Gene Symbol: Ap1g1
Description: adaptor protein complex AP-1, gamma 1 subunit
Alias: AA409002, AU041323, AW551707, Adtg, D8Ertd374e, AP-1 complex subunit gamma-1, adapter-related protein complex 1 subunit gamma-1, adaptor protein complex AP-1 subunit gamma-1, adaptor-related protein complex 1 subunit gamma-1, clathrin assembly protein complex 1 gamma-1 large chain, gamma-adaptin, gamma1-adaptin, golgi adaptor HA1/AP1 adaptin subunit gamma-1
Species: mouse
Products:     Ap1g1

Top Publications

  1. Robinson M. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. J Cell Biol. 1990;111:2319-26 pubmed
  2. Takatsu H, Sakurai M, Shin H, Murakami K, Nakayama K. Identification and characterization of novel clathrin adaptor-related proteins. J Biol Chem. 1998;273:24693-700 pubmed
    ..These data suggest that gamma2-adaptin constitute a novel adaptor-related complex that participates in a transport step different from that of AP-1. ..
  3. Ren X, Farías G, Canagarajah B, Bonifacino J, Hurley J. Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell. 2013;152:755-67 pubmed publisher
    ..A third Arf1 interaction site near the N terminus of the γ subunit is important for recruitment, but not activation. These observations lead to a model for the recruitment and activation of AP-1 by Arf1. ..
  4. Kurth I, Pamminger T, Hennings J, Soehendra D, Huebner A, Rotthier A, et al. Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. Nat Genet. 2009;41:1179-81 pubmed publisher
    ..This implicates FAM134B as critical in long-term survival of nociceptive and autonomic ganglion neurons. ..
  5. Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem. 2002;277:25400-7 pubmed
  6. Lefkir Y, Malbouyres M, Gotthardt D, Ozinsky A, Cornillon S, Bruckert F, et al. Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis. Mol Biol Cell. 2004;15:861-9 pubmed
    ..In summary, our data suggest a new role of AP-1 at an early stage of phagosome and macropinosome formation. ..
  7. Gurung R, Tan A, Ooms L, McGrath M, Huysmans R, Munday A, et al. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following . J Biol Chem. 2003;278:11376-85 pubmed
    ..Collectively, these studies demonstrate a novel membrane-targeting domain that serves to recruit SKIP and PIPP to membrane ruffles. ..
  8. Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, et al. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). Genomics. 1998;50:275-80 pubmed
    ..We present the cloning and sequencing of the human gamma-adaptin cDNA (HGMW-approved symbol ADTG) consisting of 3723 bp with an open reading frame capable of encoding a protein of 825 amino acids, 98...
  9. Muthusamy N, Faundez V, Bergson C. Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes. J Neurochem. 2012;123:60-72 pubmed publisher
    ..Altogether, our data suggest that calcyon directly interacts with ?3A and ?3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes. ..

More Information


  1. Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, et al. Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet. 2007;16:678-90 pubmed
    ..I2020T mutant LRRK2 associates with lipid rafts, similar to the WT. The lipid raft association of LRRK2 mutants as well as WT LRRK2 suggests that alteration of LRRK2 function on lipid rafts contributes to the pathogenesis of PD. ..
  2. Holt M, Varoqueaux F, Wiederhold K, Takamori S, Urlaub H, Fasshauer D, et al. Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. J Biol Chem. 2006;281:17076-83 pubmed
    ..However, neither complex assembly nor fusion was as efficient as with SNAP-25. ..
  3. Ritter B, Philie J, Girard M, Tung E, Blondeau F, McPherson P. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. EMBO Rep. 2003;4:1089-95 pubmed
    ..Disruption of this interaction blocks clathrin-mediated endocytosis. Together, our studies identify a new family of endocytic proteins that define a unique AP-2-binding motif. ..
  4. Page L, Sowerby P, Lui W, Robinson M. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. J Cell Biol. 1999;146:993-1004 pubmed
    ..The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins. ..
  5. Bogan J, Lodish H. Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol. 1999;146:609-20 pubmed
  6. Kent H, McMahon H, Evans P, Benmerah A, Owen D. Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. Structure. 2002;10:1139-48 pubmed
    ..This observation explains the demonstrated brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi complex. ..
  7. Wasiak S, Denisov A, Han Z, Leventis P, de Heuvel E, Boulianne G, et al. Characterization of a gamma-adaptin ear-binding motif in enthoprotin. FEBS Lett. 2003;555:437-42 pubmed
    ..NMR studies of the gamma-ear in complex with a synthetic peptide from enthoprotin provide structural details of the binding site for TGN accessory proteins within the gamma-ear. ..
  8. Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet M, Schaar B, et al. Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system. Mol Cell Neurosci. 2001;18:307-19 pubmed
    ..Taken together these data indicate that a certain proportion of Doublecortin interacts with AP-1 and/or AP-2 in vivo and are consistent with a potential involvement of Doublecortin in protein sorting or vesicular trafficking. ..
  9. Meyer C, Zizioli D, Lausmann S, Eskelinen E, Hamann J, Saftig P, et al. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 2000;19:2193-203 pubmed
    ..MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor. ..
  10. Govero J, Doray B, Bai H, Kornfeld S. Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development. PLoS ONE. 2012;7:e30184 pubmed publisher
    ..We conclude that the three mammalian GGAs are essential proteins that are not fully redundant. ..
  11. Zizioli D, Meyer C, Guhde G, Saftig P, Von Figura K, Schu P. Early embryonic death of mice deficient in gamma-adaptin. J Biol Chem. 1999;274:5385-90 pubmed
    ..Free beta1- or micro1 chains were not detectable, indicating that they are unstable unless they are part of AP-1 complexes. Heterozygous mice weigh less then their wild-type littermates and show impaired T cell development. ..
  12. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, et al. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. elife. 2014;3:e02362 pubmed publisher
    ..The ability of Vpu to hijack AP-dependent trafficking pathways suggests a potential common theme for Vpu-mediated downregulation of host proteins.DOI: http://dx.doi.org/10.7554/eLife.02362.001. ..
  13. Johnson K, Gagnon L, Chang B. A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice. Mamm Genome. 2016;27:200-12 pubmed publisher
    ..A null mutation of the mouse Ap1g1 gene, which encodes the gamma-1 subunit of the AP-1 complex, causes embryonic lethality when homozygous, ..