Gene Symbol: Ankrd26
Description: ankyrin repeat domain 26
Alias: 5730521P14Rik, BC008111, mKIAA1074, ankyrin repeat domain-containing protein 26
Hahn Y, Bera T, Pastan I, Lee B. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. Gene. 2006;366:238-45 pubmed
..We identified by a database search a group of additional human ankyrin repeat domain proteins, of which ANKRD26 and ANKRD30A are the best characterized; these are more distant homologs of POTE family proteins...
Fei Z, Bera T, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem. 2011;286:27761-8 pubmed publisher
We previously reported that partial disruption of the Ankrd26 gene in mice leads to hyperphagia and leptin-resistant obesity...
Raciti G, Bera T, Gavrilova O, Pastan I. Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Diabetologia. 2011;54:2911-22 pubmed publisher
b>ANKRD26 is a newly described gene located at 10p12 in humans, a locus that has been identified with some forms of hereditary obesity...
Bera T, Liu X, Yamada M, Gavrilova O, Mezey E, Tessarollo L, et al
. A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008;105:270-5 pubmed
..We have been investigating the function of a family of genes (POTE and ANKRD26) that encode proteins that are associated with the inner aspect of the cell membrane and that contain both ..
Liu X, Bera T, Kahue C, Escobar T, Fei Z, Raciti G, et al
. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PLoS ONE. 2012;7:e38130 pubmed publisher
Partial inactivation of the Ankyrin repeat domain 26 (Ankrd26) gene causes obesity and diabetes in mice and increases spontaneous and induced adipogenesis in mouse embryonic fibroblasts...
Acs P, Bauer P, Mayer B, Bera T, Macallister R, Mezey E, et al
. A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice. Brain Struct Funct. 2015;220:1511-28 pubmed publisher
..The human gene ANKRD26 is located on 10p12, a locus that is associated with some forms of hereditary obesity...
Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al
. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. ..