Gene Symbol: Amotl2
Description: angiomotin-like 2
Alias: AW549739, C79691, Lccp, MASCOT, mKIAA0989, angiomotin-like protein 2, Leman coiled-coil protein
Species: mouse
Products:     Amotl2

Top Publications

  1. Patrie K. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Biochim Biophys Acta. 2005;1745:131-44 pubmed
    ..Because of its interaction with MAGI-1 and its localization to cell-cell junctions, this novel protein has been given the name MAGI-1-associated coiled-coil tight junction protein (MASCOT).
  2. Sugihara Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, et al. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells. 2007;12:473-86 pubmed
    ..Using yeast two-hybrid screening, we found here that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, which we refer to as Amot/JEAP family proteins...
  3. Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, et al. AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun. 2014;5:3743 pubmed publisher
    ..Here we provide evidence that the scaffold protein amotL2 is needed for aortic vessel lumen expansion...
  4. Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, et al. The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep. 2017;7:9540 pubmed publisher
    ..In this report we show that p100 amotL2 forms a complex with E-cadherin that associates with radial actin filaments connecting cells over multiple layers...
  5. Wang Y, Li Z, Xu P, Huang L, Tong J, Huang H, et al. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J Biol Chem. 2011;286:41095-104 pubmed publisher
    Angiogenesis involves sprouting, migration, and proliferation of endothelial cells. The angiomotin-like2 gene (amotl2) has been found in blood vessels in zebrafish embryos, but its function in angiogenesis and underlying mechanisms remain ..
  6. Gewies A, Castineiras Vilarino M, Ferch U, Jährling N, Heinrich K, Hoeckendorf U, et al. Prdm6 is essential for cardiovascular development in vivo. PLoS ONE. 2013;8:e81833 pubmed publisher
    ..We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development. ..
  7. Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, et al. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 2009;113:244-53 pubmed publisher
    ..Taken together, our results indicate that the directional migration of capillaries in the embryo is governed by the Amot:Patj/Mupp1:Syx signaling that controls local GTPase activity. ..
  8. Zhao B, Li L, Lu Q, Wang L, Liu C, Lei Q, et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011;25:51-63 pubmed publisher
    ..Knockdown of AMOT family protein AMOTL2 in polarized Madin-Darby canine kidney (MDCK) cells leads to YAP activation, as indicated by decreased YAP tight ..
  9. Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, et al. Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev. 2007;21:2055-68 pubmed
    ..Our data demonstrate a critical role for Amot during vascular patterning and endothelial polarization. ..

More Information


  1. Mojallal M, Zheng Y, Hultin S, Audebert S, van Harn T, Johnsson P, et al. AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. Nat Commun. 2014;5:4557 pubmed publisher
    ..Here we show that AmotL2 expression correlates with loss of tissue architecture in tumours from human breast and colon cancer patients...
  2. Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
    ..This work uncovers a mechanism for the restriction of heart growth at birth, a process which impedes the regenerative potential of the mammalian heart. ..
  3. Matsumoto H, Fukui E, Yoshizawa M, Sato E, Daikoku T. Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. J Reprod Dev. 2012;58:649-53 pubmed
    ..Amot and Amotl1 were expressed in the stromal cells on days 3 and 4; expressions of Amotl2 during the same period were low...
  4. Artinian N, Cloninger C, Holmes B, Benavides Serrato A, Bashir T, Gera J. Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness. J Biol Chem. 2015;290:19387-401 pubmed publisher
    ..Utilizing a gene-trapping strategy in a mouse glioma model, we report the identification of AMOTL2 as a candidate substrate for mTORC2. AMOTL2 is phosphorylated at serine 760 by mTORC2...
  5. Poncy A, Antoniou A, Cordi S, Pierreux C, Jacquemin P, Lemaigre F. Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015;404:136-48 pubmed publisher
    ..We conclude that SOX4 is a new regulator of liver development and that it exerts a pleiotropic control on bile duct development in cooperation with SOX9. ..
  6. Bratt A, Wilson W, Troyanovsky B, Aase K, Kessler R, Van Meir E, et al. Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Gene. 2002;298:69-77 pubmed
    ..These two genes have been named angiomotin-like 1 (amotl1) and angiomotin-like 2 (amotl2). We have cloned mouse angiomotin and identified amotl1 and amotl2 homologs in mice...