Antxr2

Summary

Gene Symbol: Antxr2
Description: anthrax toxin receptor 2
Alias: 2310046B19Rik, AW561899, CMG-2, CMG2, cI-35, anthrax toxin receptor 2
Species: mouse
Products:     Antxr2

Top Publications

  1. Liu S, Crown D, Miller Randolph S, Moayeri M, Wang H, Hu H, et al. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009;106:12424-9 pubmed publisher
    ..factor A domain-containing proteins, tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2). The wide tissue expression of TEM8 and CMG2 suggest that both receptors could play a role in anthrax pathogenesis...
  2. Xu Q, Hesek E, Zeng M. Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore. Microb Pathog. 2007;43:37-45 pubmed
    ..quantitative real-time RT-PCR to not only investigate the mRNA levels of anthrax toxin receptor 1 (ANTXR1) and 2 (ANTXR2) in the murine J774A...
  3. Reeves C, Dufraine J, Young J, Kitajewski J. Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis. Oncogene. 2010;29:789-801 pubmed publisher
    The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2), but the normal physiological function is not known...
  4. Liu S, Liu J, Ma Q, Cao L, Fattah R, Yu Z, et al. Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016;113:E4079-87 pubmed publisher
    ..toxins work through the native toxin receptors tumor endothelium marker-8 and capillary morphogenesis protein-2 (CMG2), which, in other contexts, have been described as markers of tumor endothelium...
  5. Arévalo M, Navarro A, Arico C, Li J, Alkhatib O, Chen S, et al. Targeted silencing of anthrax toxin receptors protects against anthrax toxins. J Biol Chem. 2014;289:15730-8 pubmed publisher
    ..two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2)...
  6. Liu S, Miller Randolph S, Crown D, Moayeri M, Sastalla I, Okugawa S, et al. Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice. Cell Host Microbe. 2010;8:455-62 pubmed publisher
    Bacillus anthracis kills through a combination of bacterial infection and toxemia. Anthrax toxin working via the CMG2 receptor mediates lethality late in infection, but its roles early in infection remain unclear...
  7. Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah R, et al. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013;501:63-8 pubmed publisher
    ..Here we generated cell-type-specific anthrax toxin receptor capillary morphogenesis protein-2 (CMG2)-null mice and cell-type-specific CMG2-expressing mice and challenged them with the toxins...
  8. Peters D, Zhang Y, Molinolo A, Miller Randolph S, Szabo R, Bugge T, et al. Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis. Biochem Biophys Res Commun. 2012;422:393-7 pubmed publisher
    Capillary morphogenesis protein-2 (CMG2) functions as an anthrax toxin receptor that plays an essential role in anthrax pathogenesis...
  9. Kintzer A, Sterling H, Tang I, Williams E, Krantz B. Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism. PLoS ONE. 2010;5:e13888 pubmed publisher

More Information

Publications17

  1. Chen K, Liu S, Leysath C, Miller Randolph S, Zhang Y, Fattah R, et al. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting. J Biol Chem. 2016;291:22021-22029 pubmed
    ..Two PA receptors are known, with capillary morphogenesis protein 2 (CMG2) being the more important for pathogenesis and tumor endothelial marker 8 (TEM8) playing a minor role...
  2. Park S, Lee H, Ji S, Kim M, Jigden B, Lim J, et al. ANTXR2 is a potential causative gene in the genome-wide association study of the blood pressure locus 4q21. Hypertens Res. 2014;37:811-7 pubmed publisher
    ..Using a mouse model, we aimed to identify a causative gene in the 4q21 locus, in which four genes (anthrax toxin receptor 2 (ANTXR2), PR domain-containing 8 (PRDM8), FGF5 and chromosome 4 open reading frame 22 (C4orf22)) were ..
  3. Reeves C, Wang X, Charles Horvath P, Vink J, Borisenko V, Young J, et al. Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. PLoS ONE. 2012;7:e34862 pubmed publisher
    ..To evaluate the biological role of Antxr2, we generated Antxr2-/- mice...
  4. Sastalla I, Tang S, Crown D, Liu S, Eckhaus M, Hewlett I, et al. Anthrax edema toxin impairs clearance in mice. Infect Immun. 2012;80:529-38 pubmed publisher
    ..PA binding and uptake of the PA oligomer in vitro and in vivo through upregulation of the PA receptors TEM8 and CMG2 in both myeloid and nonmyeloid cells...
  5. Takahashi Y, Miyata M, Zheng P, Imazato T, Horwitz A, Smith J. Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000;1492:385-94 pubmed
    ..ABC1 was upregulated in RAW cells by cAMP, concurrent with the cAMP induction of lipid efflux to apolipoprotein A1. ..
  6. Ha S, Ham B, Mogridge J, Saftig P, Lin S, Kim S. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem. 2010;285:2120-9 pubmed publisher
    ..We found that the cytoplasmic delivery of LF by ANTXR2 was mediated by cathepsin B (CTSB) and required lysosomal fusion with LeTx-containing endosomes...
  7. Eng S, Dykes I, Lanier J, Fedtsova N, Turner E. POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. Neural Dev. 2007;2:3 pubmed
  8. Rainey G, Wigelsworth D, Ryan P, Scobie H, Collier R, Young J. Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A. 2005;102:13278-83 pubmed
    ..proteins, protective antigen (PA), binds to tumor endothelial marker 8 (TEM8) or capillary morphogenesis protein 2 (CMG2) cellular receptors...