Apba1

Summary

Gene Symbol: Apba1
Description: amyloid beta (A4) precursor protein binding, family A, member 1
Alias: 6430513E09Rik, Lin-10, Mint, Mint1, Urop11, X11, X11alpha, amyloid-beta A4 precursor protein-binding family A member 1, amyloid beta A4 precursor protein-binding family A member 1, UROP11-110, adapter protein X11alpha, mint-1, neuron-specific X11 protein, neuronal Munc18-1-interacting protein 1
Species: mouse
Products:     Apba1

Top Publications

  1. Setou M, Nakagawa T, Seog D, Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000;288:1796-802 pubmed
    ..Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B ..
  2. Misawa H, Kawasaki Y, Mellor J, Sweeney N, Jo K, Nicoll R, et al. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice. J Biol Chem. 2001;276:9264-72 pubmed
    ..Interestingly, MALS-3 protein is dramatically induced in the MALS-1/2 double knockouts, implying that dynamic changes in protein expression may play an important regulatory role for this family of synaptic PDZ proteins. ..
  3. Borg J, Straight S, Kaech S, de Taddèo Borg M, Kroon D, Karnak D, et al. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem. 1998;273:31633-6 pubmed
    ..Dlg.ZO-1 (PDZ) domains as well as an extended amino terminus. We have previously shown that the PTB domain of X11alpha (also known as Mint1) can bind to the amyloid precursor protein (APP) in a phosphotyrosine-independent fashion ..
  4. Ho A, Morishita W, Hammer R, Malenka R, Sudhof T. A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci U S A. 2003;100:1409-14 pubmed
    ..are adaptor proteins composed of divergent N-terminal sequences that bind to synaptic proteins such as CASK (Mint 1 only) and Munc18-1 (Mints 1 and 2) and conserved C-terminal PTB- and PDZ-domains that bind to widely distributed ..
  5. Ho A, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer R, et al. Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci. 2006;26:13089-101 pubmed
    ..The approximately 20% surviving Mint 1/2 double knock-out mice exhibit a decrease in weight and deficits in motor behaviors...
  6. Sullivan S, Dillon G, Sullivan J, Ho A. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid ? generation. J Biol Chem. 2014;289:15374-83 pubmed publisher
    ..We showed that wild-type Mint1 can rescue APP internalization and insertion in Mint knockout neurons...
  7. Li Z, Mulligan M, Wang X, Miles M, Lu L, Williams R. A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice. PLoS ONE. 2010;5:e12181 pubmed publisher
    ..The recent fixation of the variant in a subset of strains may have contributed to the rapid divergence of inbred strains. ..
  8. Motodate R, Saito Y, Hata S, Suzuki T. Expression and localization of X11 family proteins in neurons. Brain Res. 2016;1646:227-234 pubmed publisher
    The X11/Mint family of proteins comprises X11/X11?/Mint1, X11L/X11?/Mint2, and X11L2/X11?/Mint3...
  9. Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, et al. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS ONE. 2013;8:e64149 pubmed publisher
    ..Here, we report the identification of a new Mint1 isoform in a yeast two-hybrid screening, Mint1 826, which lacks an eleven amino acid (aa) sequence in the ..

More Information

Publications22

  1. Park J, Jung M, Kim Y, Song W, Chung S. Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11?. J Neurochem. 2012;122:1081-91 pubmed publisher
    ..Munc18-1, a central regulator of neurotransmitter release, interacts with Syntaxin 1 and X11?...
  2. Ho A, Liu X, Sudhof T. Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. J Neurosci. 2008;28:14392-400 pubmed publisher
    ..Here, we crossed conditional and constitutive Mint1, Mint2, and Mint3 knock-out mice with transgenic mouse models of Alzheimer's disease overproducing human Abeta ..
  3. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001;105:587-97 pubmed
    ..We show that CMT2A patients contain a loss-of-function mutation in the motor domain of the KIF1B gene. This is clear indication that defects in axonal transport due to a mutated motor protein can underlie human peripheral neuropathy. ..
  4. Guillaud L, Wong R, Hirokawa N. Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Nat Cell Biol. 2008;10:19-29 pubmed
    ..To address this specific question, we have investigated the mechanism behind the regulation of the KIF17-Mint1 interaction. Here we report that the tail region of the molecular motor KIF17 is regulated by phosphorylation...
  5. Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, et al. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. J Biol Chem. 2008;283:35763-71 pubmed publisher
    b>X11 and X11-like proteins (X11L) are neuronal adaptor proteins whose association to the cytoplasmic domain of amyloid beta-protein precursor (APP) suppresses the generation of amyloid beta-protein (Abeta) implicated in Alzheimer disease ..
  6. Medrihan L, Rohlmann A, Fairless R, Andrae J, Döring M, Missler M, et al. Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol. 2009;587:5095-106 pubmed publisher
  7. Verlaeten O, Casery C, Cavagna S, Naville D, Giraudon P, Belin M, et al. Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. J Mol Endocrinol. 2007;38:3-17 pubmed
    ..b>Urop11 was mainly detected in the hypothalamus and adipocytes, and was dramatically upregulated in these central and ..
  8. Dumanis S, Cha H, Song J, Trotter J, Spitzer M, Lee J, et al. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS ONE. 2011;6:e17203 pubmed publisher
    ..We also tested whether the interaction between ApoEr2 and its cytoplasmic adaptor proteins, specifically X11? and PSD-95, affected synapse and dendritic spine formation...
  9. Olsen O, Moore K, Fukata M, Kazuta T, Trinidad J, Kauer F, et al. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005;170:1127-34 pubmed
    ..The MALS/Veli-CASK-Mint-1 complex of PDZ proteins occurs on both sides of the synapse and has the potential to link transsynaptic adhesion ..
  10. Ryder J, Su Y, Liu F, Li B, Zhou Y, Ni B. Divergent roles of GSK3 and CDK5 in APP processing. Biochem Biophys Res Commun. 2003;312:922-9 pubmed
    ..Our data support a function for both GSK3 and CDK5 in APP processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease. ..
  11. Mori A, Okuyama K, Horie M, Taniguchi Y, Wadatsu T, Nishino N, et al. Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice. Neurosci Res. 2002;43:251-7 pubmed
    b>Mint-1, which is also called as X11 or mammalian Lin10, protein has been implicated in the synaptic vesicle exocytosis and the targeting and localization of synaptic membrane proteins...
  12. O Sullivan J, Comerford E, Rachidi W, Scott M, Hooper N, McMahon H. The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α. Biochim Biophys Acta. 2015;1850:2213-21 pubmed publisher
    The neuronal adaptor protein X11α is a multidomain protein with a phosphotyrosine binding (PTB) domain, two PDZ (PSD_95, Drosophila disks-large, ZO-1) domains, a Munc Interacting (MI) domain and a CASK interacting region...
  13. Samuels B, Hsueh Y, Shu T, Liang H, Tseng H, Hong C, et al. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron. 2007;56:823-37 pubmed
    ..Functional consequences include alterations in calcium influx. Mechanistically, Cdk5 regulates the interaction between CASK and liprin-alpha. These results provide a molecular explanation of how Cdk5 can promote synaptogenesis. ..