Gene Symbol: Ap1m2
Description: adaptor protein complex AP-1, mu 2 subunit
Alias: D9Ertd818e, [m]1B, mu1B, AP-1 complex subunit mu-2, AP-mu chain family member mu1B, adaptor protein complex AP-1 subunit mu-2, adaptor-related protein complex 1 mu-2 subunit, adaptor-related protein complex 1 subunit mu-2, adaptor-related protein complex AP-1, mu 2 subunit, clathrin assembly protein complex 1 medium chain 2, clathrin assembly protein complex 1 mu-2 medium chain 2, golgi adaptor HA1/AP1 adaptin mu-2 subunit, mu-adaptin 2, mu1B-adaptin
Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar R, Foelsch H, et al
. Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 1999;449:215-20 pubmed
..Here, we report the identification of a novel member of the adaptor medium chain family, named mu1B, which is closely related to the previously described mu1A (79% amino acid sequence identity)...
Nakatsu F, Kadohira T, Gilbert D, Jenkins N, Kakuta H, Copeland N, et al
. Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). Cytogenet Cell Genet. 1999;87:53-8 pubmed
..We determined the genomic structure of previously cloned murine genes for mu1B (Ap1m2) and its closely related homolog, mu1A (Ap1m1)...
Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet M, Schaar B, et al
. Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system. Mol Cell Neurosci. 2001;18:307-19 pubmed
..Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking. ..
Schreiner R, Frindt G, Diaz F, Carvajal Gonzalez J, Perez Bay A, Palmer L, et al
. The absence of a clathrin adapter confers unique polarity essential to proximal tubule function. Kidney Int. 2010;78:382-8 pubmed publisher
..Hence, our results show that differential expression of AP1B contributes to normal kidney function and illustrates possible roles of this adapter protein in kidney development, physiology, and pathology...
Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, et al
. The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice. Gastroenterology. 2011;141:621-32 pubmed publisher
..The role of AP-1B in intestinal immunity was examined in AP-1B-deficient mice (Ap1m2(-/-)) by monitoring their phenotypes, intestinal morphology, and epithelial barrier functions...
Hase K, Nakatsu F, Ohmae M, Sugihara K, Shioda N, Takahashi D, et al
. AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Gastroenterology. 2013;145:625-35 pubmed publisher
..We analyzed the intestinal epithelia of mice deficient in Ap1m2 (Ap1m2(-/-) mice), which encodes the AP-1B ?1B subunit, and compared it with 129/B6/CD1 littermates (controls)...
Uwada J, Yoshiki H, Masuoka T, Nishio M, Muramatsu I. Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan-based motif. J Cell Sci. 2014;127:3131-40 pubmed publisher
..Our data indicate that the cellular distribution of M1-mAChR is governed by the C-terminal tryptophan-based motif, which mediates constitutive internalization. ..