Ano1

Summary

Gene Symbol: Ano1
Description: anoctamin 1, calcium activated chloride channel
Alias: Tmem16a, anoctamin-1, transmembrane protein 16A
Species: mouse
Products:     Ano1

Top Publications

  1. Davis A, Shi J, Pritchard H, Chadha P, Leblanc N, Vasilikostas G, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol. 2013;168:773-84 pubmed publisher
    T16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular ..
  2. Duran C, Qu Z, Osunkoya A, Cui Y, Hartzell H. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol. 2012;302:C482-93 pubmed publisher
    ..Recently, it was shown that heterologously expressed anoctamins ANO1 and ANO2 generate currents that resemble native CaCCs...
  3. Rock J, Lopez M, Baker H, Harfe B. Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns. 2007;8:19-26 pubmed
    ..The expression of two other genes was confirmed by rtPCR. The methods described in this report will be applicable for identifying genes enriched in Shh-expressing cells throughout development. ..
  4. Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013;288:13305-16 pubmed publisher
    b>TMEM16A and 16B work as Cl(-) channel, whereas 16F works as phospholipid scramblase. The function of other TMEM16 members is unknown. Using TMEM16F(-/-) cells, TMEM16C, 16D, 16F, 16G, and 16J were shown to be lipid scramblases...
  5. Jung J, Nam J, Park H, Oh U, Yoon J, Lee M. Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin. Proc Natl Acad Sci U S A. 2013;110:360-5 pubmed publisher
    Anoctamin 1 (ANO1)/transmembrane protein 16A (TMEM16A) is a calcium-activated anion channel that may play a role in HCO(3)(-) secretion in epithelial cells...
  6. Duvvuri U, Shiwarski D, Xiao D, Bertrand C, Huang X, Edinger R, et al. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. 2012;72:3270-81 pubmed publisher
    Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied...
  7. Ousingsawat J, Martins J, Schreiber R, Rock J, Harfe B, Kunzelmann K. Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem. 2009;284:28698-703 pubmed publisher
    Molecular identification of the Ca(2+)-dependent chloride channel TMEM16A (ANO1) provided a fundamental step in understanding Ca(2+)-dependent Cl(-) secretion in epithelia...
  8. Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins J, et al. Expression and function of epithelial anoctamins. J Biol Chem. 2010;285:7838-45 pubmed publisher
    The calcium-activated chloride channel anoctamin1 (ANO1; TMEM16A) is fundamental for the function of epithelial organs. Mice lacking ANO1 expression exhibit transport defects and a pathology similar to cystic fibrosis...
  9. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters C, et al. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012;109:16354-9 pubmed publisher
    ..Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM...

More Information

Publications79

  1. Rock J, O Neal W, Gabriel S, Randell S, Harfe B, Boucher R, et al. Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem. 2009;284:14875-80 pubmed publisher
    ..Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC...
  2. Tian Y, Kongsuphol P, Hug M, Ousingsawat J, Witzgall R, Schreiber R, et al. Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J. 2011;25:1058-68 pubmed publisher
    TMEM16A (anoctamin 1, Ano1), a member of a family of 10 homologous proteins, has been shown to form an essential component of Ca(2+)-activated Cl(-) channels...
  3. Romanenko V, Catalán M, Brown D, Putzier I, Hartzell H, Marmorstein A, et al. Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem. 2010;285:12990-3001 pubmed publisher
    ..of native CaCC in mouse submandibular salivary gland acinar cells to the Ca(2+)-gated Cl(-) currents generated by Tmem16A and Best2, members from two distinct families of Ca(2+)-activated Cl(-) channels found in salivary glands...
  4. Rock J, Futtner C, Harfe B. The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol. 2008;321:141-9 pubmed publisher
    ..We determined that Tmem16a, a member of an evolutionarily conserved family of predicted transmembrane proteins, is expressed in the ..
  5. Davis A, Forrest A, Jepps T, Valencik M, Wiwchar M, Singer C, et al. Expression profile and protein translation of TMEM16A in murine smooth muscle. Am J Physiol Cell Physiol. 2010;299:C948-59 pubmed publisher
    Recently, overexpression of the genes TMEM16A and TMEM16B has been shown to produce currents qualitatively similar to native Ca(2+)-activated Cl(-) currents (I(ClCa)) in vascular smooth muscle...
  6. Hwang S, Blair P, Britton F, O Driscoll K, Hennig G, Bayguinov Y, et al. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol. 2009;587:4887-904 pubmed publisher
    ..We investigated the expression and function of a new class of CaCC, anoctamin 1 (ANO1), encoded by Tmem16a, which was discovered to be highly expressed in ICC in a microarray screen...
  7. Huang F, Rock J, Harfe B, Cheng T, Huang X, Jan Y, et al. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A. 2009;106:21413-8 pubmed publisher
    ..Having identified TMEM16A of the transmembrane proteins with unknown function (TMEM) 16 family as a CaCC subunit, we have developed ..
  8. Zhu M, Kim T, Ro S, Yan W, Ward S, Koh S, et al. A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity. J Physiol. 2009;587:4905-18 pubmed publisher
    ..Reversal of tail current analysis showed this current was due to a Cl(-) selective conductance. ICC express ANO1, a Ca(2+)-activated Cl(-) channel...
  9. Xiao Q, Yu K, Perez Cornejo P, Cui Y, Arreola J, Hartzell H. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop. Proc Natl Acad Sci U S A. 2011;108:8891-6 pubmed publisher
    ..of the dual regulation of CaCCs by voltage and Ca(2+) has recently become possible with the discovery that Ano1 (TMEM16a) is an essential subunit of CaCCs...
  10. Yang Y, Cho H, Koo J, Tak M, Cho Y, Shim W, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008;455:1210-5 pubmed publisher
    ..Here we show that transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride channel that ..
  11. Dutta A, Khimji A, Kresge C, Bugde A, Dougherty M, Esser V, et al. Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium. J Biol Chem. 2011;286:766-76 pubmed publisher
    ..The present studies in human, mouse, and rat BECs provide evidence that TMEM16A is the operative channel and contributes to Ca(2+)-activated Cl(-) secretion in response to extracellular ..
  12. Sheridan J, Worthington E, Yu K, Gabriel S, Hartzell H, Tarran R. Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem. 2011;286:1381-8 pubmed publisher
    Members of the Anoctamin (Ano)/TMEM16A family have recently been identified as essential subunits of the Ca(2+)-activated chloride channel (CaCC)...
  13. Almaca J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock J, et al. TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem. 2009;284:28571-8 pubmed publisher
    ..We show that the Ca(2+)-activated Cl(-) channel TMEM16A together with other TMEM16 proteins are activated by cell swelling through an autocrine mechanism that involves ..
  14. Stanich J, Gibbons S, Eisenman S, Bardsley M, Rock J, Harfe B, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1044-51 pubmed publisher
    b>Ano1 is a recently discovered Ca(2+)-activated Cl(-) channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in the gut...
  15. Dixon R, Hennig G, Baker S, Britton F, Harfe B, Rock J, et al. Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a. Biol Reprod. 2012;86:1-7 pubmed publisher
    ..We examined the role of a new class of Ca(2+)-activated Cl(-) channels (CaCCs)-anoctamin 1, encoded by Tmem16a-in oviduct slow wave generation...
  16. Cho H, Yang Y, Lee J, Lee B, Kim T, Jang Y, et al. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci. 2012;15:1015-21 pubmed publisher
    ..b>Anoctamin 1 (ANO1 also known as TMEM16A) is a Ca(2+)-activated chloride channel that is essential for numerous ..
  17. O Driscoll K, Pipe R, Britton F. Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing. BMC Mol Biol. 2011;12:35 pubmed publisher
    TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel...
  18. Huang W, Xiao S, Huang F, Harfe B, Jan Y, Jan L. Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron. 2012;74:179-92 pubmed publisher
    ..Having recently identified TMEM16A and TMEM16B as CaCCs, we further show that TMEM16B but not TMEM16A is important for hippocampal CaCC, laying the ..
  19. Dang S, Feng S, Tien J, Peters C, Bulkley D, Lolicato M, et al. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017;552:426-429 pubmed publisher
    Calcium-activated chloride channels (CaCCs) encoded by TMEM16A control neuronal signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic movements of the gastrointestinal system...
  20. Adomaviciene A, Smith K, Garnett H, Tammaro P. Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes. J Physiol. 2013;591:3487-505 pubmed publisher
    The recently identified TMEM16/anoctamin protein family includes Ca(2+)-activated anion channels (TMEM16A, TMEM16B), a cation channel (TMEM16F) and proteins with unclear function...
  21. Ye Z, Wu M, Wang C, Li Y, Yu C, Gong Y, et al. Characterization of Cardiac Anoctamin1 Ca²?-Activated Chloride Channels and Functional Role in Ischemia-Induced Arrhythmias. J Cell Physiol. 2015;230:337-46 pubmed publisher
    Anoctamin1 (ANO1) encodes a Ca(2+)-activated chloride (Cl(-)) channel (CaCC) in variety tissues of many species. Whether ANO1 expresses and functions as a CaCC in cardiomyocytes remain unknown...
  22. Zhang X, Lee J, Lv P, Chen W, Kim H, Wei D, et al. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A. Proc Natl Acad Sci U S A. 2015;112:2575-80 pubmed publisher
    ..preparation revealed the identity and expression of the Ca(2+)-activated Cl(-) channel transmembrane member 16A (TMEM16A) in SGNs...
  23. Iqbal J, Tonta M, Mitsui R, Li Q, Kett M, Li J, et al. Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis. Br J Pharmacol. 2012;165:2389-408 pubmed publisher
    ..Immunostaining for K(V) 4.3 and ANO1/ TMEM16A Cl(-) channel subunits co-localized with ?-SMA immunoreactive product predominately in the distal renal pelvis...
  24. Skals M, Jensen U, Ousingsawat J, Kunzelmann K, Leipziger J, Praetorius H. Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure. J Biol Chem. 2010;285:15557-65 pubmed publisher
    ..Notably, the recently described Ca(2+)-activated Cl(-) channel TMEM16A contributes substantially to HlyA-induced cell volume reduction...
  25. Gomez Pinilla P, Gibbons S, Bardsley M, Lorincz A, Pozo M, Pasricha P, et al. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1370-81 pubmed publisher
    ..No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca(2+)-activated Cl(-) channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker...
  26. Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman M, Amaral M, et al. Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep. 2017;7:12397 pubmed publisher
    ..TMEM16A (also known as anoctamin 1, ANO1) is thought to function as the Ca2+ activated secretory chloride channel independent of CFTR...
  27. Lee B, Cho H, Jung J, Yang Y, Yang D, Oh U. Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain. 2014;10:5 pubmed publisher
    ..b>Anoctamin 1 (ANO1/TMEM16A), a Ca2+ activated chloride channel is highly visible in small DRG neurons and responds to heat...
  28. Deba F, Bessac B. Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01. Mol Pain. 2015;11:55 pubmed publisher
    b>Anoctamin 1 (ANO1 or TMEM16A) Ca(2+)-gated Cl(-) channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction...
  29. Faria D, Rock J, Romão A, Schweda F, Bandulik S, Witzgall R, et al. The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int. 2014;85:1369-81 pubmed publisher
    ..we demonstrate dominant expression of the recently identified calcium-activated chloride channels, Anoctamin 1 (Ano1, TMEM16A) in human and mouse proximal tubular epithelial (PTE) cells, with some expression in podocytes ..
  30. Billig G, Pál B, Fidzinski P, Jentsch T. Ca2+-activated Cl? currents are dispensable for olfaction. Nat Neurosci. 2011;14:763-9 pubmed publisher
    ..in the main olfactory epithelium (MOE) and in the vomeronasal organ (VNO), which also expresses the related Ano1 channel. Disruption of Ano2 in mice virtually abolished Ca(2+)-activated Cl(-) currents in the MOE and VNO...
  31. Jeon J, Park J, Lee J, Jeong S, Yeo S, Kim I. Expression and immunohistochemical localization of TMEM16A/anoctamin 1, a calcium-activated chloride channel in the mouse cochlea. Cell Tissue Res. 2011;345:223-30 pubmed publisher
    ..In this study, we report on an investigation of the expression and localization of TMEM16A/anoctamin 1 (ANO1), a recently cloned Ca(2+)-activated Cl(-) channel, in the mouse cochlea by Western blot and ..
  32. Amjad A, Hernandez Clavijo A, Pifferi S, Maurya D, Boccaccio A, Franzot J, et al. Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol. 2015;145:285-301 pubmed publisher
    ..the electrophysiological properties of the native currents with those mediated by heterologously expressed TMEM16A/anoctamin1 or TMEM16B/anoctamin2 Ca(2+)-activated Cl(-) channels, which are coexpressed in microvilli of mouse ..
  33. Heinze C, Seniuk A, Sokolov M, Huebner A, Klementowicz A, Szijártó I, et al. Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. J Clin Invest. 2014;124:675-86 pubmed publisher
    ..Targeted disruption of the calcium-activated chloride channel TMEM16A, also known as ANO1, in VSMCs, intermediate cells, and pericytes eliminated CaCCs in all vessels studied...
  34. Dutta A, Woo K, Khimji A, Kresge C, Feranchak A. Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A. Am J Physiol Gastrointest Liver Physiol. 2013;304:G87-98 pubmed publisher
    ..demonstrate that, in human and mouse biliary cells, fluid flow, or shear, increases Cl(-) currents and identify TMEM16A, a Ca(2+)-activated Cl(-) channel, as the operative channel...
  35. Cole W. ANO1-ther brick in the wall--role of Ca2+-activated Cl- channels of interstitial cells of Cajal in cholinergic motor control of gastrointestinal smooth muscle. J Physiol. 2011;589:4641-2 pubmed publisher
  36. Ousingsawat J, Mirza M, Tian Y, Roussa E, Schreiber R, Cook D, et al. Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch. 2011;461:579-89 pubmed publisher
    ..Western blots and immunocytochemistry was performed in intestinal tissues from wild-type and TMEM16A knockout mice. Ion channel currents were recorded using patch clamp techniques...
  37. Catalán M, Kondo Y, Peña Munzenmayer G, Jaramillo Y, Liu F, Choi S, et al. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015;112:2263-8 pubmed publisher
    ..demonstrated that CaCC-mediated Cl(-) current and Cl(-) efflux are absent in the acinar cells of systemic Tmem16A (Tmem16A Cl(-) channel) null mice, but salivation was not assessed in fully developed glands because Tmem16A null ..
  38. Ohshiro J, Yamamura H, Saeki T, Suzuki Y, Imaizumi Y. The multiple expression of Ca²?-activated Cl? channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein. Biochem Biophys Res Commun. 2014;443:518-23 pubmed publisher
    ..b>TMEM16A, a member of the TMEM16 family, has been suggested as the molecular entity responsible for CaCC in several types ..
  39. Takayama Y, Uta D, Furue H, Tominaga M. Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A. 2015;112:5213-8 pubmed publisher
    ..caused by TRPV1 activation and a subsequent anion efflux-mediated depolarization via activation of anoctamin 1 (ANO1), a calcium-activated chloride channel, resulting from the entry of calcium through TRPV1...
  40. Cobine C, Hannah E, Zhu M, Lyle H, Rock J, Sanders K, et al. ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter. J Physiol. 2017;595:2021-2041 pubmed publisher
    ..interstitial cells of Cajal (ICC-IM) by activation of Ca2+ -activated Cl- channels (ANO1, encoded by Ano1) and voltage-dependent L-type Ca2+ channels (CavL , encoded by Cacna1c)...
  41. Edlund A, Esguerra J, Wendt A, Flodstrom Tullberg M, Eliasson L. CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med. 2014;12:87 pubmed publisher
    ..Finally, our studies demonstrate that CFTR act upstream of the chloride channel Anoctamin 1 (ANO1; TMEM16A) in the regulation of cAMP- and glucose-stimulated insulin secretion...
  42. Uslu V, Petretich M, Ruf S, Langenfeld K, Fonseca N, Marioni J, et al. Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014;46:753-8 pubmed publisher
    ..This dual molecular etiology may account for the prominent influence of variants in the 8q24 region on human facial dysmorphologies. ..
  43. Zeng F, Wind N, McClenaghan C, Verkuyl J, Watson R, Nash M. GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells. PLoS ONE. 2012;7:e47686 pubmed publisher
    ..This Zn(2+)-induced current could be suppressed by application of a TMEM16A antagonist, CaCC(inh)-A01, or by silencing Tmem16a expression...
  44. Cho S, Jeon J, Chun D, Yeo S, Kim I. Anoctamin 1 expression in the mouse auditory brainstem. Cell Tissue Res. 2014;357:563-9 pubmed publisher
    ..b>Anoctamin 1 (ANO1) has recently been cloned and characterized as a CaCC and is known to be expressed in various secretory ..
  45. Gim H, Nam J, Lee S, Shim J, Kim H, Ha K, et al. Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine. Cell Physiol Biochem. 2015;35:2422-36 pubmed publisher
    ..of quercetin and to record membrane currents of transient receptor potential melastatin (TRPM) 7 or transmembrane protein 16A (Tmem16A, anoctamin1 (ANO1)) overexpressed in human embryonic kidney (HEK) 293 cells...
  46. Suzuki T, Suzuki J, Nagata S. Functional swapping between transmembrane proteins TMEM16A and TMEM16F. J Biol Chem. 2014;289:7438-47 pubmed publisher
    The transmembrane proteins TMEM16A and -16F each carry eight transmembrane regions with cytoplasmic N and C termini...
  47. Peters C, Yu H, Tien J, Jan Y, Li M, Jan L. Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A. 2015;112:3547-52 pubmed publisher
    b>TMEM16A (transmembrane protein 16) (Anoctamin-1) forms a calcium-activated chloride channel (CaCC) that regulates a broad array of physiological properties in response to changes in intracellular calcium concentration...
  48. Buchholz B, Faria D, Schley G, Schreiber R, Eckardt K, Kunzelmann K. Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int. 2014;85:1058-67 pubmed publisher
    ..the molecular basis of calcium-dependent chloride secretion in cyst expansion, we determined the role of anoctamin 1 and 6, two recently discovered calcium-activated chloride channels both of which are expressed in epithelial ..
  49. Rock J, Harfe B. Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn. 2008;237:2566-74 pubmed publisher
    ..Here, we provide a phylogenetic analysis of mouse and human TMEM16 paralogs and report the expression of Tmem16a, Tmem16b, Tmem16c, Tmem16f, Tmem16h, Tmem16j, and Tmem16k during murine embryogenesis with an emphasis on the ..
  50. Sancho M, Garcia Pascual A, Triguero D. Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmission. Am J Physiol Renal Physiol. 2012;302:F390-400 pubmed publisher
    We investigated the cellular distribution of the calcium-activated chloride channel (CaCC), anoctamin 1, in the urethra of mice, rats, and sheep by both immunofluorescence and PCR...
  51. Zhang W, Schmelzeisen S, Parthier D, Frings S, Möhrlen F. Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. PLoS ONE. 2015;10:e0142160 pubmed publisher
    ..We identified two anoctamin channel proteins, ANO1 and ANO2, in the cerebellar cortex...
  52. Tien J, Lee H, Minor D, Jan Y, Jan L. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013;110:6352-7 pubmed publisher
    Transmembrane proteins with unknown function 16 (TMEM16A) is a calcium-activated chloride channel (CaCC) important for neuronal, exocrine, and smooth muscle functions...
  53. Schreiber R, Faria D, Skryabin B, Wanitchakool P, Rock J, Kunzelmann K. Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Pflugers Arch. 2015;467:1203-13 pubmed publisher
    ..Using intestinal-specific mouse knockout models for anoctamin 1 (Ano1) and anoctamin 10 (Ano10) and a conventional knockout model for anoctamin 6 (Ano6), we demonstrate the ..
  54. Jeon J, Paik S, Chun M, Oh U, Kim I. Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS ONE. 2013;8:e67989 pubmed publisher
    ..The transmembrane protein, TMEM16A, also called anoctamin 1 (ANO1), has been recently validated as a CaCC and is widely expressed in various secretory epithelia and ..
  55. Gritli Linde A, Vaziri Sani F, Rock J, Hallberg K, Iribarne D, Harfe B, et al. Expression patterns of the Tmem16 gene family during cephalic development in the mouse. Gene Expr Patterns. 2009;9:178-91 pubmed publisher
    b>Tmem16a, Tmem16c, Tmem16f, Tmem16h and Tmem16k belong to the newly identified Tmem16 gene family encoding eight-pass transmembrane proteins. We have analyzed the expression patterns of these genes during mouse cephalic development...
  56. Bernstein K, Vink J, Fu X, Wakita H, Danielsson J, Wapner R, et al. Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility. Am J Obstet Gynecol. 2014;211:688.e1-10 pubmed publisher
    To determine the presence of calcium activated chloride channels anoctamin 1 (ANO1) and 2 (ANO2) in human and murine uterine smooth muscle (MUSM) and evaluate the physiologic role for these ion channels in murine myometrial contractility...
  57. Yu K, Zhu J, Qu Z, Cui Y, Hartzell H. Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin. J Gen Physiol. 2014;143:253-67 pubmed publisher
    The Ca(2+)-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of physiological roles, including epithelial fluid secretion...
  58. Lian H, Cheng Y, Wu X. TMEM16A exacerbates renal injury by activating P38/JNK signaling pathway to promote podocyte apoptosis in diabetic nephropathy mice. Biochem Biophys Res Commun. 2017;487:201-208 pubmed publisher
    ..b>Transmembrane protein 16A (TMEM16A) plays an important role in multiple physiological actions...
  59. Cruz Rangel S, De Jesús Pérez J, Aréchiga Figueroa I, Rodríguez Menchaca A, Perez Cornejo P, Hartzell H, et al. Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A. J Physiol. 2017;595:1515-1531 pubmed publisher
    ..b>Transmembrane protein 16A (TMEM16A), also known as ANO1, the pore-forming subunit of a Ca2+ -dependent Cl- ..
  60. Ruppersburg C, Hartzell H. The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis. Mol Biol Cell. 2014;25:1793-807 pubmed publisher
    ..Here we show that the Ca(2+)-activated Cl ((-)) channel anoctamin-1 (ANO1/TMEM16A) is located in the primary cilium and that blocking its channel function pharmacologically or knocking it down ..
  61. Concepcion A, Vaeth M, Wagner L, Eckstein M, Hecht L, Yang J, et al. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. J Clin Invest. 2016;126:4303-4318 pubmed publisher
    ..necessary for agonist-induced chloride secretion and activation of the Ca2+-activated chloride channel (CaCC) anoctamin 1 (ANO1, also known as TMEM16A)...
  62. Zhang C, Li Y, Zhao W, Lifshitz L, Li H, Harfe B, et al. The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med. 2013;187:374-81 pubmed publisher
    ..b>Transmembrane protein 16A (TMEM16A) and TMEM16B are Cl((Ca)) channels, and activation of Cl((Ca)) channels in airway smooth muscle ..
  63. Sun M, Sui Y, Li L, Su W, Hao F, Zhu Q, et al. Anoctamin 1 calcium-activated chloride channel downregulates estrogen production in mouse ovarian granulosa cells. Endocrinology. 2014;155:2787-96 pubmed publisher
    ..The purpose of this study was to explore the expression and function of the Anoctamin 1 (ANO1) calcium-activated chloride channel (CaCC) in mouse ovary...
  64. Maurya D, Henriques T, Marini M, Pedemonte N, Galietta L, Rock J, et al. Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. PLoS ONE. 2015;10:e0129171 pubmed publisher
    b>TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development...
  65. Paulino C, Neldner Y, Lam A, Kalienkova V, Brunner J, Schenck S, et al. Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. elife. 2017;6: pubmed publisher
    The calcium-activated chloride channel TMEM16A is a member of a conserved protein family that comprises ion channels and lipid scramblases...
  66. Lee J, Jung J, Tak M, Wee J, Lee B, Jang Y, et al. Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium. Pflugers Arch. 2015;467:1677-87 pubmed publisher
    b>Anoctamin 1 (ANO1)/TMEM16A is a Cl(-) channel activated by intracellular Ca(2+) mediating numerous physiological functions. However, little is known of the ANO1 activation mechanism by Ca(2+)...
  67. Wang H, Lin C, Cheung R, Zhang Hooks Y, Agarwal A, Ellis Davies G, et al. Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells. Cell. 2015;163:1348-59 pubmed publisher
    ..ATP stimulates purinergic autoreceptors in ISCs, triggering Cl(-) efflux and osmotic cell shrinkage by opening TMEM16A Ca(2+)-activated Cl(-) channels...
  68. Dauner K, Lissmann J, Jeridi S, Frings S, Möhrlen F. Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose. Cell Tissue Res. 2012;347:327-41 pubmed publisher
    ..Two family members,ANO 1 (TMEM16A) and ANO 2 (TMEM16B), are expressed in the various sensory and respiratory tissues of the nose...
  69. Ma M, Gao M, Guo K, Wang M, Li X, Zeng X, et al. TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase-Derived Reactive Oxygen Species Generation in Hypertension. Hypertension. 2017;69:892-901 pubmed publisher
    ..However, the role of TMEM16A in vascular endothelial dysfunction during hypertension is unclear...
  70. Maurya D, Menini A. Developmental expression of the calcium-activated chloride channels TMEM16A and TMEM16B in the mouse olfactory epithelium. Dev Neurobiol. 2014;74:657-75 pubmed publisher
    ..Calcium-activated chloride channels are involved in several physiological processes including olfactory perception. TMEM16A and TMEM16B, members of the transmembrane protein 16 family (TMEM16), are responsible for calcium-activated ..