Gene Symbol: Ampd3
Description: adenosine monophosphate deaminase 3
Alias: AMP deaminase 3, AMP deaminase H-type, heart-type AMPD
Species: mouse
Products:     Ampd3

Top Publications

  1. Cheng J, Morisaki H, Toyama K, Ikawa M, Okabe M, Morisaki T. AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency. Genes Cells. 2012;17:913-22 pubmed publisher
    ..Human AMPD3 deficiency is a type of erythrocyte-specific enzyme deficiency found in individuals without clinical symptoms, ..
  2. Wang X, Morisaki H, Sermsuvitayawong K, Mineo I, Toyama K, Ogasawara N, et al. Cloning and expression of cDNA encoding heart-type isoform of AMP deaminase. Gene. 1997;188:285-90 pubmed
    ..The coding region of this cDNA was quite homologous to the human AMPD3 gene which encodes the erythrocyte-type (E) isoform of AMPD, although the H-isoform of rodent AMPD was reported to ..
  3. Li P, Ogino K, Hoshikawa Y, Morisaki H, Cheng J, Toyama K, et al. Remote reperfusion lung injury is associated with AMP deaminase 3 activation and attenuated by inosine monophosphate. Circ J. 2007;71:591-6 pubmed
    ..AMPD activity, myeloperoxidase (MPO) activity, IMP, AMPD3 mRNA and tumor necrosis factor (TNF)-alpha in the lungs before and after reperfusion were analyzed...
  4. Lee S, Wang Y, Kim S, Han J. AMPD3 is involved in anthrax LeTx-induced macrophage cell death. Protein Cell. 2011;2:564-72 pubmed publisher
    ..b>AMP deaminase 3 (AMPD3), an enzyme that converts AMP to IMP, was identified to be mutated in one of the resistant clones...
  5. Yi K, Rubinstein B, Unruh J, Guo F, Slaughter B, Li R. Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. J Cell Biol. 2013;200:567-76 pubmed publisher
  6. Li P, Ogino K, Hoshikawa Y, Morisaki H, Toyama K, Morisaki T, et al. AMP deaminase 3 plays a critical role in remote reperfusion lung injury. Biochem Biophys Res Commun. 2013;434:131-6 pubmed publisher
    ..However, the function of Ampd2 and Ampd3 subtype has not been elucidated in remote reperfusion rodent lung injury...
  7. Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, et al. AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 2013;154:505-17 pubmed publisher
    ..These data suggest AMPD2-related PCH as a potentially treatable early-onset neurodegenerative disease. ..
  8. Daniels I, O Brien W, Nath V, Zhao Z, Lee C. AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism. PLoS ONE. 2013;8:e75418 pubmed publisher
    ..To test this hypothesis, we generated mice deficient in adenosine monophosphate deaminase 3 (AMPD3), the key catabolic enzyme for 5'-AMP in erythrocytes...
  9. Rybakowska I, Romaszko P, Zabielska M, Turyn J, Kaletha K, Barton P, et al. Effect of AMP-deaminase 3 knock-out in mice on enzyme activity in heart and other organs. Nucleosides Nucleotides Nucleic Acids. 2014;33:319-22 pubmed publisher
    ..b>AMPD3 floxed mice were crossed with Mer-Cre-Mer mice. Tamoxifen was injected to induce Cre recombinase...

More Information


  1. O Brien W, Berka V, Tsai A, Zhao Z, Lee C. CD73 and AMPD3 deficiency enhance metabolic performance via erythrocyte ATP that decreases hemoglobin oxygen affinity. Sci Rep. 2015;5:13147 pubmed publisher
    ..of endogenous erythrocyte AMP levels modulates systemic metabolism, we generated mice deficient in both CD73 and AMPD3, the key catabolic enzymes for extracellular and intra-erythrocyte AMP, respectively...
  2. Hortle E, Nijagal B, Bauer D, Jensen L, Ahn S, Cockburn I, et al. Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice. Blood. 2016;128:1290-301 pubmed publisher
    ..N-ethyl-N-nitrosourea-induced mutation that causes a gain of function in adenosine 5'-monophosphate deaminase (AMPD3)...
  3. Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, et al. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017;23:223-234 pubmed publisher HDAC3-depleted muscles, a fuel switch caused by the activation of anaplerotic reactions driven by AMP deaminase 3 (Ampd3) and catabolism of branched-chain amino acids...
  4. O Brien W, Ling H, Zhao Z, Lee C. New insights on the regulation of the adenine nucleotide pool of erythrocytes in mouse models. PLoS ONE. 2017;12:e0180948 pubmed publisher
    ..adenine nucleotide levels corresponding to altered oxygen saturation in mice deficient in both CD73 and AMPD3. Here we further investigate how these Ampd3-/-/Cd73-/- mice respond to the administered dose of AMP in comparison ..
  5. Sermsuvitayawong K, Wang X, Nagabukuro A, Matsuda Y, Morisaki H, Toyama K, et al. Genomic organization of Ampd3, heart-type AMPD gene, located in mouse chromosome 7. Mamm Genome. 1997;8:767-9 pubmed