Gene Symbol: Anxa2
Description: annexin A2
Alias: AW215814, Cal1h, annexin A2, 33-kDa calcimedin, 33-kDa lymphocyte Ca<2+>- binding protein, 33kDa lymphocyte Ca<2+>- binding protein, 36-kDa calelectrin, PAP-IV, annexin II, annexin-2, calpactin I heavy chain, calpactin-1 heavy chain, chromobindin-8, lipocortin II, p36, placental anticoagulant protein IV, protein I
Species: mouse
Products:     Anxa2

Top Publications

  1. Waters K, Stenoien D, Sowa M, von Neubeck C, Chrisler W, Tan R, et al. Annexin A2 modulates radiation-sensitive transcriptional programming and cell fate. Radiat Res. 2013;179:53-61 pubmed publisher
    We previously established annexin A2 as a radioresponsive protein associated with anchorage independent growth in murine epidermal cells...
  2. Hayes M, Shao D, Grieve A, Levine T, Bailly M, Moss S. Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate. Biochim Biophys Acta. 2009;1793:1086-95 pubmed publisher
    ..The calcium and anionic phospholipid-binding protein annexin A2 is necessary for macropinocytic rocketing and has been shown to bind both PI(4,5)P2 and the barbed-ends of F-..
  3. Ling Q, Jacovina A, Deora A, Febbraio M, Simantov R, Silverstein R, et al. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest. 2004;113:38-48 pubmed
    ..However, previous in vitro studies have suggested that the endothelial cell surface protein annexin II can stimulate t-PA-mediated plasminogen activation in the complete absence of fibrin...
  4. Genetos D, Wong A, Watari S, Yellowley C. Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK. Bone. 2010;47:1013-9 pubmed publisher
    ..This suggests that VEGF induction of Annexin A2 is not mediated via VEGF-R1 agonism alone but by VEGF-R1 and Neuropilin-1 or Neuropilin-2 heterodimers...
  5. Scharf B, Clement C, Wu X, Morozova K, Zanolini D, Follenzi A, et al. Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nat Commun. 2012;3:755 pubmed publisher
    ..b>Annexin A2 recruitment to damaged organelles is shown by two-dimensional DIGE protein profiling, endosomal fractionation, ..
  6. Mayer G, Poirier S, Seidah N. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J Biol Chem. 2008;283:31791-801 pubmed publisher
    ..and mass spectrometry analysis, we demonstrated that PCSK9 binds to a approximately 33-kDa protein identified as annexin A2 (AnxA2) but not to the closely related annexin A1...
  7. Weber T, Opresko L, Waisman D, Newton G, Quesenberry R, Bollinger N, et al. Regulation of the low-dose radiation paracrine-specific anchorage-independent growth response by annexin A2. Radiat Res. 2009;172:96-105 pubmed publisher
    Here we identify the release of annexin A2 into the culture medium in response to low-dose X-radiation exposure and establish functional linkages to an established paracrine factor-mediated anchorage-independent growth response...
  8. Zhao W, Chen G, Chen H, Pascale A, Ravindranath L, Quon M, et al. Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor. J Biol Chem. 2003;278:4205-15 pubmed
    b>Annexin II is secreted into the extracellular environment, where, via interactions with specific proteases and extracellular matrix proteins, it participates in plasminogen activation, cell adhesion, and tumor metastasis and invasion...
  9. Garver W, Hossain G, Winscott M, Heidenreich R. The Npc1 mutation causes an altered expression of caveolin-1, annexin II and protein kinases and phosphorylation of caveolin-1 and annexin II in murine livers. Biochim Biophys Acta. 1999;1453:193-206 pubmed
    ..The expression of annexin II was significantly increased in homozygous liver homogenates and the Triton X-100 insoluble floating fraction (..

More Information


  1. Law A, Ling Q, Hajjar K, Futter C, Greenwood J, Adamson P, et al. Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina. Mol Biol Cell. 2009;20:3896-904 pubmed publisher
    ..These findings reveal that anx A2 is involved in the circadian regulation of outer segment phagocytosis, and they provide new insight into the protein machinery that regulates phagocytic function in RPE cells. ..
  2. Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten M, Prat A, et al. PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. J Lipid Res. 2011;52:1383-91 pubmed publisher
    ..Thus, PCSK9 downregulates LDLR levels during brain development and following transient ischemic stroke in adult mice. ..
  3. He K, Sui G, Xiong H, Broekman M, Huang B, Marcus A, et al. Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2. J Biol Chem. 2011;286:15428-39 pubmed publisher
    ..b>Annexin A2 (A2) heterotetramer (A2·p11)(2) is a key profibrinolytic complex that assembles plasminogen and tissue ..
  4. Rescher U, Gerke V. Annexins--unique membrane binding proteins with diverse functions. J Cell Sci. 2004;117:2631-9 pubmed
    ..Among other things, this is evident in annexin A1- and A2-knockout mice, which show impaired regulation of neutrophil extravasation and defects in plasmin generation, respectively. ..
  5. Saris C, Kristensen T, D EUSTACHIO P, Hicks L, Noonan D, Hunter T, et al. cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). J Biol Chem. 1987;262:10663-71 pubmed
    ..Analysis of the same RNA samples for p36 mRNA levels showed that expression of p11 and p36 mRNAs is not always coordinated...
  6. Jung Y, Wang J, Song J, Shiozawa Y, Wang J, Havens A, et al. Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood. 2007;110:82-90 pubmed
    ..OBs, a cell blot analysis was used that revealed 2 major bands that corresponded to monomers and multimers of annexin II (Anxa2). Immunohistochemistry revealed that OBs and marrow endothelial cells express Anxa2 at high levels...
  7. Lin L, Wu C, Hu K. Tissue plasminogen activator activates NF-?B through a pathway involving annexin A2/CD11b and integrin-linked kinase. J Am Soc Nephrol. 2012;23:1329-38 pubmed publisher
    ..The protease-independent action of tPA required its membrane receptor, annexin A2. tPA induced the aggregation and interaction of annexin A2 with integrin CD11b, and ablation of CD11b or ..
  8. Hamre K, Chepenik K, Goldowitz D. The annexins: specific markers of midline structures and sensory neurons in the developing murine central nervous system. J Comp Neurol. 1995;352:421-35 pubmed
    ..Annexin I has a very restricted distribution, only present in the midline raphe of the brainstem. Annexin II is present in the spinal cord, brainstem and mesencephalon...
  9. Bhattacharjee G, Ahamed J, Pawlinski R, Liu C, Mackman N, Ruf W, et al. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res. 2008;102:457-64 pubmed publisher
    ..We show here that annexin 2 acts as a receptor for factor Xa on the surface of human umbilical vein endothelial cells and that annexin 2 ..
  10. Geschwind D, Ou J, Easterday M, Dougherty J, Jackson R, Chen Z, et al. A genetic analysis of neural progenitor differentiation. Neuron. 2001;29:325-39 pubmed
    ..This combination of methods demonstrates the power of using custom microarrays derived from RDA-subtracted libraries for both gene discovery and gene expression analysis in the central nervous system. ..
  11. Swisher J, Burton N, Bacot S, Vogel S, Feldman G. Annexin A2 tetramer activates human and murine macrophages through TLR4. Blood. 2010;115:549-58 pubmed publisher
    ..Specifically, annexin A2, found in a heterotetrameric complex with S100A10, not only serves as a key extracellular binding partner for ..
  12. Burkart A, Samii B, Corvera S, Shpetner H. Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem. 2003;278:18360-7 pubmed
    ..b>Annexin II, previously implicated in cholesterol trafficking, was associated in a complex with SHP-2, and both proteins ..
  13. Valapala M, Vishwanatha J. Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2. J Biol Chem. 2011;286:30911-25 pubmed publisher
    b>Annexin A2 (AnxA2), a Ca(2+)-dependent phospholipid-binding protein, is known to associate with the plasma membrane and the endosomal system...
  14. Hou Y, Yang L, Mou M, Hou Y, Zhang A, Pan N, et al. Annexin A2 regulates the levels of plasmin, S100A10 and Fascin in L5178Y cells. Cancer Invest. 2008;26:809-15 pubmed publisher
    b>Annexin A2 (ANXA2) was reported as the receptor, activator, expression enhancer, or cooperator for plasmin, S100A10, and others...
  15. Defour A, Medikayala S, van der Meulen J, Hogarth M, Holdreith N, Malatras A, et al. Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle. Hum Mol Genet. 2017;26:1979-1991 pubmed publisher
    ..Here, we show that similar to dysferlin, lack of annexin A2 (AnxA2) also results in poor myofiber repair and progressive muscle weakening with age...
  16. Dadhania V, Muskhelishvili L, Latendresse J, Mehendale H. Hepatic Overexpression of Annexin A1 and A2 in Thioacetamide-Primed Mice Protects Them Against Acetaminophen-Induced Liver Failure and Death. Int J Toxicol. 2016;35:654-665 pubmed
    ..Our data indicate that hepatic overexpression of ANX1 and ANX2 inhibits APAP-induced expansion of liver injury. ..
  17. Fey M, Moffat G, Vik D, Meisenhelder J, Saris C, Hunter T, et al. Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons. Biochim Biophys Acta. 1996;1306:160-70 pubmed
    p36 (also termed annexin II) is a 39 kDa Ca2+/phospholipid-binding, membrane-associated protein that is a protein-tyrosine kinase substrate...
  18. Seidah N, Poirier S, Denis M, Parker R, Miao B, Mapelli C, et al. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE. 2012;7:e41865 pubmed publisher
    ..Accordingly, the quest for PCSK9 inhibitors has major clinical implications. We have previously identified annexin A2 (AnxA2) as an endogenous binding partner and functional inhibitor of PCSK9...
  19. Avenali L, Narayanan P, Rouwette T, Cervellini I, Sereda M, Gomez Varela D, et al. Annexin A2 regulates TRPA1-dependent nociception. J Neurosci. 2014;34:14506-16 pubmed publisher
    ..Using an unbiased proteomics-based approach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse sensory neurons...
  20. Stukes S, Coelho C, Rivera J, Jedlicka A, Hajjar K, Casadevall A. The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection. J Immunol. 2016;197:1252-61 pubmed publisher
    ..Using murine macrophages deficient in the membrane phospholipid binding protein, annexin A2 (ANXA2), we observed a significant decrease in both phagocytosis of yeast cells and the frequency of nonlytic ..
  21. Hamilton B, Frankel W, Kerrebrock A, Hawkins T, FitzHugh W, Kusumi K, et al. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996;379:736-9 pubmed
    ..We propose a model based on these results, in which RORalpha interacts with the thyroid hormone signalling pathway to induce Purkinje-cell maturation. ..
  22. Fang W, Fa Z, Xie Q, Wang G, Yi J, Zhang C, et al. Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans. CNS Neurosci Ther. 2017;23:291-300 pubmed publisher
    ..b>Annexin A2 (AnxA2) is an important signaling protein involved in several intracellular processes such as membrane ..
  23. Zhang S, Yu M, Guo Q, Li R, Li G, Tan S, et al. Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway. Sci Rep. 2015;5:15859 pubmed publisher
    ..Here we reveal a role for annexin A2 (AnxA2) in host defense against infection as anxa2(-/-) mice were highly susceptible to Gram-negative bacteria-..
  24. Lennon N, Kho A, Bacskai B, Perlmutter S, Hyman B, Brown R. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003;278:50466-73 pubmed
    ..We propose a model of muscle membrane healing mediated by dysferlin that is relevant to both normal and dystrophic muscle and defines the annexins as potential muscular dystrophy genes. ..
  25. Foley K, Rucki A, Xiao Q, Zhou D, Leubner A, Mo G, et al. Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer. Sci Signal. 2015;8:ra77 pubmed publisher
    ..3D (Sema3D) is increased in PDA tumors, and the presence of antibodies against the pleiotropic protein annexin A2 (AnxA2) in the sera of some patients after surgical resection of PDA is associated with longer recurrence-free ..
  26. Valapala M, Thamake S, Vishwanatha J. A competitive hexapeptide inhibitor of annexin A2 prevents hypoxia-induced angiogenic events. J Cell Sci. 2011;124:1453-64 pubmed publisher
    ..b>Annexin A2 (AnxA2) is an endothelial cell-surface receptor for the generation of active proteolytic factors, such as ..
  27. Luo M, Flood E, Almeida D, Yan L, Berlin D, Heerdt P, et al. Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. J Exp Med. 2017;214:2535-2545 pubmed publisher
    ..Here, we report that the phospholipid-binding protein, annexin A2 (ANXA2) functions to maintain vascular integrity in the face of alveolar hypoxia...
  28. He K, Deora A, Xiong H, Ling Q, Weksler B, Niesvizky R, et al. Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11. J Biol Chem. 2008;283:19192-200 pubmed publisher
    The annexin A2 (A2) heterotetramer, consisting of two copies of A2 and two copies of S100A10/p11, promotes fibrinolytic activity on the surface of vascular endothelial cells by assembling plasminogen and tissue plasminogen activator (tPA) ..
  29. Jacomo R, Santana Lemos B, Lima A, Assis P, Lange A, Figueiredo Pontes L, et al. Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia. Blood. 2012;120:207-13 pubmed publisher
    ..APL blasts overexpress annexin II (ANXII), a receptor for tissue plasminogen activator (tPA), and plasminogen, thereby increasing plasmin ..
  30. Jung Y, Wang J, Lee E, McGee S, Berry J, Yumoto K, et al. Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow. Mol Cancer Res. 2015;13:197-207 pubmed publisher
    b>Annexin 2 (ANXA2) plays a critical role in hematopoietic stem cell (HSC) localization to the marrow niche. In part, ANXA2 supports HSCs by serving as an anchor for stromal-derived factor-1 (CXCL12/SDF-1)...
  31. Genetos D, Wong A, Weber T, Karin N, Yellowley C. Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells. PLoS ONE. 2014;9:e107482 pubmed publisher
    ..We employed shRNA to generate annexin A2 (AnxA2)- or annexin A5 (AnxA5)-knockdown pre-osteoblasts, and determined whether proliferation or osteogenic ..
  32. Huang B, Deora A, He K, Chen K, Sui G, Jacovina A, et al. Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice. Blood. 2011;118:2918-29 pubmed publisher
    ..Here, we report that the proliferative phase of OIR requires transcriptional induction of the annexin A2 (A2) gene through the direct action of the hypoxia-inducible factor-1 complex...
  33. Sarkar S, Swiercz R, Kantara C, Hajjar K, Singh P. Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells. Gastroenterology. 2011;140:583-595.e4 pubmed publisher
    ..We investigated whether Annexin A2 (AnxA2), a progastrin receptor, activates NF-κB and β-catenin in vivo...
  34. Dai F, Zhang Y, Kang Y, Wang Q, Gaisano H, Braunewell K, et al. The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem. 2006;281:21942-53 pubmed
    ..Increased VILIP-1 enhanced insulin secretion in a cAMP-associated manner. Down-regulation of VILIP-1 was accompanied by decreased cAMP accumulation but increased insulin gene transcription. ..
  35. San I, Prost G, Williams J, Moss S, Nuber U. High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2. Biochem Biophys Res Commun. 2016;478:573-9 pubmed publisher
    ..Proteome analyses of Podxl-overexpressing and control NSPs revealed increased levels of Annexin A2 (ANXA2)...
  36. Teixeira T, Cruz L, Mortara R, da Silva C. Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction. Parasit Vectors. 2015;8:493 pubmed publisher
    ..Here we describe the role of Annexin A2 and ARF-6 during extracellular amastigote-mammalian cell interactions...
  37. Zhao S, Huang L, Wu J, Zhang Y, Pan D, Liu X. Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy. Mol Vis. 2009;15:1231-42 pubmed
    b>Annexin A2 has been shown to play a role in many neovascularization diseases...
  38. Mickleburgh I, Burtle B, Hollås H, Campbell G, Chrzanowska Lightowlers Z, Vedeler A, et al. Annexin A2 binds to the localization signal in the 3' untranslated region of c-myc mRNA. FEBS J. 2005;272:413-21 pubmed
    ..factor to the perinuclear localization element in the 3'UTR of c-myc mRNA and identify this protein as annexin A2. Gel retardation and UV cross-linking experiments showed that proteins in fibroblast extracts formed complexes ..
  39. Madureira P, Hill R, Miller V, Giacomantonio C, Lee P, Waisman D. Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis. Oncotarget. 2011;2:1075-93 pubmed
    ..b>Annexin A2 is unique among the annexins in that it possesses redox sensitive cysteine(s)...
  40. Lima e Silva R, Shen J, Gong Y, Seidel C, Hackett S, Kesavan K, et al. Agents that bind annexin A2 suppress ocular neovascularization. J Cell Physiol. 2010;225:855-64 pubmed publisher
    ..It has recently been demonstrated to bind annexin A2 on cultured tumor and vascular endothelial cells and to suppress blood vessel growth on chick chorioallantoic ..
  41. Schuliga M, Langenbach S, Xia Y, Qin C, Mok J, Harris T, et al. Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2. Am J Respir Cell Mol Biol. 2013;49:751-8 pubmed publisher
    ..The knockdown of annexin A2, a component of the putative plasminogen receptor comprised of annexin A2 and S100A10, attenuated plasminogen ..
  42. Chepenik K, Shipman Appasamy P, Ahn N, Goldowitz D. Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J Craniofac Genet Dev Biol. 1995;15:171-81 pubmed
    ..inducing regimen of dexamethasone stimulated accumulation of lipocortin I protein and mRNA, but not lipocortin II (annexin II) protein...
  43. Morozova K, Sridhar S, Sidhar S, Zolla V, Clement C, Scharf B, et al. Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion. Nat Commun. 2015;6:5856 pubmed publisher
    ..Here we show that the membrane curvature-inducing protein annexin A2 contributes to the formation of these vesicles and their fusion to form phagophores...
  44. Dassah M, Almeida D, Hahn R, Bonaldo P, Worgall S, Hajjar K. Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells. J Cell Sci. 2014;127:828-44 pubmed publisher
    ..We observed that the AnxA2(-/-) lung basement membrane specifically lacks collagen VI (COL6), and postulated that ANXA2 directs bronchial ..
  45. Saris C, Tack B, Kristensen T, Glenney J, Hunter T. The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell. 1986;46:201-12 pubmed
    We have isolated and sequenced a full-length cDNA clone for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain)...
  46. de Graauw M, Cao L, Winkel L, van Miltenburg M, Le Dévédec S, Klop M, et al. Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation. Oncogene. 2014;33:2610-9 pubmed publisher
    ..We show that depletion of the actin and endocytosis regulatory protein annexin A2 (AnxA2) in a panel of four triple negative breast cancer (TNBC) cell lines affected EGFR endocytosis...
  47. Rihan K, Antoine E, Maurin T, Bardoni B, Bordonné R, Soret J, et al. A new cis-acting motif is required for the axonal SMN-dependent Anxa2 mRNA localization. RNA. 2017;23:899-909 pubmed publisher
    ..We recently showed that SMN depletion gives rise to a decrease in the axonal transport of the mRNAs encoding Annexin A2 (Anxa2)...
  48. Liu F, Gamez G, Myers D, Clemmons W, Lam W, Jobe S. Mitochondrially mediated integrin ?IIb?3 protein inactivation limits thrombus growth. J Biol Chem. 2013;288:30672-81 pubmed publisher
  49. Brunskill E, Park J, Chung E, Chen F, Magella B, Potter S. Single cell dissection of early kidney development: multilineage priming. Development. 2014;141:3093-101 pubmed publisher
    ..This is followed by a combination of gene repression, which turns off the genes associated with most possible lineages, and the activation of increasing numbers of genes driving the chosen developmental direction. ..
  50. Huebner K, Cannizzaro L, Frey A, Hecht B, Hecht F, Croce C, et al. Chromosomal localization of the human genes for lipocortin I and lipocortin II. Oncogene Res. 1988;2:299-310 pubmed
    The human genes which code for Lipocortin I and Lipocortin II, proteins that inhibit phospholipase A2 (PLA2) activity, have been regionally localized in the human genome by chromosomal in situ hybridization and segregation analysis in ..
  51. Amadio P, Tarantino E, Sandrini L, Tremoli E, Barbieri S. Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice. Thromb Haemost. 2017;117:1486-1497 pubmed publisher
    ..PTGS2-/- thrombi have greater fibrin content, higher number of F4/80+, TF+ and ANXA2+ cells, and lower S100A10+ cells...
  52. Li R, Tan S, Yu M, Jundt M, Zhang S, Wu M. Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway. J Immunol. 2015;195:3901-11 pubmed publisher
    Earlier studies reported that a cell membrane protein, Annexin A2 (AnxA2), plays multiple roles in the development, invasion, and metastasis of cancer...
  53. Jung Y, Shiozawa Y, Wang J, Patel L, Havens A, Song J, et al. Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp Hematol. 2011;39:151-166.e1 pubmed publisher
    Previously, we reported that annexin-2 (anxa2) plays an important role in hematopoietic stem cell (HSC) localization to the endosteal/osteoblastic marrow niche...
  54. Wang X, Shaw D, Sakhon O, Snyder G, Sundberg E, Santambrogio L, et al. The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infect Immun. 2016;84:1796-1805 pubmed publisher
    ..Here, we describe that loop 2 of sialostatin L2, an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflammasome during infection with the rickettsial agent Anaplasma ..
  55. te Vruchte D, Lloyd Evans E, Veldman R, Neville D, Dwek R, Platt F, et al. Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. J Biol Chem. 2004;279:26167-75 pubmed
    ..Both annexin 2 and 6, membrane-associated proteins that are important in endocytic trafficking, show distorted distributions in ..
  56. Hayashi A, Nakashima K, Yamagishi K, Hoshi T, Suzuki A, Baba H. Localization of annexin II in the paranodal regions and Schmidt-Lanterman incisures in the peripheral nervous system. Glia. 2007;55:1044-52 pubmed
    b>Annexin II (AX II) is a member of the family of calcium-dependent actin- and phospholipid-binding proteins implicated in numerous intracellular functions such as signal transduction, membrane trafficking, and mRNA transport, as well as in ..
  57. Das R, Burke T, Plow E. Histone H2B as a functionally important plasminogen receptor on macrophages. Blood. 2007;110:3763-72 pubmed
    ..Three previously characterized Plg-Rs (alpha-enolase, annexin 2, and p11) and a recently identified Plg-R (histone H2B [H2B]) were assessed for their contribution to Plg ..
  58. Anji A, Kumari M. A cis-acting region in the N-methyl-d-aspartate R1 3'-untranslated region interacts with the novel RNA-binding proteins beta subunit of alpha glucosidase II and annexin A2--effect of chronic ethanol exposure in vivo. Eur J Neurosci. 2011;34:1200-11 pubmed publisher
    ..The ?4 RNA-protein complex harbored GII? and a second trans-acting protein identified as annexin A2 (AnxA2). Ethanol-sensitive GII? was upregulated by 70% in ethanol-exposed CC...
  59. Jacovina A, Deora A, Ling Q, Broekman M, Almeida D, Greenberg C, et al. Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis. J Clin Invest. 2009;119:3384-94 pubmed publisher
    ..The annexin A2 complex (termed "A2") is the cell surface coreceptor for plasminogen and TPA and accelerates the ..
  60. Meadows S, Cleaver O. Annexin A3 Regulates Early Blood Vessel Formation. PLoS ONE. 2015;10:e0132580 pubmed publisher
    ..Our results are the first to reveal an in vivo function for Anxa3 during vascular development and represent a previously unexplored aspect of annexin biology. ..
  61. Amiguet P, D EUSTACHIO P, Kristensen T, Wetsel R, Saris C, Hunter T, et al. Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene. Biochemistry. 1990;29:1226-32 pubmed
    ..This protein has recently been named calpactin I heavy chain since it is the large subunit of a Ca2(+)-dependent phospholipid and actin binding heterotetramer...
  62. Popova N, Morris R. Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci. Curr Top Microbiol Immunol. 2004;280:111-37 pubmed
  63. Yamane T, Yamamoto Y, Nakano Y, Nakagaki T, Ohkubo I, Ariga H. Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells. Biochem Biophys Res Commun. 2015;467:472-7 pubmed publisher
    ..We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in..
  64. Xu T, Rumsby M. Phorbol ester-induced translocation of PKC epsilon to the nucleus in fibroblasts: identification of nuclear PKC epsilon-associating proteins. FEBS Lett. 2004;570:20-4 pubmed
    ..have been characterised as matrin 3, transferrin, Rac GTPase activating protein 1, vimentin, beta-actin and annexin II by MALDI-TOF-MS...
  65. Ly K, Saavedra Y, Canuel M, Routhier S, Desjardins R, Hamelin J, et al. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. J Biol Chem. 2014;289:17732-46 pubmed publisher
    b>Annexin A2 (AnxA2) was reported to be an extracellular endogenous inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) activity on cell-surface LDL receptor degradation...
  66. Li C, Sathyamurthy A, Oldenborg A, Tank D, Ramanan N. SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014;34:4027-42 pubmed publisher
    ..Thus, our findings reveal a novel phosphorylation and activation of SRF by GSK-3 that is critical for SRF-dependent axon growth in mammalian central neurons. ..
  67. Oh Y, Gao P, Lee K, Ceglia I, Seo J, Zhang X, et al. SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell. 2013;152:831-43 pubmed publisher
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