Gene Symbol: Ap1s1
Description: adaptor protein complex AP-1, sigma 1
Alias: AP19, AP-1 complex subunit sigma-1A, HA1 19 kDa subunit, adapter-related protein complex 1 sigma-1A subunit, adapter-related protein complex 1 subunit sigma-1A, adaptor protein complex AP-1 sigma-1A subunit, adaptor protein complex AP-1 subunit sigma-1A, adaptor-related protein complex 1 subunit sigma-1A, adaptor-related protein complex AP-1, sigma 1, clathrin assembly protein complex 1 sigma-1A small chain, clathrin coat assembly protein AP19, golgi adaptor HA1/AP1 adaptin sigma-1A subunit, sigma 1a subunit of AP-1 clathrin, sigma-adaptin 1A, sigma1A-adaptin
Species: mouse
Products:     Ap1s1

Top Publications

  1. Cooper S, Ranger Moore J, Bowden T. Differential inhibition of UVB-induced AP-1 and NF-kappaB transactivation by components of the jun bZIP domain. Mol Carcinog. 2005;43:108-16 pubmed
  2. Paradis P, MacLellan W, Belaguli N, Schwartz R, Schneider M. Serum response factor mediates AP-1-dependent induction of the skeletal alpha-actin promoter in ventricular myocytes. J Biol Chem. 1996;271:10827-33 pubmed
    ..Thus, AP-1 factors activate a hypertrophy-associated gene via SRF, without detectable binding to the promoter or to SRF. ..
  3. Foletta V. Transcription factor AP-1, and the role of Fra-2. Immunol Cell Biol. 1996;74:121-33 pubmed
    ..The analysis and determination of the function of Fra-2 will provide further information on the role of AP-1. ..
  4. Ameyar Zazoua M, Wisniewska M, Bakiri L, Wagner E, Yaniv M, Weitzman J. AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene. Oncogene. 2005;24:2298-306 pubmed
    ..In addition, we show that AP-1 dimers cooperate with oncogenic Ras in the transcriptional activation of the p14/p19ARF promoter. Thus, AP-1 heterodimers may contribute to the regulation of ARF expression upon oncogenic signaling. ..
  5. Doray B, Lee I, Knisely J, Bu G, Kornfeld S. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Mol Biol Cell. 2007;18:1887-96 pubmed
    ..These findings provide new insights into the trafficking mechanisms of D/EXXXL[LI]-mediated sorting signals. ..
  6. Glyvuk N, Tsytsyura Y, Geumann C, D Hooge R, Hüve J, Kratzke M, et al. AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J. 2010;29:1318-30 pubmed publisher
    ..The sigma1B-deficient mice have reduced motor coordination and severely impaired long-term spatial memory. These data reveal a molecular mechanism for a severe human X-chromosome-linked mental retardation. ..
  7. Baltes J, Larsen J, Radhakrishnan K, Geumann C, Kratzke M, Petersen C, et al. ?1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. J Cell Sci. 2014;127:3477-87 pubmed publisher
    ..Vertebrates express three AP1 ?1 subunit isoforms - ?1A, ?1B and ?1C (also known as AP1S1, AP1S2 and AP1S3, respectively)...
  8. Kirchhausen T, Davis A, Frucht S, Greco B, Payne G, Tubb B. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991;266:11153-7 pubmed
    AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells...
  9. Takatsu H, Sakurai M, Shin H, Murakami K, Nakayama K. Identification and characterization of novel clathrin adaptor-related proteins. J Biol Chem. 1998;273:24693-700 pubmed
    ..These data suggest that gamma2-adaptin constitute a novel adaptor-related complex that participates in a transport step different from that of AP-1. ..

More Information


  1. Hwang Y, Lee J, Hahm E, Jung K, Lee J, Park C, et al. Momordin I, an inhibitor of AP-1, suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival. Biochem Biophys Res Commun. 2005;337:815-23 pubmed
    ..In conclusion, the present results demonstrate for the first time that momordin I is a potent inhibitor of osteoclast differentiation via the reduction of NF-kappaB and AP-1, and also suppresses osteoclast function and survival. ..
  2. Moreno E, Moreno Delgado D, Navarro G, Hoffmann H, Fuentes S, Rosell Vilar S, et al. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: ?1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 2014;34:3545-58 pubmed publisher
    ..These findings suggest that a combination therapy of ?1R antagonists with H3 receptor agonists could serve to reduce some effects of cocaine. ..