Gene Symbol: Ap1m1
Description: adaptor-related protein complex AP-1, mu subunit 1
Alias: AA408894, AP47, Adtm1A, Cltnm, mu1A, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, adapter-related protein complex 1 subunit mu-1, adaptor protein complex AP-1 mu-1 subunit, adaptor-related protein complex 1 mu-1 subunit, clathrin assembly protein complex 1 medium chain 1, clathrin assembly protein complex 1 mu-1 medium chain 1, clathrin coat assembly protein AP47, clathrin coat-associated protein AP47, golgi adaptor HA1/AP1 adaptin mu-1 subunit, mu-adaptin 1, mu1A-adaptin
Species: mouse
Products:     Ap1m1

Top Publications

  1. Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar R, Foelsch H, et al. Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 1999;449:215-20 pubmed
    ..a novel member of the adaptor medium chain family, named mu1B, which is closely related to the previously described mu1A (79% amino acid sequence identity)...
  2. Meyer C, Zizioli D, Lausmann S, Eskelinen E, Hamann J, Saftig P, et al. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 2000;19:2193-203 pubmed
    ..Targeted disruption of the mouse mu1A-adaptin gene causes embryonic lethality at day 13.5...
  3. Ren X, Farías G, Canagarajah B, Bonifacino J, Hurley J. Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell. 2013;152:755-67 pubmed publisher
    ..A third Arf1 interaction site near the N terminus of the γ subunit is important for recruitment, but not activation. These observations lead to a model for the recruitment and activation of AP-1 by Arf1. ..
  4. Guo X, Mattera R, Ren X, Chen Y, Retamal C, González A, et al. The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells. Dev Cell. 2013;27:353-66 pubmed publisher
    ..We conclude that expression of distinct μ1 isoforms in epithelial cells expands the repertoire of signals recognized by AP-1 for sorting of a broader range of cargoes to the basolateral surface. ..
  5. Nakatsu F, Kadohira T, Gilbert D, Jenkins N, Kakuta H, Copeland N, et al. Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). Cytogenet Cell Genet. 1999;87:53-8 pubmed
    ..the genomic structure of previously cloned murine genes for mu1B (Ap1m2) and its closely related homolog, mu1A (Ap1m1)...
  6. Bonnemaison M, Bäck N, Lin Y, Bonifacino J, Mains R, Eipper B. AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins. Traffic. 2014;15:1099-121 pubmed publisher
    ..Coimmunoprecipitation experiments with PAM-1 mutants revealed an influence of the luminal domains of PAM-1 on this interaction. Thus, AP-1A is crucial for normal SG biogenesis, function and composition. ..
  7. Nakayama Y, Goebl M, O Brine Greco B, Lemmon S, Pingchang Chow E, Kirchhausen T. The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem. 1991;202:569-74 pubmed
    We have cloned and sequenced mouse brain AP47, the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1...
  8. Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet M, Schaar B, et al. Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system. Mol Cell Neurosci. 2001;18:307-19 pubmed
    ..Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking. ..
  9. Doray B, Lee I, Knisely J, Bu G, Kornfeld S. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Mol Biol Cell. 2007;18:1887-96 pubmed
    ..These findings provide new insights into the trafficking mechanisms of D/EXXXL[LI]-mediated sorting signals. ..

More Information


  1. Bonifacino J. Adaptor proteins involved in polarized sorting. J Cell Biol. 2014;204:7-17 pubmed publisher
    ..The clathrin-associated adaptor protein 1 (AP-1) complex plays a preeminent role in this process, although other adaptors and coat proteins, such as AP-4, ARH, Numb, exomer, and retromer, have also been implicated. ..
  2. Hirata Y, Funato Y, Miki H. Basolateral sorting of the Mg²⁺ transporter CNNM4 requires interaction with AP-1A and AP-1B. Biochem Biophys Res Commun. 2014;455:184-9 pubmed publisher
    ..These results imply that CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B. ..
  3. Bonnemaison M, Bäck N, Duffy M, Ralle M, Mains R, Eipper B. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem. 2015;290:21264-79 pubmed publisher
    ..Altered luminal cuproenzyme function may contribute to deficits observed when the AP-1 function is compromised. ..
  4. Dib K, Tikhonova I, Ivetic A, Schu P. The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif. J Biol Chem. 2017;292:6703-6714 pubmed publisher
  5. Meyer C, Eskelinen E, Guruprasad M, Von Figura K, Schu P. Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate. J Cell Sci. 2001;114:4469-76 pubmed
    ..We analyzed transport of MPR300 in mu1A-adaptin-deficient fibroblasts, which lack a functional AP-1 clathrin adaptor complex...
  6. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, et al. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. elife. 2014;3:e02362 pubmed publisher
    ..The ability of Vpu to hijack AP-dependent trafficking pathways suggests a potential common theme for Vpu-mediated downregulation of host proteins.DOI: http://dx.doi.org/10.7554/eLife.02362.001. ..