop a minimally intrusive, highly accurate pre-screen that would allow tailoring timing/intensity of screening and surveillance. ..
  2. Spectral Markers for Early Detection of Colon Neoplasia
    Hemant Roy; Fiscal Year: 2007
    ..In the future these spectral markers may be assayed with a 4D-ELF probe during rectal examination, thus providing a practical and accurate means of determining the optimal CRC screening regimen. ..
  3. Improving colonoscopic miss rate by real time microvascular blood analysis
    Hemant Roy; Fiscal Year: 2007
    ..This could have major importance for colon cancer prevention efforts in the United States. ..
  4. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  5. HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Chinthalapally V Rao; Fiscal Year: 2010
    ....
  6. Role of IL10 and TGFb1 in colon cancer
    SUSAN ERDMAN; Fiscal Year: 2007
    ..Information gained from these studies may elucidate pivotal mechanisms and uncover novel strategies for prevention and treatment of human colon cancer. ..
  7. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2006
    ..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
  8. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2007
    ..iNOS-selective inhibitors suppress chemically-induced colon carcinogenesis and also tumor formation in transgenic APC min mice...
  9. Role of IL10 and TGFb1 in colon cancer
    Susan E Erdman; Fiscal Year: 2010
    ..We propose to build upon our recent scientific breakthroughs and test strategies in mice that will stimulate potent and highly beneficial Treg to prevent cancer and impart healthful longevity in humans. ..
  10. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    ..3c) The mechanism whereby bile acids activate metalloproteases will be determined by exploring the roles of PKC, Ca2+, and Src in bile acid-induced HB-EGF release. ..
  11. Cell adhesion, signal transduction and cytoskeletal regulation in Drosophila
    Mark Peifer; Fiscal Year: 2009
    ..We hypothesize that Ena helps generate distinct actin structures using different domains and partners, and that Ena is integrated with other actin regulators in filopodia. We will test these hypotheses. ..
  12. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2010
    ..Its role in human cancer was first identified through the tumor suppressor Adenomatous polyposis coli (APC), mutated in most colon cancers. We now know that APC is a critical negative regulator of Wnt signaling...
  13. Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea Polyphenols
    Joshua D Lambert; Fiscal Year: 2010
    ..e. preexisting fatty liver disease) in which individuals may be sensitized to the hepatotoxic effects of EGCG. ..
  14. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..The hypothesis is that cardiac fibrosis will be regulated by urokinase activity and other functions of PAI-I which will be further pursued in future studies of mice expressing functional mutations of PAI-1. ..
  15. Analyses of Progression to Colon Cancer in a Spectrum of Pathways
    William Dove; Fiscal Year: 2009
    ..changes (loss-of-heterozygosity), to that involving stochastic epigenetic silencing of the tumor suppressor locus Apc, and to another involving induced inflammation...
  16. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2009
    ..Its role in human cancer was first identified through the tumor suppressor Adenomatous polyposis coli (APC), mutated in most colon cancers. We now know that APC is a critical negative regulator of Wnt signaling...
  17. Physical Activity Measurement in Older Adults
    Lisa Colbert; Fiscal Year: 2007
    ..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. ..
  18. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2002
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..
  19. RESEARCH TRAINING IN GASTROENTEROLOGY
    Jean Pierre Raufman; Fiscal Year: 2007
    ..We therefore submit this application to address these goals and to impact upon the shortage of physician-scientists and other researchers in the field of Gastroenterology ..
  20. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..in response to topical application of a tumor promoter (TPA), in human colon tumor cells with an inactivated APC gene, and in human and azoxymethane-induced rodent colon tumors providing the first evidence suggesting that this ..