Gene Symbol: Anxa1
Description: annexin A1
Alias: Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1, annexin A1, annexin I, annexin-1, calpactin II, calpactin-2, chromobindin-9, lipocortin 1, lipocortin I, p35, phospholipase A2 inhibitory protein
Species: mouse
Products:     Anxa1

Top Publications

  1. Golovkina T, Dzuris J, Van Den Hoogen B, Jaffe A, Wright P, Cofer S, et al. A novel membrane protein is a mouse mammary tumor virus receptor. J Virol. 1998;72:3066-71 pubmed
    ..The MTVR sequence clone is unique, shows no homology to known membrane proteins, and is transcribed in many tissues. ..
  2. Solito E, Christian H, Festa M, Mulla A, Tierney T, Flower R, et al. Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. FASEB J. 2006;20:1498-500 pubmed
    b>Annexin A1 (ANXA1) has an important role in cell-cell communication in the host defense and neuroendocrine systems...
  3. Yang Y, Aeberli D, Dacumos A, Xue J, Morand E. Annexin-1 regulates macrophage IL-6 and TNF via glucocorticoid-induced leucine zipper. J Immunol. 2009;183:1435-45 pubmed publisher
    Annexin-1 (ANXA1) is a mediator of the anti-inflammatory actions of endogenous and exogenous glucocorticoids (GC)...
  4. Dalli J, Rosignoli G, Hayhoe R, Edelman A, Perretti M. CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway. Am J Pathol. 2010;177:176-86 pubmed publisher
    ..shown that deletion of CFTR is associated with lower expression of the endogenous anti-inflammatory protein Annexin A1 (AnxA1), we investigated further this possible functional connection using a validated CFTR inhibitor...
  5. Perretti M, D Acquisto F. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol. 2009;9:62-70 pubmed publisher
    ..In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in ..
  6. Croxtall J, Gilroy D, Solito E, Choudhury Q, Ward B, Buckingham J, et al. Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. Biochem J. 2003;371:927-35 pubmed
    The Ca(2+)- and phospholipid-binding protein Anx-A1 (annexin 1; lipocortin 1) has been described both as an inhibitor of phospholipase A(2) (PLA(2)) activity and as a mediator of glucocorticoid-regulated cell growth and eicosanoid ..
  7. D Acquisto F, Paschalidis N, Sampaio A, Merghani A, Flower R, Perretti M. Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. Eur J Immunol. 2007;37:3131-42 pubmed
    ..These results demonstrate a novel modulatory role of endogenous Annexin-1 in TCR signaling and T cell differentiation and suggest this protein might play a dual and complementary role in the innate and adaptive immune response. ..
  8. Yang Y, Morand E, Getting S, Paul Clark M, Liu D, Yona S, et al. Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis Rheum. 2004;50:976-84 pubmed
    b>Annexin 1 (Anx-1) is a putative mediator of the antiinflammatory actions of glucocorticoids (GCs)...
  9. Hannon R, Croxtall J, Getting S, Roviezzo F, Yona S, Paul Clark M, et al. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J. 2003;17:253-5 pubmed
    The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of glucocorticoid action in inflammation and in the control of ..

More Information


  1. Rondepierre F, Bouchon B, Papon J, Bonnet Duquennoy M, Kintossou R, Moins N, et al. Proteomic studies of B16 lines: involvement of annexin A1 in melanoma dissemination. Biochim Biophys Acta. 2009;1794:61-9 pubmed publisher
    ..Two differentially expressed proteins which had not been previously associated to melanoma progression, annexin A1 (ANXA1) and creatine kinase B (CKB), were found both in cells and in tumours...
  2. Yona S, Buckingham J, Perretti M, Flower R. Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol. 2004;142:890-8 pubmed
    The role of the glucocorticoid-regulated protein annexin 1 during the process of phagocytosis has been studied using annexin 1 null peritoneal macrophages...
  3. Yi M, Schnitzer J. Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice. Proc Natl Acad Sci U S A. 2009;106:17886-91 pubmed publisher
    Despite 2 decades of research, no clear function for annexin A1 (AnxA1) has been established...
  4. Damazo A, Sampaio A, Nakata C, Flower R, Perretti M, Oliani S. Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. BMC Immunol. 2011;12:59 pubmed publisher
    ..Annexin-A1 (AnxA1) is one mediator of endogenous anti-inflammation, affording regulation of leukocyte trafficking and activation in ..
  5. Huggins A, Paschalidis N, Flower R, Perretti M, D Acquisto F. Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. FASEB J. 2009;23:985-96 pubmed publisher
    ..Together, these findings suggest that inhibition of Anx-A1 expression or function in dendritic cells might represent a useful way to modulate the adaptive immune response and pathogen-induced T-cell-driven immune diseases. ..
  6. Ng F, Wong K, Guan S, Mustafa F, Kajiji T, Bist P, et al. Annexin-1-deficient mice exhibit spontaneous airway hyperresponsiveness and exacerbated allergen-specific antibody responses in a mouse model of asthma. Clin Exp Allergy. 2011;41:1793-803 pubmed publisher
    ..Annexin-1 (ANXA1) is an anti-inflammatory protein which has been described as an endogenous protein responsible for some anti-..
  7. Souza D, Fagundes C, Amaral F, Cisalpino D, Sousa L, Vieira A, et al. The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice. J Immunol. 2007;179:8533-43 pubmed
  8. Damazo A, Yona S, D Acquisto F, Flower R, Oliani S, Perretti M. Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. Am J Pathol. 2005;166:1607-17 pubmed
    ..Here we demonstrate that the counterregulator annexin 1 (AnxA1) is critical for controlling experimental endotoxemia...
  9. Yang Y, Toh M, Clyne C, Leech M, Aeberli D, Xue J, et al. Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1. J Immunol. 2006;177:8148-53 pubmed
    b>Annexin 1 (Anx-1) is a mediator of the anti-inflammatory actions of glucocorticoids, but the mechanism of its anti-inflammatory effects is not known...
  10. Patel H, Kornerup K, Sampaio A, D Acquisto F, Seed M, Girol A, et al. The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis. 2012;71:1872-80 pubmed publisher
    To establish the role and effect of glucocorticoids and the endogenous annexin A1 (AnxA1) pathway in inflammatory arthritis...
  11. Babbin B, Laukoetter M, Nava P, Koch S, Lee W, Capaldo C, et al. Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol. 2008;181:5035-44 pubmed
    ..b>AnxA1 is a potent anti-inflammatory protein that has been implicated to play a critical immune regulatory role in models ..
  12. Santos J, González Sánchez L, Matabuena Deyzaguirre M, Villa Morales M, Cozar P, Lopez Nieva P, et al. A role for stroma-derived annexin A1 as mediator in the control of genetic susceptibility to T-cell lymphoblastic malignancies through prostaglandin E2 secretion. Cancer Res. 2009;69:2577-87 pubmed publisher
    ..Through the development of nonoverlapping subcongenic strains, it has been further shown that Anxa1 may be a candidate resistance gene on the basis of its differential expression in thymus stroma cells after gamma-..
  13. Damazo A, Yona S, Flower R, Perretti M, Oliani S. Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol. 2006;176:4410-8 pubmed
    ..In this study, we have focused on the glucocorticoid-regulated anti-inflammatory mediator annexin 1. Induction of peritonitis in wild-type mice rapidly (4 h) produced the expected signs of inflammation, including ..
  14. Paschalidis N, Huggins A, Rowbotham N, Furmanski A, Crompton T, Flower R, et al. Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle. 2010;9:784-93 pubmed
    We have recently shown that endogenous Annexin-A1 (AnxA1) plays a homeostatic regulatory role in mature T cells by modulating the strength of TCR signaling...
  15. Fan X, Krahling S, Smith D, Williamson P, Schlegel R. Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. Mol Biol Cell. 2004;15:2863-72 pubmed
    ..Jurkat T lymphocytes and human peripheral T lymphocytes, but not apoptotic thymocytes, were stained by anti-annexin I but not II...
  16. Kosicka A, Cunliffe A, MacKenzie R, Zariwala M, Perretti M, Flower R, et al. Attenuation of plasma annexin A1 in human obesity. FASEB J. 2013;27:368-78 pubmed publisher
    ..b>Annexin A1 (AnxA1) is an endogenous glucocorticoid regulated protein, which modulates systemic anti-inflammatory processes ..
  17. Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed publisher
    ..We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1...
  18. Akasheh R, Pini M, Pang J, Fantuzzi G. Increased adiposity in annexin A1-deficient mice. PLoS ONE. 2013;8:e82608 pubmed publisher
    Production of Annexin A1 (ANXA1), a protein that mediates the anti-inflammatory action of glucocorticoids, is altered in obesity, but its role in modulation of adiposity has not yet been investigated...
  19. Maderna P, Yona S, Perretti M, Godson C. Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). J Immunol. 2005;174:3727-33 pubmed
    ..The glucocorticoid-inducible protein annexin 1 and annexin 1-derived peptides show potent anti-inflammatory responses in acute and chronic inflammation...
  20. Bizzarro V, Fontanella B, Franceschelli S, Pirozzi M, Christian H, Parente L, et al. Role of Annexin A1 in mouse myoblast cell differentiation. J Cell Physiol. 2010;224:757-65 pubmed publisher
    b>Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein involved in a broad range of cellular events. This study used molecular and microscopy approaches to explore the role of ANXA1 in mouse myoblast C2C12 cell differentiation...
  21. Chatterjee B, Yona S, Rosignoli G, Young R, Nourshargh S, Flower R, et al. Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol. 2005;78:639-46 pubmed
    The role of the endogenous anti-inflammatory mediator annexin 1 (AnxA1) in controlling polymorphonuclear leukocyte (PMN) trafficking and activation was addressed using the recently generated AnxA1 null mouse...
  22. Vago J, Nogueira C, Tavares L, Soriani F, Lopes F, Russo R, et al. Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis. J Leukoc Biol. 2012;92:249-58 pubmed publisher
    This study aimed at assessing whether AnxA1, a downstream mediator for the anti-inflammatory effects of GCs, could affect the fate of immune cells in tissue exudates, using LPS-induced pleurisy in BALB/c mice...
  23. Gastardelo T, Damazo A, Dalli J, Flower R, Perretti M, Oliani S. Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation. Am J Pathol. 2009;174:177-83 pubmed publisher
    ..The purpose of this study was twofold: to reveal cellular events associated with the protective role of endogenous annexin A1 (AnxA1) in inflammation and to highlight the potential involvement of members of the formyl peptide receptor (..
  24. Reynolds S, Reynolds P, Snyder J, Whyte F, Paavola K, Stripp B. CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. Am J Physiol Lung Cell Mol Physiol. 2007;293:L114-23 pubmed
    ..We demonstrate a shift in the isoelectric point of the immunomodulatory protein annexin A1 (ANXA1) to more acidic isoforms in CCSP-/- mice...
  25. Lennon N, Kho A, Bacskai B, Perlmutter S, Hyman B, Brown R. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003;278:50466-73 pubmed
    ..We propose a model of muscle membrane healing mediated by dysferlin that is relevant to both normal and dystrophic muscle and defines the annexins as potential muscular dystrophy genes. ..
  26. Roviezzo F, Getting S, Paul Clark M, Yona S, Gavins F, Perretti M, et al. The annexin-1 knockout mouse: what it tells us about the inflammatory response. J Physiol Pharmacol. 2002;53:541-53 pubmed
    The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postulated to be a mediator of glucocorticoids ..
  27. Yazid S, Leoni G, Getting S, Cooper D, Solito E, Perretti M, et al. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol. 2010;30:1718-24 pubmed publisher
    ..05) in the flow chamber assay, and this effect was reversed by specific anti-AnxA1 or a combination of antiformyl peptide receptors 1 and 2, but not irrelevant control, antibodies...
  28. Warne J, John C, Christian H, Morris J, Flower R, Sugden D, et al. Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. Am J Physiol Endocrinol Metab. 2006;291:E1264-73 pubmed
    In this study, epididymal adipose tissue from male annexin 1 (ANXA1)-null and wild-type control mice were used to explore the potential role of ANXA1 in adipocyte biology...
  29. D Acquisto F, Merghani A, Lecona E, Rosignoli G, Raza K, Buckley C, et al. Annexin-1 modulates T-cell activation and differentiation. Blood. 2007;109:1095-102 pubmed
  30. McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies G, et al. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. J Immunol. 2010;185:6317-28 pubmed publisher
    ..The protein annexin A1 (ANXA1) is key to the phagocytosis of apoptotic leukocytes during peripheral inflammatory resolution, but the ..
  31. Cristante E, McArthur S, Mauro C, Maggioli E, Romero I, Wylezinska Arridge M, et al. Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A. 2013;110:832-41 pubmed publisher
    ..Here we show that the glucocorticoid anti-inflammatory messenger annexin A1 (ANXA1) is expressed in brain microvascular endothelial cells, where it regulates BBB integrity...
  32. Brancaleone V, Dalli J, Bena S, Flower R, Cirino G, Perretti M. Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol. 2011;186:4905-14 pubmed publisher
    ..In this article, we focused on lipoxin A(4) (LXA(4)) and annexin A1 (AnxA1) because these two very different mediators converge on a single receptor, formyl peptide receptor type 2 ..
  33. Yazid S, Gardner P, Carvalho L, Chu C, Flower R, Solito E, et al. Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease. J Autoimmun. 2015;58:1-11 pubmed publisher
    ..This data supports Anx-A1 as an early and critical regulator of Th17 cell driven autoimmune diseases such as uveitis. ..
  34. Rackham C, Vargas A, Hawkes R, Amisten S, Persaud S, Austin A, et al. Annexin A1 Is a Key Modulator of Mesenchymal Stromal Cell-Mediated Improvements in Islet Function. Diabetes. 2016;65:129-39 pubmed publisher
    ..We demonstrated high expression of annexin A1 (ANXA1) mRNA by MSCs and confirmed expression at the protein level in lysates and MSC-conditioned media by ..
  35. Machado I, Santin J, Drewes C, Gil C, Oliani S, Perretti M, et al. Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab. 2014;307:E754-63 pubmed publisher
    ..Here, we investigated the dependence of glucocorticoid receptor activation and glucocorticoid-regulated protein annexin A1 (ANXA1) on ACTH-induced neutrophilia and the phenotype of blood neutrophil after ACTH injection, focusing on ..
  36. Horlacher T, Noti C, de Paz J, Bindschädler P, Hecht M, Smith D, et al. Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated heparan sulfate and heparin. Biochemistry. 2011;50:2650-9 pubmed publisher
    b>Annexin A1 is a multifunctional, calcium-dependent phospholipid binding protein involved in a host of processes including inflammation, regulation of neuroendocrine signaling, apoptosis, and membrane trafficking...
  37. Pan B, Kong J, Jin J, Kong J, He Y, Dong S, et al. A novel anti-inflammatory mechanism of high density lipoprotein through up-regulating annexin A1 in vascular endothelial cells. Biochim Biophys Acta. 2016;1861:501-12 pubmed publisher
    High density lipoprotein (HDL) as well as annexin A1 have been reported to be associated with cardiovascular protection. However, the correlation between HDL and annexin A1 was still unknown...
  38. John C, Sahni V, Mehet D, Morris J, Christian H, Perretti M, et al. Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. FASEB J. 2007;21:1037-46 pubmed
    ..that some members of this receptor family may also be targets for certain anti-inflammatory molecules, including annexin A1 (ANXA1), which is an important mediator of glucocorticoid (GC) action...
  39. Bizzarro V, Belvedere R, Dal Piaz F, Parente L, Petrella A. Annexin A1 induces skeletal muscle cell migration acting through formyl peptide receptors. PLoS ONE. 2012;7:e48246 pubmed publisher
    b>Annexin A1 (ANXA1, lipocortin-1) is a glucocorticoid-regulated 37-kDa protein, so called since its main property is to bind (i.e. to annex) to cellular membranes in a Ca(2+)-dependent manner...
  40. Cui Z, Yokoi N, Kuramoto T, Kitada K, Serikawa T. Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes. Exp Anim. 1998;47:83-8 pubmed
    ..In addition, four conserved regions were newly revealed. The method described in this study appears to be simple and efficient for constructing a whole genome comparative map of the rat and mouse. ..
  41. Philipps C, Rose John S, Rincke G, Furstenberger G, Marks F. cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I. Biochem Biophys Res Commun. 1989;159:155-62 pubmed
    We isolated and sequenced mouse lipocortin I cDNA clones from a lambda gt10 cDNA library prepared from Swiss 3T3 mRNA. The homology with human lipocortin I at the amino acid level is 86%...
  42. Holland A, Henry M, Meleady P, Winkler C, Krautwald M, Brinkmeier H, et al. Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers. Molecules. 2015;20:11317-44 pubmed publisher
    ..Annexin, lamin, and vimentin were identified as universal dystrophic markers. ..
  43. Hughes E, Cover P, Buckingham J, Gavins F. Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation. Br J Pharmacol. 2013;169:539-53 pubmed publisher
    ..Here, we investigated the influence of gender, oestrogen and the anti-inflammatory protein annexin A1 (AnxA1) on lipopolysaccharide (LPS)-induced leukocyte-endothelial cell interactions in murine cerebral and ..
  44. Damazo A, Moradi Bidhendi N, Oliani S, Flower R. Role of annexin 1 gene expression in mouse craniofacial bone development. Birth Defects Res A Clin Mol Teratol. 2007;79:524-32 pubmed
    b>Annexin 1 is a 37-kDa protein that has complex intra- and extracellular effects...
  45. Gimenes A, Andrade T, Mello C, Ramos L, Gil C, Oliani S. Beneficial effect of annexin A1 in a model of experimental allergic conjunctivitis. Exp Eye Res. 2015;134:24-32 pubmed publisher
    b>Annexin A1 (ANXA1), a 37 kDa glucocorticoid-regulated protein, is a potent anti-inflammatory mediator effective in terminating acute inflammatory response, and its role in allergic settings has been poorly studied...
  46. A Gonzalez N, Quintana J, Garcia Silva S, Mazariegos M, González de la Aleja A, Nicolás Ávila J, et al. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med. 2017;214:1281-1296 pubmed publisher
    ..Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis. ..
  47. Machado I, Spatti M, Hastreiter A, Santin J, Fock R, Gil C, et al. Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway. J Cell Physiol. 2016;231:2418-27 pubmed publisher
    ..We recently showed that the glucocorticoid-regulated protein, Annexin A1 (AnxA1) modulates neutrophil homeostasis and here we address the effects of AnxA1 on steady-state neutrophil ..
  48. Sena A, Pedrotti L, Barrios B, Cejas H, Balderramo D, Diller A, et al. Lack of TNFRI signaling enhances annexin A1 biological activity in intestinal inflammation. Biochem Pharmacol. 2015;98:422-31 pubmed publisher
    We evaluated whether the lack of TNF-α signaling increases mucosal levels of annexin A1 (AnxA1); the hypothesis stems from previous findings showing that TNF-α neutralization in Crohn's disease patients up-regulates systemic AnxA1 ..
  49. Girol A, Mimura K, Drewes C, Bolonheis S, Solito E, Farsky S, et al. Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro. J Immunol. 2013;190:5689-701 pubmed publisher
    b>Annexin A1 (AnxA1) is a protein that displays potent anti-inflammatory properties, but its expression in eye tissue and its role in ocular inflammatory diseases have not been well studied...
  50. Raffay T, Locy M, Hill C, Jindal N, Rogers L, Welty S, et al. Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1. Biomed Res Int. 2013;2013:408485 pubmed publisher
    ..Expression of lung SCGB and annexin A1 (ANXA1) is persistently altered in CCSP knockout mice suggesting that CCSP indirectly influences innate immune ..
  51. Lima K, Vago J, Caux T, Negreiros Lima G, Sugimoto M, Tavares L, et al. The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. J Biol Chem. 2017;292:13758-13773 pubmed publisher
    b>Annexin A1 (AnxA1) is a glucocorticoid-regulated protein known for its anti-inflammatory and pro-resolving effects...
  52. de Paula Silva M, Barrios B, Macció Maretto L, Sena A, Farsky S, Correa S, et al. Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis. Biochem Pharmacol. 2016;115:104-13 pubmed publisher
    ..The anti-inflammatory protein, annexin A1 (AnxA1), has been associated with the protection of the gastrointestinal mucosa...
  53. Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, et al. Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. Hepatology. 2014;60:531-44 pubmed publisher
    b>Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in terminating acute inflammatory responses. However, its role in chronic settings is less investigated...
  54. Huang P, Zhou Y, Liu Z, Zhang P. Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells. Mediators Inflamm. 2016;2016:1701059 pubmed
    ..Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles in T cell differentiation...
  55. Hamre K, Chepenik K, Goldowitz D. The annexins: specific markers of midline structures and sensory neurons in the developing murine central nervous system. J Comp Neurol. 1995;352:421-35 pubmed
    ..Annexin IV is the first annexin to be expressed on embryonic day (E) 9.5 while annexin I is the last to be expressed (E11.5)...
  56. Ciechonska M, Key T, Duncan R. Efficient reovirus- and measles virus-mediated pore expansion during syncytium formation is dependent on annexin A1 and intracellular calcium. J Virol. 2014;88:6137-47 pubmed publisher
    ..We now report that RNA interference (RNAi) knockdown of annexin A1 (AX1) expression dramatically reduced both reptilian reovirus p14 and measles virus F and H protein-mediated ..
  57. Oliani S, Ciocca G, Pimentel T, Damazo A, Gibbs L, Perretti M. Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation. Inflamm Res. 2008;57:450-6 pubmed publisher
  58. Chapman L, Epton M, Buckingham J, Morris J, Christian H. Evidence for a role of the adenosine 5'-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells. Endocrinology. 2003;144:1062-73 pubmed
    b>Annexin 1 (ANXA1) has a well-demonstrated role in early delayed inhibitory feedback of glucocorticoids in the pituitary...
  59. Deussing J, Tisljar K, Papazoglou A, Peters C. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. Gene. 2000;251:165-73 pubmed
    ..Northern blot analysis of RNA from multiple tissues revealed a ubiquitous expression of cathepsin F in mouse and man. ..
  60. Wright A, Kawakami Y, Pavan W. Mart1 is located on mouse chromosome 19 and is excluded as a candidate for ep and ru. Mamm Genome. 1997;8:377-8 pubmed
  61. Swa H, Shaik A, Lim L, Gunaratne J. Mass spectrometry based quantitative proteomics and integrative network analysis accentuates modulating roles of annexin-1 in mammary tumorigenesis. Proteomics. 2015;15:408-18 pubmed publisher
    Annexin-1 (ANXA1) is known to be involved in important cellular processes and implicated in cancer. Our previous study showed its roles in cell migration and DNA-damage response processes in breast cancer initiation...
  62. Bist P, Leow S, Phua Q, Shu S, Zhuang Q, Loh W, et al. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-?B: implication in breast cancer metastasis. Oncogene. 2011;30:3174-85 pubmed publisher
    ..We show that Annexin-1 (ANXA1) is involved in this process, and suppression of ANXA1 in highly metastatic breast cancer cells impedes migration ..
  63. Markoff A, Gerke V. Expression and functions of annexins in the kidney. Am J Physiol Renal Physiol. 2005;289:F949-56 pubmed
    ..Last but not least, some annexins seem to work as extracellular autocrine modulators of receptor function under different physiological conditions. ..
  64. Tzelepis F, Verway M, Daoud J, Gillard J, Hassani Ardakani K, Dunn J, et al. Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest. 2015;125:752-68 pubmed publisher
    ..Collectively, these data indicate that annexin1 is essential in immunity to Mtb infection and mediates the power of DC efferocytosis and cross-presentation. ..
  65. Leikina E, Melikov K, Sanyal S, Verma S, Eun B, Gebert C, et al. Extracellular annexins and dynamin are important for sequential steps in myoblast fusion. J Cell Biol. 2013;200:109-23 pubmed publisher
  66. Montero Melendez T, Dalli J, Perretti M. Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ. 2013;20:567-75 pubmed publisher
    ..Comparison of genome-wide gene expression data generated with annexin A1 (AnxA1) with the CMap revealed significant alignment with gene profiles elicited by histone deacetylase ..
  67. Park J, Baik S, Han S, Cho H, Choi H, Kim H, et al. Annexin A1 restores A?1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell. 2017;16:149-161 pubmed publisher
    ..b>Annexin A1 (ANXA1), an anti-inflammatory messenger, is expressed in brain endothelial cells and regulates the BBB integrity...
  68. Verma S, Leikina E, Melikov K, Gebert C, Kram V, Young M, et al. Cell-surface phosphatidylserine regulates osteoclast precursor fusion. J Biol Chem. 2018;293:254-270 pubmed publisher