Gene Symbol: Anapc1
Description: anaphase promoting complex subunit 1
Alias: 2610021O03Rik, AI047775, AI853536, AW547281, Apc1, Mcpr, tsg24, anaphase-promoting complex subunit 1, cyclosome subunit 1, meiotic check point regulator, mitotic checkpoint regulator, testis-specific gene 24 protein
Starborg M, Brundell E, Gell K, Hoog C. A novel murine gene encoding a 216-kDa protein is related to a mitotic checkpoint regulator previously identified in Aspergillus nidulans. J Biol Chem. 1994;269:24133-7 pubmed
..The bimE gene has been shown to be a mitotic checkpoint regulator, negatively regulating entry into mitosis in A. nidulans...
Jorgensen P, Gräslund S, Betz R, Stahl S, Larsson C, Hoog C. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene. 2001;262:51-9 pubmed
..We have previously investigated the mouse Apc1 protein (previously also called Tsg24), the largest subunit of the APC/C...
Davis E, Wille L, Chestnut B, Sadler P, Shakes D, Golden A. Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Genetics. 2002;160:805-13 pubmed
..Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion. ..
Sun J, Karoulia Z, Wong E, Ahmed M, Itoh K, Xu P. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol. 2013;33:927-36 pubmed publisher
..Together, our results indicate that anaphase-promoting complex/cyclosome (APC/C)-Cdh1 specifically targets EYA1 for degradation during M-to-G(1) transition, failure of which may compromise cell proliferation and survival. ..
Cao J, Dai X, Wan L, Wang H, Zhang J, Goff P, et al
. The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Sci Signal. 2015;8:ra87 pubmed publisher
..Thus, our findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma. ..
Fan M, Rhee J, St Pierre J, Handschin C, Puigserver P, Lin J, et al
. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 2004;18:278-89 pubmed
..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes. ..