Gene Symbol: Ang
Description: angiogenin, ribonuclease, RNase A family, 5
Alias: AI385586, Ang1, Rnase5, Rnase5a, angiogenin, RNase 5, angiogenin, ribonuclease A family, member 1, angiogenin-1, ribonuclease 5
Species: mouse
Products:     Ang

Top Publications

  1. Dyer K, Rosenberg H. The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression. Nucleic Acids Res. 2005;33:1077-86 pubmed
    ..The RNase 4 and RNase 5/ang 1 shared locus breaks a pattern that is otherwise canonical among the members of the RNase A gene superfamily...
  2. Bond M, Vallee B. Isolation and sequencing of mouse angiogenin DNA. Biochem Biophys Res Commun. 1990;171:988-95 pubmed
    The mouse genomic DNA for angiogenin, a potent blood vessel inducing protein, has been isolated from a bacteriophage library using the human angiogenin gene as a probe...
  3. Brown W, Nobile V, Subramanian V, Shapiro R. The mouse angiogenin gene family: structures of an angiogenin-related protein gene and two pseudogenes. Genomics. 1995;29:200-6 pubmed
    b>Angiogenin, a homologue of pancreatic ribonuclease, is a potent inducer of blood vessel formation...
  4. Holloway D, Hares M, Shapiro R, Subramanian V, Acharya K. High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins. Protein Expr Purif. 2001;22:307-17 pubmed
    b>Angiogenin (Ang) is a small basic protein which belongs to the pancreatic ribonuclease superfamily. It potently induces the formation of new blood vessels and has emerged as a promising anticancer target...
  5. Hooper L, Stappenbeck T, Hong C, Gordon J. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol. 2003;4:269-73 pubmed
    ..We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against ..
  6. Fu H, Feng J, Liu Q, Sun F, Tie Y, Zhu J, et al. Stress induces tRNA cleavage by angiogenin in mammalian cells. FEBS Lett. 2009;583:437-42 pubmed publisher
    ..More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro ..
  7. Subramanian V, Feng Y. A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis. Hum Mol Genet. 2007;16:1445-53 pubmed
    Mutations in human angiogenin (hANG), an angiogenic member of the RNase A superfamily, have been recently reported in patients with amyotrophic lateral sclerosis (ALS), a progressive late-onset neurodegenerative disorder...
  8. Holloway D, Chavali G, Hares M, Subramanian V, Acharya K. Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies. Acta Crystallogr D Biol Crystallogr. 2005;61:1568-78 pubmed
    b>Angiogenin is an unusual member of the pancreatic ribonuclease superfamily that induces blood-vessel formation and is a promising anticancer target...
  9. Xie J, Wu T, Xu K, Huang I, Cleaver O, Huang C. Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol. 2009;175:1315-27 pubmed publisher

More Information


  1. Apte S, Fukai N, Beier D, Olsen B. The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. J Biol Chem. 1997;272:25511-7 pubmed
    ..The stringent co-expression of these two genes suggests common regulatory pathways that may have important functional implications for the activation of pro-gelatinase A in health and disease. ..
  2. Goncalves K, Silberstein L, Li S, Severe N, Hu M, Yang H, et al. Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell. 2016;166:894-906 pubmed publisher
    ..Here, we define a novel mechanism by which a niche-secreted RNase, angiogenin (ANG), distinctively alters the functional characteristics of primitive hematopoietic stem/progenitor cellsĀ (..
  3. Hare L, Schwarz Q, Wiszniak S, Gurung R, Montgomery K, Mitchell C, et al. Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Dev Biol. 2015;404:14-26 pubmed publisher
    ..Our results confirm the lethality associated with heterozygous expression of the Pik3ca(H1047R) mutation during development and likely explain the lack of inherited germline PIK3CA mutations in humans. ..
  4. Yamasaki S, Ivanov P, Hu G, Anderson P. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol. 2009;185:35-42 pubmed publisher
    ..We show that angiogenin, a secreted ribonuclease, is required for stress-induced production of tiRNAs...
  5. Ibaragi S, Yoshioka N, Kishikawa H, Hu J, Sadow P, Li M, et al. Angiogenin-stimulated rRNA transcription is essential for initiation and survival of AKT-induced prostate intraepithelial neoplasia. Mol Cancer Res. 2009;7:415-24 pubmed publisher
    b>Angiogenin (ANG), originally identified as an angiogenic ribonuclease, has recently been shown to play a direct role in prostate cancer cell proliferation by mediating rRNA transcription...
  6. Han R, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, et al. Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?. Circ Res. 2004;94:1115-23 pubmed
    ..We conclude that eNOS plays a previously unrecognized role in lung development, which may have relevance for clinical syndromes of neonatal respiratory distress. ..
  7. Hamada K, Sasaki T, Koni P, Natsui M, Kishimoto H, Sasaki J, et al. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 2005;19:2054-65 pubmed
    ..phenotypes depend strongly on p110gamma rather than on p85alpha and were associated with decreased expression of Ang-1, VCAM-1, connexin 40, and ephrinB2 but increased expression of Ang-2, VEGF-A, VEGFR1, and VEGFR2...
  8. Yang W, Yang D, Na S, Sandusky G, Zhang Q, Zhao G. Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005;280:9330-5 pubmed
  9. Billingsley G, Cox D, Duncan A, Goodfellow P, Grzeschik K. Regional localization of loci on chromosome 14 using somatic cell hybrids. Cytogenet Cell Genet. 1994;66:33-8 pubmed
    ..This study also defines a hybrid cell panel with seven mapping intervals, that will be useful for further physical mapping of new loci. ..
  10. De Franco M, Carneiro P, Peters L, Vorraro F, Borrego A, Ribeiro O, et al. Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice. Mamm Genome. 2007;18:263-9 pubmed
    ..QTL analysis has detected two inflammatory loci modulating ear wound healing on chromosomes 1 and 14. These results suggest the involvement of the acute inflammation modifier QTL in the wound-healing phenotype. ..
  11. Kieran D, Sebastia J, Greenway M, King M, Connaughton D, Concannon C, et al. Control of motoneuron survival by angiogenin. J Neurosci. 2008;28:14056-61 pubmed publisher
    Mutations in the hypoxia-inducible factor angiogenin (ANG) have been identified in Amyotrophic Lateral Sclerosis (ALS) patients, but the potential role of ANG in ALS pathogenesis was undetermined...
  12. Peters K, Kontos C, Lin P, Wong A, Rao P, Huang L, et al. Functional significance of Tie2 signaling in the adult vasculature. Recent Prog Horm Res. 2004;59:51-71 pubmed
    ..domain (ExTek) was designed that blocked the activation of Tie2 by its activating ligand, angiopoietin 1 (Ang1)...
  13. Steinhelper M, Field L. Assignment of the angiogenin gene to mouse chromosome 14 using a rapid PCR-RFLP mapping technique. Genomics. 1992;12:177-9 pubmed
  14. Joyal J, Nim S, Zhu T, Sitaras N, Rivera J, Shao Z, et al. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med. 2014;20:1165-73 pubmed publisher
    ..In contrast, classical plasma membrane activation of F2rl1 leads to the expression of distinct genes, including Ang1, that are involved in vessel maturation...
  15. Li L, Pan X, Shu J, Jiang R, Zhou Y, Chen J. Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway. Biochimie. 2014;103:89-100 pubmed publisher
    ..RI could suppress activities of ribonuclease and angiogenin (ANG) through closely combining with them...
  16. Koike S, Keino Masu K, Masu M. Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway. Biochem Biophys Res Commun. 2010;400:66-71 pubmed publisher
    ..These results reveal the signal transduction defects that underlie the abnormalities in Enpp2(-/-) embryos. ..
  17. Sebastia J, Kieran D, Breen B, King M, Netteland D, Joyce D, et al. Angiogenin protects motoneurons against hypoxic injury. Cell Death Differ. 2009;16:1238-47 pubmed publisher
    ..We have recently identified mutations in the hypoxia-responsive gene, angiogenin (ANG), in ALS patients, and have shown that ANG is constitutively expressed in motoneurons...
  18. Bai Y, Cui M, Meng Z, Shen L, He Q, Zhang X, et al. Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway. Biochem Biophys Res Commun. 2009;378:296-301 pubmed publisher
    ..Neurogenesis is linked to angiogenesis via certain growth factors. We propose that angiopoietin-1 (Ang1), which is similar to VEGF, has a unique role in neurogenesis independent of its role in angiogenesis...
  19. Dyer K, Rosenberg H. The RNase a superfamily: generation of diversity and innate host defense. Mol Divers. 2006;10:585-97 pubmed
    ..leukocytes, (2) RNase 7, an anti-pathogen ribonuclease identified in human skin, and (3) RNase 5, also known as angiogenin, another rapidly-evolving ribonuclease known to promote blood vessel growth with recently-discovered ..
  20. Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida Araki K, et al. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004;279:34741-9 pubmed
    ..These results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development. ..
  21. Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004;18:901-11 pubmed
    ..This indicates that Hey1/Hey2 are essential transducers of Notch signals in cardiovascular development that may mediate arterial cell fate decision. ..
  22. Ardelt A, McCullough L, Korach K, Wang M, Munzenmaier D, Hurn P. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke. 2005;36:337-41 pubmed
    ..Brain angiopoietin-1 (Ang-1), Ang-2, Tie-1, Tie-2, vascular endothelial growth factor (VEGF), VEGF R1, and VEGF R2 mRNA levels were ..
  23. Baumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, et al. Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood. 2006;107:4754-62 pubmed
    ..No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling. ..
  24. Liu S, Young S, Varisco B. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol. 2014;306:L1104-16 pubmed publisher
    ..At PND7 and PND14, 60-95% of angiogenin(+) cells were associated with elastin remodeling...
  25. Iyer S, Holloway D, Acharya K. Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues. FEBS J. 2013;280:302-18 pubmed publisher
    b>Angiogenin (Ang) is a potent inducer of neovascularization. Point mutations in human Ang have been linked to cancer progression and two neurodegenerative diseases: amyotrophic lateral sclerosis and Parkinson's disease...
  26. Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, et al. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol. 2011;178:2897-909 pubmed publisher
    ..or iv) leakage after bradykinin challenge in the presence of vascular stabilization by the angiopoietin-1 (Ang1) mimic COMP-Ang1 for 7 days...
  27. Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, et al. Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice. Am J Physiol Renal Physiol. 2010;299:F991-F1003 pubmed publisher
    ATRAP [ANG II type 1 receptor (AT1R)-associated protein] is a molecule which directly interacts with AT1R and inhibits AT1R signaling...
  28. Ibaragi S, Yoshioka N, Li S, Hu M, Hirukawa S, Sadow P, et al. Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription. Clin Cancer Res. 2009;15:1981-8 pubmed publisher
    b>Angiogenin (ANG) undergoes nuclear translocation and stimulates rRNA transcription in both prostate cancer cells and endothelial cells...
  29. Yoshida T, Semprun Prieto L, Wainford R, Sukhanov S, Kapusta D, Delafontaine P. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. 2012;153:1411-20 pubmed publisher
    Angiotensin II (Ang II), which is elevated in many chronic disease states such as end-stage renal disease and congestive heart failure, induces cachexia and skeletal muscle wasting by increasing muscle protein breakdown and reducing food ..
  30. Liu S, Lv J, Han L, Ichikawa T, Wang W, Li S, et al. A pro-inflammatory role of deubiquitinating enzyme cylindromatosis (CYLD) in vascular smooth muscle cells. Biochem Biophys Res Commun. 2012;420:78-83 pubmed publisher
  31. Skorupa A, King M, Aparicio I, Dussmann H, Coughlan K, Breen B, et al. Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. J Neurosci. 2012;32:5024-38 pubmed publisher
    ..Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder affecting motoneurons. Mutations in angiogenin, encoding a member of the pancreatic RNase A superfamily, segregate with ALS...
  32. Wang G, Coleman C, Chan J, Faraco G, Marques Lopes J, Milner T, et al. Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. Am J Physiol Regul Integr Comp Physiol. 2013;304:R1096-106 pubmed publisher
    ..may play a role in the neurohumoral dysfunction underlying the hypertension induced by "slow-pressor" ANG II infusion...
  33. Zhou N, Fan W, Li M. Angiogenin is expressed in human dermal papilla cells and stimulates hair growth. Arch Dermatol Res. 2009;301:139-49 pubmed publisher
    ..The goal of this study was to examine the expression of angiogenin, a potent angiogenic factor, in human DPCs, and to determine its role in hair growth...
  34. Fuxe J, Lashnits E, O Brien S, Baluk P, Tabruyn S, Kuhnert F, et al. Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation. Am J Pathol. 2010;176:2009-18 pubmed publisher
    ..pulmonis-infected mouse airways. Similar to M. pulmonis infection, systemic overexpression of angiopoietin-1 (Ang1) resulted in remodeling of airway capillaries into venular-like vessels that expressed venous markers like P-..
  35. Gu H, Cui M, Bai Y, Chen F, Ma K, Zhou C, et al. Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells. Biochem Biophys Res Commun. 2010;392:178-82 pubmed publisher
    Angiopoietin-1 (Ang1) is a ligand for the endothelial-specific tyrosine kinase receptor Tie2 and has been shown to play an essential role in embryonic vasculature development...
  36. Bond M, Strydom D, Vallee B. Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim Biophys Acta. 1993;1162:177-86 pubmed
    ..Like human angiogenin they display extremely low ribonucleolytic activities toward wheat-germ RNA, yeast RNA, poly(C) and poly(U)...