Gene Symbol: Antxr1
Description: anthrax toxin receptor 1
Alias: 2310008J16Rik, 2810405N18Rik, Antrx1, Tem8, anthrax toxin receptor 1, tumor endothelial marker 8
Species: mouse
Products:     Antxr1

Top Publications

  1. Liu S, Crown D, Miller Randolph S, Moayeri M, Wang H, Hu H, et al. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009;106:12424-9 pubmed publisher
    ..cells by binding to either of 2 von Willebrand factor A domain-containing proteins, tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2)...
  2. Bonuccelli G, Sotgia F, Frank P, Williams T, de Almeida C, Tanowitz H, et al. ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection. Am J Physiol Cell Physiol. 2005;288:C1402-10 pubmed
    ..ATR is one of the splice variants of the tumor endothelial marker 8 (TEM8) gene...
  3. Cullen M, Seaman S, Chaudhary A, Yang M, Hilton M, Logsdon D, et al. Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res. 2009;69:6021-6 pubmed publisher
    b>Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an anthrax toxin receptor...
  4. Arévalo M, Navarro A, Arico C, Li J, Alkhatib O, Chen S, et al. Targeted silencing of anthrax toxin receptors protects against anthrax toxins. J Biol Chem. 2014;289:15730-8 pubmed publisher
    ..Anthrax toxins enter cells via two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2)...
  5. Hu K, Olsen B, Besschetnova T. Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts. Matrix Biol. 2017;62:105-114 pubmed publisher
    Our previous studies of Antxr1 knockout mice suggested that fibrotic skin abnormalities in these mice are associated with increased VEGF signaling...
  6. Carson Walter E, Watkins D, Nanda A, Vogelstein B, Kinzler K, St Croix B. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001;61:6649-55 pubmed
    ..Accordingly, we have further characterized four such genes, TEM1, TEM5, TEM7, and TEM8, all of which contain putative transmembrane domains...
  7. Michaud E, Culiat C, Klebig M, Barker P, Cain K, Carpenter D, et al. Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. BMC Genomics. 2005;6:164 pubmed
    ..The ability of ENU to induce mutations that cause various types of changes in proteins will provide additional insights into the functions of mammalian proteins that may not be detectable by knockout mutations. ..
  8. Yang M, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad M, et al. The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton. Biochim Biophys Acta. 2011;1813:39-49 pubmed publisher
    b>Tumor endothelial marker 8 (TEM8) is an integrin-like cell surface protein upregulated on tumor blood vessels and a potential vascular target for cancer therapy...
  9. Chaudhary A, Hilton M, Seaman S, Haines D, Stevenson S, LeMotte P, et al. TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types. Cancer Cell. 2012;21:212-26 pubmed publisher
    ..b>Tumor endothelial marker 8 (TEM8), also known as anthrax toxin receptor 1 (ANTXR1), is a highly conserved cell-surface protein ..

More Information


  1. Xu Q, Hesek E, Zeng M. Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore. Microb Pathog. 2007;43:37-45 pubmed
    We used quantitative real-time RT-PCR to not only investigate the mRNA levels of anthrax toxin receptor 1 (ANTXR1) and 2 (ANTXR2) in the murine J774A...
  2. Sastalla I, Tang S, Crown D, Liu S, Eckhaus M, Hewlett I, et al. Anthrax edema toxin impairs clearance in mice. Infect Immun. 2012;80:529-38 pubmed publisher
    ..increased PA binding and uptake of the PA oligomer in vitro and in vivo through upregulation of the PA receptors TEM8 and CMG2 in both myeloid and nonmyeloid cells...
  3. Andersen N, Boguslawski E, Naidu A, Szot C, Bromberg White J, Kits K, et al. Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia. PLoS ONE. 2016;11:e0146586 pubmed publisher
    Anthrax toxin receptor 1/tumor endothelial marker 8 (Antxr1 or TEM8) is up-regulated in tumor vasculature and serves as a receptor for anthrax toxin, but its physiologic function is unclear...
  4. Liu S, Liu J, Ma Q, Cao L, Fattah R, Yu Z, et al. Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016;113:E4079-87 pubmed publisher
    ..The ability to give repeated doses of toxins, coupled with the specific targeting of tumor endothelial cells, suggests that our strategy should be efficacious for a wide range of solid tumors. ..
  5. Chen K, Liu S, Leysath C, Miller Randolph S, Zhang Y, Fattah R, et al. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting. J Biol Chem. 2016;291:22021-22029 pubmed
    ..are known, with capillary morphogenesis protein 2 (CMG2) being the more important for pathogenesis and tumor endothelial marker 8 (TEM8) playing a minor role...
  6. Liu S, Zhang Y, Hoover B, Leppla S. The receptors that mediate the direct lethality of anthrax toxin. Toxins (Basel). 2012;5:1-8 pubmed publisher
    Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) ..